کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8259043 | 1534630 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of Dyrk1A level on alcohol metabolism
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کلمات کلیدی
ADHNQO1HcyDYRK1ACBSCYP2E1PON1HHcyALTDTNBNrf2flavin adenine dinucleotideDCPIPCTLXMEsNAD(P)H: quinone oxidoreductasenicotinamide adenine dinucleotide, reducedALDH2,6-dichlorophenolindophenol - 2،6-dichlorophenolindophenol5,5′-dithiobis-(2-nitrobenzoic acid) - 5،5'-dithiobis- (2-nitrobenzoic acid)S-Adenosylhomocysteine hydrolase - S-آدنوزیل هوموسستئین هیدرولازAlanine aminotransferase - آلانین آمینوترانسفرازaldehyde dehydrogenase - آلدئید دهیدروژنازXenobiotic metabolizing enzymes - آنزیم های متابولیزه XenobioticEthanol - اتانولAlcohol dehydrogenase - الکل دهیدروژنازFAD - بدcytochrome P450 2E1 - سیتوکروم P450 2E1SAHH - شفاNuclear factor-erythroid 2-related factor 2 - عامل فاکتور هسته ای - عامل 2 وابسته به erythroid 2Mice - موشNAD - نادانhomocysteine - هوموسیستئینHyperhomocysteinemia - هیپر هوموسایستنمیParaoxonase 1 - پاراکسوناز 1Liver - کبدControl - کنترل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Alcoholic liver diseases arise from complex phenotypes involving many genetic factors. It is quite common to find hyperhomocysteinemia in chronic alcoholic liver diseases, mainly due to deregulation of hepatic homocysteine metabolism. Dyrk1A, involved in homocysteine metabolism at different crossroads, is decreased in liver of hyperhomocysteinemic mice. Here, we hypothesized that Dyrk1A contributes to alcohol-induced hepatic impairment in mice. Control, hyperhomocysteinemic and mice overexpressing Dyrk1A were fed using a Lieber-DeCarli liquid diet with or without ethanol (5% v/v ethanol) for one month, and liver histological examination and liver biochemical function tests were performed. Plasma alanine aminotransferase and homocysteine levels were significantly decreased in mice overexpressing Dyrk1A compared to control mice with or without alcohol administration. On the contrary, the mean plasma alanine aminotransferase and homocysteine levels were significantly higher in hyperhomocysteinemic mice than that of control mice after alcohol administration. Paraoxonase 1 and CYP2E1, two phase I xenobiotic metabolizing enzymes, were found increased in the three groups of mice after alcohol administration. However, NQO1, a phase II enzyme, was only found increased in hyperhomocysteinemic mice after alcohol exposure, suggesting a greater effect of alcohol in liver of hyperhomocysteinemic mice. We observed positive correlations between hepatic alcohol dehydrogenase activity, Dyrk1A and ADH4 protein levels. Importantly, a deleterious effect of alcohol consumption on hepatic Dyrk1A protein level was found. Our study reveals on the one hand a role of Dyrk1A in ethanol metabolism and on the other hand a deleterious effect of alcohol administration on hepatic Dyrk1A level.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1862, Issue 9, September 2016, Pages 1495-1503
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1862, Issue 9, September 2016, Pages 1495-1503
نویسندگان
Marjorie Renon, Béatrice Legrand, Etienne Blanc, Fabrice Daubigney, Cindy Bokobza, Marie Mortreux, Jean-Louis Paul, Jean-Maurice Delabar, Hélène Rouach, Karine Andreau, Nathalie Janel,