
Synthesis and biological evaluation of novel 6,7-dihydro-5H-cyclopenta[d]pyrimidine and 5,6,7,8-tetrahydroquinazoline derivatives as sigma-1 (Ï1) receptor antagonists for the treatment of pain
Keywords: Ï1R; sigma-1 receptor; Ï2R; sigma-2 receptor; NMDA; N-methyl-d-aspartate; CNS; central nervous system; PNS; peripheral nervous system; KO; knockout; WT; wild-type; [3H]-DTG; [3H]-di-o-tolylguanidine; SAR; structure-active relationship; FRET; fluorescenc