دانلود مقالات ISI درباره Mptp + ترجمه فارسی

Selective loss of dopaminergic neurons in the substantia nigra pars compacta after systemic administration of MPTP facilitates extinction learning

Keywords: Reconsolidation; Extinction; MPTP; Parkinson's disease; Dopamine;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2 + leak in cardiomyocytes: Role of adenine nucleotide translocase

Keywords: AK2; adenylate kinase 2; ANT; adenine nucleotide translocase; Ap5A; P1P5-diadenosine-5′-pentaphosphate; BA; bongkrekic acid; C; carnitine; CsA; cyclosporine A; DPI; diphenyleneiodonium; FA; fatty acid; FKBP12.6; FK506 binding protein 12.6 kDa; IK1; inw

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Attenuation of neuroinflammatory responses and behavioral deficits by Ligusticum officinale (Makino) Kitag in stimulated microglia and MPTP-induced mouse model of Parkinson׳s disease

Keywords: Microglia; Ligusticum officinale Makino; Ferulic acid; Neuroinflammation; MPTP; Parkinson׳s disease;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits

Keywords: DAT; dopamine transporter; PD; Parkinson's disease; DAT-tg; dopamine transporter over-expressing transgenic; DAT-KO; dopamine transporter knock-out; VMAT2; vesicular monoamine transporter 2; VMAT2-kd; vesicular monoamine transporter 2 knock-down; MPTP; 1-

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Neuroprotection in Parkinsonian-treated mice via estrogen receptor α activation requires G protein-coupled estrogen receptor 1

Keywords: 17β-Estradiol; Estrogen receptor; GPER1; MPTP; Neuroprotection; Akt;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Research reportThe combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson׳s disease therapy

Keywords: Combination therapy; MPTP; Neurodegenerative disease; Calpain 1; AIM;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Anti-neuroinflammatory effects of DPTP, a novel synthetic clovamide derivative in in vitro and in vivo model of neuroinflammation

Keywords: Clovamide derivative; Lipopolysaccharide; Microglia; MPTP; NeuroinflammationDPTP, [3-(3,4-dihydroxy-phenyl)-2-[4-(3-trifluoromethylphenyl)-but-2-enoylamino]-propionic acid methyl ester; LPS, lipopolysaccharide; NO, nitric oxide; COX-2, cyclooxygenase; ERK

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

MicroRNA-7: A miRNA with expanding roles in development and disease

Keywords: ACK1; activated CDC42 kinase 1; BASP1; brain abundant, membrane attached signal protein 1; c-Myc; v-Myc avian myelocytomatosis viral oncogene homolog; CD57; cluster of differentiation 57; CD44; cluster of differentiation 44; ciRS-7; circular RNA sponge fo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Cyclophilin D and myocardial ischemia-reperfusion injury: A fresh perspective

Keywords: ANT; adenine nucleotide translocator; ATP; adenosine triphosphate; ATP5G; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); BAK; BCL2-antagonist/killer; BAX; BCL2-associated X protein; BCL-2; B cell lymphoma protein 2; C1QBP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Transiently impaired neurogenesis in MPTP mouse model of Parkinson's disease

Keywords: MPTP; Animal model; Parkinson's disease; Neurogenesis

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Mitochondrial 2′, 3′-cyclic nucleotide 3′-phosphodiesterase (CNP) interacts with mPTP modulators and functional complexes (I-V) coupled with release of apoptotic factors

Keywords: Brain mitochondria; CNP, 2′, 3′-cyclic nucleotide 3′-phosphodiesterase; Permeability transition pore; Ca2+ transport; 2′,3′-cAMP; 2′,3′-cyclic adenosine monophosphate; 2′,3'-cNADP; 2′,3′-cyclic nicotinamide adenine dinucleotide phosp

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Chronic MPTP treatment produces hyperactivity in male mice which is not alleviated by concurrent trehalose treatment

Keywords: Parkinson's disease; MPTP; Probenecid; Behavior; Locomotor activity; Mice;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents

Keywords: Parkinson's disease; Deoxygedunin; Neuroprotection; Brain derived neurotrophic factor; 6-Hydroxydopamine; MPTP;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular chaperones and neuronal proteostasis

Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; 17-DMAG; 17-dimethylamino-ethylamino-17-demethoxygeldanamycin; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ARSACS; autosomal recessive spastic ataxia of Charlevoix-Saguena

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Tanshinone IIA prevents the loss of nigrostriatal dopaminergic neurons by inhibiting NADPH oxidase and iNOS in the MPTP model of Parkinson's disease

Keywords: Parkinson's disease; Microglia; NADPH oxidase; iNOS; Tanshinone IIA; MPTP

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin MPTP in C57BL/6 mice

Keywords: Parkinson's disease; MPTP; Valeriana wallichii D.C.; Dopamine; Tyrosine hydroxylase; Antioxidants

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Increased brain bio-distribution and chemical stability and decreased immunogenicity of an engineered variant of GDNF

Keywords: 6-OHDA; 6-Hydroxy-dopamine; BBB; Blood-brain-barrier; CEX; Cation Exchange chromatography; CHO; Chinese Hamster Ovary; DOPAC; Dihydroxyphenylacetic acid; Dopa; 3,4-dihydroxyphenylalanine; DA; Dopamine; ECM; Extracellular matrix; GDNF; Glial cell line-de

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease

Keywords: 6-OHDA; 6-hydroxy-dopamine; Akt, PKB; protein kinase B, serine/threonine-specific protein kinase; BDNF; brain derived neurotrophic factor; CaMKIIβ; calcium-calmodulin-dependent protein kinase II β isoform; cAMP; 3′,5′-cyclic adenosine monophosphate;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

GPER1-mediated immunomodulation and neuroprotection in the myenteric plexus of a mouse model of Parkinson's disease

Keywords: 17β-estradiol; GPER1; Ileum; Inflammation; Innate immune response; Intestine; Immunophenotype; MPTP; Myenteric plexus; Neuroprotection;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta

Keywords: DA; dopaminergic; EF-5; 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide; egln1; egl nine homologue1; GFAP; Glial Fibrillary Acidic Acid; HIF; Hypoxia Inducible Factor; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PBS; phosphat

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Different cell death responses induced by eupomatenoid-5 in MCF-7 and 786-0 tumor cell lines

Keywords: 786-0; human kidney cancer cell line; 7-AAD; 7-aminoactinomycin D; ATP; adenosine triphosphate; DCE; dichloromethanic crude extract; DCF; 2,7-dichlorofluorescein; DCFH; 2,7-dichlorodihydrofluorescein; DCFH-DA; dichlorofluorescin diacetate; DMSO; dimethyl

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2015 سفارش ترجمه

Mitofusin 2 ameliorates hypoxia-induced apoptosis via mitochondrial function and signaling pathways

Keywords: AIf; apoptosis-inducing factor; ANOVA; analysis of variance; ATP; adenosine triphosphate; Bcl-2; B Cell Leukemia 2; Bax; Bcl-2 associated X protein; CCA; common carotid artery; CCK-8; cell counting kit-8; CoCl2; cobalt chloride; Ct; critical threshold; DM

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2015 سفارش ترجمه

Current knowledge and pharmacological profile of berberine: An update

Keywords: 5-HT; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; AChE; acetylcholinesterase; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; BBB; blood brain barrier; BChE; butyrylcholinestesrase; CD; cluster of differentiation; Cdk; cyclin-dependent ki

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2015 سفارش ترجمه

Neuroprotective effects of 5-(4-hydroxy-3-dimethoxybenzylidene)-thiazolidinone in MPTP induced Parkinsonism model in mice

Keywords: 5-(4-hydroxy-3-dimethoxybenzylidene)-2-thioxo-4-thiazolidinone; Parkinson's disease; MPTP; MPP+; Mitochondrial dysfunction;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2015 سفارش ترجمه

α-Asarone attenuates microglia-mediated neuroinflammation by inhibiting NF kappa B activation and mitigates MPTP-induced behavioral deficits in a mouse model of Parkinson's disease

Keywords: α-Asarone; Microglia; Neuroinflammation; MPTP; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2015 سفارش ترجمه

The protein l-isoaspartyl (d-aspartyl) methyltransferase protects against dopamine-induced apoptosis in neuroblastoma SH-SY5Y cells

Keywords: 6-OHDA; 6-hydroxydopamine; AdoMet; S-adenosyl-l-methionine; CaPIMT1; chick pea PIMT; DA; dopamine; DMSO; dimethyl sulfoxide; gly-LDL; glycated Low-Density Lipoprotein; H2DCFDA; 2′,7′-dichlorodihydrofluorescein diacetate; MAO; monoamine oxidase; MPTP;

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2015 سفارش ترجمه

Detection and distribution of opioid peptide receptors in porcine myocardial tissue

Keywords: APAAP; alkaline phosphatase-anti-alkaline phosphatise; BCIP/NBT; 5-bromo-4-chloro-3-indolylphosphate/nitroblue tetrazolium; EOP; endogenous opioid peptides; ERK; extracellular regulated kinase; GPCR; G-protein-coupled receptors; mKATP-channels; ATP-depend

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Organelle communication: Signaling crossroads between homeostasis and disease

Keywords: Organelles; Endoplasmic reticulum; Mitochondria; Calcium signaling; BNIP1; BCL2/adenovirus E1B interacting protein 1; Ca2+; calcium; CERT; ceramide transfer protein; CMT2A; Charcot-Marie-Tooth type 2A; Δψmt; mitochondrial transmembrane potential; Dr

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Effects of l-tryptophan on l-DOPA-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque model of Parkinson's disease

Keywords: 5-HT; 5-Hydroxytryptamine; 5-HTP; 5-Hydroxytryptophan; BBB; Blood-brain barrier; DA; Dopamine; l-DOPA; l-3,4-Dihydroxyphenylalanine; l-AADC; l-Amino acid decarboxylase; LID; l-DOPA-induced dyskinesia; MPTP; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Disruption of lateral olivocochlear neurons with a dopaminergic neurotoxin depresses spontaneous auditory nerve activity

Keywords: Olivocochlear efferents; Auditory nerve; MPTP; Guinea pig; Cochlea;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Maternal exposure to bisphenol A may increase the risks of Parkinson's disease through down-regulation of fetal IGF-1 expression

Keywords: AMY; amygdala; AFP; alpha fetoglobulin; AKT; protein kinase B; BPA; bisphenol A; DA; dopamine; 6-OHDA; 6-OH-dopamine; DOPAC; dihydroxyphenylacetic acid; EB; embryoid body; EDC; environmental endocrine disruptors; ESCs; embryonic stem cells; FACS; fluoresc

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

In silico identification of potent inhibitors of alpha-synuclein aggregation and its in vivo evaluation using MPTP induced Parkinson mice model

Keywords: Parkinson disease; Alpha-synuclein; ADME; Toxicity; Docking; CNB-001; MPTP

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity

Keywords: AD; Alzheimer's disease; ANOVA; one-way analysis of variance; ATCC; American type culture collection; DA; dopamine; 7,8-DHF; 7,8-dihydroxyflavone; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; ECL; enhanced chemiluminescence; F

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Research reportAnti-Parkinson effects of a selective alpha2C-adrenoceptor antagonist in the MPTP marmoset model

Keywords: ANOVA; analysis of variance; CNS; central nerve system; DA; dopamine; DA-ergic; dopaminergic; GPi; globus pallidus interna; LC; locus coeruleus; l-DOPA; l-dihydroxy-phenylalanine; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NE; noradrenergic; PPN;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Abnormal structure-specific peptide transmission and processing in a primate model of Parkinson's disease and l-DOPA-induced dyskinesia

Keywords: Parkinson's disease; Mass spectrometry; Peptides; l-DOPA-induced dyskinesia; Primate; MPTP;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Mitochondria express several nicotinic acetylcholine receptor subtypes to control various pathways of apoptosis induction

Keywords: ACh; acetylcholine; nAChR; nicotinic acetylcholine receptor; cyt c; cytochrome c; DhβE; dihydro-β-erythroidine; MLA; methyllycaconitine; MPTP; mitochondria permeability transition pore; CaMKII; calcium-calmodulin-dependent kinase; PI3K; phosphatidylinos

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases

Keywords: MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Gαs; α-subunit of the stimulatory guanine nucleotide-binding protein; ARH; ADP-ribosyl-acceptor hydrolase; AIF; apoptosis-inducing factor; mito-PARP1cd; catalytic domain of PARP1 with a mitochondrial t

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibition of the microglial response is essential for the neuroprotective effects of Rho-kinase inhibitors on MPTP-induced dopaminergic cell death

Keywords: Dopamine; Neuroprotection; Neuroinflammation; Microglia; Parkinson; Rho; LME; l-leucine methyl ester; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-metil-4-fenil-1,2,3,6 tetrahidropiridine; PD; Parkinson's disease; ROCK; Rho-associated Kinase; TH; tyrosine h

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

l-DOPA-induced behavioral sensitization of motor activity in the MPTP-treated common marmoset as a Parkinson's disease model

Keywords: Parkinson's disease; Common marmoset; Monkey; MPTP; l-DOPA; Behavioral sensitization; Motor activity; Dyskinesia;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson's disease

Keywords: Paeonia suffruticosa; Parkinson's disease; Mitochondria dysfunction; MPTP;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson׳s disease

Keywords: Trim27; Parkinson׳s Disease; Apoptosis; MPTP

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Ceftriaxone mediated rescue of nigral oxidative damage and motor deficits in MPTP model of Parkinson's disease in rats

Keywords: Ceftriaxone; Ropinirole; Neuroprotection; MPTP; Oxidative damage

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Dietary administration of paraquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice

Keywords: Paraquat; C57BL/6J mice; Dopamine; Substantia nigra; MPTP;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Downregulation of PMCA2 increases the vulnerability of midbrain neurons to mitochondrial complex I inhibition

Keywords: Calcium; PMCA2; Neuronal vulnerability; Parkinson's disease; MPTP; Midbrain neurons

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

1H NMR-based metabolomics study on a goldfish model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Keywords: MPTP; Goldfish; Parkinson’s disease; Metabolomics; 1H NMR

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson's disease mice

Keywords: CNB-001; Parkinson's disease; Inflammation; Apoptosis; MPTP;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Effects of gypenosides on anxiety disorders in MPTP-lesioned mouse model of Parkinson׳s disease

Keywords: Gypenosides; Gynostemma pentaphyllum; MPTP; Elevated plus-maze; Dopamine; Serotonin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Raloxifene activates G protein-coupled estrogen receptor 1/Akt signaling to protect dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice

Keywords: Raloxifene; GPER; MPTP; Neuroprotection; Akt; Dopamine; Striatum;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Gene expression regulation of Bcl2, Bax and cytochrome-C by geraniol on chronic MPTP/probenecid induced C57BL/6 mice model of Parkinson's disease

Keywords: Parkinson's disease; MPTP; Geraniol; Neuroprotective; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay

Keywords: ANT; adenine nucleotide translocase; CsA; cyclosporin A; Cyp-D; cyclophillin D; IR; ischaemia and reperfusion; Lmax; length at which maximum developed force was recorded; Lopt; 95% of Lmax; LWa; work required to lengthen the active muscle; LWp; work requi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه