Monitoring polyglutamine toxicity in yeast
Keywords: تولید نوروژنیک; Yeast; Polyglutamine; Protein misfolding; Neurodegeneration; Huntington's disease;
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Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease
Keywords: تولید نوروژنیک; Parkinson disease; Caenorhabditis elegans; Dopamine; Neurodegeneration; Synuclein;
Conversion of bacterially expressed recombinant prion protein
Keywords: تولید نوروژنیک; PrP; prion protein; rPrP; recombinant mouse PrP; rPrP-res; the proteinase K-resistant recombinant PrP form that is associated with prion infectivity; PMCA; Protein Misfolding Cyclic Amplification; Prion; Recombinant protein; In vitro conversion; Infectivi
Alteration of the CNS pathway to the hippocampus in a mouse model of Niemann-Pick, type C disease
Keywords: تولید نوروژنیک; Autosomal recessive disorder; Synaptic loss; Neurodegeneration; Hippocampal CNS pathway; Pseudorabies virus;
Site-directed mutagenesis of the glycine-rich loop of death associated protein kinase (DAPK) identifies it as a key structure for catalytic activity
Keywords: تولید نوروژنیک; Death associated protein kinase; Calmodulin; Glycine-rich region; Neurodegeneration; Central nervous system; Phosphorylation; Protein kinase inhibitor;
Housekeeping gene expression in myogenic cell cultures from neurodegeneration and denervation animal models
Keywords: تولید نوروژنیک; Neurodegeneration; Denervation; Muscle; Real-time PCR; Housekeeping;
AMSH is required to degrade ubiquitinated proteins in the central nervous system
Keywords: تولید نوروژنیک; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMSH; associated molecule with the SH3 domain of STAM; AMPAR; α-amino-3-hydroxy-5-methyl-isoxazolepropionic acid receptor; CHMP; chromatin modifying protein; ESCRT; endosomal sorting complexe
A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan terriers
Keywords: تولید نوروژنیک; ATP13A2; Kufs disease; PARK9; Kufor-Rakeb syndrome; Parkinson's disease; Dog; Neurodegeneration;
Galanin and α-MSH autoantibodies in cerebrospinal fluid of patients with Alzheimer's disease
Keywords: تولید نوروژنیک; Alzheimer's disease; α-MSH; Autoantibodies; CSF; Galanin; Neurodegeneration;
Reduced striatal acetylcholine efflux in the R6/2 mouse model of Huntington's disease: An examination of the role of altered inhibitory and excitatory mechanisms
Keywords: تولید نوروژنیک; Microdialysis; Neurodegeneration; Cholinergic; Basal ganglia; Striatum; Transgenic;
Zebrafish as a model to understand autophagy and its role in neurological disease
Keywords: تولید نوروژنیک; Zebrafish; Autophagy; Neurodegeneration;
Antioxidant and acetylcholinesterase inhibitory activity of selected southern African medicinal plants
Keywords: تولید نوروژنیک; Acetylcholinesterase; Alzheimer's disease; Antioxidant; Medicinal plants; Neurodegeneration
Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis
Keywords: تولید نوروژنیک; Anandamide; EAE; EPSC; Excitotoxicity; FAAH; Neurodegeneration;
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration
Keywords: تولید نوروژنیک; c-Jun N-terminal kinase inhibitor; JNK; Neurodegeneration; Trisubstituted thiophene;
Single particle analysis of tau oligomer formation induced by metal ions and organic solvents
Keywords: تولید نوروژنیک; Tau; Alpha-synuclein; Neurodegeneration; Dementia; Alzheimer; Oligomer; Fluorescence correlation spectroscopy;
Melanopsin-expressing retinal ganglion cells: implications for human diseases
Keywords: تولید نوروژنیک; Melanopsin; Hereditary optic neuropathies; Circadian; Aging; Neurodegeneration; Mitochondria
Dendritic changes in visual pathways in glaucoma and other neurodegenerative conditions
Keywords: تولید نوروژنیک; glaucoma; dendrite; dendritic spine; LGN; SC; RGC; visual pathway; neurodegeneration
Bilirubin Injury to Neurons and Glial Cells: New Players, Novel Targets, and Newer Insights
Keywords: تولید نوروژنیک; astrocyte and microglia reactivity; neurodegeneration; neuroinflammation; neuron-glia interplay; oligodendrocytes; RNS; ROS; unconjugated bilirubin
Does idiopathic REM sleep behavior disorder (iRBD) really exist? What are the potential markers of neurodegeneration in iRBD?
Keywords: تولید نوروژنیک; REM sleep behavior disorder; Neurodegeneration; α-Synucleinopathies; Markers; Olfaction; Autonomic function
MicroRNA-101 downregulates Alzheimer’s amyloid-β precursor protein levels in human cell cultures and is differentially expressed
Keywords: تولید نوروژنیک; Aging; Amyloid; Alzheimer; Dementia; Neurodegeneration; Non-coding RNA; Post-transcriptional
Plasma β-amyloid peptides in canine aging and cognitive dysfunction as a model of Alzheimer's disease
Keywords: تولید نوروژنیک; Amyloid-beta protein; Plasma; Alzheimer's disease; Animal behavior; Canine; ELISA; Neurodegeneration; Brain aging
The pathological prion protein forms ionic conductance in lipid bilayer
Keywords: تولید نوروژنیک; CNS; central nervous system; TSEs; transmissible spongiform encephalopathies; PrPTSE; pathologic isoform of the prion protein; PrPC; physiologic isoform of the prion protein; PrP27-30; protease resistant core of pathologic PrP; Prion; Transmissible spon
Alzheimer-associated mutant ubiquitin impairs spatial reference memory
Keywords: تولید نوروژنیک; Ubiquitin-proteasome system; Neurodegeneration; Transgenic mouse model; Mutant ubiquitin; Behavior;
TDP-43 toxicity in yeast
Keywords: تولید نوروژنیک; Yeast; TDP-43; ALS; Neurodegeneration; Screens; Protein misfolding; Human disease;
Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease
Keywords: تولید نوروژنیک; Parkinson's disease; Chronic MPTP/probenecid model; Neurodegeneration; Neuroprotection; Mitochondrial dysfunction;
Role of microglia in CNS inflammation
Keywords: تولید نوروژنیک; Antigen presentation; Cell death; Granulocytes; Macrophages; Neurodegeneration;
Cellular and Molecular NeuroscienceResearch PaperIdentification and localization of a neuron-specific isoform of TAF1 in rat brain: implications for neuropathology of DYT3 dystonia
Keywords: تولید نوروژنیک; TAF1; DYT3 dystonia; striosome; neurodegeneration; transcription dysregulation syndrome; BSA; bovine serum albumin; C-TAF1; common form of the TAF1 gene; DARPP-32; the dopamine and cAMP-regulated phosphoprotein of 32 kDa; GCL; granule cell layer; H; hilus
A method to solubilise protein aggregates for immunoassay quantification which overcomes the neurofilament “hook” effect
Keywords: تولید نوروژنیک; Protein aggregates; Neurodegeneration; Protein biomarker; Motor neuron disease; SOD1 mice;
Nmnat exerts neuroprotective effects in dendrites and axons
Keywords: تولید نوروژنیک; Nmnat; Dendrite; Axon; Motor neuron; Neurodegeneration; Drosophila;
Research reportICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor
Keywords: تولید نوروژنیک; Streptozotocin; Neurodegeneration; Memory impairment; Nicotinic receptor; Mitochondria;
Inflammation and gliosis in neurological diseases – clinical implications
Keywords: تولید نوروژنیک; Neurodegeneration; Multiple sclerosis; Parkinson's disease; Alzheimer's disease; Stroke
Shape alterations in the striatum in chorea-acanthocytosis
Keywords: تولید نوروژنیک; Neuroacanthocytosis; Chorea-acanthocytosis; Chorea; Caudate; Striatum; Neurodegeneration
Angiotensin II Type 1 receptor (AT1) signaling in astrocytes regulates synaptic degeneration-induced leukocyte entry to the central nervous system
Keywords: تولید نوروژنیک; Astrocytes; BBB; Inflammation; Neurodegeneration; AT1; AT2; Leukocyte infiltration; Candesartan
MRI measures of neuroprotection and repair in multiple sclerosis
Keywords: تولید نوروژنیک; Multiple sclerosis; Magnetic resonance imaging; Neurodegeneration; Demyelination; Clinical trials
Ferritin as an important player in neurodegeneration
Keywords: تولید نوروژنیک; Ferritin; Neurodegeneration; Iron; Oxidative stress
Mutation frequency is not elevated in the cerebellum of harlequin/Big Blue® mice but Class II deletions occur preferentially in young harlequin cerebellum
Keywords: تولید نوروژنیک; Apoptosis-inducing factor; Reactive oxygen species; cII mutation assay; Cerebellum; Premature aging; Neurodegeneration
Oleuropein and derivatives from olives as Tau aggregation inhibitors
Keywords: تولید نوروژنیک; Hydroxytyrosol; Oleuropein; Tau; Fibrillization; Neurodegeneration; Nutrition
Protective effects of antioxidants and anti-inflammatory agents against manganese-induced oxidative damage and neuronal injury
Keywords: تولید نوروژنیک; Manganese; Oxidative stress; Medium spiny neurons; Neurodegeneration; Vitamin E; Trolox; Ibuprofen
A knockout of the caspase 2 gene produces increased resistance of the nigrostriatal dopaminergic pathway to MPTP-induced toxicity
Keywords: تولید نوروژنیک; Dopamine; MPTP; Parkinson's disease; Caspase 2; Cell death; Neurodegeneration; Tyrosine hydroxylase
Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease
Keywords: تولید نوروژنیک; Innate immune system; Complement system; Microglia; Neurodegeneration; Dopamine
Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease
Keywords: تولید نوروژنیک; Hypocretin; Orexin; Hypothalamus; Sleep; Reward; Huntington's disease; Neurodegeneration; R6/2 mouse; Histamine; Glucose;
Endothelin, astrocytes and glaucoma
Keywords: تولید نوروژنیک; endothelin; astrocytes; glaucoma; neurodegeneration; astrogliosis
Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma
Keywords: تولید نوروژنیک; Neuroprotection; Transsynaptic degeneration; Neurodegeneration; Glutamate; NMDA; Memantine
Respiratory and sniffing behaviors throughout adulthood and aging in mice
Keywords: تولید نوروژنیک; Olfaction; Neurodegeneration; Alzheimer's disease; Amyloid-beta; APP; Orienting; Respiration
Effects of short-term hormonal replacement on learning and on basal forebrain ChAT and TrkA content in ovariectomized rats
Keywords: تولید نوروژنیک; Alzheimer; Ovariectomy; Neurodegeneration; Estrogens; Progesterone; Basal forebrain; ChAT; TrkA; Learning;
Inducible dopaminergic glutathione depletion in an alpha-synuclein transgenic mouse model results in age-related olfactory dysfunction
Keywords: تولید نوروژنیک; Parkinson's disease; olfactory deficits; smell test; oxidative stress; neurodegeneration; mitochondrial dysfunctiona-syn, alpha-synuclein; DA, dopaminergic cells; Dox, doxycycline; DTg, dual transgenic; EPL, external plexiform layer; GCL, granule cell lay
Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain
Keywords: تولید نوروژنیک; Scutellaria baicalensis Georgi; Bupleurum scorzonerifolfium Willd; Iron; Substantia nigra; α-Synuclein aggregation; Neurodegeneration; Apoptosis;
Epigenetics in neurodegeneration: A new layer of complexity
Keywords: تولید نوروژنیک; AD; Alzheimer's disease; PD; Parkinson's disease; Aβ; amyloid-β; SN; substantia nigra; APP; amyloid precursor protein; EOAD; early-onset Alzheimer's disease; LOAD; late-onset Alzheimer's disease; SNP; several single nucleotide polymorphisms; MZ; monozyg
Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives
Keywords: تولید نوروژنیک; Alzheimer's disease; Neurodegeneration; Aβ, γ-secretase; ε cleavage
Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density
Keywords: تولید نوروژنیک; Neurodegeneration; Inflammation; Microglia density; Substantia nigra; Striatum;