One-pot modification of 5â²-capped RNA based on methionine analogs
Keywords: Methionine analogs; mRNA; Click chemistry; Methyltransferase; Methionine adenosyltransferase;
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Ethnomedical research and review of Q'eqchi Maya women's reproductive health in the Lake Izabal region of Guatemala: Past, present and future prospects
Keywords: COX-2; Cyclooxygenase 2; E2; Estradiol; ERα, ERβ; estrogen receptor alpha and beta; ERE; estrogen responsive element; GC; granulosa cells; 5-HT; Serotonin; 5-HT1-7; Serotonin receptors 1-7; IC50; median inhibitory concentration; Ki; Inhibition constant;
Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies
Keywords: Lipoviral Particle; Vaccination; Viral Escape; Lipid; apo; apolipoprotein; E2; envelope glycoprotein E2; HCV; hepatitis C virus; HCVcc; cell cultureâderived HCV; Jc1E2(FLAG); J6-JFH1 chimera with FLAG epitope in E2; JFH1; Japanese fulminant hepatitis vi
TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene
Keywords: 3D; three dimensional; Ad-EGFP; adenovirus vector encoding enhanced green fluorescent protein; APOE; apolipoprotein E; Aqp1; aquaporin 1; Arg; arginine; bHLH; basic helix-loop-helix; BMDSC; bone marrow-derived stem cell; BMP; bone morphogenetic protein; B
The RNA 3D Motif Atlas: Computational methods for extraction, organization and evaluation of RNA motifs
Keywords: HL; Hairpin Loop; IL; Internal Loop; 3WJ; 3-way Junction; 4WJ; 4-way Junction; MHJ; Multi-Helix Junction; 2D structure; Secondary structure; PDB; Protein Data Bank; NDB; Nucleic Acid Database; WC; Watson-Crick; non-WC; non-Watson-Crick; BP; basepair; NR;
Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome
Keywords: Sensory Neurons; Drug; Treatment; Transient Receptor Potential Cation Channel Subfamily V Member 1; Ca2+; calcium; DRG; dorsal root ganglia; HRH1; histamine receptor H1; HV; healthy volunteer; IBS; irritable bowel syndrome; mRNA; messenger RNA; TRPV1; tra
ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer
Keywords: Transcriptome; Editome; RNA Editing; ADARs; ADAR; adenosine deaminase that act on RNA; A-to-G; adenosine to guanosine; A-to-I; adenosine to inosine; CDS; coding sequences; CM; catalytic mutant; DR; down-regulation; edt; edited; EV; empty vector; GC; gastr
Regulation of vitamin D receptor expression by retinoic acid receptor alpha in acute myeloid leukemia cells
Keywords: Vitamin D receptor; Retinoic acid receptor alpha; Expression; mRNA; Target gene; Differentiation;
MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway
Keywords: miRs; microRNAs; mRNA; messenger RNA; allo-HSCT; allogeneic hematopoietic stem cell transplantation; aGVHD; acute graft-versus-host disease; MicroRNA; T cell; CD28/B7 co-stimulatory signaling pathway; Inflammatory cytokine;
Misoprostol modulates the gene expression prostaglandin E2 and oxidative stress markers in myometrial cells
Keywords: mRNA; Prostaglandin receptors; Term pregnancy; Myometrium; Uterus; Pharmacogenomic;
Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma
Keywords: Sleeping Beauty; Liver Cancer; RalGAPs; Kinase Inhibitor; CCG; candidate cancer genes; CIS; common transposon insertion site; gCIS; gene-centric common transposon insertion site-calling method; GTPase; guanosine triphosphatase; HBsAg; hepatitis B surfac
NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis
Keywords: Apoe; Apolipoprotein e; CTGF; Connective tissue growth factor; CNN; Calponin; DN; Dominant negative; ECM; Extracellular matrix; FBS; Foetal bovine serum; HG; High glucose; LCA; Left common carotid artery; mRNA; Messenger ribonucleic acid; MASM; Mouse Aort
Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein Response
Keywords: Netrin; UPR; Hepatocyte; Translation; ATF6; activated transcription factor 6; CMV; cytomegalovirus; DAPK; death-associated protein kinase; DMS; dimethyl sulfate; DR; dependence receptor; DTT; dithiothreitol; eIF2α; Eukaryotic translation initiation facto
Original ResearchFull Report: Basic and Translational-LiverTumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib
Keywords: Liver Cancer; Mouse Model; Immune Response; Neovascularization; CCR; C-C chemokine receptor; HCC; hepatocellular carcinoma; HIF1; hypoxia-inducible factor 1; MAPK; mitogen-activated protein kinase; mRNA; messenger RNA; MVD; microvascular density; nPBN; no
Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis
Keywords: AAV; Adeno-associated viruses; ATP; Adenosine Triphosphate; ALS-FTD; ALS combined with frontotemporal dementia; ALS; Amyotrophic lateral sclerosis; ALSoD; Amyotrophic lateral sclerosis online database; C9orf72; Chromosome 9 open reading frame 72; ERGIC; E
Alterations in mRNA and protein expression of glutamate transporters in rat hippocampus after paraoxon exposure
Keywords: Hippocampus; Glutamate transporter; mRNA; Paraoxon;
Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes
Keywords: ABC; ATP-binding cassette transporter; AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase; AhR; arylhydrocarbon receptor; AKR1C1; aldo-keto reductase 1C1; APO; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BAs; bile acids; BSEP; b
De novo sequencing and transcriptome analysis of venom glands of endoparasitoid Aenasius arizonensis (Girault) (=Aenasius bambawalei Hayat) (Hymenoptera, Encyrtidae)
Keywords: De novo assembly; Illumina technology; RNA-seq; Transcriptome; Venom glands; Aenasius arizonensis.; RNA-seq; Ribonucleic Nucleic Acid: sequencing; mRNA; messenger RNA; ORF; open reading frame; RT-PCR; reverse transcription polymerase chain reaction; NCBI;
Characterization of TNF-α- and IL-17A-Mediated Synergistic Induction of DEFB4 Gene Expression in Human Keratinocytes through IκBζ
Keywords: AP-1; activator protein-1; C/EBP-β; CCAAT-enhancer-binding protein-β; ERK; extracellular signal-regulated kinase; hBD2; human β-defensin 2; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; mRNA; messenger RNA; OCT1; octamer transcr
Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma
Keywords: TGFβ; Signal Transduction; Mouse Model; Liver Cancer; α-SMA; α-smooth muscle actin; BDL; bile duct ligation; DDC; 3,5-diethoxycarbonyl-1,4-dihydro-collidin; DEN; diethylnitrosamine; HCC; hepatocellular carcinoma; HSC; hepatic stellate cell; mRNA; messe
Opportunities and Challenges for Pancreatic Circulating Tumor Cells
Keywords: Circulating Tumor Cells; Metastasis; Pancreatic Adenocarcinoma; cfDNA; cell-free DNA; CK; cytokeratin; CPC; circulating pancreas cell; CTC; circulating tumor cell; DAPI; 4ʹ,6-diamidino-2-phenylindole; EMT; epithelial-to-mesenchymal transition; EPCAM; epi
Loss of CRABP-II Characterizes Human Skin Poorly Differentiated Squamous Cell Carcinomas and Favors DMBA/TPA-Induced Carcinogenesis
Keywords: AKT; v-akt murine thymoma viral oncogene homolog 1; pAKT; phosphorylated AKT; ATRA; all-trans retinoic-acid; CRABP-II; cellular retinoic acid binding protein-II; CRBP-I; cellular retinol binding protein-I; DMBA; 7,12-dimethylbenz[a]anthracene; EGF; epider
The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
Keywords: PNPLA3; TM6SF2; NASH; Arachidonic Acid; BMI; body mass index; CI; confidence interval; DHS; Dallas Heart Study; ER; endoplasmic reticulum; HWE; Hardy-Weinberg equilibrium; IFG; impaired fasting glucose; MBOAT7; membrane bound O-acyltransferase domain cont
Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-regulation of Scavenger Receptor Class B, Type 1
Keywords: Hypertriglyceridemia; Lipid-Sensing; Fat Absorption; Triglyceride-Rich Lipoproteins; apoB; apolipoprotein B; BBM; brush-border membrane; CM; chylomicron; DMSO; dimethyl sulfoxide; LXR; liver X receptor; mRNA; messenger RNA; PDZK1; PDZ-containing kidney pr
Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice
Keywords: ApoEâ/â; apolipoprotein E-deficient; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HCD; high-cholesterol diet; HDL; high-density lipoprotein; HUVEC; human umbilical vein endothelial cells; ICAM-1; intracellular adhesion molecule-1; LDL; low-densi
Human age estimation from blood using mRNA, DNA methylation, DNA rearrangement, and telomere length
Keywords: Human age estimation; Blood biomarkers; Forensic; DNA methylation; Gene expression; mRNA; sjTREC; Telomere length;
An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease
Keywords: Bile Acids; Farnesoid X Receptor; Metabolic Disease; Ceramides; BSH; bile salt hydrolase; CA; cholic acid; cAMP; cyclic adenosine monophosphate; CDCA; chenodeoxycholic acid; CYP; cytochrome P450s; CYP7A1; CYP with cholesterol 7α-hydroxylase; DCA; deoxych
Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques
Keywords: DLS; Dynamic light scattering; DOL; Degree of labeling; FCS; Fetal calf serum; GAPDH; Glyceraldehyde 3-phosphate dehydrogenase; HA; Hyaluronan; IFN; Interferon; i.m.; Intramuscular; ISG; Interferon stimulated gene; IVIVC; In vitro-in vivo-correlation; LN;
Stanniocalcin-1 attenuates ischemic cardiac injury and response of differentiating monocytes/macrophages to inflammatory stimuli
Keywords: ANOVA; analysis of variance; ATCC; American Type Culture Collection; cDNA; complementary deoxyribonucleic acid; CM; conditioned medium; CO; cardiac output; Ct; critical threshold; CXCL2; chemokine (C-X-C motif) ligand 2; D; diastolic; DAMP; damage-associa
Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury
Keywords: A2AR; adenosine A2A receptor; CNS; central nervous system; CTCF; corrected total cell fluorescence; EDTA; ethylenediamine tetraacetic acid; EGTA; ethylene glycol tetraacetic acid; EHP; elevated hydrostatic pressure; FBS; fetal bovine serum; GCL; ganglion
Neuroplasticity and MRI: A perfect match
Keywords: AChEI; Acetyl choline esterase inhibitor; AD; Axial diffusivity; ADC; Apparent diffusion coefficient; ASL; Arterial spin labeling; BBB; Blood-brain barrier; BDNF; Brain-derived neurotrophic factor; BrdU; Bromodeoxyuridine; BOLD; Blood-oxygenation level-
Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease
Keywords: Portal Hypertension; CPEB; Cytoplasmic Polyadenylation; Alternative RNA Processing; ARE; AU-rich element; AurKA; Aurora kinase A; CPE; cytoplasmic polyadenylation element; CPEB; cytoplasmic polyadenylation element-binding protein; iKO; inducible knockout
Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients
Keywords: Th17 Cell; Virus-Induced Autoimmunity; Neonatal Immune System; IL17âProducing γδ T Cells; BA; biliary atresia; CCR6; C-C chemokine receptor type 6; ELISA; enzyme-linked immunosorbent assay; FACS; fluorescence-activated cell sorting; IFN; interferon; I
Core Fucosylation on T Cells, Required for Activation of T-Cell Receptor Signaling and Induction of Colitis in Mice, Is Increased in Patients With Inflammatory Bowel Disease
Keywords: T-Cell Signaling; Activation; Glycosylation; Oligosaccharide; DSS; dextran sodium sulfate; FUT8; α1-6 fucosyltransferase; H&E; hematoxylin and eosin; IBD; inflammatory bowel disease; IL; interleukin; mAb; monoclonal antibody; MLN; mesenteric lymph node;
Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-Derived Erythropoietin and Anemia
Keywords: Microbiome; NASH; Mouse Model; Red Blood Cells; antagomiR-122; cholesterol-modified RNA oligonucleotide; CD-HFD; choline-deficient-high-fat diet; C/EBPα; CAAT/enhancer-binding protein α; EPO; erythropoietin; HCC; hepatocellular carcinoma; IP; intraper
OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors
Keywords: Mouse Model; Colon Cancer; Signal Transduction; Tumor Suppression; co-IP; co-immunoprecipitation; CRC; colorectal cancer; EMT; epithelial-to-mesenchymal transition; HDAC; histone deacetylase; IB; immunoblotting; mRNA; messenger RNA; TBE; T-cell factor 4 b
C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits
Keywords: Spleen Tyrosine Kinase; DNA Methylation; Tumor Suppressor; Inflammatory Homeostasis; CES; composite expression score; CLEC2; C-type lectin-like receptor 2; EMT; epithelial to mesenchymal transition; GSK3; glycogen synthase kinase 3; IHC; immunohistochemis
Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers
Keywords: Air pollution; allergy; controlled human exposure; inflammatory markers; multi-omics; BAL; Bronchoalveolar lavage; BEC; Bronchial epithelial cell; DE; Diesel exhaust; DEA; Diesel exhaust plus allergen; DES; Diesel exhaust plus saline; FAA; Filtered air pl
A novel PLP1 frameshift mutation causing a milder form of Pelizaeus–Merzbacher disease
Keywords: Pelizaeus–Merzbacher disease; Spastic paraplegia 2; Proteolipid protein; Myelination; Magnetic resonance imaging; mRNA; Nonsense-mediated decay
DLEC1 is not silenced solely by promoter methylation in head and neck squamous cell carcinoma
Keywords: HNSCC; head and neck squamous cell carcinoma; DLEC1; Deleted in lung and esophageal cancer 1; TSGs; tumor suppressor genes; HPV; human papilloma virus; qRT-PCR; reverse transcription and quantitative PCR; mRNA; messenger RNA; MSP; Methylation-Specific PCR
A co-expression network analysis reveals lncRNA abnormalities in peripheral blood in early-onset schizophrenia
Keywords: lncRNAs; Long non-coding RNAs; EOS; Early-onset schizophrenia; TDCs; Typically developing controls; WGCNA; Weighted gene co-expression network analysis; GO; Gene Ontology; CCA; Canonical correlation analysis; SCZ; Schizophrenia; DISC2; Disrupted in Schizo
Alterations in DNA-methylation of the dopamine-receptor 2 gene are associated with abstinence and health care utilization in individuals with a lifetime history of pathologic gambling
Keywords: PG; pathological gambling; D2/D3 receptor; Dopamine D2/Dopamine D3 receptor; PET; positron emission tomography; DRD2; dopamine receptor D2; DNA; deoxyribonucleic acid; mRNA; messenger ribonucleic acid; CpG; cytosine-phosphate-guanine; STARPAG; stability o
Myc and mRNA capping
Keywords: c-Myc; Capping; mRNA; 7-methylguanosine; Transcription;
Determining tissue origin of circulating epithelial cells (CEC) in patients with differentiated thyroid cancer by real-time PCR using thyroid mRNA probes
Keywords: cDNA; complementary deoxyribonucleic acid; CEC; circulating epithelial cells; DTC; differentiated thyroid cancer; EpCAM; epithelial cell adhesion molecule; FITC; fluoroisothiocyanate; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; mRNA; messenger ribonu
Calreticulin mRNA expression and clinicopathological characteristics in acute myeloid leukemia
Keywords: CALR; mRNA; AML; MPN; ALL
Rift Valley fever virus NSS gene expression correlates with a defect in nuclear mRNA export
Keywords: mRNA; Rift Valley fever virus; NSS; RNA export; PABP1;
Myocardial ischemic preconditioning in a porcine model leads to rapid changes in cardiac extracellular vesicle messenger RNA content
Keywords: Extracellular vesicles; mRNA; Transcription; Ischemic preconditioning; Myocardium
Simple and inexpensive ribosome profiling analysis of mRNA translation
Keywords: Ribosome profiling; Deep sequencing; mRNA; Transcriptomics;
Role of microRNAs -29b-2, â 155, â 197 and â 205 as diagnostic biomarkers in serum of breast cancer females
Keywords: miRs; Micro-RNAs; PCR; polymerase chain reaction; RNA; ribonucleic acid; mRNA; messenger RNA; MREs; micro-RNA recognition elements; UTR; untranslated region; TCL1A; T-cell leukemia/lymphoma; Breast cancer; miR-29b-2; miR-155; miR-197; miR-205; Metastasis;
Integration analysis of miRNA and mRNA expression profiles in swine testis cells infected with Japanese encephalitis virus
Keywords: Japanese encephalitis virus; MicroRNA; mRNA; Integration analysis;