Keywords: T1D; type 1 diabetes mellitus; MDSC; myeloid-derived suppressor cells; ROS; reactive oxygen species; NO; nitric oxide; PBMC; peripheral blood mononuclear cells; STZ; streptozotocin; LNMMA; NG-monomethyl-L-arginine; MnTBAP; Mn(III) tetra (4-benzoic acid) p
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Keywords: NO; nitric oxide; O2â; superoxide anion radical; CO3â; carbonate anion radical; NO2; nitrogen dioxide radical, HO, hydroxyl radical; ONOOâ/ONOOH; peroxynitrite, DAF-2-DA, diaminofluorescein diacetate; DAFT; diaminofluorescein triazole; DAF; diaminof
Protection against gamma-radiation injury by protein tyrosine phosphatase 1B
Keywords: DE; Differentially Expressed Gen; FDR; False Discovery Rates; GSH; glutathione; GSNO; S-nitroso-glutathione; GSEA; Gene Set Enrichment Analysis; JNK; c-Jun N-terminal kinase; KEGG; Kyoto encyclopedia of genes and genomes; LPS; lipopolysaccharide; KO; knoc
Reactive oxygen species mediate cancer stem-like cells and determine bortezomib sensitivity via Mcl-1 and Zeb-1 in mantle cell lymphoma
Keywords: ALDH; aldehyde dehydrogenase; ALL; acute lymphocytic leukemia; AML; acute myeloid leukemia; CLL; chronic lymphocytic leukemia; CML; chronic myelogeneous leukemia; CSC; cancer stem cells; DEAB; diethylaminobenzaldehyde; DHE; dihydroethidium; DMNQ; 2,3-dime
Does MnTBAP ameliorate DNA fragmentation and in vivo fertility of frozen-thawed Arabian stallion sperm?
Keywords: Stallion; Sperm; MnTBAP; Cryopreservation; DNA fragmentation; Reactive oxygen species; Fertility trial;
Genetic or pharmacological superoxide-hydrogen peroxide imbalances modulate the in vitro effects of lithium on glycogen synthase kinase-3β
Keywords: GSK-3β; Glycogen synthase kinase 3 beta; TNF-α; Tumor necrosis factor alpha; IL-10; Interleukin 10; Li; Lithium; S; Superoxide; HP; Hydrogen peroxide; SNP; Single nucleotide polymorphism; MnSOD/SOD2; Superoxide dismutase manganese-dependent enzyme; MTS;
Brazil nut improves the oxidative metabolism of superoxide-hydrogen peroxide chemically-imbalanced human fibroblasts in a nutrigenomic manner
Keywords: Val16Ala-SOD2 polymorphism; Selenium; Seleno-L-methionine; Paraquat; MnTBAP; Nutrigenomic effect; Ala; alanine; BN; Brazil nut; BNs; Brazil nuts; BNAE; Brazil nut aqueous extract; CAT; catalase (E.C. 1.11.1.6); DCFH-DA; 2â²,7â²-Dichlorodihydrofluorescei
Redox control of cancer cell destruction
Keywords: ABC transporters; ATP-binding cassette transporters; ADCC; antibody-dependent cell-mediated cytotoxicity; ADCP; antibody-dependent cancer cell phagocytosis; AML; acute myeloid leukemia; APE1; apurinic/apyrimidinic endonuclease 1; ASK-1; apoptosis signal-r
MnTBAP increases BMPR-II expression in endothelial cells and attenuates vascular inflammation
Keywords: MnTBAP; Endothelial cell; Inflammation; BMPR-II
DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts
Keywords: ADMA; asymmetric dimethylarginine; NOS; nitric oxide synthase; DDAH; dimethylarginine dimethylaminohydrolase; miRNA; microRNA; WT; wild type; KO; knockout; MEFs; mouse embryonic fibroblasts; tBHP; tert-butyl hydroperoxide; ROS; reactive oxygen species; NO
Urea-induced ROS cause endothelial dysfunction in chronic renal failure
Keywords: Urea; Endothelial cells; ROS; Prostacyclin synthase; CRF; chronic renal failure; ROS; reactive oxygen species; GlcNAc; O-linked-N-acetylglucosamine; UCP-1; uncoupling protein 1; MnTBAP; manganese tetrakis (4-benzoic acid) porphyrin;
MnTBAP stimulates angiogenic functions in endothelial cells through mitofusin-1
Keywords: MnTBAP; Endothelial cell; Angiogenesis
GCDCA down-regulates gene expression by increasing Sp1 binding to the NOS-3 promoter in an oxidative stress dependent manner
Keywords: Cholestatic liver disease; Endothelial nitric oxide synthase; Oxidative stress; Transcription factor Sp1; Glycochenodeoxycholic acid; ADHP; 0-acetyl-3, 7-dihydroxyphenoxazine; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BDL; bile duct
Peroxynitrite-mediated glyoxalase I epigenetic inhibition drives apoptosis in airway epithelial cells exposed to crystalline silica via a novel mechanism involving argpyrimidine-modified Hsp70, JNK, and NF-κB
Keywords: Glo1; glyoxalase I; MG; methylglyoxal; AGE; advanced glycation end product; AP; argpyrimidine; ROS; reactive oxygen species; RNS; reactive nitrogen species; miRNA; micro-RNA; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; L-NAME; l-Ï-
Hydrogen peroxide administered into the rat spinal cord at the level elevated by contusion spinal cord injury oxidizes proteins, DNA and membrane phospholipids, and induces cell death: Attenuation by a metalloporphyrin
Keywords: 2,3 and 2,5-DHBA; 2,3- and 2,5-dihydroxybenzoic acid; 8-OHdG; 8-hydroxy-2-deoxyguanosine; ACSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; DNP; 2,4-dinitrophenyl; H2O2; hydrogen peroxide; [H2O2]; hydrogen peroxide concentration; HNE; 4-h
The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: Role in nitrate tolerance
Keywords: GTN; glyceryl trinitrate; NO; nitric oxide; ALDH-2; aldehyde dehydrogenase-2; O2â; superoxide anions; PN; peroxynitrite; cGMP; cyclic guanosine monophosphate; PLTs; platelets; MnTBAP; Mn(III)tetrakis(4-Benzoic acid) porphyrin; IS-5-MN; isosorbide-5-mono
Armillaria mellea component armillarikin induces apoptosis in human leukemia cells
Keywords: A. mellea; Armillaria mellea; AML; acute myeloid leukemia; G. elata; Gastrodia elata; MFI; mean fluorescence intensity; MnTBAP; Mn(III)tetrakis (4-benzoic acid) porphyrin chloride; MTS; 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophe
Mitochondrial superoxide mediates mitochondrial and endoplasmic reticulum dysfunctions in TRAIL-induced apoptosis in Jurkat cells
Keywords: DCFH-DA; 2â²,7â²-Dichlorodihydrofluorescein diacetate; DHE; dihydroethidine; ÎΨm; mitochondrial membrane potential; ER; endoplasmic reticulum; FCCP; carbonyl cyanide p-trifluoromethoxyphenylhydrazone; FITC; fluorescein isothiocyanate; GRP78; glucose-r
Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status
Keywords: Nlrp3 inflammasome; IL-1β; ROS; Mitochondria; ATP; MnTBAP; DPI; FCCP; Antimycin A; Serum amyloid A; Mouse peritoneal macrophages; Free radicals;
Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism
Keywords: BCA; bicinchoninic acid; BPS; bathophenanthroline disulfonate; BSA; bovine serum albumin; CHO; Chinese hamster ovary; CHX; cycloheximide; Dcytb; duodenal cytochrome b; DHA; dehydroascorbate; DFO; desferrioxamine; DMT1; divalent metal transporter, isoform
Compartmentalized oxidative stress in dopaminergic cell death induced by pesticides and complex I inhibitors: Distinct roles of superoxide anion and superoxide dismutases
Keywords: ARE; antioxidant response elements; DHE; dihydroethidium; ETC; electron transport chain; CuZnSOD; copper/zinc SOD; IMS; intermembrane space; MnSOD; manganese SOD; MPP+; 1-methyl-4-phenylpyridinium; ÎΨm; mitochondrial membrane potential; MnTBAP; Mn(III)t
Can permeable super oxide dismutase mimetic agents improve the quality of frozen–thawed ram semen?
Keywords: Cryopreservation; Ram semen; MnTBAP; Capacitation; In vitro fertilization
Moderate superoxide production is an early promoter of mitochondrial biogenesis in differentiating N2a neuroblastoma cells
Keywords: A, db-cAMP; dibutyryl cyclic AMP; B; basal conditions; CREB; cAMP responsive element binding protein; ERK1/2; extracellular signal-regulated kinase; F; forskolin; H2DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; MAPK; mitogen-activated protein kin
Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis
Keywords: BCECF-AM; 2â²,7â²-bis(2-carboxyethyl)-5(6)-carboxyfluorescein tetrakis(acetoxymethyl) ester; BSA; bovine serum albumin; CVD; cardiovascular disease; DiI; 1,1â²-dioctadecyl-3,3,3â²,3â²,-tetramethylindocarbocyanine perchlorate; FA; fatty acid; FFA; fre
Mitochondrial superoxide mediates doxorubicin-induced keratinocyte apoptosis through oxidative modification of ERK and Bcl-2 ubiquitination
Keywords: DOX; doxorubicin; ROS; reactive oxygen species; zVAD-fmk; benzyloxy-carbonyl-Val-Ala-Asp-(OMe) fluoromethyl ketone; zIETD-fmk; benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone; zLEHD-fmk; benzyloxycarbonyl-Leu-Glu(OMe)-His-Asp(OMe)-fluoromet
Estrogen receptor potentiates mTORC2 signaling in breast cancer cells by upregulating superoxide anions
Keywords: ER; estrogen receptor; ROS; reactive oxygen species; O2â¢â; superoxide anion; mTORC2; mammalian target of rapamycin complex 2; NAC; N-acetyl-l-cysteine; MnTBAP; Mn(III) tetrakis-(4-benzoic acid) porphyrin; E2; 17-β-estradiol; DHE; dihydroethidium; FBS
Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species
Keywords: âÏ; mitochondrial membrane potential; DAPI; 4â²,6-diamidino-2-phenylindole; DHE; hydroethidine; FCS; fetal calf serum; FCCP; carbonyl cyanide p-trifluoromethoxyphenylhydrazone; GSIS; glucose-stimulated insulin secretion; KRH; Hepes-buffered Krebs-Ri
Immune responses to novel allergens and modulation of inflammation by vitamin K3 analogue: A ROS dependent mechanism
Keywords: BAL; Bronchoalveolar Lavage; IL; Interleukin; IFN; Interferon; TNF; Tumor Necrosis Factor; SPT; Skin Prick Test; PHA; Phytohemagglutinin; ConA; Concanavalin A; PBMC; Peripheral Blood Mononuclear Cells; CHSS; Contributory Health Service Scheme; ROS; Reacti
Non-nucleoside reverse transcriptase inhibitor efavirenz increases monolayer permeability of human coronary artery endothelial cells
Keywords: Efavirenz; HAART; Endothelial permeability; Tight junction protein; Oxidative stress; Antioxidant; Ginkgolide B; MnTBAP; JNK; NFκB;
Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways
Keywords: SOD; superoxide dismutase; MnP, MnIIITE-2PyP5+; Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin (AEOL-10113); MnTnHex-2-PyP5+; Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin; FeTM-4-PyP5+; Fe(III) meso-tetrakis(N-methylpyridinium-4-yl)por
Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes
Keywords: MnTE-2-PyP; MnTM-2-PyP; MnTBAP; SOD mimics; Peroxynitrite scavengers; Antioxidants; Mn porphyrins
Inactivation of mitochondrial respiratory chain complex I leads mitochondrial nitric oxide synthase to become pro-oxidative
Keywords: RCC; respiratory chain complex; NO; nitric oxide; NOS; nitric oxide synthase; mtNOS; mitochondrial nitric oxide synthase; GSNO; S-nitrosoglutathione; DMPO; (5,5-dimethylpyrroline-N-oxide); ROS; reactive oxygen species; DTPA; diethylene triamine pentaaceti
Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments
Keywords: OA; osteoarthritis; ROS; reactive oxygen species; MnTBAP; Mn(III) tetrakis(4-benzoic acid)porphyrin; MMP; matrix metalloproteinase; FN-f; 110-kDa fibronectin fragment; MAP kinases; mitogen-activated protein kinase; NF-κB; nuclear factor-κB; JNK; c-Jun N
Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms
Keywords: ALD; alcoholic liver disease; PKC; protein kinase C; MAPK; mitogen-activated protein kinase; ERK1/2; extracellular signaling-regulated kinase type 1 and type 2; JNK1/2; c-Jun N-terminal kinase type 1 and type 2; NF-κB; nuclear factor kappa B; AP-1; activ
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair
Keywords: amyotrophic lateral sclerosis; ataxia-telangiectasia-like disorder; Werner syndrome; xeroderma pigmentosum; nitric oxide synthase; superoxide dismutase; AfXPB; Archaeoglobus fulgidus XPB; AH; autoinhibitory helix; ALS; amyotrophic lateral sclerosis; ATL
Reactive oxygen species mediation of Baizhu-induced apoptosis in human leukemia cells
Keywords: ROS; reactive oxygen species; PI; propidium iodide; NAC; N-acetyl cysteine; MnTBAP; Mn(III) tetrakis (4-benzoic acid) porphyrin chloride; Baizhu; Atractylodes macrocephala Koidz; Apoptosis; Reactive oxygen species;
Beryllium-stimulated reactive oxygen species and macrophage apoptosis
Keywords: Be; beryllium; CBD; chronic beryllium disease; BAL; bronchoalveolar lavage; ROS; reactive oxygen species; MnTBAP; 5,10,15,20-tetrakis (4-benzoic acid) porphyrin manganese(III); DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; DCF; 2â²,7â²-dichlorofluor
Increased superoxide anion in rostral ventrolateral medulla contributes to hypertension in spontaneously hypertensive rats via interactions with nitric oxide
Keywords: aCSF; artificial cerebrospinal fluid; AdGFP; adenovirus encoding green fluorescence protein; AdeNOS; adenovirus encoding endothelial nitric oxide synthase; cGMP; guanosine 3â²,5â²-cyclic monophosphate; Cu/ZnSOD; cupper/zinc superoxide dismutase; HEt; hy