Thrombin induced by the extrinsic pathway and PAR-1 regulated inflammation at the site of fracture repair
Keywords: Thrombin; PAR-1; MCP-1; Migration; Fracture model;
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Inhibition of coagulation proteases Xa and IIa decreases ischemia-reperfusion injuries in a preclinical renal transplantation model
Keywords: α-SMA; α-smooth muscle actin; DCD; donors deceased after cardiac death; EMT; epithelial-mesenchymal transition; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HAEC; human aortic endothelial cell; HES; hematoxylin-eosin-s
Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism
Keywords: CCL2; MCP-1; DRG; Regeneration; Macrophage; Neuroinflammation; STAT3
Anti-obesity effects of Asian dayflower, Commelina communis, in mice with high-fat diet-induced obesity and in 3T3-L1 cells
Keywords: C/EBP; CCAAT/enhancer-binding protein; PPAR; peroxisome proliferator-activated receptor; GLUT; glucose transporter; CCT; C.âcommunis tea; WAT; white adipose tissue; HFD; high-fat diet; LFD; low-fat diet; qPCR; quantitative PCR; TBP; TATA-binding protein
Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity
Keywords: ANOVA; analysis of variance; ATF-1; activating transcription factor-1; CCL-2; chemokine ligand 2; CCL-8; chemokine ligand 8; CCL-18; chemokine ligand 18; CCR-1; chemokine receptor 1; CRBN; cereblon; CRE; cAMP responsive element; CREB; cAMP responsive elem
4â²-O-β-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats
Keywords: 4â²-O-β-D-glucosyl-5-O-methylvisamminol; Phosphatidylinositol-3-kinase; Protein kinase B; Transient middle cerebral artery occlusion; Tumor necrotic factor-α; Bad; Bcl-2-associated death promoter; BrdU; 5-Bromo-2â²-deoxyuridine; BWI; Brain water ind
Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis
Keywords: TGF-β; transforming growth factor β; IL-6; interleukin-6; STAT3; signal-transducer and activator of transcription; RORα; retinoid acid-related orphan receptor α; ICAM-1; intercellular adhesion molecule-1; MCP-1; monocyte chemoattractant protein-1; PGE
Splenectomy exacerbates atrial inflammatory fibrosis and vulnerability to atrial fibrillation induced by pressure overload in rats: Possible role of spleen-derived interleukin-10
Keywords: AAC; abdominal aortic constriction; AF; atrial fibrillation; BCL; basic cycle length; BW; body weight; CD; cluster of differentiation; HW; heart weight; IACT; interatrial conduction time; IL; interleukin; LA; left atrium; MCP-1; monocyte chemoattractant p
1,25(OH)2D3 inhibits oxidative stress and monocyte adhesion by mediating the upregulation of GCLC and GSH in endothelial cells treated with acetoacetate (ketosis)
Keywords: CVD; cardiovascular disease; T1D; type 1 diabetes; VD; vitamin D; AA; acetoacetate; ROS; reactive oxygen species; ICAM-1; intercellular adhesion molecule-1; MCP-1; monocyte chemotactic protein-1; GSH; glutathione; GCLC; glutamate cysteine ligase catalytic
TRESK contributes to pain threshold changes by mediating apoptosis via MAPK pathway in the spinal cord
Keywords: ANOVA; analysis of variance; DRG; dorsal root ganglia; ERK; extracellular signal-regulated kinase; IL; interleukin; JNK; c-Jun N-terminal kinase; K2P; two-pore domain K+; MAPK; mitogen-activated protein kinase; MCP-1; monocyte chemotactic protein-1; MIP-2
Androgen-androgen receptor system improves chronic inflammatory conditions by suppressing monocyte chemoattractant protein-1 gene expression in adipocytes via transcriptional regulation
Keywords: MCP-1; Androgen; Androgen receptor, AR; Adipocyte; Macrophage; Chronic inflammation;
Longxuetongluo capsule inhibits atherosclerosis progression in high-fat diet-induced ApoEâ/â mice by improving endothelial dysfunction
Keywords: Chinese dragon's blood; Longxuetongluo capsule; Anti-atherosclerosis; Endothelial dysfunction; CG; chow diet group; COX-2; cyclooxygenase-2; DMEM; Dulbecco's modified Eagle's medium; EG; ezetimibe-treated group; eNOS; endothelial nitric oxide synthase
A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy
Keywords: AMR; antibody-mediated rejection; AR; acute rejection; CKD; chronic kidney disease; CR; chronic rejection; DSA; donor specific antibodies; IF/TA; interstitial fibrosis/tubular atrophy; KIM-1; kidney injury molecule 1; MCP-1; macrophage chemotactic protein
Terpene glycoside component from Moutan Cortex ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-related inflammatory responses
Keywords: TCM; traditional Chinese Medicine; MC; Moutan Cortex; TG; terpene glycoside; DN; diabetic nephropathy; STZ; streptozotocin; AGEs; advanced glycation end-products; ER; endoplasmic reticulum; 4-PBA; 4-phenylbutyric acid; AG; amino guanidine; TEM; transmissi
Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice
Keywords: ApoEâ/â; apolipoprotein E-deficient; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HCD; high-cholesterol diet; HDL; high-density lipoprotein; HUVEC; human umbilical vein endothelial cells; ICAM-1; intracellular adhesion molecule-1; LDL; low-densi
Stauntoside B inhibits macrophage activation by inhibiting NF-κB and ERK MAPK signalling
Keywords: NO; nitric oxide; PGE2; prostaglandin E2; NSAIDs; non-steroidal anti-inflammatory drugs; qRT-PCR; quantitative real-time polymerase chain reaction; LPS; lipopolysaccharide; IFN-γ; interferon γ; G-CSF; granulocyte colony stimulating factor; TNF-α; tumor
Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice
Keywords: COX-2; cyclooxygenase-2; PGE2; prostaglandin E2;; RCD; regular chow diet; MCD; methionine and choline deficient diet; CCl4; carbon tetrachloride; NAFLD; non-alcoholic fatty liver disease; NL; normal liver; NAS; non-alcoholic steatosis; NASH; non-alcoholic
T helper 17 cells may drive neuroprogression in major depressive disorder: Proposal of an integrative model
Keywords: 5-HT; serotonin; CCL20; chemokine (C-C motif) ligand 20; CCR6; CC-chemokine receptor 6; CNS; central nervous system; CRF; corticotrophin releasing factor; CRP; C-reactive protein; EAE; experimental autoimmune encephalomyelitis; GM-CSF; granulocyte-macroph
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
Keywords: AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor; CXCL; CXC chemokine ligan
Proinflammatory cytokines modulate the chemokine CCL2 (MCP-1) in human annulus cells in vitro: CCL2 expression and production
Keywords: CCL2; MCP-1; Intervertebral disc; Cell culture; TNF-β; IL-1α
Association of monocyte chemoattractant protein 1 (MCP-1) gene polymorphism with lupus nephritis in Egyptian patients
Keywords: MCP-1; ∼2518 gene polymorphism; SLE; Lupus nephritis
The role of Duffy antigen receptor for chemokines in keloids
Keywords: DARC; Duffy antigen receptor for chemokines; CCL2; CC chemokine ligand 2; CXCL8; CXC chemokine ligand 8; MMP2; matrix metalloproteinase 2; DAB; 3, 3â²-diaminobenzidine; ECL; enhanced chemiluminescence; ELISA; enzyme-linked immunosorbent assay analysis; M
Association of neopterin as a marker of immune system activation and juvenile rheumatoid arthritis activity
Keywords: MCP-1; TNF-α; Rheumatoid arthritisMCP-1; FNT-α; Artrite reumatoide
Suppression of methylmercury-induced IL-6 and MCP-1 expressions by N-acetylcysteine in U-87MG human astrocytoma cells
Keywords: Methylmercury; MCP-1; IL-6; N-acetylcysteine; Astrocytes; Reactive oxygen species
Hesperidin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting HMGB1 release
Keywords: Hesperidin; High-mobility group box 1; Acute lung injury; Macrophage; TNF-α; MCP-1
Inhibitory effects of teuclatriol, a sesquiterpene from salvia mirzayanii, on nuclear factor-κB activation and expression of inflammatory mediators
Keywords: Macrophage; Endothelial cell; TNF-α; MCP-1; TLR2; Salvia mirzayanii;
The role of the Th17 cytokines IL-17 and IL-22 in Rheumatoid Arthritis pathogenesis and developments in cytokine immunotherapy
Keywords: IL-17; IL-22; Th17 cells; Rheumatoid Arthritis; Immunotherapy; AIA; antigen-induced arthritis; CCR; c-c chemokine receptor; CIA; collagen-induced arthritis; CRP; C-reactive protein; CTLA-8; cytotoxic T lymphocyte associated antigen 8; DMARDs; disease modi
Serum cytokine profiles of patients with interstitial lung disease associated with anti-CADM-140/MDA5 antibody positive amyopathic dermatomyositis
Keywords: Dermatomyositis; Interstitial lung disease; Cytokine; Chemokine CX3CL1; Ab; antibody; ADM; amyopathic dermatomyositis; CT; computed tomography; CX3CL1; chemokine (C-X3-C motif) ligand 1; EGF; epidermal growth factor; FGF-2; fibroblast growth factors-2; Fl
Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, in Diabetic Macular Edema
Keywords: AE; adverse event; BCVA; best-corrected visual acuity; CI; confidence interval; DME; diabetic macular edema; ETDRS; Early Treatment Diabetic Retinopathy Study; Lp-PLA2; lipoprotein-associated phospholipase A2; lyso-PC; lysophosphatidylcholine; MCP-1; mono
Excessive bile acid activated NF-kappa B and promoted the development of alcoholic steatohepatitis in farnesoid X receptor deficient mice
Keywords: Alcoholic liver disease; Alcoholic steatohepatitis; Farnesoid X receptor; Lieber-DeCarli ethanol diet; FXR; farnesoid X receptor; ALD; alcoholic liver disease; ASH; alcoholic steatohepatitis; ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; CYP2E
Pregnant women infected with pandemic influenza A(H1N1)pdm09 virus showed differential immune response correlated with disease severity
Keywords: A(H1N1)pdm09; pandemic influenza H1N1, 2009; IL; interleukin; IFN-β; interferon beta; MCP-1; monocyte chemoattractant protein 1; TNF-α; tumor necrosis factor-alpha; TGF-β; transforming growth factor-β; Influenza virus; A(H1N1)pdm09; Cytokines; Chemoki
MicroRNA-494 inhibits the growth and angiogenesis-regulating potential of mesenchymal stem cells
Keywords: microRNAs; miRNAs or miRs; miR-494; microRNA-494-3p; MSCs; mesenchymal stem cells; dMSCs; decidua-derived MSCs; PE; preeclampsia; mi-494; miR-494 mimic; mi-NC; miR-494 mimic negative control; si-RNA; small interfering RNA; VEGF; vascular endothelial growt
Fli-1 controls transcription from the MCP-1 gene promoter, which may provide a novel mechanism for chemokine and cytokine activation
Keywords: Transcriptional factors; Gene regulation; Chemokines; Inflammation; Fli-1; MCP-1
Aspirin resistance in adult patients after Fontan surgery
Keywords: FC; Fontan circulation; G-CSF; granulocyte colony-stimulating factor; MCP-1; monocyte chemotactic protein-1; MIP-1β; macrophage inflammatory protein-1β; sVCAM-1; vascular cell adhesion protein 1; SVEF; single ventricle ejection fraction; TAT; thrombin a
Lariciresinol-4-O-β-D-glucopyranoside from the root of Isatis indigotica inhibits influenza A virus-induced pro-inflammatory response
Keywords: IL-6; interleukin-6; IL-8; interleukin-8; MCP-1; monocytes chemotactic factor; IP-10; interferon gamma-induced protein 10; IFN-α; interferon alpha; NF-κB; Nuclear factor-κB; TNF-α; tumor necrosis factor alpha; RNP; ribonucleoprotein; MTT; methylthiazo
Basic ScienceLECT2 induces atherosclerotic inflammatory reaction via CD209 receptor-mediated JNK phosphorylation in human endothelial cells
Keywords: ANOVA; Analysis of variance; CVD; Cardiovascular diseases; LECT2; Leukocyte cell-derived chemotaxin 2; HUVEC; Human umbilical vein endothelial cells; ICAM-1; Intercellular adhesion molecule-1; IL-1β; Interleukin-1β; JNK; c-Jun N-terminal kinases; MCP-1;
Functional roles of HIV-1 Vpu and CD74: Details and implications of the Vpu-CD74 interaction
Keywords: AGTR1; angiotensin II type 1 receptor; β-TrCP; β-transducin repeat-containing protein; CD74-ICD; CD74 intracellular domain; CLIP; class-II-associated Ii-chain peptide; ER; endoplasmic reticulum; ERK-1/2; p44/p42 extracellular-signal-regulated kinase fam
Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice
Keywords: Inflammation; Atherosclerosis; Oxidative stress; Txnip; thioredoxin interacting protein; WT; wild type; VSMC; vascular smooth muscle cells; TKO; Txnip knockout; Trx; thioredoxin; DHE; dihydroethidium; Eh; redox potential; Eâ²0; midpoint potential; ROS; r
Lipopolysaccharide-induced murine embryonic resorption involves changes in endocannabinoid profiling and alters progesterone secretion and inflammatory response by a CB1-mediated fashion
Keywords: Endocannabinoid system; CB1 knockout; Decidua; Embryotoxicity; 2-AG; 2-arachidonoylglycerol; 2-LG; 2-linoleoyl-sn-glycerol; 2-OG; 2-oleoyl-sn-glycerol; AEA; anandamide; AGly; N-arachidonoylglycine; CB1; cannabinoid receptor type 1; CB1-KO; CB1 receptor kn
APRIL promotes proliferation, secretion and invasion of fibroblast-like synoviocyte from rats with adjuvant induced arthritis
Keywords: AA; adjuvant-induced arthritis; APRIL; a proliferation-inducing ligand; BAFF; B-cell activating factor; BCMA; B cell maturation antigen; CIA; collagen-induced arthritis; DCs; dendritic cells; FLS; fibroblast-like synoviocyte; GCs; germinal centers; HSPGs;
Effect of chronic p,pâ²-dichlorodiphenyldichloroethylene (DDE) exposure on high fat diet-induced alterations in glucose and lipid metabolism in male C57BL/6H mice
Keywords: DDE; p,pâ²-dichlorodiphenyldichloroethylene; DDT; p,pâ²-dichlorodiphenyltrichloroethane; T2D; type 2 diabetes mellitus; POP; spersistent organic pollutants; OC; organochlorine compound; NHANES; National Health and Nutrition Examination Survey; AAALAC; A
Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis
Keywords: Silicosis; MCP-1; Migration; Fibroblast; CCR2; MCPIP1;
Telmisartan mediates anti-inflammatory and not cognitive function through PPAR-γ agonism via SARM and MyD88 signaling
Keywords: AP-1; activator protein-1; ANOVA; analysis of variance; AT1; angiotensin II receptor 1; BBB; blood brain barrier; C; control; CaCl2; calcium chloride; CMC; carboxy methyl cellulose; CSF; cerebrospinal fluid; JNK/c-Jun; c-Jun N-terminal kinases; COX-2; cyc
A shift toward T helper 2 responses and an increase in modulators of innate immunity in depressed patients treated with escitalopram
Keywords: Depression; Cytokine; Escitalopram; Multiplex assay; Inflammation; Antidepressant; ELISA; enzyme-linked immunosorbent assay; SSRIs; selective serotonin reuptake inhibitors; IL; interleukin-1; TNF-α; tumor necrosis factor alpha; IFN-γ; interferon gamma;
Apelin protects against acute renal injury by inhibiting TGF-β1
Keywords: AKI; Acute kidney injury; ATN; Acute tubular necrosis; TGF-β1; Transforming growth factor- β1; HAT; Histone acetyltransferase; HDAC; Histone deacetylase; HMTs; Histone methyltransferases; HDMs; Histone demethyltransferases; H/R; Hypoxia/reperfusion; I/R
Early Dynamics of P-selectin and Interleukin 6 Predicts Outcomes in Ischemic Stroke
Keywords: Carotid stenosis; ischemic stroke; poststroke infection; P-selectin; MCP-1; IL-6;
Rehmannia glutinosa (Gaertn.) DC. polysaccharide ameliorates hyperglycemia, hyperlipemia and vascular inflammation in streptozotocin-induced diabetic mice
Keywords: ANOVA; analysis of variance; BSA; bovine serum albumin; BW; body weight; CVD; cardiovascular disease; FBG; fasting blood glucose; FT-IR; Fourier transform infrared; GC; gas chromatography; GLUT2; glucose transporter 2; GPC; gel permeation chromatography;
Experimental model for ELF-EMF exposure: Concern for human health
Keywords: AD, Alzheimer’s disease; ELF, extremely low frequency; EMFs, electromagnetic fields; HD, Huntington disease; LF, low frequency; MCP-1, monocyte chemoattractant protein-1; PMA, phorbol-12-myristate-13-acetate; PEMF, pulsed EMFELF-EMF; HaCaT; K562; MCP-1; S
High glucose activates Raw264.7 macrophages through RhoA kinase-mediated signaling pathway
Keywords: AGE; Advanced glycation endproduct; AP-1; Activator protein 1; CVD; Cardiovascular disease; DM; Diabetes mellitus; ERK; Extracellular regulated protein kinase; HF; Hydroxyfasudil; HG; High glucose; IKK; IκB kinase; JNK; c-Jun N-terminal kinase; LDL; Low
MCP-1 stimulates spinal microglia via PI3K/Akt pathway in bone cancer pain
Keywords: Bone cancer pain; MCP-1; PI3K; Spine; Microglia