دانلود مقالات ISI درباره Mtor + ترجمه فارسی

Protective effect and mechanism of Muntingia calabura Linn. fruit ethanolic extract against vascular endothelial growth factor production in nickel-stimulated hepatocellular carcinoma cells

Keywords: MFEE; M. calabura Linn. fruit ethanolic extract; Ni; nickel; VEGF; vascular endothelial growth factor; RAF1; Raf-1 proto-oncogene, serine/threonine kinase; MEK1/2; mitogen-activated protein kinase 1/2; ERK1/2; extracellular-signal-regulated kinase1/2; JAK

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Intravesical Immunomodulatory Imiquimod Enhances Bacillus Calmette-Guérin Downregulation of Nonmuscle-invasive Bladder Cancer

Keywords: BCG; Intravesical; mTOR; Toll-like; Urothelial cancer;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Bardoxolone methyl induces neuritogenesis in Neuro2a cells

Keywords: Akt; v-Akt Murine Thymoma Viral Oncogene; ARE; Antioxidant Responsive Element; BDNF; Brain Derived Neurotrophic Factor; CDDO; 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid; CHOP; C/EBP homologous protein; DR5; Death Receptor 5; ERK; Extracellular signal Re

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

miR-5590-3p inhibited tumor growth in gastric cancer by targeting DDX5/AKT/m-TOR pathway

Keywords: microRNA-5590-3p (miR-5590-3p); Gastric cancer (GC); DEAD (Asp-Glu-Ala-Asp) box helicase 5 (DDX5); AKT; mTOR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

4′-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling

Keywords: 4′-hydroxywogonin; Colorectal cancer; Vascular endothelial growth factor-A; PI3K; AKT; Angiogenesis; 4′-HW; 4′-hydroxywogonin; PI3K; phosphatidylinositol 3 kinase; VEGF-A; vascular endothelial growth factor-A; GAPDH; glyceraldehyde-3-phosphate dehyd

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Vitexin reverses the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR/Ulk1 pathway

Keywords: MCAO; middle cerebral artery occlusion; Bcl-2; B cell lymphoma 2; Bax; Bcl-2-associated X protein; Ki-67; identified by monoclonal antibody; LDH; lactate dehydrogenase; MDA; malondialdehyde; NO; nitric oxide; IL; interleukin; TNF-; αtumor necrosis factor

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Mechanistic target of rapamycin (MTOR) protein expression in the tumor and its microenvironment correlates with more aggressive pathology at cystectomy

Keywords: mTOR; Neoadjuvant chemotherapy; Immunohistochemistry; Radical cystectomy; Tumor microenvironment;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Roles of microRNA in prostate cancer cell metabolism

Keywords: AMPK; adenosine monophosphate-activated protein kinase; HIF-1α; hypoxia-inducible factor 1-alpha; mTOR; mammalian target of rapamycin; PI3K/AKT; phosphatidylinositol 3-kinase; ATP; adenosine triphosphate; TCA cycle; tricarboxylic acid cycle; GLUTs; gluco

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

MiR-145 ameliorates neuropathic pain via inhibiting inflammatory responses and mTOR signaling pathway by targeting Akt3 in a rat model

Keywords: TNF-α; tumor necrosis factor; IL; interleukin; CNS; central nervous system; Neuropathic pain; MiR-145; Inflammation; mTOR; Akt-3;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer

Keywords: Bigelovin; Liver cancer; Apoptosis and autophagy; mTOR; ROS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

mTOR up-regulation of BEX4 promotes lung adenocarcinoma cell proliferation by potentiating OCT4

Keywords: Lung adenocarcinoma; BEX4; OCT4; mTOR;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Interaction between mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53/p21/p16

Keywords: mTOR; Autophagy; VSMC senescence; p53; p21; p16;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain

Keywords: mTOR; Pain; Multiple sclerosis; Depression; Alzheimer's disease; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Underlying action mechanism of a novel antioxidant peptide derived from Allium tuberosum Rottler protein hydrolysates and its protective effects on hydrogen peroxide induced cell injury

Keywords: Antioxidant peptide; Allium tuberosum Rottler; Free radicals; Oxidative damage; Akt/mTOR signaling pathway; DPPH; 1, 1-diphenyl-2-picrylhydrazyl; ABTS; 2, 2′-azinobis-3-ethylbenzthiazoline-6-sulphonate; ACN; acetonitrile; TFA; triflouroacetic acid; LCâ€

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

A gene expression profile associated with perineural invasion identifies a subset of HNSCC at risk of post-surgical recurrence

Keywords: Head and neck squamous cell carcinoma; Perineural invasion; The Cancer Genome Atlas (TCGA); Gene expression; ALI; angiolymphatic invasion; CPE; consensus purity estimation score; DFS; disease free survival; ECS; extracapsular spread; FDR; false discovery

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

The expression of p-mTOR and COUP-TFII correlates with increased lymphangiogenesis and lymph node metastasis in prostate adenocarcinoma

Keywords: Prostate; Adenocarcinoma; mTOR; NR2F2; Metastasis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting of microRNA-21-5p protects against seizure damage in a kainic acid-induced status epilepticus model via PTEN-mTOR

Keywords: ANOVA; analysis of variance; Ant-Scr; antagomir scrambled oligonucleotide; DG; dentate gyrus; EEG; electroencephalogram; FDR; false discovery rate; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; IPI; initial precipitating injury; KA; kainic acid; Ant-21

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways

Keywords: Akt; protein kinase B; Atg; autophagy related gene; CNS; central nervous system; COX-2; cyclooxygenase-2; CQ; chloroquine; ERK; extracellular signal-regulated kinase; IL-1β; interleukin-1β; iNOS; inducible nitric oxide synthase; JNK; c-jun NH2-terminal

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Expression of the miR-150 tumor suppressor is restored by and synergizes with rapamycin in a human leukemia T-cell line

Keywords: microRNA; miR-150; mTOR; Cell cycle; Proliferation; Rapamycin; Acute lymphoblastic leukemia; Jurkat; Gene network;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

NF-κB-induced WIP1 expression promotes colorectal cancer cell proliferation through mTOR signaling

Keywords: Colorectal cancer (CRC); Cell proliferation; Wild-type p53-induced protein 1 (WIP1); NF-κB; mTOR; p21;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacological effects and potential therapeutic targets of DT-13

Keywords: ADP; adenosine diphosphate; Akt; protein kinsase B; ALT; alanine transaminase; APD; action potential duration; AST; aspartate transaminase; Atg; autophagocytosis associated protein; CCR5; C, C chemokine receptor type 5; CXCR4; C-X-C chemokine receptor typ

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells

Keywords: IL-1α; B cells; Antibody; Xbp-1; mTOR;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer

Keywords: Rectal cancer; Memory T cells; IL-2; Metformin; mTOR;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Gallotannin derivatives from mango (Mangifera indica L.) suppress adipogenesis and increase thermogenesis in 3T3-L1 adipocytes in part through the AMPK pathway

Keywords: ATCC; American Type Culture Collection; AMPK; AMP-activated protein kinase; BAT; brown adipose tissue; C/EBPα; CCAAT/enhancer binding protein α; CPT1; carnitine palmitoyltransferase I; DCFH-DA; 2′,7′-dichlorofluorescein diacetate; DMEM; Dulbecco's

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Exosomes as a liquid biopsy for lung cancer

Keywords: Alix; ALG 2 interacting protein X; ALK; anaplastic lymphoma kinase; AREG; Amphiregulin; Atg2; autophagy related protein 2; AUC; area under the curve; BAL; bronchoalveolar lavage; circRNA; circular RNA; CSE; cigarette smoke extract; CTC; circulating tumor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Design and synthesis of alkyl substituted pyridino[2,3-D]pyrimidine compounds as PI3Kα/mTOR dual inhibitors with improved pharmacokinetic properties and potent in vivo antitumor activity

Keywords: PI3K; phosphoinositide 3-kinase; mTOR; mammalian target of rapamycin; TSC; tuberous sclerosis; DDQ; 2,3-dicyano-5,6-dichlorobenzoquinone; THF; tetrahydrofuran; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; MRT; mean retention time; PI3Kα/

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer

Keywords: ACT; Adoptive cell therapy; APCs; Antigen presenting cells; CAR; Chimeric antigen receptor; CCR5; CC-chemokine receptor 5; CFSE; Carboxyfluorescein succinimidyl ester; CRC; Colorectal cancer; GSK-3β; Glycogen synthase kinase-3β; IFN-γ; Interferon-γ; L

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

The short-term presence of oleate or octanoate alters the phosphorylation status of Akt, AMPK, mTOR, CREB, and FoxO1 in liver of rainbow trout (Oncorhynchus mykiss)

Keywords: Trout; Liver; Fatty acid; Akt; AMPK; mTOR; CREB; FoxO1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Homocysteine up-regulates ETB receptors via suppression of autophagy in vascular smooth muscle cells

Keywords: AMPK; AMP-activated protein kinase; CVDs; Cardiovascular diseases; DAPI; 4,6-diamido-2-phenylindole dihydrochloride; DMEM; Dulbecco's modified Eagle's medium; DMSO; Dissolved in dimethyl sulfoxide; ET; Endothelin; ET-1; Endothelin-1; ETA; Endothelin type

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

mTORC1 pathway disruption abrogates the effects of the ciliary neurotrophic factor on energy balance and hypothalamic neuroinflammation

Keywords: Obesity; Inflammation; CNTF; S6K1; mTOR; Microglia; Glia cells; Hypothalamus;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

The metaplastic effects of NMDA receptors blockade on reactivation of instrumental memories in rats

Keywords: Akt; protein kinase B; ALP; active lever presses; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; Amy; amygdala; ANOVA; analysis of variance; BLA; basolateral complex of amygdala; CeA; central nucleus of amygdala; Cx; context; DAB;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Radiation-Induced Endothelial Vascular Injury

Keywords: angiogenesis; apoptosis; cytokines; senescence; ATM; ataxia telangiectasia mutated; CD; cluster of differentiation; EC; endothelial cell; HUVEC; human umbilical vein endothelial cell; IGF; insulin-like growth factor; IGFBP; insulin-like growth factor bind

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

miR-199a-3p regulates brown adipocyte differentiation through mTOR signaling pathway

Keywords: BAT; miR-199a-3p; Adipogenesis; Mitochondrial function; mTOR;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Long-term inhibition of PDE5 ameliorates aging-induced changes in rat testis

Keywords: Actb/ACTB; gene/protein for β-actin; AKT; protein for protein kinase B (AKT/PRKGB); BSA; bovine serum albumin; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; Cyp11a1; gene for cytochrome P450 side chain cleavage enzyme; Cyp17

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Upregulation of EphB3 in gastric cancer with acquired resistance to a FGFR inhibitor

Keywords: FGFR inhibitor; Gastric cancer; Resistance; EphB3; mTOR;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Alpha, 2'-dihydroxy-4,4'-dimethoxydihydrochalcone inhibits cell proliferation, invasion, and migration in gastric cancer in part via autophagy

Keywords: TEM; transmission electron microscope; DCFDA; dihydrodichlorofluorescein diacetate; MEK; mitogen activated protein kinase kinase; ERK; extracellular signal-regulated kinase; mTOR; mammalian target of rapamycin; ROS; reactive oxygen species; PDX; patient

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

First-in human, phase 1, dose-escalation pharmacokinetic and pharmacodynamic study of the oral dual PI3K and mTORC1/2 inhibitor PQR309 in patients with advanced solid tumors (SAKK 67/13)

Keywords: PQR309; mTOR; PI3K; Phase 1; Solid tumours;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Immunosuppression, Race, and Donor-Related Risk Factors Affect De novo Cancer Incidence Across Solid Organ Transplant Recipients

Keywords: BMI; body mass index; CNI; calcineurin inhibitor; HR; hazard ratio; mTOR; mammalian target of rapamycin; SRTR; Scientific Registry of Transplant Recipients; SOT; solid organ transplant;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Dietary supplementation of A-type procyanidins from litchi pericarp improves glucose homeostasis by modulating mTOR signaling and oxidative stress in diabetic ICR mice

Keywords: A-type procyanidins; Oxidative stress; Glucose homeostasis; Type 2 diabetes; mTOR; ACC1; acetyl coenzyme A carboxylase 1; ACL; ATP-citrate lyase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AUC; area under curve; BAT; brown adipose tis

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis

Keywords: CML; chronic myeloid leukemia; EGFR; Epidermal growth factor receptor; FUS1; Fused in sarcoma-1; GST; Glutathione S-transferase; IGF-1; Insulin-like growth factor-1; JAK/STAT; Janus tyrosine kinase/signal transducer and activator of transcription; MMP-1;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats

Keywords: AKT; Ischemic penumbra; mTOR; Resveratrol; STAT3; Stroke;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

eIF4E Phosphorylation in Prostate Cancer

Keywords: eIF4E; eukaryotic translation initiation factor 4E; mTOR; mammalian target of rapamycin; PCa; prostate cancer; Mnk; mitogen activated protein kinase interacting protein kinase; ADT; androgen deprivation therapy; MAPK; mitogen-activated protein kinase; CRP

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI

Keywords: AAV2; adeno-associated virus serotype-2; C2 (3, 4, 5, etc.); cervical spinal cord level 2 (3, 4, 5, etc.); CMAP; compound muscle action potential; CNS; central nervous system; CTB; cholera toxin subunit B; EMG; electromyography; GAP; GTPase-activating pro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio)

Keywords: dpf; days post-fertilization; mTOR; mechanistic target of rapamycin; PCB; polychlorinated biphenyl; RyR; ryanodine receptor; Ca2+-dependent signaling; Fish behavior; Insecticide; Neurodevelopment; Pesticide; Pyrethroid;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

KRAS-Mutant non-small cell lung cancer: From biology to therapy

Keywords: BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Brain damage and neurological symptoms induced by T-2 toxin in rat brain

Keywords: ANOVA; one-way analysis of variance; ATA; alimentary toxic aleukia; atg14; autophagy related 14; atg5; autophagy related 5; bax; Bcl 2 associated X; BBB; Blood brain barrier; BPB; Blood placenta barrier; BSA; bovine serum albumin; Caspase-3; Cysteinyl asp

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

AMPK induced memory improvements in the diabetic population: A case study

Keywords: Type 2 diabetes (T2D); Alzheimer's disease (AD); Mild cognitive impairment (MCI); Ketogenic diet; High intensity interval training (HIIT); AMPK; mTOR;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Possible use of Punica granatum (Pomegranate) in cancer therapy

Keywords: 27HC; 27-hydroxycholesterol; 8-OHdG; 8-hydroxy-2′ -deoxyguanosine; 8-oxodG; 8-oxo-7,8-dihydro-2′-deoxyguanosine; APC; adenomatous polyposis coli; AR; androgen receptors; AOM; azoxymethane; ATP; adenosine triphosphate; B(a)P; benzo(a)pyrene; Bad; Bcl-2

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?

Keywords: Neurodegenerative diseases; mTOR; omega-3; Docosahexaenoic acid; Eicosapentaenoic acid;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling

Keywords: Plk2; Polo-like kinase 2; TSC; tuberous sclerosis complex; mTOR; mammalian target of rapamycin; p70S6K/S6K; S6: Ribosomal protein S6 kinase; AMPK; AMP-responsive protein kinase; REDD 1; regulated in DNA damage and development 1; 4EBP1; eukaryotic translat

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه