Keywords: Phytopolyphenol; Hepatoprotection; Acetaminophen overdose; Drug-induced toxicity; Enol-based cytoprotectants; APAP; acetaminophen; NAPQI; N-acetyl-p-benzoquinonimine; PBS; phosphate buffered saline; 2-ACP; 2-acetylcyclopentanone; NAC; N-acetylcysteine; GS
مقالات ISI (ترجمه نشده)
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Keywords: AAP; 4-aminophenazone; ALP; alkaline phphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CAT; catalase; CYPs; cytochrome P 450s; DHBS; 3,5-Dichloro -2-hydroxybenzene sulfonic acid; EDTA; ethylenediaminetetraacetic acid; GGT; gamma g
Keywords: Acn; acetonitrile; GSH; glutathione; GST; glutathione S-transferase; HKM; human kidney microsomes; HLM; human liver microsomes; HPLC; high-performance liquid chromatography; I.S.; internal standard; LC-MS; liquid chromatography mass spectrometry; NAPQI;
Keywords: DILI; Immune-mediated; Tolerance; Antigen; Immune cells homing; DILI; drug-induced liver injury; HLA; human leukocyte antigen; APCs; antigen presenting cells; DCs; dendritic cells; LSECs; liver sinusoidal endothelial cells; KCs; Kupffer cells; APAP; aceta
Keywords: 1H NMR; proton nuclear magnetic resonance spectroscopy; MS; mass spectrometry; GCMS; gas chromatography-mass spectrometry; UPLC; ultraperformance liquid chromatography; ESI-QTOFMS; electrospray ionization-quadrupole time-of-flight mass spectrometry; PCA
Keywords: High-throughput; Hepatotoxicity; Organotypic culture models; Multi-cellular; Chemical mixtures; ADH; Alcohol dehydrogenase; APAP; acetaminophen; CS; collagen sandwich; CYP; cytochrome P450; EtOH; ethanol; GSH; glutathione; HFC; 7-hydroxy-4-(trifluoromethy
Keywords: 2-APB; 2-aminoethoxy-diphenyl-borate; ALT; alanine aminotransferase; ANOVA; analysis of variance; APAP; acetaminophen; ATP; adenosine triphosphate; CBX; carbenoxolone; Cx; connexin; ELISA; enzyme-linked immunosorbent assay; FRAP; fluorescence recovery aft
Keywords: CYP; Cytochrome P450; NAPQI; N-acetyl-p-benzoquinone imine; NEC; Necrotizing enterocolitis; NIAPAS; Neonatal Infant Acute Pain Assessment Scale; NICU; Neonatal intensive care unit; PDA; Patent ductus arteriosus; VLGA; Very low gestational age;
Keywords: PCT; paracetamol; HPC; hydroperoxide content; LPX; lipid peroxidation; PCC; protein carbonyl content; SOD; superoxide dismutase; CAT; catalase; GPx; glutathione peroxidase; LC-MS/MS; liquid chromatography-tandem mass spectrometry; MS; mass spectrometer; L
Keywords: PAPS; 3â²-Phosphoadenosine 5â²-phosphosulfate; DTNB; 5,5â²-Dithiobis(2-nitrobenzoic acid); APAP; Acetaminophen; ALT; Alanine aminotrasferase; BSA; Bovine serum albumin; CCl4; Carbon tetrachloride; Ccr2; C-C chemokine receptor 2; CFB; Clofibrate; CD;
Keywords: ALT; alanine aminotransferase; APAP; acetaminophen; CD; cluster of differentiation; Cx; connexin; ELISA; enzyme-linked immunosorbent assay; GJIC; gap junctional intercellular communication; GSH; glutathione; GSSG; glutathione disulfide; hepaCAM; hepatocyt
Keywords: ALT; alanine aminotransferase; APAP; acetaminophen; ConA; concanavalin A; CYP; cytochrome P450; ET; endotoxin; FasL; Fas ligand; Gal; D-galactosamine; GSH; glutathione; IFNγ; interferon γ; NAPQI; N-acetyl-p-benzoquinone imine; p-JNK; c-jun N-terminal ki
Keywords: ALP; alkaline phosphatise; ALT; alanine transaminase; APAP; acetaminophen; AST; aspartate transaminase; ATP; adenosine triphosphate; G-GT; gamma-glutamyl transpeptidase; HDL-C; high-density lipoprotein cholesterol; LDL-C; low-density lipoprotein cholester
Keywords: LT; liver transplantation; ALF; acute liver failure; APAP; acetaminophen; NAPQI; N-acetyl-p-benzoquinone imine; DAMP; damage-associated molecular pattern; HMGB1; high-mobility group box-1 protein; DNA; deoxyribonucleic acid; TLR4; toll-like receptor 4; Na
Keywords: CYP; cytochrome P450; 3-D; three-dimensional; APAP; acetaminophen; NAPQI; N-acetyl-p-benzoquinone imine; GSH; glutathione; ROS; reactive oxygen species; UGT; UDP-glucuronosyltransferase; SULT; sulfotransferase; ABT; 1-aminobenzotriazole; mBCl; monochlorob
Keywords: 3-HB; 3-Hydroxybutyrate; ALP; alkaline phosphatase; ALT; alanine aminotransferase; APAP; acetaminophen; AST; aspartate aminotransferase; ATP; adenosine-5â²-triphosphate; CHOL; cholesterol; CTRL; control; CYP450; cytochrome P450; GGT; γ-glutamyl transfer
Keywords: SOD; superoxide dismutase; GPx; glutathione peroxidases; CAT; catalase; GSH; reduced glutathione; GSSG; oxidized glutathione; GST; glutathione S-transferase; GR; glutathione reductase; mtDNA; mitochondrial DNA; DOX; doxorubicin; APAP; acetaminophen; NAPQI
Activation of the capsaicin-receptor TRPV1 by the acetaminophen metabolite N-arachidonoylaminophenol results in cytotoxicity
Keywords: Acetaminophen; NAPQI; Analgesia; AM404; TRPV1; Neurotoxicity;
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro
Keywords: Nuclear factor erythroid-2-related factor 2 (Nrf2); Acetaminophen (APAP); Acute liver injury; Oxidative stress; Ginsenoside Rg1; ALT; alanine transaminase; ARE; antioxidant element; AST; aspartate transaminase; CAT; catalase; GCL; glutamate-cysteine ligas
Role of cytochrome P450s in the generation and metabolism of reactive oxygen species
Keywords: Cytochrome P450; Reactive oxygen species; Reaction uncoupling; CYP; cytochrome P450; ROS; reactive oxygen species; NAPQI; N-acetyl-p-benzo-quinone-imine; HETE; hydroxyeicosatetraenoic acid; EET; epoxyeicosatrienoic acid;
A new bioluminescent imaging technology for studying oxidative stress in the testis and its impacts on fertility
Keywords: APAP; Acetaminophen; NAPQI; n-acetyl-p-benzoquinone imine; HCR; Hepatocellular carcinoma reporter; PCL-1; Peroxy Caged Luciferin-1; MDA; Malondialdehyde; SOD; Superoxide dismutase; GSH-Px; Glutathione peroxidase; GSH; Reduced glutathione; ROS; Reactive ox
Natural product andrographolide alleviated APAP-induced liver fibrosis by activating Nrf2 antioxidant pathway
Keywords: APAP; acetaminophen; Nrf2; nuclear factor erythroid 2-related factor 2; Andro; andrographolide; HSCs; hepatic stellate cells; ROS; reactive oxygen species; ECMs; extracellular matrix proteins; Egr1; early growth factor 1; Keap1; kelch-like ECH-associated
Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice
Keywords: 3-NT; 3-nitro-tyrosine; ALI; acute liver injury; ALT; alanine aminotransferase; APAP; acetaminophen; AST; aspartate aminotransferase; CAT; catalase; Cl-Cas-3; cleavage Caspase-3; CYP2E1; cytochrome P450 2E1; ERK1/2; extracellular signal-regulated kinase 1
Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes
Keywords: APAP; Acetaminophen; NAPQI; N-Acetyl-p-benzoquinone imine; GSH; reduced glutathione; APAP-cys; 3-(cystein-S-yl)-acetaminophen; NO; Nitric Oxide; iNOS; Inducible nitric oxide synthase (NOS2); nNOS; Neuronal nitric oxide synthase (NOS1); GSNO; S-Nitrosoglut
Long-term acetaminophen treatment induced liver fibrosis in mice and the involvement of Egr-1
Keywords: APAP; acetaminophen; Egr-1; early growth response 1; COL; collagen; TGF-β; transforming growth factor-β; α-SMA; α-smooth muscle actin; NAPQI; N-acetyl-p-benzoquinoneimine; ECMs; extracellular matrix proteins; OTC; over-the-counter; ALF; acute liver fa
An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure
Keywords: Hepatotoxicity; Metabolism; Hepatitis; AcetaSTAT; ALF; acute liver failure; ALFSG; Acute Liver Failure Study Group; ALI; acute liver injury; ALT; alanine aminotransferase; 3-cys-A or adduct; 3-(cysteine-S-yl) acetaminophen protein-adduct; HPLC-EC; high-p
Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver
Keywords: ALF; acute liver failure; NAPQI; N-acetyl-p-benzoquinone imine; UGT; UDP-glucuronosyltransferase; SULT; sulfotransferase; CYP; cytochrome P450; 3â²-UTR; 3â²-untranslated region; SNP; single nucleotide polymorphism; miRNA; microRNA; UDPGA; uridine diphos
N-acetylcysteine amide, a promising antidote for acetaminophen toxicity
Keywords: GSH-prodrug; Acetaminophen; Hepatotoxicity; Oxidative stress; NAPQI; Glutathione
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation
Keywords: ALT; alanine aminotransferase; APAP; acetaminophen; AST; aspartate aminotransferase; CYP; cytochrome P450; GSH; glutathione; NAPQI; N-acetyl-p-benzoquinone imine; SinA; Schisandrin A; SinB; Schisandrin B; SinC; Schisandrin C; SolA; Schisandrol A; SolB; Sc
The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes
Keywords: APAP; Acetaminophen; NAPQI; N-Acetyl-p-benzoquinone imine; GSH; Reduced glutathione; APAP-cys; 3-(cystein-S-yl)-acetaminophen; NO; Nitric Oxide; iNOS; Inducible nitric oxide synthase (NOS2); nNOS; Neuronal nitric oxide synthase (NOS1); GSNO; S-Nitrosoglut
Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2
Keywords: AMC; 7-amino-4-methylcoumarin; CDDO-Me; methyl-2-cyano-3,12-dioxooleana-1, 9(11)dien-28-oate; DNCB; 2,4-dinitrochlorobenzene; Gclm; glutamate-cysteine ligase regulatory subunit; HIF-1α; hypoxia-inducible factor 1α; IAA; iodoacetamide; Keap1; Kelch-lik
The molecular mechanism underlying the hepatoprotective potential of Moringa oleifera leaves extract against acetaminophen induced hepatotoxicity in mice
Keywords: Antioxidant enzyme; Antioxidant response element (ARE); Cytochrome P450 2E1/1A2/2A6; Inflammatory cytokines; Nuclear factor erythroid 2-related factor 2 (Nrf2); MO; Moringa oleifera; APAP; acetaminophen; GSH; glutathione; Nrf2; nuclear factor-erythroid 2
Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases
Keywords: PTKs; protein tyrosine kinases; PTPs; protein tyrosine phosphatases; PTP1B; protein tyrosine phosphatase 1B; NAFLD; non-alcoholic fatty liver disease; HCC; hepatocellular carcinoma; DSPs; dual specificity phosphatases; LMW; low molecular weight; RPTPs; tr
Trapping of NAPQI, the intermediate toxic paracetamol metabolite, by aqueous sulfide (S2−) and analysis by GC–MS/MS
Keywords: Acetaminophen; Liver; Mice; NAPQI; Quantification; 3-Thio-paracetamol
The role of intrahepatic CD3Â +/CD4Â â/CD8Â â double negative T (DN T) cells in enhanced acetaminophen toxicity
Keywords: GrB; granzyme B; DN T; double negative T; APAP; acetaminophen; DILI; drug-induced liver injury; NAPQI; n-acetyl-benzoquinone imine; NK; natural killer; CTL; cytotoxic T lymphocytes; FasL; Fas ligand; Gr; granzyme; i.p; intraperitoneally; ALT; alanine tran
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Keywords: AFB; aflatoxin B1; AhR; aryl hydrocarbon receptor; APAP; acetaminophen; BaP; benzo(α) pyrene; BMD; benchmark dose; BNA; Bayesian network analysis; BPDE; benzo(a) pyrene diolepoxide; CDKN1A; cyclin-dependent kinase inhibitor 1A; cDNA; copy DNA; CES; criti
Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats
Keywords: ET; endothelin; NAC; N-acetylcysteine; PBS; phosphate buffered saline; TNF-α; tumor necrosis factor-α; ALT; alanine aminotransferase; AST; aspartate aminotransferase; SOD; Superoxide dismutases; GSH; Glutathione; MDA; Malondialdehyde; NAPQI; N- asetil-
Research ArticleARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis
Keywords: ARC; apoptosis repressor with caspase recruitment domain; JNK; c-Jun N-terminal kinase; AAP; acetaminophen; HIV-1; human immunodeficiency virus 1; HMGB1; chromatin protein high mobility group box-1; NAC; N-acetylcysteine; NAPQI; N-acetyl-p-benzoquinone im
Research ArticleCHOP is a critical regulator of acetaminophen-induced hepatotoxicity
Keywords: DILI; drug induced liver injury; APAP; acetaminophen (N-acetyl-p-aminophenol); NAPQI; N-acetylbenzoquinoneimine; GSH; glutathione; ER; endoplasmic reticulum; UPR; unfolded protein response; ALI; acute liver injury; ROS; reactive oxygen species; ALT; alani
A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells
Keywords: ATP; adenosine triphosphate; DMSO; dimethyl sulfoxide; GSH; glutathione; IU; international unit; NAPQI; N-acetyl-p-benzoquinone imine; ROS; reactive oxygen species; HepG2; Cytotoxicity; Metabolic stress; Cytosensor; Mitochondrial respiration; Respiratory
A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification
Keywords: Abcc; ATP-binding cassette subfamily C multidrug-resistance transporters; ALT; alanine transaminase; Aox1; aldehyde oxidase-1; APAP; acetaminophen (paracetamol); BSO; buthionine sulfoximine; Cre; bacteriophage P1 cyclization recombinase; CYP; cytochrome P
Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase
Keywords: STK; stem cell-derived tyrosine kinase; IL; interleukin; MCP-1; monocyte chemoattractant protein-1; NAPQI; N-acetyl-p-benzoquinone-imine; Cyp; cytochrome P450; TNFα; tumor necrosis factor-α; TNFR; tumor necrosis factor receptor; HO-1; heme oxygenase-1;
Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes
Keywords: 1-ABT; 1-aminobenzotriazole; BA; bile acid; BSEP/Bsep; human/rat bile salt export pump; CYP450; cytochrome P450; DILI; drug-induced liver injury; IC50; 50% inhibitory concentration; Ki; inhibition constant; LDH; lactate dehydrogenase; NAPQI; N-acetyl-p-be
Macrophage activation by factors released from acetaminophen-injured hepatocytes: Potential role of HMGB1
Keywords: AA; acetaminophen; CM-H2DCFDA; 5-(and-6)-chloromethyl-2â², 7â²-dichlorodihydro-fluorescein diacetate acetyl ester; COX; cyclooxygenase; DTPA; diethylene triamine pentaacetic acid; EGTA; ethylene glycol-bis(2-aminoethylether)-N,N,Nâ²,Nâ²-tetraacetic ac
Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity
Keywords: ALT; alanine aminotransferase; APAP; acetaminophen, paracetamol, N-acetyl-p-aminophenol; AST; aspartate aminotransferase; AUC; area under the curve; AUC0-â; AUC to infinity; ClT; total body clearance; Cn; final plasma concentration; λz; apparent term
Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells
Keywords: APAP; acetaminophen; NAPQI; N-acetyl-p-benzoquinoneimine; GSH; glutathione; ALT; alanine aminotransferase; CM-H2DCFDA; 5-(and-6)-chloromethyl-2â²7â²-dichlorodihydrofluorescein diacetate; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidaz
Pain Management in the Cirrhotic Patient: The Clinical Challenge
Keywords: OTCA; over-the-counter analgesic; COX-2; cyclooxygenase 2; CYP; cytochrome P450; FDA; Food and Drug Administration; GFR; glomerular filtration rate; HCV; hepatitis C virus; NAPQI; N-acetyl-p-benzoquinone imine; NSAID; nonsteroidal anti-inflammatory drug;
Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB
Keywords: DILI; drug-induced liver injury; CRMs; chemically reactive metabolites; GSH; glutathione; Nrf2; nuclear factor-erythroid 2 (NF-E2)-related factor; NF-κB; NF-kappa B; ARE; anti-oxidant response element; NAPQI; N-acetyl-p-benzoquinineimine; DNCB; dinitroch
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen
Keywords: Acetaminophen; Clofibrate; Peroxisome proliferators; Hepatoprotection; NQO1; NAPQI
Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography–mass spectrometry
Keywords: Affinity; On-line; Pronase; Protein adduct formation; Digestion; Protein; Albumin; LC–MS; NAPQI