Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1
Keywords: Diabetes; Diabetic nephropathy; EGCG; KEAP1; NRF2; Oxidative stress;
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The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
Keywords: Age-related macular degeneration; Complement; Inflammation; Mitochondrial dynamics; Nrf2; Oxidative stress; Retinal pigment epithelium;
α-Lipoic acid ameliorated oxidative stress induced by perilla oil, but the combination of these dietary factors was ineffective to cause marked deceases in serum lipid levels in rats
Keywords: Perilla oil; α-Lipoic acid; α-Linolenic acid; Hepatic lipogenesis; Hepatic fatty oxidation; Antioxidant system; Rat; Apex nuclease 1; apurinic/apyrimidinic endodeoxyribonuclease 1; HPLC; high-performance liquid chromatography; Keap1; kelch-like ECH-asso
Gill structural integrity changes in fish deficient or excessive in dietary isoleucine: Towards the modulation of tight junction protein, inflammation, apoptosis and antioxidant defense via NF-κB, TOR and Nrf2 signaling pathways
Keywords: Isoleucine; Grass carp (Ctenopharyngodon idella); Structural integrity; Tight junction; Inflammation; Antioxidant defense; Gill; ZO-1; zonula occludens-1; IL-1β; interleukin 1β; IL-8; interleukin 8; TNF-α; tumor necrosis factor α; IL-10; interleukin 1
Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation
Keywords: Sulforaphane (PubChem CID: 5350); Dimethyl Sulfoxide (PubChem CID: 679); ARE; antioxidant response element; CREB; cAMP-response element-binding protein; DAB; diaminobenzidine; DMSO; dimethyl sulfoxide; 4E-BP1; eukaryotic translation initiation factor 4E-b
Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25Â years of research in chemistry and biology
Keywords: Isoprostanes; Neuroprostanes; Phytoprostanes; Lipid Peroxidation; Polyunsaturated fatty acids; AA; Arachidonic acid; AD; Alzheimer's disease; AdA; Adrenic acid; ALA; α-Linolenic acid; APCI; Atmospheric pressure chemical ionization; BHT; Butylated hydroxy
Redox signaling in the gastrointestinal tract
Keywords: HNE; 4-hydroxynonenal; 8-OHdG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; AP-1; Activator protein 1; APC; Adenomatous polyposis coli; APE-1; Apurinic/apyrimidinic endonuclease 1; Math1; Atonal homolog 1; Bax; BCL2-associated X protein; β-TrCP; Beta-transduci
Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity
Keywords: p62/Sqstm1; p62; phosphorylated-p62; p-p62; protein-protein interaction; PPI; nuclear factor erythroid 2 related factor-2; Nrf2; Kelch-like ECH-associated protein 1; Keap1; human hepatocellular carcinoma; HCC; cerium ammonium nitrite; CAN; fluorescent pol
Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application
Keywords: O3; ozone; MIXs; antioxidant mixtures; RHE; reconstructed human epidermis; OS; oxidative stress; ROS; reactive oxygen species; HNE; 4-hydroxy2-nonenal; HNE-PA; 4-hydroxy2-nonenal protein adducts; ELISA; enzyme-linked immunosorbent assay; NF-κB; nuclear f
Tetramethylpyrazine improves the recovery of spinal cord injury via Akt/Nrf2/HO-1 pathway
Keywords: Spinal cord injury; Tetramethylpyrazine; Akt; Nrf2; HO-1
Protective effect of hyperoside on cardiac ischemia reperfusion injury through inhibition of ER stress and activation of Nrf2 signaling
Keywords: Hyperoside; Ischemia/reperfusion injury; Cardioprotection; ER stress; Nrf2
Transfer of three transcription factors via a lentiviral vector ameliorates spatial learning and memory impairment in a mouse model of Alzheimer's disease
Keywords: AD; Alzheimer's disease; LV; Lentiviral vector; Ascl1, Brn2 and Ngn2; ABN gene; Ascl1; Achaete-scute complex homolog 1; Brn2; POU class 3 homeobox 2; Ngn2; Neurogenin 2; Aβ; Amyloid-β; BDNF; Brain-derived neurotrophic factor; Nrf2; Nuclear factor-E2-rel
Regulation of Keap1-Nrf2 signaling: The role of epigenetics
Keywords: Nrf2; Keap1; Epigenetics; DNA methylation; miRNAs; Histone modifications; Oxidative stress;
Fungicide prochloraz induces oxidative stress and DNA damage in vitro
Keywords: DNA damage; Nrf2; Oxidative stress; Prochloraz;
Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells
Keywords: FMO3; Flavin-containing monoxygenase-3; NRF2; Nuclear factor (erythroid-derived 2)-like 2; KEAP1; Kelch-like ECH-associated protein 1; NQO1; NAD(P)H:quinone oxidoreductase-1; HMOX1; heme oxygenase-1; tBHP; tert-butyl hydroperoxide; tBHQ; tert-butyl hydroq
Involvement of Nrf2-mediated heme oxygenase-1 expression in anti-inflammatory action of chitosan oligosaccharides through MAPK activation in murine macrophages
Keywords: Chitosan oligosaccharides; HO-1; Nrf2; MAPKs; Anti-inflammatory;
Molecular evolution of antioxidant and hypoxia response in long-lived, cancer-resistant blind mole rats: The Nrf2-Keap1 pathway
Keywords: Nrf2; nuclear factor erythroid 2-related factor 2; ROS; reactive oxygen species; ARE; antioxidant response element; EpRE; electrophile response element; Keap1; Kelch-like ECH-associated protein 1; EPO; erythropoietin; VEGF; vascular endothelial growth fac
S-allyl-l-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress
Keywords: Mitochondrial dysfunction; Oxidative stress; Nrf2; Alzheimer's disease; Aging;
Oroxylin A attenuates cigarette smoke-induced lung inflammation by activating Nrf2
Keywords: Oroxylin A; Cigarette smoke; Nrf2;
Taurine protects against As2O3-induced autophagy in pancreas of rat offsprings through Nrf2/Trx pathway
Keywords: As2O3; Nrf2; Trx; Taurine; Autophagy
56Fe ion irradiation induced apoptosis through Nrf2 pathway in mouse testis
Keywords: 56Fe ion irradiation; Nrf2; Apoptosis; Testis
Hyperin inhibits nuclear factor kappa B and activates nuclear factor E2-related factor-2 signaling pathways in cisplatin-induced acute kidney injury in mice
Keywords: Hyperin; Cisplatin; Nrf2; Kidney injury;
Expression of nuclear factor, erythroid 2-like 2-mediated genes differentiates tuberculosis
Keywords: Nrf2; Tuberculosis; Gene expression; Molecular signature;
ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling
Keywords: ALS; Amyotrophic lateral sclerosis; ARE; Antioxidant response element; FTLD; Frontotemporal lobar degeneration; IKKβ; Inhibitor of nuclear factor kappa-B kinase subunit beta; Keap1; Kelch-like ECH-associated protein 1; KIR; Keap1-interacting region; LIR;
Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides
Keywords: Electrophilic signaling; 8-Nitro-cGMP; NO; Redox signaling; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; ERK; extracellular signal-regulated kinase; GSH; glutathione; GST; glutathione S-transferase; HNE; 4-hydroxy-2-nonenal; iNOS; inducible type of NO syn
Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathway
Keywords: Ischemia-reperfusion; H2S; HSP70; PI3K; Akt; Nrf2
Roles of Nrf2 in drug and chemical toxicity
Keywords: Nrf2; Keap1; Drug toxicity; Adverse drug reaction; Oxidative stress; Liver; Lung;
Dissecting the Keap1/Nrf2 pathway through proteomics
Keywords: KEAP1; NRF2; E3 ubiquitin ligase; Proteomics; Mass spectrometry; Protein interaction network; Post-translational modification; Oxidative stress;
Optimal ROS Signaling Is Critical for Nuclear Reprogramming
Keywords: CRISPR/Cas9; iPSCs; NADPH oxidase; Nrf2; nuclear reprogramming; reactive oxygen species
Epicatechin isolated from Tripterygium wilfordii extract reduces tau-GFP-induced neurotoxicity in zebrafish embryo through the activation of Nrf2
Keywords: Tauopathy; Nrf2; Neurotoxicity; Zebrafish; Epicatechin; Tripterygium wilfordii;
Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish
Keywords: Arsenic; Detoxification; Gene induction; Nrf2; Sulforaphane; Zebrafish;
Lipopolysaccharide-induced preconditioning protects against traumatic spinal cord injury by upregulating Nrf2 expression in rats
Keywords: Lipopolysaccharide; Nrf2; Traumatic spinal cord injury; Anti-oxidant;
Protective effects of pogostone against LPS-induced acute lung injury in mice via regulation of Keap1-Nrf2/NF-κB signaling pathways
Keywords: Acute lung injury (ALI); Lipopolysaccharide (LPS); Pogostone (PO); Nrf2; NF-κB;
Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation
Keywords: Remote ischemic postconditioning; TOPK; PTEN; Akt; NF-κB; Nrf2;
Therapeutic effect of ent-kaur-16-en-19-oic acid on neutrophilic lung inflammation and sepsis is mediated by Nrf2
Keywords: Kaurenoic acid; Anti-inflammation; Nrf2; Neutrophilic lung inflammation; Sepsis;
Suppression of NRF2–ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells
Keywords: NRF2; Chemotherapeutic resistance; Arsenic trioxide; Leukemia; Ethionamide; Isoniazid; Cytotoxicity
Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression
Keywords: Antidepressant; Neurite outgrowth; Nrf2; TBE-31; MCE-1; Inflammation;
Silencing Nrf2 impairs glioma cell proliferation via AMPK-activated mTOR inhibition
Keywords: Nrf2; ATP; AMPK/mTOR; Glioma; Proliferation;
Obestatin attenuated doxorubicin-induced cardiomyopathy via enhancing long noncoding Mhrt RNA expression
Keywords: Obestatin; Mhrt; Nrf2; Caspase-3; Cell apoptosis
BRCA1 deficiency increases the sensitivity of ovarian cancer cells to auranofin
Keywords: Auranofin; BRCA1; Nrf2; DNA damage; Ovarian cancer
Antioxidant defenses at transcriptional and enzymatic levels and gene expression of Nrf2-Keap1 signaling molecules in response to acute zinc exposure in the spleen of the large yellow croaker Pseudosciaena crocea
Keywords: Large yellow croaker; Nrf2; Gene expression; Zinc exposure; Oxidative stress
Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway
Keywords: Nrf2; Tanshinone IIA; Hepatoprotection; Oxidative stress; AcetaminophenALT, alanine transaminase; APAP, acetaminophen; ARE, antioxidant element; AST, aspartate transaminase; CAT, catalase; Cry, cryptotanshinone; GCLC, glutamate-cysteine ligase catalytic s
Wheat bran feruloyl oligosaccharides ameliorate AAPH-induced oxidative stress in HepG2 cells via Nrf2 signalling
Keywords: Feruloyl oligosaccharides (FOs); Nrf2; AAPH; HepG2;
Research reportNrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning
Keywords: Sirt1; sirtuin 1; HBO-PC; hyperbaric oxygen preconditioning; MCAO; middle cerebral artery occlusion; Nrf2; nuclear factor erythroid-2 related factor 2; SOD1; superoxide dismutase 1; HO-1; heme oxygenase 1; MDA; malondialdehyde; siRNA; short interfering RN
Anti-hyperlipidemic and anti-peroxidative role of pterostilbene via Nrf2 signaling in experimental diabetes
Keywords: Pterostilbene; Streptozotocin; Nrf2; Lipids; Diabetes; Dyslipidemia
Quercetin phospholipid complex significantly protects against oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway
Keywords: Age-related macular degeneration; Quercetin; Phospholipid complex; Oxidative stress; Nrf2
Luteolin ameliorates dextran sulfate sodium-induced colitis in mice possibly through activation of the Nrf2 signaling pathway
Keywords: Luteolin; DSS-induced colitis; Nrf2; HO-1; iNOS; MDA
Lycopene inhibits ICAM-1 expression and NF-κB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells
Keywords: Lycopene; Intercellular adhesion molecule-1; Nuclear factor-κB; Nrf2; Retinal pigment epithelial cell
The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation and oxidative state
Keywords: Trillin; Acute lung injury; Nrf2; HO-1; NF-κB