دانلود مقالات ISI درباره حداکثر غلظت پلاسما + ترجمه فارسی

Adaptation of the quality by design concept in early pharmaceutical development of an intranasal nanosized formulation

Keywords: حداکثر غلظت پلاسما; API; active pharmaceutical ingredient; Cmax; maximum plasma concentration; CQA; critical quality attribute; CPP; critical process parameter; EMA; European Medicines Agency; FDA; Food and Drug Administration; HA; sodium hyaluronate; ICH; International Conf

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2015 سفارش ترجمه

Liquid chromatography-tandem mass spectrometric assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma

Keywords: حداکثر غلظت پلاسما; AUC0−∞; area under the plasma concentration-time curve; CDK; cyclin-dependent kinase; Cmax; maximum plasma concentration; EDTA; ethylenediaminetetraacetic acid; i.p.; intraperitoneal; IS; internal standard; MYCN; V-myc myelocytomatosis viral related

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Ex vivo reversal of the anticoagulant effects of edoxaban

Keywords: حداکثر غلظت پلاسما; aPTT; Activated partial thromboplastin time; Cmax; Maximum plasma concentration; FEIBA; Factor VIII inhibitor bypass activity; FEU; Fibrinogen equivalent units; FX; Factor X; FXa; Factor Xa; LMWH; Low-molecular-weight heparin; NOACs; Novel oral anticoagul

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Simplified LC-MS/MS method enabling the determination of azithromycin in human plasma after a low 100 mg dose administration

Keywords: حداکثر غلظت پلاسما; AZI; azithromycin; Cmax; maximum plasma concentration; D-AZI; descladinose azithromycin; IS; internal standard; LLE; liquid-liquid extraction; m/z; mass/charge ratio; n; number of observations; Azithromycin; Liquid chromatography/tandem mass spectrometr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Non-clinical pharmacokinetics and pharmacodynamics of rVIII-SingleChain, a novel recombinant single-chain factor VIII

Keywords: حداکثر غلظت پلاسما; AUC; area under the observed average plasma concentration vs. time curve; AUC0-last; AUC up to the last quantifiable sampling time; CI; confidence interval; CL; clearance; Cmax; maximum plasma concentration; ELISA; enzyme-linked immunosorbent assay; FL; f

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Influence of the physiological variability of fasted gastric pH and tablet retention time on the variability of in vitro dissolution and simulated plasma profiles

Keywords: حداکثر غلظت پلاسما; BCS; biopharmaceutics classification system; Cmax; maximum plasma concentration; GI; gastrointestinal; IIV; interindividual variability; IOV; interoccasion variability; MMC; migrating motoric complex; RSD; relative standard deviation; Gastric pH variabili

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

A study of Semen Strychni-induced renal injury and herb-herb interaction of Radix Glycyrrhizae extract and/or Rhizoma Ligustici extract on the comparative toxicokinetics of strychnine and brucine in rats

Keywords: حداکثر غلظت پلاسما; AUC; area under concentration-time curve; Cmax; maximum plasma concentration; CYP450; cytochrome P450; P-gp; P-glycoprotein; CMC-Na; sodium carboxymethylcellulose; IS; internal standard; RG; Radix Glycyrrhizae; RL; Rhizoma Ligustici; GL; Radix Glycyrrhi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA)

Keywords: حداکثر غلظت پلاسما; GCP-II; glutamate carboxypeptidase-II; PSMA; prostate specific membrane antigen; NAALADase; N-acetylated-alpha-linked acidic dipeptidase; NAAG; N-acetyl-aspartyl glutamate; 2-PMPA; 2-phosphonomethyl pentanedioic acid; 2-PMSA; 2-phosphonomethyl succinic ac

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Toxicokinetic study and absolute oral bioavailability of deoxynivalenol, T-2 toxin and zearalenone in broiler chickens

Keywords: حداکثر غلظت پلاسما; α-ZAL; α-zearalanol; α-ZEL; α-zearalenol; β-ZAL; β-zearalanol; β-ZEL; β-zearalenol; ACN; acetonitrile; AUC; area under the plasma concentration-time curve; BW; body weight; Cl; clearance; Cmax; maximum plasma concentration; DON; deoxynivalenol;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: Examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia

Keywords: حداکثر غلظت پلاسما; 5-HT2; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; AM; allosteric modulator; AUC; area under curve; AUCINF; area under curve extrapolated to infinity; AUClast; area under curve from dosing to observation; AUMC; area under first moment curve; CL; total

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacokinetics, pharmacodynamics and toxicity of a combination of metoprolol succinate and telmisartan in Wistar albino rats: Safety profiling

Keywords: حداکثر غلظت پلاسما; LC-MS/MS; Liquid Chromatography-Mass Spectroscopy/Mass Spectroscopy; MET; metoprolol succinate; TEL; telmisartan; IS; Internal Standard; CPCSEA; Committee for the Purpose of Control and Supervision of Experiments on Animals; IAEC; Institutional Animal

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signaling pathways

Keywords: حداکثر غلظت پلاسما; Cmax; maximum plasma concentration; COX-2; cyclooxygenase-2; Erk1/2; extracellular signal-regulated kinase 1/2; IκB; inhibitor κB; IL-6; interleukin-6; iNOS; inducible nitric oxide synthase; JNK; c-Jun NH2-terminal kinase; LDH; lactate dehydrogenase; LP

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Potential for food-drug interactions by dietary phenolic acids on human organic anion transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11)

Keywords: حداکثر غلظت پلاسما; ACN; anthocyanin; BCRP; breast cancer resistance protein; Cmax; maximum plasma concentration; CHO; Chinese hamster ovary; DDI; drug-drug interaction; ES; estrone sulfate; fu; fraction unbound in plasma; FDA; Food and Drug Administration; HEK; human embr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Loading 3-deazaneplanocin A into pegylated unilamellar liposomes by forming transient phenylboronic acid-drug complex and its pharmacokinetic features in Sprague-Dawley rats

Keywords: حداکثر غلظت پلاسما; ANOVA; one-way analysis of variance; AUC0-∞; area under the concentration-time curve from time zero to infinity; BW; body weight; cis diol; vicinal hydroxyl groups; CL; clearance; Cmax; maximum plasma concentration; Cr; creatinine; DZNep; 3-deazanep

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Oil matrix effects on plasma exposure and urinary excretion of phenolic compounds from tomato sauces: Evidence from a human pilot study

Keywords: حداکثر غلظت پلاسما; ALA; aldehydic form of ligstroside aglycone; ALA ox; aldehydic form of ligstroside aglycone oxidized; AOA; aldehydic form of oleuropein aglycone; AOA ox; aldehydic form of oleuropein aglycone oxidized; AUClast; area under the plasma concentration-versus-t

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Benzocaine-induced methemoglobinemia in an acute-exposure rat model

Keywords: حداکثر غلظت پلاسما; BMD; benchmark dose; BMDL; lower 95% confidence limit of benchmark dose; Cmax; maximum plasma concentration; FDA; US Food and Drug Administration; HPLC; high performance liquid chromatography; McTween; 0.2% methylcellulose and 0.1% polysorbate 80; NOAEL;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia

Keywords: حداکثر غلظت پلاسما; AUC(0-∞); area under concentration-time curve from t = 0 to last time; CL/F; apparent clearance; Cmax; maximum plasma concentration; CSS; Chaihu-Shugan-San; C-t; concentration-time; FA; ferulic acid; FD; functional dyspepsia; GE; gastric empty

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: Essential roles of CYP2A5 and target-tissue metabolic activation

Keywords: حداکثر غلظت پلاسما; P450 or CYP; cytochrome P450; CPR; NADPH-cytochrome P450 reductase; GC; gas chromatography; MS; mass spectrometry; HPLC; high-performance liquid chromatography; AUC; area under the concentration-time curve; Cmax; maximum plasma concentration; Tmax; time w

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

P-glycoprotein and cytochrome P450 3A4 involvement in risperidone transport using an in vitro Caco-2/TC7 model and an in vivo model

Keywords: حداکثر غلظت پلاسما; ab; apical to basolateral; AQ; absorptive quotient; AUCT; area under the curve; ba; basolateral to apical; ClR; renal clearance; Cmax; maximum plasma concentration; CYP; cytochrome P450; ER; efflux ratio; F; fraction not metabolised; FA; fraction absorbed

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Neurochemical, pharmacokinetic, and behavioral effects of the novel selective serotonin reuptake inhibitor BMS-505130

Keywords: حداکثر غلظت پلاسما; nPG; nucleus paragigantocellularis; PE; premature ejaculation; SSRI; selective serotonin reuptake inhibitor; Cmax; maximum plasma concentration; BMS-505130; Microdialysis; Selective serotonin reuptake inhibitor (SSRI); Serotonin transporter (SERT); Tail s

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Pharmacokinetics of DA-8159, a new erectogenic, administered at 10:00 h versus 22:00 h in rats

Keywords: حداکثر غلظت پلاسما; AUC; total area under the plasma concentration-time curve from time zero to time infinity; MRT; mean residence time; CL; time-averaged total body clearance; CLR; time-averaged renal clearance; CLNR; time-averaged nonrenal clearance; Vss; apparent volume

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

New model for intravenous drug administration and blood sampling in the awake rat, designed to increase quality and throughput for in vivo pharmacokinetic analysis

Keywords: حداکثر غلظت پلاسما; ADME; absorption distribution metabolism excretion; AUC; area under the curve; Cl; total plasma clearance; Cmax; maximum plasma concentration; Hct; haematocrit; LC-MS/MS; liquid chromatography coupled to tandem mass spectrometry; NCE; new chemical entity;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

A phase I and pharmacologic study of idarubicin, cytarabine, etoposide, and the multidrug resistance protein (MDR1/Pgp) inhibitor PSC-833 in patients with refractory leukemia

Keywords: حداکثر غلظت پلاسما; AML; acute myeloid leukemia; ALL; acute lymphoblastic leukemia; CR; complete response; PR; partial response; ara-C; cytarabine; MDR1; multidrug resistance; Pgp; P-glycoprotein; SWOG; southwest oncology group; DLT; dose limiting toxicity; MTD; maximum tole

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Human variability in xenobiotic metabolism and pathway-related uncertainty factors for chemical risk assessment: a review

Keywords: حداکثر غلظت پلاسما; ADI; acceptable daily intake; BMD; benchmark dose; CSAF; chemical-specific adjustment factor; LOAEL; low observed adverse effect level; NOAEL; no observed adverse effect level; RfD; reference dose; TDI; tolerable daily intake; AUC; area under the plasma-c

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه