
An overview of experimental designs in HPLC method development and validation
Keywords: 2D-HPLC; two-dimensional HPLC; AEMC; anion-exchange membrane chromatography; ANOVA; analysis of variance; BBD; Box-Behnken design; CC; chaotropic chromatography; CCD; central composite Design; CEX-HPLC; cation exchange high performance liquid chromatograp