
Polymerase proofreading domain mutations: New opportunities for immunotherapy in hypermutated colorectal cancer beyond MMR deficiency
Keywords: مجاهدین خلق; CRC; colorectal cancer; mCRC; metastatic CRC; CTLA4; cytotoxic T-lymphocyte-associated antigen 4; EGFR; epithelial growth factor receptor; HR; hazard ratio; MAP; mitogen-activated protein; mAb; monoclonal antibody; MEK; mitogen-activated protein/extracell