کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4136975 | 1271996 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species
ترجمه فارسی عنوان
کوئرستین در برابر سمیت هپاتوآنن ناشی از استامینوفن با کاهش اکسیژن واکنش دهنده و گونه های نیتروژن محافظت می کند
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کلمات کلیدی
NADPHGSHGPXNAPQIALTLDL-CHDL-CAPAPAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPAST - آسپارتات ترانس آمینازalanine transaminase - آلانین ترانس آمینازALP - آلکالن فسفاتازAcetaminophen - استامینوفن aspartate transaminase - ترانس آمیناز آسپارتاتAlkaline phosphatise - فسفاتاز قلیاییhigh-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالreduced nicotinamide adenine dinucleotide phosphate - کاهش نیکوتین آمید آدنین دینکلوتید فسفاتreduced glutathione - کاهش گلوتاتیونLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کمgamma-glutamyl transpeptidase - گاما گلوتامیل ترانسپپتیدازglutathione reductase - گلوتاتیون ردوکتازglutathione peroxidase - گلوتاتیون پراکسیداز
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
چکیده انگلیسی
High or toxic doses of acetaminophen (APAP), a mild analgesic and antipyretic drug, can cause life-threatening hepatic and renal dysfunction. This study is designed to investigate the potential protective role of quercetin to attenuate the hepatorenal toxicity induced by a high single oral dose (3Â g/kg) of APAP in rats. Three main groups of Sprague-Dawley rats were used: quercetin, APAP and quercetin plus APAP-receiving animals. Corresponding control animals were also used. Interestingly, oral supplementation of quercetin (15Â mg/kg/day) prior to APAP intoxication dramatically reduced APAP-induced hepatorenal toxicity as evidenced by measuring serum lipid profile, total protein, urea, creatinine, ALT, AST, ALP, G-GT and liver tissue content of TC and TG. Quercetin treatment markedly prevented the generation of TBARS and PCC with substantial improvement in terms of GSH and activities of antioxidant enzymes in both liver and kidney homogenates. The relationship between quercetin and NO levels which is still a matter of debate, was also investigated. NO levels in serum, liver and kidney tissues were significantly inhibited in quercetin pre-treated animals. Furthermore, quercetin administration significantly inhibited the reduction of liver and kidney contents of ATP parcels associated with this hepatorenal toxicity. These results suggest that the protective role of quercetin in the prevention of APAP-induced hepatorenal toxicity in rats was associated with the decrease of oxidative and nitrosative stress in hepatic and renal tissues as well as its capacity to improve the mitochondrial energy production. However, clinical studies are warranted to investigate such an effect in human subjects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathophysiology - Volume 22, Issue 1, March 2015, Pages 49-55
Journal: Pathophysiology - Volume 22, Issue 1, March 2015, Pages 49-55
نویسندگان
Mostafa M. El-Shafey, Gamil M. Abd-Allah, Ahmed M. Mohamadin, Gamaleldin I. Harisa, Amr D. Mariee,