کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844184 | 1561031 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A co-expression network analysis reveals lncRNA abnormalities in peripheral blood in early-onset schizophrenia
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کلمات کلیدی
mRNAWGCNAlncRNAsPANSSDSM-IVDISC1tDCSCCAlong non-coding RNA - RNA بدون رمزگذاری طولانیLong non-coding RNAs - RNA های بدون کدگذاری طولانیSCZ - SBSDisrupted in Schizophrenia 1 - اختلال در اسکیزوفرنی 1Mitochondrial dysfunction - اختلال در عملکرد میتوکندریEarly-onset schizophrenia - اسکیزوفرنی زودهنگامSchizophrenia - اسکیزوفرنی یا شیزوفرنیWeighted gene co-expression network analysis - تجزیه و تحلیل شبکه همبستگی ژن با وزنCanonical correlation analysis - تجزیه و تحلیل همبستگی کانونیCo-expression network - شبکه همگام سازیEOs - عناوینpositive and negative syndrome scale - مقیاس مثبت و منفی سندرمGene ontology - هستیشناسی ژنی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression and disease processes especially in neuropsychiatric disorders. To explore the potential regulatory roles of lncRNAs in schizophrenia, we performed an integrated co-expression network analysis on lncRNA and mRNA microarray profiles generated from the peripheral blood samples in 19 drug-naïve first-episode early-onset schizophrenia (EOS) patients and 18 demographically matched typically developing controls (TDCs). Using weighted gene co-expression network analysis (WGCNA), we showed that the lncRNAs were organized into co-expressed modules, and two lncRNA modules were associated with EOS. The mRNA networks were constructed and three disease-associated modules were identified. Gene Ontology (GO) analysis indicated that the mRNAs were highly enriched for mitochondrion and related biological processes. Moreover, our results revealed a significant correlation between lncRNAs and mRNAs using the canonical correlation analysis (CCA). Our results suggest that the convergent lncRNA alteration may be involved in the etiologies of EOS, and mitochondrial dysfunction participates in the pathological process of the disease. Our findings may shed light on the pathogenesis of schizophrenia and facilitate future diagnosis and therapeutic strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 63, 3 December 2015, Pages 1-5
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 63, 3 December 2015, Pages 1-5
نویسندگان
Yan Ren, Yuehua Cui, Xinrong Li, Binhong Wang, Long Na, Junyan Shi, Liang Wang, Lixia Qiu, Kerang Zhang, Guifen Liu, Yong Xu,