Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane
Keywords: Cancer; Chemoprevention; Sulforaphane; Nrf2;
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Molecular similarity guided optimization of novel Nrf2 activators with 1,2,4-oxadiazole core
Keywords: Keap1; Kelch-like ECH-associated protein-1; Nrf2; nuclear factor erythroid 2-related factor 2; ARE; antioxidant response element; NQO1; NAD(P)H/quinone oxidoreductase; HO-1; heme oxygenase-1; γ-GCS; γ-glutamyl cysteine synthetase; VS; virtual screening;
Development of Keap1-interactive small molecules that regulate Nrf2 transcriptional activity
Keywords: Keap1; Nrf2; Protein-protein interactions; Ubiquitination; Parkinson's disease; Alzheimer's disease; Cancer chemoprevention;
Miltirone protects human EA.hy926 endothelial cells from oxidized low-density lipoprotein-derived oxidative stress via a heme oxygenase-1 and MAPK/Nrf2 dependent pathway
Keywords: Miltirone; Nrf2; HO-1; Endothelial dysfunction; Oxidative stress; Ox-LDL; oxidized low-density lipoprotein; ROS; reactive oxygen species; SOD; superoxide dismutase; GST; glutathione S-transferase; Nrf2; NF-E2-related factor 2; ARE: antioxidant-response el
Dietary leucine improves flesh quality and alters mRNA expressions of Nrf2-mediated antioxidant enzymes in the muscle of grass carp (Ctenopharyngodon idella)
Keywords: Grass carp (Ctenopharyngodon idella); Leucine; Flesh quality; Antioxidant enzyme; Gene expression; Nrf2;
Carnosic acid attenuates unilateral ureteral obstruction-induced kidney fibrosis via inhibition of Akt-mediated Nox4 expression
Keywords: TGF-β; transforming growth factor-β; CA; carnosic acid; α-SMA; α-smooth muscle actin; COLI; collagen I; FN; fibronectin; PAI-1; plasminogen activator inhibitor-1; Nox4; NADPH oxidase 4; ROS; reactive oxygen species; Nrf2; nuclear factor erythroid-2 re
Wheat bran feruloyl oligosaccharides ameliorate AAPH-induced oxidative stress in HepG2 cells via Nrf2 signalling
Keywords: Feruloyl oligosaccharides (FOs); Nrf2; AAPH; HepG2;
Cyanidin-3-O-glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation
Keywords: Cyanidin 3-O-glucoside (PubChem CID; 12303203); Wedelolactone (PubChem CID: 5281813); Anthocyanin; Cyanidin; NF-kB; Nrf2; Inflammatory bowel diseases; Caco-2 cells;
Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
Keywords: Biochanin A; LPS; Nrf2; NLRP3; TXNIP;
Research reportNrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning
Keywords: Sirt1; sirtuin 1; HBO-PC; hyperbaric oxygen preconditioning; MCAO; middle cerebral artery occlusion; Nrf2; nuclear factor erythroid-2 related factor 2; SOD1; superoxide dismutase 1; HO-1; heme oxygenase 1; MDA; malondialdehyde; siRNA; short interfering RN
Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway
Keywords: T. chebula; Terminalia chebula Retz.; Glycer-AGEs; glyceraldehyde-derived advanced glycation end-products; NASH; nonalcoholic steatohepatitis; ROS; reactive oxygen species; ARE; antioxidant response element; Nrf2; nuclear factor E2-related factor 2; MAP k
Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways
Keywords: SG; Sophoraflavanone G; LPS; lipopolysaccharide; NO; nitric oxide; PGE2; prostaglandin E2; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; IL-1β; interleukin-1β; PI3K; phosphoinositi
Up-regulation of nuclear factor E2-related factor 2 (Nrf2) represses the replication of SVCV
Keywords: SVCV; Nrf2; Oxidative stress;
Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet
Keywords: Keap1; Nrf2; Ampk; Diabetes; Gluconeogenesis; LipogenesisAcc, acetyl-CoA carboxylase; Ampk, AMP-activated protein kinase; C/ebpβ, CCAAT/enhancer-binding protein beta; CDDO-Im, 1[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole; CDDO-Me, 2-cyano-3,12
Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells
Keywords: Quercetin; Quercetin-7-gallate; Methyl gallate; Nrf2; Heme oxygenase-1; Metabolism; ARE; antioxidant response element; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; Gapdh; glyceraldehyde-3-phosphate dehydrogenase; GCLC; glutamate-c
Acute exposure to waterborne cadmium induced oxidative stress and immunotoxicity in the brain, ovary and liver of zebrafish (Danio rerio)
Keywords: Fish; Oxidative stress; Immunotoxicity; Cadmium exposure; Nrf2; NF-κB;
Nutritive values, flavor amino acids, healthcare fatty acids and flesh quality improved by manganese referring to up-regulating the antioxidant capacity and signaling molecules TOR and Nrf2 in the muscle of fish
Keywords: Antioxidant; Flesh quality; Grass carp; Manganese; Nrf2; Muscle;
Impact of Dyrk1A level on alcohol metabolism
Keywords: ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; ALT; alanine aminotransferase; CYP2E1; cytochrome P450 2E1; CBS; cysthathionine beta synthase; CTL; control; DCPIP; 2,6-dichlorophenolindophenol; DTNB; 5,5â²-dithiobis-(2-nitrobenzoic acid); Dyrk1
2,3,4â²,5-tetrahydroxystilbene-2-O-β-d-glucoside exerts anti-inflammatory effects on lipopolysaccharide-stimulated microglia by inhibiting NF-κB and activating AMPK/Nrf2 pathways
Keywords: THSG; Microglia; Anti-Neuroinflammation; AMPK; Nrf2;
NRF2-targeted therapeutics: New targets and modes of NRF2 regulation
Keywords: Autophagy; Cancer; Chemoprevention; Diabetes; Electrophiles; NRF2;
Research ArticleDownregulation of Nrf2 promotes autophagy-dependent osteoblastic differentiation of adipose-derived mesenchymal stem cells
Keywords: Nrf2; Oxidative stress; Adipose derived stem cells; Differentiation;
Zinc acclimation mitigated high zinc induced oxidative stress by enhancing antioxidant defenses in large yellow croaker Pseudosciaena crocea
Keywords: Zinc acclimation; Antioxidant response; Nrf2; Gene expression; Large yellow croaker
Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice
Keywords: HF, high fat; HFM, high fat plus metformin; BDNF, brain derived neurotrophic factor; NGF, nerve growth factor; NT3, neurotrophin 3; Nrf2, nuclear factor erythroid 2-related factorMetformin; BDNF; Water maze; Nrf2; NGF; Neurotrophin 3
Role of miR-155 in fluorooctane sulfonate-induced oxidative hepatic damage via the Nrf2-dependent pathway
Keywords: PFOS; miR155; Oxidative stress; Nrf2; Hepatotoxicity
Fusaric acid induces mitochondrial stress in human hepatocellular carcinoma (HepG2) cells
Keywords: Fusaric acid; Sirt3; Nrf2; Lon protease; PGC-1α; pCREB; HSP70; Caspase 3/7
Novel compound from Polygonum multiflorum inhibits inflammatory response in LPS-stimulated microglia by upregulating AMPK/Nrf2 pathways
Keywords: Polygonum multiflorum; Microglia; Anti-neuroinflammation; AMPK; Nrf2
Inhibitory effects of geraniin on LPS-induced inflammation via regulating NF-κB and Nrf2 pathways in RAW 264.7 cells
Keywords: NF-κB; Anti-inflammation; RAW 264.7 cells; Geraniin; Nrf2; ROS
Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats
Keywords: Rutin; Diabetic neuropathy; Oxidative stress; Hydrogen sulfide; Nrf2; Neuroinflammation
Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling
Keywords: Paraquat; Salvianolic acid B; Pulmonary fibrosis; Nrf2; NOX4; TGF-β1/Smad3 signaling pathway
Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets
Keywords: Nuclear factor erythroid 2-like 2; Nrf2; Antioxidant response element; Coho salmon; Paralog
Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells
Keywords: Hexavalent chromium; Inflammation; Transformed cells; ROS; Nrf2
Iron gene expression profile in atherogenic Mox macrophages
Keywords: acLDL; acetylated LDL; ApoEâ/â; Â cells or mice deficient in the gene coding for apolipoprotein E; ATH; atherosclerosis; BMDM; bone marrow-derived macrophages; CP/Cp; ceruloplasmin (gene Cp); EDTA; ethylenediaminetetraacetic acid; ffe; flat iron mutat
Hydrogen sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2
Keywords: AD; Alzheimer's disease; Aβ; beta-amyloid; APP; beta-amyloid precursor protein; ARE; antioxidant response element; BACE1; β-site APP-cleaving enzyme 1; CBS; cystathionine-β-synthase; DG; dentate gyrus; GST; glutathione S-transferase; HO-1; heme oxygena
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy
Keywords: 15-Deoxy-Δ12; 14-prostaglandin J2; Concanavalin A; HO-1; Autophagy; Nrf2
Therapeutic effect of Mahaenggamseok-tang on neutrophilic lung inflammation is associated with NF-κB suppression and Nrf2 activation
Keywords: ALI; acute lung injury; HPLC; high-performance liquid chromatography; RT-PCR; reverse transcription-polymerase chain reaction; LPS; lipopolysaccharide; Nrf2; nuclear erythroid 2-related factor 2; NF-κB; nuclear factor kappa-light-chain-enhancer of activa
TLR-7 agonist attenuates airway reactivity and inflammation through Nrf2-mediated antioxidant protection in a murine model of allergic asthma
Keywords: Airway inflammation; TLR-7 agonist; NADPH oxidase; Nrf2; Cu/Zn SODBAL, bronchoalveolar lavage; DETC, diethylthiocarbamate; iNOS, inducible nitric oxide synthase; i.n., intranasal; MyD88-IP, MyD88 inhibitory peptide; Nrf2, nuclear factor E2-related factor
Downregulation of Nrf2 by the combination of TRAIL and Valproic acid induces apoptotic cell death of TRAIL-resistant papillary thyroid cancer cells via suppression of Bcl-xL
Keywords: Nrf2; TRAIL; Valproic acid; Bcl-xL; TRAIL-resistant; Papillary thyroid cancer;
Partial contribution of the Keap1–Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells
Keywords: Cadmium; Keap1; Nrf2; Metallothionein; Antioxidant response element
Neonatal ventral hippocampus lesion changes nuclear restricted protein/brain (NRP/B) expression in hippocampus, cortex and striatum in developmental periods of rats
Keywords: E18; embryonic day 18; NRF2; Nuclear Factor-related 2; NRP/B; nuclear restricted protein/brain; NS; normal saline; NVHL; neonatal ventral hippocampal lesions; PD; postnatal day; RT-qPCR; real-time quantitative PCR; TBST; Tween/Tris-buffered saline; schizo
How sodium arsenite improve amyloid β-induced memory deficit?
Keywords: Sodium arsenite; Alzheimer's disease; Amyloid β; Nrf2; Oxidative stress; CREB;
Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways
Keywords: ARE; antioxidant response element; HBMEC-3; human brain micro-vascular endothelial cell-3; Keap1; Kelch-like ECH-associated protein 1; MCP-1; monocyte chemoattractant protein-1; Nrf2; NF-erythroid 2-related factor 2; SAE; sepsis-associated encephalopathy;
Increase in antioxidant activity by sheep/goat whey protein through nuclear factor-like 2 (Nrf2) is cell type dependent
Keywords: Antioxidant; C2C12; EA.hy926; Nrf2; Whey protein; AREs; antioxidant response elements; ATF4; activating transcription factor 4; CAT; catalase; CDNB; 1-chloro-2,4-dinitrobenzene; DETAPAC; diethylenetriaminepentaactic acid; DTT; dithiothreitol; EDTA; ethyle
Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression
Keywords: Nrf2; nuclear factor erythroid 2-related factor 2; G-CSF; granulocyte colony-stimulating factor; HSCs; hematopoietic stem cells; HPCs; hematopoietic progenitor cells; 3LL; Lewis lung carcinoma; RBC; red blood cell; DPPH; 2, 2-diphenyl-1-picryl-hydrazyl; T
Nitrosopersulfide (SSNOâ) targets the Keap-1/Nrf2 redox system
Keywords: Hmox1; heme oxygenase-1; Keap-1; Kelch-like ECH-associated protein; SSNOâ; nitrosopersulfide; Nrf2; nuclear factor (erythroid-derived 2)-like 2; PDE; phosphodiesterase; sGC; soluble guanylate cyclase; NO and H2S cross talk; Nitroxyl; Nitrosopersulfide;
Vam3 ameliorates total body irradiation-induced hematopoietic system injury partly by regulating the expression of Nrf2-targeted genes
Keywords: Vam3; Ionizing irradiation; Hematopoietic system; Reactive oxygen species; Nrf2;
Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis
Keywords: Pulmonary fibrosis; Celastrol; Bleomycin; Collagen; Phase II enzymes; Nrf2
NF-E2-related factor 2 deletion facilitates hepatic fatty acids metabolism disorder induced by high-fat diet via regulating related genes in mice
Keywords: NAFLD; Nrf2; Fatty acids metabolism; High-fat diet; ICR mice;
The cross-talk between electrophiles, antioxidant defence and the endocannabinoid system in fibroblasts and keratinocytes after UVA and UVB irradiation
Keywords: UV radiation; Fibroblasts; Keratinocytes; ROS; Nrf2
GastrointestinalIn vivo imaging of antioxidant response element activity during liver regeneration after partial hepatectomy
Keywords: Antioxidant response element; Liver regeneration; Nrf2; HO-1; In vivo imaging; Bioluminescence; Partial hepatectomy; Oxidative stress;
Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance
Keywords: immunosurveillance; innate immunity; interleukin-17D; NK cells; Nrf2; tumor rejection