Comparative metabolism of Lappaconitine in rat and human liver microsomes and in vivo of rat using ultra high-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry

- 51 metabolites of Lappaconitine were detected in rats and human, and 48 metabolites were firstly identified.
- The metabolic fate of Lappaconitine in liver microsomes of rats and human was compared.
- The metabolic pathways of Lappaconitine in rats after oral administration were also investigated.