Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Nuclear receptor; ERRγ; Selective ligand; Amide; Agonist;
مقالات ISI گیرنده هسته‌ای، گیرنده‌های هسته‌ای (ترجمه نشده)
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Identification of potent RORβ modulators: Scaffold variation
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Nuclear receptor; RORβ; Selective ligand; Aminothiophene;
Ess2 bridges transcriptional regulators and spliceosomal complexes via distinct interacting domains
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Transcription; Nuclear receptor; Splicing; lncRNA;
The vitamin D receptor (VDR) binds to the nuclear matrix via its hinge domain: A potential mechanism for the reduction in VDR mediated transcription in mitotic cells
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Vitamin D receptor; Vitamin D; Nuclear matrix; Genomic functions; Mutant; Mitosis; Nuclear receptor;
Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Pregnane X receptor; Nuclear receptor; Silanol; Sila-substitution; C/Si-exchange; Alcohol/silanol-exchange; T0901317;
Fat-specific protein 27 is a novel target gene of liver X receptor α
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; PPAR; LXR; Fatty liver; Nuclear receptor; FSP27; fat-specific protein 27; CIDE; cell death-inducing DNA fragmentation factor 45-like effector; LD; lipid droplet; TG; triglyceride; PPAR; peroxisome proliferator-activated receptor; CREBH; cyclic AMP-respons
Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; ABC; ATP-binding cassette transporter; ADAR; adenosine deaminase acting on RNA; ADH; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; ALS; amyotrophic lateral sclerosis; AZIN1; antizyme inhibitor 1; AMPA; α-amino-3-hydroxy
Insights into the role of hepatocyte PPARα activity in response to fasting
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Nuclear receptor; PPARα; Fasting; NAFLD; NASH; Steatosis; FGF21; Ketone bodies; Lipolysis; Transcriptome;
Intrinsically disordered N-terminal domain of the Helicoverpa armigera Ultraspiracle stabilizes the dimeric form via a scorpion-like structure
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; NRs; nuclear receptors; NTD; N-terminal domain; DBD; DNA-binding domain; LBD; ligand-binding domain; EcR; ecdysone receptor; Usp; Ultraspiracle; IDR; intrinsically disordered region; HaUsp; Usp from Helicoverpa armigera; HaUsp_ÎNTD; Usp from Helicoverpa
Effects of farnesoid-X-receptor SUMOylation mutation on myocardial ischemia/reperfusion injury in mice
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Nuclear receptor; Farnesoid X receptor; Ischemia-reperfusion; Apoptosis;
HR38, an ortholog of NR4A family nuclear receptors, mediates 20-hydroxyecdysone regulation of carbohydrate metabolism during mosquito reproduction
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Hormone; Nuclear receptor; Metabolism; Mosquito; Disease vector;
Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; NR; nuclear receptor; FXR; farnesoid X receptor; RXR; retinoid X receptor; PXR; pregnane X receptor; VDR; Vitamin D receptor; TGR5; G protein-coupled bile acid receptor; Lrh1; liver receptor homolog 1; Mdr; multidrug resistance protein; Abcb4; ATP Bindi
Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Nuclear receptor; Pregnane and xenobiotic receptor (PXR); Stable cell lines; Herbal drugs; High throughput screening; Promoter-reporter; Small molecules;
Genetic disruption of the nuclear receptor Nur77 (Nr4a1) in rat reduces dopamine cell loss and l-Dopa-induced dyskinesia in experimental Parkinson's disease
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; NGFI-B; Nuclear receptor; Transcription factor; Dopamine denervation; Mutant transgenic rat; Knockout mice; Substantia nigra; Striatum;
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor
Endocrine Disruptor Compounds (EDCs) and agriculture: The case of pesticides
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Pesticide; Endocrine Disruptor; Nuclear receptor; Risk; Hazard; Mechanism;
Pregnane X receptor (PXR) signaling in seabream primary hepatocytes exposed to extracts of seawater samples collected from polycyclic aromatic hydrocarbons (PAHs)-contaminated coastal areas
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Nuclear receptor; PXR; CYP3A; LXR; Polycyclic aromatic hydrocarbons; Gene transcription; Endocrine disruption; Adriatic sea;
Alisol B 23-acetate from the rhizomes of Alisma orientale is a natural agonist of the human pregnane X receptor
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Alisol B 23-acetate; Alisma orientale; Pregnane X receptor; Alisma rhizome; Nuclear receptor; CYP3A4; cytochrome P450 3A4; DMEs; drug metabolizing enzymes; HPH; human primary hepatocyte; ABA; alisol B 23-acetate; PXR; pregnane X receptor; SRC-1; steroid r
Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; SRCs; steroid receptor coactivators; NR; nuclear receptor; PR; progesterone receptor; HATs; histone acetyltransferases; CBP; CREB-binding protein; HDACs; histone deacetylases; HMTs; histone methyltransferases; BRDs; bromodomains; bHLH-PAS; basic helix-loo
SRC2-3 binds to vitamin D receptor with high sensitivity and strong affinity
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; VDR; vitamin D receptor; LBD; ligand-binding domain; DRIP; vitamin D receptor interacting protein; SRC; steroid receptor coactivator; SPR; surface plasmon resonance; AF2; activation-function 2; Vitamin D; Nuclear receptor; Coactivator; SRC2-3; Surface pla
Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Detoxification; Dioxin; Cross-talk; Nuclear receptor; Skatole;
Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; ANXA 1, ANXA 2, ANXA5; annexins; ATRA; all-trans retinoic acid; EMT; epithelial-mesenchymal transition; FBS; fetal bovine serum; G3P; glyceraldehyde-3-phosphate dehydrogenase; NDKB; nucleoside diphosphate kinase B; NPM; nucleophosmin; NR; nuclear receptor
Drug discovery targeting heme-based sensors and their coupled activities
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Drug discovery; Heme-based sensor; Nucleotide cyclase; Phosphodiesterase; Histidine protein kinase; Nuclear receptor;
Rev-erb regulation of cholesterologenesis
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Nuclear receptor; Rev-erb; Cholesterol synthesis; Statins; Atherosclerosis;
Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; FGF; fibroblast growth factor; PXR; pregnane X receptor; NR; nuclear receptor; CAR; constitutive androstane receptor; CYP; cytochrome P450; CYP7A1; cholesterol 7α-hydroxylase; CYP8B1; sterol 12α-hydroxylase; HFD; high fat diet; KO; knockout; ob; obesity
RNA sequencing indicates that atrazine induces multiple detoxification genes in Daphnia magna and this is a potential source of its mixture interactions with other chemicals
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Gene expression; Mixture model; Nuclear receptor; Aquatic toxicology; Induction; Concentration-dependent; ADH; Alcohol dehydrogenase; AUC; Area under the curve; ABC transporter; ATP-binding cassette transporter; BPA; Bisphenol A; CATAM; Computational Appr
Xenobiotics and the Glucocorticoid Receptor
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; GC; Glucocorticoids; GR; Glucocorticoid Receptor; NR; Nuclear receptor; PXR; Pregnane X receptor; CAR; Constituitive androstane receptor; SCN; Supra-chiasmic nucleus; CBG; Corticosteroid binding globulin; HSD; Hydroxysteroid dehydrogenase; MR; Minerocorti
RIPK1 binds to vitamin D receptor and decreases vitamin D-induced growth suppression
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; 1,25D3; 1α, 25-dihydroxyvitamin D3; RIPK1; receptor interacting protein kinase 1; VDR; vitamin D receptor; Apoptosis; Cancer; Necroptosis; Nuclear receptor; Receptor interacting protein kinase 1; Vitamin D; Vitamin D receptor;
Characterization of the differential coregulator binding signatures of the Retinoic Acid Receptor subtypes upon (ant)agonist action
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; MARCoNI; Microarray Assay for Real-time Coregulator-Nuclear Receptor Interaction; NR; Nuclear Receptor; RAR; Retinoic Acid Receptor; AtRA; all-trans-Retinoic Acid; Am80; 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid; CD2
PARP, transcription and chromatin modeling
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; ABCA1; ATP-binding cassette transporter A1; ADP-ribosylation; adenosine diphosphate ribosylation; ALC1; amplified in-liver-cancer 1; AR; androgen receptor; ARH3; ADP-ribosylhydrolase 3; ART; ADP-ribosyl transferase; ASF/SF2; alternative splicing factor/sp
ReviewOn the regulatory importance of 27-hydroxycholesterol in mouse liver
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; 7-DHC; 7-dehydrocholesterol; T-MAS; testis meiosis activating sterol; FF-MAS; follicular fluid meiosis activating sterol; Cholesterol metabolism; Gene expression; Nuclear receptor; Oxysterols; Cytochrome P-450; Cyp27-/- mice; Lipoprotein lipase; Abcg8; Sr
Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; KDAC; lysine deacetylase; KDACi; lysine deacetylase inhibitor; KAT; lysine acetyltransferase; GR; glucocorticoid receptor; VPA; valproic acid; NR; nuclear receptor; Dex; dexamethasone; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HDAC; histone deacety
Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; ChIP; chromatin immunoprecipitation; DIC; differential interference contrast; DM; differentiation medium; DSG; Di(N-succinimidyl) glutarate; EM; expansion medium; Fxr; farnesoid x receptor; IPA; Ingenuity Pathway Analysis; Lxr; Liver x receptor; NR; nucle
Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1-AKT-mTOR Axis in Mice
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Cholesterol; Cholestyramine; Fatty Liver; Nuclear Receptor; ACAT; acyl-CoA:cholesterol acyltransferase; CE; cholesterol ester; ChTM; cholestyramine; CQ; chloroquine; CYP7A1; cholesterol 7α-hydroxylase; DIO; diet-induced obesity; ER; endoplasmic reticulum
ReviewThe role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Vitamin D; Calcitriol; Vitamin D receptor; Epigenetics; Nuclear receptor; Cancer; Methylation; Epidemiology;
The interrelationship between bile acid and vitamin A homeostasis
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; ATGL; Adipose triglyceride lipase; ADH; Alcohol dehydrogenase; ALD; Alcoholic liver disease; atRA; All-trans retinoic acid; ASBT/SLC10A2; Apical sodium-dependent bile salt transporter; ABCA1; ATP-binding cassette transporter member 1; BCMO1; Beta-carotene
Genome-wide identification of nuclear receptor (NR) genes and the evolutionary significance of the NR1O subfamily in the monogonont rotifer Brachionus spp.
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Nuclear receptor; NRs; Rotifer; Endocrine system;
WAFs lead molting retardation of naupliar stages with down-regulated expression profiles of chitin metabolic pathway and related genes in the copepod Tigriopus japonicus
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Water accommodated fraction (WAF); Molting; Chitin metabolic pathway; Nuclear receptor; Copepod; Tigriopus japonicus;
RNAi suppression of nuclear receptor genes results in increased susceptibility to sulfoxaflor in brown planthopper, Nilaparvata lugens
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; AHR; aryl hydrocarbon receptor; BLAST; basic local alignment search tool; CAR; constitutive androstane receptor; CYP; cytochrome P450; DBD; DNA-binding domain; ERR; estrogen-related receptor; EST; expressed sequence tag; GR; glucocorticoid receptor; HNF4;
Identification, expression pattern and functional characterization of As-kip2 in diapause embryo restarting process of Artemia sinica
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; As-kip2; p57Kip2 mRNA from Artemia sinica; As-KIP2; p57Kip2 protein from Artemia sinica; As-CARP-1; cell cycle and apoptosis regulator 1 protein from Artemia sinica; As-SODD; silencer of death domain protein from Artemia sinica; CDK; cyclin-dependent kina
Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Estrogen-related receptor α; ERRα; Nuclear receptor; Anti-diabetic; Metabolic syndrome; Indazole; Thiazolidenedione; TZD; Insulin resistance; ERR; estrogen-related receptor; ER; estrogen receptor; ERE; estrogen response element; ERRE; estrogen-related r
Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Nuclear receptor; LXR; Transcription; NASH; Lipogenesis; Drug discovery;
Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Human iPS cells; Enterocyte-like cells; CYP3A4 induction; Nuclear receptor; CDX2; caudal type homeobox 2; CYP3A4; cytochrome P450 3A4; DEX; dexamethasone; EGF; epidermal growth factor; FGF2; fibroblast growth factor 2; FXR; farnesoid X receptor; GR; gluco
TLX: An elusive receptor
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Nuclear receptor; Small molecule; Druggability; Structure-based drug design; Coregulator; Protein-protein interaction surface
Transcriptional regulation of the human Liver X Receptor α gene by Hepatocyte Nuclear Factor 4α
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; LXR; HNF-4α; Gene regulation; HDL; Oxysterols; ABCA1; ATP Binsing Cassette Transporter A1; ChIP; Chromatin Immunoprecipitation; ChIP-seq; Chromatin Immunoprecipitation followed by sequencing; DNAP; DNA Affinity Precipitation; HNF-4; Hepatocyte Nuclear Fa
Monitoring of the retinoic acid receptor-retinoid X receptor dimerization upon DNA binding by native mass spectrometry
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; NR; nuclear receptor; RAR; retinoic acid receptor; RXR; retinoic X receptor; DNA; deoxyribonucleic acid; RA; all-trans retinoic acid (RA); DR; direct repeat; RARE; RAR response element; ESI-MS; electrospray ionization mass spectrometry; DBD; DNA binding d
Effects of thyroid hormone transporters MCT8 and MCT10 on nuclear activity of T3
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Thyroid hormone; Transporter; Deiodinase; Nuclear receptor;
Inhibition of RORα/γ suppresses atherosclerosis via inhibition of both cholesterol absorption and inflammation
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Drug discovery; Nuclear receptor; Atherosclerosis; Cholesterol; Heart disease; ROR;
Stimulation of orphan nuclear receptor HR38 gene expression by PTTH in prothoracic glands of the silkworm, Bombyx mori
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Ecdysone; PTTH; Signaling; Nuclear receptor; HR38; Immediate early gene;
Résistances aux hormones stéroïdes : physiologie et pathologie
Keywords: گیرنده هسته‌ای، گیرنده‌های هسته‌ای; Syndrome de résistance; Hormone stéroïde; Récepteur nucléaire; Mutation; Resistance Syndrome; Steroid Hormone; Nuclear Receptor; Mutation;