کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5828245 | 1558955 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats
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کلمات کلیدی
ALTNACGSHMDAO.D.PBSNAPQIDMRTET-1CMCBOSN-acetylcysteine - N-استیل سیستئینROS - ROSAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازendothelin - اندوتلینBosentan - بوسنتانANOVA - تحلیل واریانس Analysis of varianceone-way analysis of variance - تحلیل واریانس یک راههEnzyme-linked immunosorbent assay - تست الیزاELISA - تست الیزاtumor necrosis factor-α - تومور نکروز عامل αSOD - سدHepatotoxicity - سمیت کبدsuperoxide dismutases - سوکسوکس دیسموتازهاTNF-α - فاکتور نکروز توموری آلفاPhosphate buffered saline - فسفات بافر شورmalondialdehyde - مالون دی آلدهیدRat - موش صحراییhuman immunodeficiency virus - ویروس نقص ایمنی انسانیHIV - ویروس نقص ایمنی انسانی Paracetamol - پاراستامولGlutathione - گلوتاتیونReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats](/preview/png/5828245.png)
چکیده انگلیسی
Paracetamol is one of the first rank drugs which cause hepatic damage during drug intoxications. Endothelin (ET) which is known as one of the most potent vasoactive agent has been shown to contribute in the pathophysiology of various diseases. We hypothesized that bosentan, which is a non-selective ET-1 receptor antagonist, can prevent liver damage. This study included 49 female rats. Groups; I: Healthy group, II: Paracetamol (2 g/kg orally). Groups 3, 4 and 5 received NAC 140 mg/kg (2 doses), BOS 45 mg/kg and BOS 90 mg/kg orally, respectively. 1 h after administration of pretreatment drugs, Groups 3, 4, 5 were given paracetamol. VI: received BOS 90 mg/kg. VII: received 140 mg/kg NAC (2 doses). According to biochemical results, TNF-α, ALT and AST levels were statistically increased in the paracetamol group, these parameters were improved in the bosentan groups. Paracetamol administration decreased SOD activity, GSH level and increased level of MDA in the liver, while bosentan administration significantly improved these parameters. In immunohistochemical staining ET-1 receptor expression was excessively increased in paracetamol group, but not in bosentan groups when compared to healthy control. All these results suggest that bosentan exerted protective effects against experimentally induced paracetamol toxicity in liver.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 726, 5 March 2014, Pages 87-95
Journal: European Journal of Pharmacology - Volume 726, 5 March 2014, Pages 87-95
نویسندگان
Muhammed Yayla, Zekai Halici, Bunyami Unal, Yasin Bayir, Erol Akpinar, Fatma Gocer,