کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6138522 | 1594219 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Lyssavirus glycoprotein: A key to cross-immunity
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کلمات کلیدی
RABVmAbsRSAPEPASAVSVRIGG protein - جی پروتئینCross-neutralization - خنثی سازی صلیبRelative solvent accessibility - دسترسی پذیری نسبیWorld Health Organization - سازمان بهداشت جهانیaccessible surface area - سطح دسترسی قابل دسترسRabies - هاریVesicular stomatitis virus - ویروس vesicular stomatitisLyssavirus - ویروس لیساRabies virus - ویروس هاریMonoclonal antibodies - پادتنهای تَکتیرهPost-exposure prophylaxis - پیشگیری از پس از مواجههWHO - کهGlycoprotein - گلیکوپروتئین
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Rabies is an acute viral encephalomyelitis in warm-blooded vertebrates, caused by viruses belonging to Rhabdovirus family and genus Lyssavirus. Although rabies is categorised as a neglected disease, the rabies virus (RABV) is the most studied amongst Lyssaviruses which show nearly identical infection patterns. In efforts to improving post-exposure prophylaxis, several anti-rabies monoclonal antibodies (mAbs) targeting the glycoprotein (G protein) sites I, II, III and G5 have been characterized. To explore cross-neutralization capacity of available mAbs and discover new possible B-cell epitopes, we have analyzed all available glycoprotein sequences from Lyssaviruses with a focus on sequence variation and conservation. This information was mapped on the structure of a representative G protein. We proposed several possible cross-neutralizing B-cell epitopes (GUVTTTF, WLRTV, REECLD and EHLVVEEL) in complement to the already well-characterized antigenic sites. The research could facilitate development of novel cross-reactive mAbs against RABV and even more broad, against possibly all Lyssavirus members.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 498, November 2016, Pages 250-256
Journal: Virology - Volume 498, November 2016, Pages 250-256
نویسندگان
Sindisiwe G. Buthelezi, Heini W. Dirr, Ereck Chakauya, Rachel Chikwamba, Lennart Martens, Tsepo L. Tsekoa, Stoyan H. Stoychev, Elien Vandermarliere,