Keywords: دامنه درون سلولی Notch; ANK; ankyrin; CADASIL; cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; CSL; CBF1, Suppressor of Hairless Lag 1; CHYS1; chondroitin sulfate synthase; Dll; Delta-like; EGF; epidermal growth factor; EOGT; EGF domai
مقالات ISI دامنه درون سلولی Notch (ترجمه نشده)
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Keywords: دامنه درون سلولی Notch; LRIC; limb remote ischemic conditioning; NICD; Notch intracellular domain; α-SMA; α-smooth muscle actin; MCAO; middle cerebral artery occlusion; CBF; cerebral blood flow; PreC; ischemic pre-conditioning; PerC; ischemic per-conditioning; PostC; ischemic
Keywords: دامنه درون سلولی Notch; 5-FU; 5-Fluorouracil; ABCB5; ATP-binding cassette sub-family B member 5; ABCC2; ATP-binding cassette sub-family C member 2; ABCG2; ATP-binding cassette sub-family G member 2; ACs; Anthocyanins; ALDH; aldehyde dehydrogenase; AML; acute myeloid leukemia; AP
Keywords: دامنه درون سلولی Notch; cAMP; Cyclic Adenosine Monophosphate; COPD; Chronic Obstructive Pulmonary Disease; CCSP; Club Cell Secretory Protein; CF; Cystic Fibrosis; EGFR; Epidermal Growth Factor Receptor; EMT; Epithelial to Mesenchymal Transition; ERK; Extracellular Signal-Regulat
Keywords: دامنه درون سلولی Notch; ALK1; activin receptor-like kinase1; ANG/Ang; angiopoietin; Bcl-xL; b-cell lymphoma-extra large; BM; bone marrow; BMDCs; bone marrow derived cells; BMP; bone morphogenetic protein; Bv8; bombina variagata peptide 8; CAFs; cancer/carcinoma associated fibrob
Keywords: دامنه درون سلولی Notch; Pancreatic cancer; Angiogenesis; Vascular endothelial growth factor (VEGF); ANGPT; angiopoietin; BRAF; serine/threonine-protein kinase B-raf; CAF; cancer associated fibroblast; Cdkn2a; cyclin-dependent kinase inhibitor 2A; CI; confidence interval; CSF1R;
Keywords: دامنه درون سلولی Notch; 4NQO; 4-nitroquinoline 1-oxide; ADH; alcohol dehydrogenase; ALDH; acetaldehyde dehydrogenase; CYP2E1; cytochrome P450 2E1; Edh; EH-domain containing gene; ELOVL; very long chain fatty acid elongase; GPCRs; G-protein coupled receptors; HNE; 4-hydroxynonena
Keywords: دامنه درون سلولی Notch; KCs; kupffer cells; JNKs; C-Jun N-terminal kinases; MAPKs; mitogen-activated protein kinases; CCR2; C-C motif chemokine receptor 2; ATMs; Adipose tissue macrophages; HFD; high-fat diet; MLK3; mixed-lineage kinase 3; PPAR; peroxisome proliferator-activat
Keywords: دامنه درون سلولی Notch; ATCC; American Type Culture Collection; Bglap; bone gamma carboxyglutamate protein; BMP; bone morphogenetic protein; BSA; bovine serum albumin; CCN; Cyr61, connective tissue growth factor and Nov; CMV; cytomegalovirus; Col2.3; 2.3Â kb fragment of Col1a1;
Keywords: دامنه درون سلولی Notch; Aβ; amyloid β protein; NFT; neurofibrillary tangles; APP; amyloid precursor protein; PSs; presenilins; NICD; Notch intracellular domain; mTOR; mammalian Target of Rapamycin; PP2A; protein phosphatase 2; GSK-3; glycogen synthase kinase-3; CTFS; cytosol-s
Successful liver-directed gene delivery by ERCP-guided hydrodynamic injection (with videos)
Keywords: دامنه درون سلولی Notch; AKT; protein kinase B; CBD; common bile duct; CHD; common hepatic duct; NICD; notch intracellular domain; PCR; polymerase chain reaction; CMV-SB; pCytomegalovirus Sleep Beauty;
The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma
Keywords: دامنه درون سلولی Notch; Allergic asthma; Notch signaling; Gata3; TH2 immunity; house dust mite; recombination signal-binding protein for IgJκ region; stapled α-helical peptide derived from mastermind-like 1; BAL; Bronchoalveolar lavage; BHR; Bronchial hyperreactivity; DC; De
Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling
Keywords: دامنه درون سلولی Notch; BMSCs; bone marrow stem cells; BrdU; 5-bromo-2â²-deoxyuridine; CMs; cardiomyocytes; CSCs; cardiac stem cells; DAPI; 4â²,6-diamidino-2-phenylindole; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; FITC; fluo
Maternal Consumption of High-fat Diet in Mice Alters Hypothalamic Notch Pathway, NPY Cell Population and Food Intake in Offspring
Keywords: دامنه درون سلولی Notch; ARC; arcuate nucleus; Ascl1; achaete-scute homolog 1; bHLH; basic helix-loop-helix; BMP; bone morphogenetic protein; BrDU; 5-bromo-2â²-deoxyuridine; BSA; bovine serum albumin; BW; body weight; Ct; comparative threshold cycle; Cy3; cyanine 3; DAB; 3,3â²-
Natural and synthetic polymers/bioceramics/bioactive compounds-mediated cell signalling in bone tissue engineering
Keywords: دامنه درون سلولی Notch; ALP; alkaline phosphatase; ANG; angiogenin; AuNPs; gold nanoparticles; BMP; bone morphogenetic protein; BSP; bone sialoprotein; BTE; bone tissue engineering; COL1; collagen type 1; CSL; CBF1/Su(H)/Lag-1 protein; ERK; extracellular signal-regulated kinase;
In silico analysis, seasonal variation and gonadotropic regulation of jag1 and its receptor notch1 in testis of spotted snakehead Channa punctatus
Keywords: دامنه درون سلولی Notch; DSL; Delta, Serrate and LAG2; EGF; Epidermal growth factor; hCG; Human chorionic gonadotropin; ORF; Open reading frame; RT-PCR; Reverse transcription polymerase chain reaction; qPCR; Quantitative polymerase chain reaction; ANOVA; Analysis of variance; TMD
Inhibition of miR-363 protects cardiomyocytes against hypoxia-induced apoptosis through regulation of Notch signaling
Keywords: دامنه درون سلولی Notch; miRNAs; microRNAs; FBS; fetal bovine serum; RT-qPCR; real-time quantitative polymerase chain reaction; LDH; lactate dehydrogenase; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NICD; Notch intracellular domain; UTR; untranslated regio
Inhibition of Notch signalling has ability to alter the proximal and distal TCR signalling events in human CD3+ αβ T-cells
Keywords: دامنه درون سلولی Notch; TCR; T cell receptor; Dll; delta-like ligand; GSI-X; γ-secretase inhibitor; HES1; hairy enhancer of split1; IFN-γi; nterferon-γ; NICD; Notch intracellular domain; Jag; jagged; NRARP; Notch-regulated ankyrin repeat protein; αβ T cells; T cell anergy;
Inscuteable maintains type I neuroblast lineage identity via Numb/Notch signaling in the Drosophila larval brain
Keywords: دامنه درون سلولی Notch; Drosophila larval brain neuroblasts (NBs); Inscuteable (Insc); NB lineage maintenance; Type I and type II NBs; Numb/Notch signaling; Ase; Asense; Dpn; Deadpan; Erm; Earmuff; GMCs; ganglion mother cells; INPs; intermediate neural progenitors; Insc; Inscute
Emerin suppresses Notch signaling by restricting the Notch intracellular domain to the nuclear membrane
Keywords: دامنه درون سلولی Notch; CSL; CBF1/suppressor hairless/Lag-1; NEXT; Notch1 extracellular truncation; NICD; Notch intracellular domain; ADAM; A disintegrin and metalloproteinase; CoA; Coactivators; CoR; Corepressors; PM; Plasma membrane; NE; Nuclear envelope; NGPS; Néstor-Guiller
The metalloproteinase ADAM10: A useful therapeutic target?
Keywords: دامنه درون سلولی Notch; APL; Acute Promyelocytic Leukemia; ADAM; A Disintegrin And Metalloproteinase; AP2; Adaptor Protein-2; AD; Alzheimer's Disease; Aβ; Amyloid beta; APP; Amyloid Precursor Protein; ACE; Angiotensin Converting Enzyme; APRIL; A Proliferation-Inducing Ligand; B
Redox signaling in the gastrointestinal tract
Keywords: دامنه درون سلولی Notch; HNE; 4-hydroxynonenal; 8-OHdG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; AP-1; Activator protein 1; APC; Adenomatous polyposis coli; APE-1; Apurinic/apyrimidinic endonuclease 1; Math1; Atonal homolog 1; Bax; BCL2-associated X protein; β-TrCP; Beta-transduci
Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration; disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling
Keywords: دامنه درون سلولی Notch; Invasion; Jagged1; Metastasis; Migration; Notch signaling; Prostate cancer; ADAM; A disintegrin and metalloproteinase; BMECs; bone marrow endothelial cells; BMS; bone marrow stroma; Dll; Delta-like ligand; FL-Jag; full-length Jagged; JCTF; Jagged1 C-termi
DLL4+ dendritic cells: Key regulators of Notch Signaling in effector T cell responses
Keywords: دامنه درون سلولی Notch; APC; antigen presenting cell; CTL; cytotoxic T lymphocyte; DC; dendritic cell; cDC; conventional dendritic cell; pDC; plasmacytoid dendritic cell; CMP; common myeloid progenitor; HPC; hematopoietic progenitor cell; MDP; macrophage and DC progenitor; HSCT;
The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development
Keywords: دامنه درون سلولی Notch; BLPD; B-cell lymphoproliferative disease; EtOH; ethanol; HF; hair follicle; LICD; ligand intracellular domain; msx2LOF; Msx2-Cre+/tg-mediated loss of function; NICD; Notch intracellular domain; N1VG; hypomorphic Notch1 allele; PSmsx2LOF; Preselin1 and Pre
Lack of galectin-3 increases Jagged1/Notch activation in bone marrow-derived dendritic cells and promotes dysregulation of T helper cell polarization
Keywords: دامنه درون سلولی Notch; Th; T helper; WT; wild-type; Lgals3â/â; galectin-3-deficient mice; BMDC; bone marrow-derived dendritic cell; DCs; dendritic cells; NICD; Notch intracellular domain; APC; antigen presenting cell; Treg; T regulatory cell; qPCR; quantitative polymerase c
Cardiomyocyte Lineage Specification in Adult Human Cardiac Precursor Cells Via Modulation of Enhancer-Associated Long Noncoding RNA Expression
Keywords: دامنه درون سلولی Notch; cardiac precursor cells; differentiation; heart disease; lncRNAs; miRNAs; NOTCH; CARMEN; (CAR)diac (M)esoderm (E)nhancer-associated (N)oncoding RNA; CPC; cardiac precursor cell; DLL1; Delta-like1; GO; gene ontology; J1; Jagged1; lncRNA; long noncoding RNA
Clinical Application of Basic ScienceNotch signaling and new therapeutic options in liver disease
Keywords: دامنه درون سلولی Notch; Jag-1; Jagged-1; Dll; Delta-like; NICD; Notch intracellular domain; RBP-Jκ; recombination signal binding protein immunoglobulin kappa J; MAML1; mastermind-like 1; Hes1; hairy enhancer of split-1; Hey1; hairy enhancer of split-related with YRPW motif1; So
Frequent mutations in NOTCH1 ligand-binding regions in Japanese oral squamous cell carcinoma
Keywords: دامنه درون سلولی Notch; OSCC; oral squamous cell carcinoma; HNSCC; head and neck squamous cell carcinoma; NECD; NOTCH extracellular domain; NICD; NOTCH intracellular domain; TALL; T-cell acute lymphoblastic leukemia; EGF; epidermal growth factor; T stage; tumor stage; N stage; l
The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation
Keywords: دامنه درون سلولی Notch; Kidney fibrosis; Epithelial-to-mesenchymal transition; Fibroblast; Notch; TGF-β; DBZ; dibenzazepine; UUO; unilateral ureteral obstruction; NICD; Notch intracellular domain; ICN; intracellular domain of Notch; TECs; tubular epithelial cells; ECM; extracel
Notch4 reveals a novel mechanism regulating Notch signal transduction
Keywords: دامنه درون سلولی Notch; ANK; ankyrin repeat; DSL; Delta, Serrate and Lag-2; JAG1; Jagged1; DLL1; Delta-like 1; DLL4; Delta-like 4; E; embryonic day; EC; extracellular domain; EGF; epidermal growth factor; ER; endoplasmic reticulum; ES; embryonic stem; HD; heterodimerisation doma
ADAM10 Regulates Notch Function in Intestinal Stem Cells of Mice
Keywords: دامنه درون سلولی Notch; CBC; Intestinal Epithelium; Development; Differentiation; ADAM10; A disintegrin and metalloproteinase domain-containing protein 10; CBCs; crypt-based columnar cells; Dll; Delta-like ligand; EGFP; enhanced green fluorescent protein; IP; intraperitoneally;
Ferritin light chain interacts with PEN-2 and affects γ-secretase activity
Keywords: دامنه درون سلولی Notch; Aβ; β-amyloid; AD; Alzheimer's disease; APP; β-amyloid precursor protein; CTF; carboxyl-terminal fragment; FTH; ferritin heavy chain; FTL; ferritin light chain; HEK293Swe; HEK293 cells stably expressing human APP Swedish mutations; NICD; notch intracel
Basic NeuroscienceAn improved cell-based method for determining the γ-secretase enzyme activity against both Notch and APP substrates
Keywords: دامنه درون سلولی Notch; GSI; γ-secretase inhibitor; GSM; γ-secretase modulator; NICD; Notch intracellular domain; β-Amyloid; Aβ; 2B; 7CHO-2B7; γ-Secretase; Notch; Aβ; Alzheimer's Disease; Modulator; NICD;
Notch ligand endocytosis: Mechanistic basis of signaling activity
Keywords: دامنه درون سلولی Notch; ADAM; a disintegrin and metalloprotease; AFM; atomic force microscopy; CSL; CBF1, Su(H), LAG-1; Dll; Delta-like; EDTA; ethylenediaminetetraacetic acid; GSI; γ-secretase inhibitor; HD; heterodimerization domain; LNRs; Lin12/Notch repeats; NECD; Notch extr
Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice
Keywords: دامنه درون سلولی Notch; Genetically Engineered Mouse Model; Notch Activation; Gene Expression Profiling; AFP; α-fetoprotein; GFP; green fluorescent protein; GSI; γ-secretase inhibitor; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; Igf2; insulin-like growth factor 2; I
hCLP46 regulates U937 cell proliferation via Notch signaling pathway
Keywords: دامنه درون سلولی Notch; hCLP46; human CAP10-like protein 46Â kDa; Poglut; protein O-glucosyltransferase; Poglut1; protein O-glucosyltransferase1 (mammalian); CDKI; cyclin-dependent kinase inhibitor; CDKN1B (p27); cyclin-dependent kinase inhibitor 1B; RB; retinoblastoma; CSL; CBF
Delta-like 1-Lysine613 regulates notch signaling
Keywords: دامنه درون سلولی Notch; Dll1; Delta-like 1; DSL; Delta/Serrate/Lag2; Notch-ICD; Notch intracellular domain; Notch-ECD; Notch extracellular domain; HES1; Hairy/enhancer of Split 1; HEY1; Hairy/enhancer of split related with YRPW motif protein 1; CSL; Suppressor of Hairless/Lag1;
Selective repression of Notch pathway target gene transcription
Keywords: دامنه درون سلولی Notch; CSL; Notch intracellular domain; Transcription; Development; Differentiation; Epigenetic
Notch: Architect, Landscaper, and Guardian of the Intestine
Keywords: دامنه درون سلولی Notch; Intestine; Stem Cells; Homeostasis; Notch; Colon Cancer; AES; Amino terminal Enhancer of Split; AMP; adult midgut progenitor; bHLH; basic helix-loop-helix; CBC; columnar base cell; Dll; Delta-like ligand; EB; enteroblast; EC; enterocyte; EE; enteroendocri
Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis
Keywords: دامنه درون سلولی Notch; AD; Alzheimer's disease; PSEN; presenilin; APP; amyloid precursor protein; Aβ; β-amyloid; FAD; familial forms of AD; SVZ; subventricular zone; SGZ; subgranular zone; DG; dentate gyrus; NSCs; neural stem cells; DCX; doublecortin; NPC; neural progenitor c
Role of Notch and its oncogenic signaling crosstalk in breast cancer
Keywords: دامنه درون سلولی Notch; 4T1 cells; mouse mammary cancer cell line; ADAM; a disintegrin and metalloprotease; Akt; protein kinase B; ALDH; aldehyde dehydrogenase; ANK; ankyrin; Axin2; the Axin-related protein; BALB/c; an albino, laboratory-bred strain of the house mouse; Bcl-2; B-
Notch signaling and Atoh1 expression during hair cell regeneration in the mouse utricle
Keywords: دامنه درون سلولی Notch; CSF; cerebrospinal fluid; GER; greater epithelial ridge; NICD; Notch intracellular domain; PBS; phosphate-buffered saline; PFA; paraformaldehyde; qRTPCR; quantitative real-time polymerase chain reaction;
Atonal Homolog 1 Is Required for Growth and Differentiation Effects of Notch/γ-Secretase Inhibitors on Normal and Cancerous Intestinal Epithelial Cells
Keywords: دامنه درون سلولی Notch; Biomarkers; Cell Fate Specification; Basic Helix-Loop-Helix Transcription Factor; Notch Intracellular Domain; APC; adenomatosis polyposis coli; ATOH1; atonal homolog 1; BrdU; bromodeoxyuridine; CRC; colorectal cancer; DAPT; N-[N-(3,5-difluorophenacetyl)-l
Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury
Keywords: دامنه درون سلولی Notch; cerebral ischemia; γ-secretase; hippocampus; neurogenesis; regeneration; aCSF; artificial cerebrospinal fluid; APP; amyloid precursor protein; aSVZ; anterior subventricular zone; BrdU; bromodeoxyuridine; DCX; doublecortin; DLL4; delta-like protein 4; DMS
Intestinal Deletion of Pofut1 in the Mouse Inactivates Notch Signaling and Causes Enterocolitis
Keywords: دامنه درون سلولی Notch; BSA; bovine serum albumin; CVA; crypt-villus axis; GALT; gut-associated lymphoid tissue; GSI; γ-secretase inhibitor; HES; hairy and enhancer of split; HRP; horseradish peroxidase; NICD; Notch intracellular domain; MLN; mesenteric lymph nodes; PCR; polyme
Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders
Keywords: دامنه درون سلولی Notch; ADAM; a disintegrin and metalloprotease; ACDL; acidic dileucine; ADDL; amyloid-β derived diffusible ligands; APP; amyloid precursor protein; Aph; anterior pharynx defective phenotype; APLP; APP-like protein; AICD; APP intracellular domain; AD; Alzheimer'
Fe65 does not stabilize AICD during activation of transcription in a luciferase assay
Keywords: دامنه درون سلولی Notch; Aβ; β-amyloid peptide; APP; amyloid precursor protein; AICD; APP intracellular domain; sαAPP; soluble α-amyloid precursor protein; BACE; β-site APP-cleaving enzyme; CHO; Chinese hamster ovary; CTF; C-terminal fragment of APP; DAPT; N-[N-(3,5-difluoro
Zinc-induced downregulation of Notch signaling is associated with cytoplasmic retention of Notch1-IC and RBP-Jk via PI3k–Akt signaling pathway
Keywords: دامنه درون سلولی Notch; Notch intracellular domain; RBP-Jk; Zinc; Phosphatidylinositol 3-kinase; Akt; Cytoplasmic retention; Wortmannin; LY294002
Matrix Metalloproteinase-9 Regulates MUC-2 Expression Through Its Effect on Goblet Cell Differentiation
Keywords: دامنه درون سلولی Notch; AB; Alcian Blue; CA; carbonic anhydrase; ECM; extracellular matrix; MMP; matrix metalloproteinases; NICD; Notch intracellular domain; PAS; periodic acid-Schiff stain; WT; wild type;