Decreased expression of l-dopa-induced dyskinesia by switching to ropinirole in MPTP-treated common marmosets
Keywords: MPTP; Primates; l-Dopa; Ropinirole; Dyskinesia
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Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease
Keywords: Parkinson; Gastrointestinal; Dopamine; Colon; Gastric; MPTP; Constipation; Enteric; Gut; Myenteric
Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection
Keywords: Laser capture microdissection; MPTP; Parkinson's disease; Tyrosine hydroxylase; Quantitative Western blot; Dopamine; Immunohistochemistry; β-Actin; Substantia nigra;
Interaction between nicotine and MPTP/MPP+ in rat brain endothelial cells
Keywords: ARBEC; BBB; MPP+; MPTP; Nicotine; Parkinson's disease
Motor deficits and altered striatal gene expression in aphakia (ak) mice
Keywords: Ache; acetylcholinesterase; ak; aphakia; DA; dopamine; Drd; dopamine receptor; Chrm; cholinergic muscarinic; Chrn; cholinergic nicotinic; Comt; catechol-o-methyl transferase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Maoa; monoamine oxidase A; MPTP
MPTP administration in mice changes the ratio of splice isoforms of fosB and rgs9
Keywords: Pre-mRNA splicing; Dopamine; MPTP; FosB; RGS9; Neurodegeneration
Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: Diminished compensatory mechanisms as a prelude to parkinsonism
Keywords: Aging; Dopamine; Substantia nigra; Parkinsonism; MPTP; Monkey
Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter
Keywords: DJ-1; Parkinson; Dopamine transporter; Striatum; MPTP; Substantia nigra; Transgenic; Dopamine
Correlation between levels of pigment epithelium-derived factor and vascular endothelial growth factor in the striatum of patients with Parkinson's disease
Keywords: Parkinson's disease; PEDF; VEGF; MPTP
Neurotoxicity studies with the monoamine oxidase B substrate 1-methyl-3-phenyl-3-pyrroline
Keywords: Monoamine oxidase B; Neurotoxicity; MPTP; 1-Methyl-3-phenyl-3-pyrroline; 1-Methyl-3-phenylpyrrole; Dopamine; Striata
Endurance exercise promotes cardiorespiratory rehabilitation without neurorestoration in the chronic mouse model of Parkinsonism with severe neurodegeneration
Keywords: electrocardiogram; dopamine; MPTP; Parkinson’s disease; probenecid; rodent treadmillANOVA, analysis of variance; ApEn, approximate entropy; DA, dopamine; DOPAC, 3,4-dihydroxyphenylacetic acid; ECG, electrocardiogram; EDTA, ethylenediaminetetraacetic acid;
Neuroinflammation in Parkinson’s patients and MPTP-treated mice is not restricted to the nigrostriatal system: Microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb
Keywords: Olfactory bulb; Substantia nigra; Parkinson’s disease; MPTP; IL-1; IL-1 receptor; Microglia; Neuroinflammation
MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity
Keywords: Parkinson's disease; Parkin; Alpha-synuclein; MPTP; DSP-4; Substantia nigra; Locus coeruleus; Dopamine; Norepinephrine
Research ReportToxic influence of subchronic paraquat administration on dopaminergic neurons in rats
Keywords: 3-MT; 3-methoxytyramine; 5-HIAA; 5-hydroxyindoleacetic acid; DOPAC; 3,4-dihydroxyphenylacetic acid; DAT; dopamine transporter; GABA; γ-aminobutyric acid; GAD; glutamic acid decarboxylase; HVA; homovanillic acid; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydro
Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS
Keywords: ATP; adenosine triphosphate; bHLH; basic helix-loop-helix; BMP; bone morphogenic protein; BrdU; bromodeoxy uridine; CD44; cell determinant-44; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; CNTF; ciliary neurotrophic factor; CXCR4; receptor f
Mitochondrial permeability transition relevance for apoptotic triggering in the post-ischemic heart
Keywords: I/R; ischemia/reperfusion; mPTP; mitochondrial permeability transition pore; TUNEL; terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling; AIF; apoptosis-inducing factor; ANT; adenine nucleotide translocator; VDAC; voltage-dependent anion
The COX-2 inhibitor parecoxib produces neuroprotective effects in MPTP-lesioned rats
Keywords: Parecoxib; MPTP; Tyrosine hydroxylase; COX-2; Parkinson's disease
Pael receptor is involved in dopamine metabolism in the nigrostriatal system
Keywords: Parkinson's disease; Parkin; Striatum; Substantia nigra; AR-JP; GPR37; MPTP; 6-OHDA
Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson's disease
Keywords: neuroprotection; inflammation; immunocytochemistry; striatum; substantia nigra; tyrosine hydroxylase; Alb; albumin; ANOVA; factor analysis of variance; CR3; complement receptor type 3; DAT; dopamine transporter; EPO; erythropoietin; GFAP; glial fibrillary
Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson's disease
Keywords: cytokine/chemokine; tumor necrosis factor α; macrophage inflammatory protein 1; interleukin 6; monocyte chemoattractant protein 1; strain differences; Cxcr4; CXC chemokine receptor 4; Cx3cl1; chemokine ligand 1; Cx3cr1; CX3C chemokine receptor 1; DA; dop
Brain regions and genes affecting postural control
Keywords: P; postnatal; PKC; protein kinase C; MPTP; methyl-phenyl-tetrahydroyridine; 6-OHDA; 6-hydroxydopamine; CO; cytochrome oxidase; EMG; electromyographic; Cerebellum; Basal ganglia; Motor coordination; Motor cortex; Gene knockout;
The role of mitochondria in protection of the heart by preconditioning
Keywords: 5HD; 5-hydroxydecanoate; AMPK; AMP activated protein kinase; ANT; Adenine nucleotide translocase; APD; Action potential duration; BCDH; branched chain 2-oxoacid dehydrogenase; CrK; creatine kinase; CsA; cyclosporin A; CyP; cyclophilin; Cx43; connexin43; G
Amphetamine-induced locomotor activity is reduced in mice following MPTP treatment but not following selegiline/MPTP treatment
Keywords: Amphetamine; MPTP; Locomotor activity; Parkinson's disease; Striatum; Dopamine;
Imidaprilat, an angiotensin-converting enzyme inhibitor exerts neuroprotective effect via decreasing dopamine efflux and hydroxyl radical generation induced by bisphenol A and MPP+ in rat striatum
Keywords: MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-methyl-4-phenylpyridinium ion; ACE; angiotensin-converting enzyme; HPLC; high-performance liquid chromatography; OH; hydroxyl free radical; 2,3-DHBA; 2,3-dihydroxybenzoic acid; DA; Dopamine; Angi
Ebselen effects on MPTP-induced neurotoxicity
Keywords: Ebselen; MPTP; Monoamine oxidase; Neuroprotection; SH-SY5Y cell
Potential neuroprotective effect of low dose whole-body γ-irradiation against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity in C57 mice
Keywords: Low dose irradiation; MPTP; Neuroprotection; Parkinson's disease;
Age-related severity of dopaminergic neurodegeneration to MPTP neurotoxicity causes motor dysfunction in C57BL/6 mice
Keywords: MPTP; Parkinson's disease; Aging; Dopaminergic degeneration; Tail suspension test; Motor dysfunction;
In vitro and in vivo neuroprotection by γ-glutamylcysteine ethyl ester against MPTP: Relevance to the role of glutathione in Parkinson's disease
Keywords: GSH, glutathione; PD, Parkinson's disease; GCEE, γ-glutamylcysteinyl ethyl ester; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineGlutathione; Parkinson's disease; γ-Glutamylcysteinyl ethyl ester; Tyrosine hydroxylase; MPTP
The role of tissue transglutaminase in 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in differentiated human SH-SY5Y neuroblastoma cells
Keywords: MPP+; 1-methyl-4-phenylpyridinium ion; MPTP; 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine; PD; Parkinson's disease; R283; 1,3,dimethyl-2-[(2-oxopropyl) thio] imidazolium chloride; TG; transglutaminase; TG2; tissue transglutaminase; Parkinson's disease; MP
The neuroprotection conferred by activating the mitochondrial ATP-sensitive K+ channel is mediated by inhibiting the mitochondrial permeability transition pore
Keywords: mitokatp; MPTP; Brain; Ischemia and reperfusion injury; Neuroprotection
Dopamine turnover is upregulated in the caudate/putamen of asymptomatic MPTP-treated rhesus monkeys
Keywords: Dopamine metabolites; Tyrosine hydroxylase; Dopamine turnover; Presymptomatic compensation; MPTP; Parkinson's disease
Sphingosine impairs mitochondrial function by opening permeability transition pore
Keywords: Sphingosine; Heart; Mitochondria; Cyclosporine; Bcl-2; MPTP; mitochondrial permeability transition pore; WT; wild-type; RCR; respiratory control ratio; TPP+; tetraphenylphosphonium; NOE; N-oleoylethanolamine;
Statistical parametric mapping of immunopositive cell density
Keywords: Cell count; Statistical parametric mapping; MPP+; MPTP; Microglia; Iba-1; Dopamine neuron; Substantia nigra
WldS mice are protected against the Parkinsonian mimetic MPTP
Keywords: Parkinson's disease; MPTP; Wallerian degeneration; Neurodegeneration
In vivo modulation of the Parkinsonian phenotype by Nrf2
Keywords: Nrf2; Parkinsonism; MPTP; Neuroprotection; Knockout mice; Brain
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced acute transient dystonia in monkeys associated with low striatal dopamine
Keywords: Parkinsonism; Macaca fascicularis; Macaca nemestrina; MPTP; positron emission tomographyAIR, automated image registration; FDOPA, [18F]-6-fluoro-DOPA; ic, intracarotid; Kocc, influx constant for [18F]-6-fluoro-DOPA using occipital reference region; MPTP,
Insomnia following hypocretin2-saporin lesions of the substantia nigra
Keywords: ventral tegmental area; locomotion; wakefulness; sleep; rats; EEG; electroencephalogram; EMG; electromyogram; HCRT2-sap; hypocretin2-saporin; MLR; mesencephalic locomotor region; MPTP; l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NeuN; neuronal nuclei; N
Mice lacking alpha-synuclein are resistant to mitochondrial toxins
Keywords: MPTP; Paraquat; 3-Nitropropionic acid; Malonate; MPP+; MPP+ levels; Vesicular uptake; DHBA
Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques
Keywords: Amphetamine; Apomorphine; phMRI; Rhesus macaque; Parkinson's disease; MPTP;
Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits
Keywords: Parkinson's disease; Dopamine; DOPAC; TGF-β2; Substantia nigra; Susceptibility genes; MPTP; Monoamine oxidase-B;
Lesions in monkey globus pallidus externus exacerbate parkinsonian symptoms
Keywords: Parkinson's disease; Pallidotomy; Globus pallidus; Radio frequency ablation; MPTP; Monkey
Comparison of [18F]FDOPA, [18F]FMT and [18F]FECNT for imaging dopaminergic neurotransmission in mice
Keywords: Quad-HIDAC; Small-animal PET imaging; [18F]FDOPA; [18F]FMT; [18F]FECNT; MPTP
Microarrays in Parkinson's Disease: A Systematic Approach
Keywords: Microarray; Parkinson's disease; human; MPTP; α-synuclein; gene expression;
Increased sensitivity to MPTP in human α-synuclein A30P transgenic mice
Keywords: MPTP; Rotenone; Synuclein; Transgenic mice; Parkinson's disease; Lewy body; Tyrosine hydroxylase; Substantia nigra; Dopamine
Basal ganglia lesions after MPTP administration in rhesus monkeys
Keywords: MPTP; Nonhuman primates; Globus pallidus; Striatum; Necrosis; Aging; Stroke; Parkinson's disease; Gene therapy
Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys
Keywords: Chronic inflammation; Astrocytes; ICAM-1; Parkinson disease; MPTP
Does increased excitatory drive from the subthalamic nucleus contribute to dopaminergic neuronal death in Parkinson's disease?
Keywords: Excitotoxicity; Subthalamic nucleus; Dopaminergic neurons; Parkinson's disease; Basal ganglia; MPTP; Glutamic acid; Substantia nigra; Neuroprotection; Neurodegeneration
Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism
Keywords: Angiotensin; Angiotensin-converting enzyme; MPTP; Captopril; Neuroprotection; Oxidative stress; Parkinson; Dopamine; Striatum
Bradykinin prevents reperfusion injury by targeting mitochondrial permeability transition pore through glycogen synthase kinase 3β
Keywords: Bradykinin; Reperfusion injury; mPTP; GSK-3β
Neuroprotective effects of cystamine in aged parkinsonian mice
Keywords: Parkinson's disease; Aging; MPTP; Dopamine; Neuroprotection