Keywords: Saquinavir; Fexofenadine; Cremophor EL; P-gp; Oral absorption
مقالات ISI (ترجمه نشده)
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Keywords: MMPs; matrix metalloproteinases; MSC; mesenchymal stem cells; MPs; microparticles; miRNA; microRNA; MVs; microvesicles; MDR; multidrug resistance; NSCLC; non-small cell lung carcinoma; P-gp; P-glycoprotein; PYK2; proline-rich tyrosine kinase 2; Biomarker;
Keywords: AMPK; AMP-activated protein kinase; ACC; acetyl-CoAcarboxylase; COX; cyclooxygenase; CDK; cyclin-dependent kinase; CaMK; Ca2+/calmodulin-dependent protein kinase; CPT; Cholinephosphotransferase; Egr; early growth response gene; ERK; extracellular signal-r
Keywords: ECM; extracellular matrix; IFP; interstitial fluid pressure; EPR; enhanced permeation and retention; AI; angiogenesis inhibitors; VEGF; vascular endothelial growth factor; VDA; vascular disrupting agent; CEP; circulating endothelial progenitor; TACE; tran
Keywords: HCC; hepatocellular carcinoma; MDR; multidrug resistance; DOX; doxorubicin; Cur; curcumin; DOX/Cur-NPs; doxorubicin and curcumin co-delivery lipid nanoparticles; DEN; diethylnitrosamine; ALT; alanine aminotransferase; AST; aspartate transaminase; P-gp; P-
Keywords: 2-ME; 2-methoxyestradiol; CAIX; carbonic anhydrase IX; CSC; cancer stem cell; Dtx; docetaxel; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; FIH-1; factor inhibiting HIF-1; GSCs; glioma stem cells; HIF-1; hypoxia-inducible factor-1;
Keywords: μm; micrometer; °C; degree Celsius; Ac; acetone; AcN; acetonitrile; AUC; area under curve; BCS; Biopharmaceutics Classification System; CC; calibration curve; CFR; CO2 flow rate; cm; centimeter; Cmax; maximum plasma concentration; CO2; carbon dioxide; C
Keywords: SL; sphingolipid; S1P; sphingosine 1-phosphate; GCS; glucosylceramide synthase; GC; glucosylceramide; AC; ceramidase; SphK; sphingosine kinase; PPMP; D-threo-1-phenyl-2-hexadecanoylamino-3-morpholino-1-propanol; PDMP; D-threo-1-phenyl-2-decanoylamino-3-mo
Keywords: Steviol glucuronide; OAT3; Uptake transport; Food-drug interaction; BCRP; breast cancer resistant protein; MATE; multidrug and toxin extrusion protein; MRP; multidrug resistant protein; OAT; organic anion transporter; OATP; organic anion transport protein
Keywords: ABC; ATP binding cassette; AD; Alzheimer's disease; ApoE; Apolipoprotein E; AQP; Aquaporin; Aβ; Amyloid-β; AβPP; Aβ precursor protein; BACE-1; β-site AβPP cleaving enzyme 1; BBB; Blood-brain barrier; CBF; Cerebral blood flow; CSF; Cerebrospinal fl
Keywords: ABCB1; adenosine triphosphate-binding cassette transporter 1; ASC; apoptosis-associated Speck-like protein containing Caspase recruitment domain; ATP; adenosine triphosphate; Bcl-2; B-cell lymphoma 2; BD; Behcetʼs disease; Ca2+; calcium; Caspase; cystein
Keywords: ABC; ATP-binding cassette; GSH; glutathione; IC50; half-maximal inhibitory concentration; IFN-γ; interferon-gamma; iNOS; inducible NO synthase; IRF-1; interferon regulatory factor-1; ITC; isothiocyanate; Kobs; Pseudo-first order reaction rate constant; L
Keywords: Purines; Microwave-assisted synthesis; Antiproliferative agents; Cell cycle analysis; HeLa; human cervical carcinoma cells; MEP; molecular electrostatic potential; MW; microwave irradiation; P-gp; P-glycoprotein; UPQIILJRYHYHQB-UHFFFAOYSA-N; FLDPTZXFXIMRB
Keywords: LPS; lipopolysaccharide; IL-6; interleukin-6; DMEs; drug-metabolizing enzymes; Ces (mouse) or CES (human); carboxylesterases; CYP; cytochrome P450; PXR; pregnane X receptor; CAR; constitutive androstane receptor; RXR; retinoid X receptor; NFκB; nuclear f
Keywords: DMEM; Dulbecco's Modified Eagle Medium; DMSO; Dimethylsulfoxide; Dox; Doxorubicin; RSV; Resveratrol; MCF-7/adr; Doxorubicin-resistant MCF-7; ABC transporter; ATP-binding cassette transporter; MDR; Multi-drug resistance; MRP; Multi-drug resistance associat
Keywords: P-gp; P-glycoproteins; BEs; bioactive excipients; AP; apical; BL; basolateral; Papp; apparent permeability; CYP3A4; cytochrome P450 3A; HCC; hepatocellular carcinoma; BBB; blood-brain barrier; ER; Estrogen receptor; Cell line; Nanomedicine; Permeability
Keywords: P-gp; P-glycoprotein; CYP-3A4; cytochrome P450 3A4; AUC; area under plasma concentration curve; CVS; cardiac vascular system; CNS; central nervous system; BaP; benzo(a)pyrene; PIP; piperine; CUR; curcumin; MCF-7; Michigan Cancer Foundation-7; Bioenhancer;
Keywords: 5FU; 5-fluorouracile; ABC; ATP-binding cassette; AUC; area under the curve; BCRP; breast cancer resistance protein; Cmax; maximum (peak) plasma concentration; CYP; cytochrome p450 enzymes; DDI; drug-drug interactions; EIAEDS; enzyme-inducing antiepilept
Keywords: AAN; aristolochic acid nephropathy; ADME; absorption, distribution, metabolism and excretion; CYT P450; cytochrome P450; DPP-IV; dipeptidyl peptidase IV; GLP1; glucagon like peptide 1; GLUT4; glucose transporter 4; GSH; glutathione; GST; glutathione-S-tra
Keywords: Supersaturated polymeric micelle; Cyclosporine A; Soluplus®; Supersaturation degree; Oral bioavailability; Cellular uptake and transport; CsA; cyclosporine A; CsD; cyclosporine D; P-gp; P-glycoprotein; PMs; polymeric micelles; HPMC-AS; hydroxypropyl meth
Keywords: APC; apparent partition coefficient; BCRP; breast cancer resistance protein; CH; cholate; cLPM; canalicular liver plasma membrane; DC; deoxycholate; GC; glycocholate; GDC; glycodeoxycholate; HNAP; hydroxy-2-naphthoic acid; Mw; molecular weight; MATE; mult
Keywords: ADR; Adriamycin-resistant; AFM; Atomic force microscopic; CTAB; Cetyltrimethylammonium bromide; DMAB; Didodecyldimethylammonium bromide; ERC; Endocytic recycling compartment; ERCC1; Excision repair cross-complementation group 1; GCS; Glucosylceramide synt
Keywords: Caco-2 cells; Doxorubicin; Surfactants; In vivo; Rats; P-gp; Inhibitor
Astragali radix and its main bioactive compounds activate the Nrf2-mediated signaling pathway to induce P-glycoprotein and breast cancer resistance protein
Keywords: P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; HQ; Astragali radix; AS-IV; astragaloside IV; CS; calycosin; FMNT; formononetin; Nrf2; nuclear factor E2-related factor-2; HDIs; herb-drug interactions; AREs; antioxidant response elements; K
The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers
Keywords: AD; Decoction of processed aconite root; ALD; Decoction of processed aconite root and honey-processed liquorice; AP; Apical; BCRP; Breast cancer resistance protein; BL; Basolateral; DDAs; Diester-diterpenoid alkaloids; EIC; Extracted ion chromatogram; ER;
Blood-brain barrier permeability and neuroprotective effects of three main alkaloids from the fruits of Euodia rutaecarpa with MDCK-pHaMDR cell monolayer and PC12 cell line
Keywords: EF; Euodiae Fructus; EDM; evodiamine; RCP; rutaecarpine; DEDM; dehydroevodiamine; Papp; apparent permeability coefficients; P-gp; P-glycoprotein; MPP+; 1-methyl-4-phenylpyridinium ion; H2O2; hydrogen peroxide; TCM; traditional Chinese medicine; BBB; blood
PPARs are mediators of anti-cancer properties of superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with conjugated linoleic acid
Keywords: SPIONs; CLA; Breast cancer 4T1 cells; PPARs; P-gp; ALDH3A1;
In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein
Keywords: BBB; blood-brain barrier; BCRP; Breast Cancer Resistance Protein; BSA; bovine serum albumin; DAD; diode-array detection; DBH; dopamine β-hydroxylase; DDIs; drug-drug interactions; DMSO; dimethyl sulfoxide; EMA; European Medicines Agency; HBSS; Hanks bala
Physiological based pharmacokinetic modeling to estimate in vivo Ki of ketoconazole on renal P-gp using human drug-drug interaction study result of fesoterodine and ketoconazole
Keywords: Physiological based pharmacokinetic model; P-gp; Renal excretion; Fesoterodine; Ketoconazole;
Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors
Keywords: Alzheimer's disease; BACE-1; Amino-1,4-oxazines; pKa; P-gp;
Syntheses and evaluations of the methoxy modified 99mTc-labeled triphenyl phosphonium cations: Potential radiometallic probes for multidrug resistance detection
Keywords: Multidrug resistance; 99mTc; Tumor; Triphenylphosphonium cation; P-gp; Cyclopentadieny;
Retina Compatible Interactions and Effective Modulation of Blood Ocular Barrier P-gp Activity by Third-Generation Inhibitors Improve the Ocular Penetration of Loperamide
Keywords: P-gp inhibitors; electroretinography; elacridar; tariquidar; blood aqueous barrier (BAB); blood retinal barrier (BRB); ABC; adenosine tri-phosphate-binding cassette; AH; aqueous humor; BAB; blood aqueous barrier; BM; Bruch's membrane; BOB; blood ocular
TIPE2 sensitizes osteosarcoma cells to cis-platin by down-regulating MDR1 via the TAK1- NF-κB and - AP-1 pathways
Keywords: OS; Osteosarcoma; MDR1; Multidrug resistance protein 1; P-gp; p-glycoprotein; TIPE2; Tumor necrosis factor TNF- alpha induced protein 8-like 2; EAE; Autoimmune encephalomyelitis; MDR; Multidrug resistance; PI; Propidium iodide; HCC; Hepatocellular carcino
Quantification of membrane transporter proteins in human lung and immortalized cell lines using targeted quantitative proteomic analysis by isotope dilution nanoLC-MS/MS
Keywords: BCRP; breast cancer resistant protein; BEAS; bronchial epithelium and adenovirus; MDCK; madin darby canine kidney; MDR1; multidrug resistance protein 1 (also known as P-gp); MRM; multiple reaction monitoring; MRP; multidrug resistance-associated protein;
Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
Keywords: AhR; aryl hydrocarbon receptor; AP1; activating protein 1; ARE; antioxidant-response element; CAR; constitutive androstane receptor; CYP; cytochrome P450; DREs; dioxin-responsive elements; EMSA; electromobility gel shift assay; FBS; fetal bovine serum; GS
Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics
Keywords: ABC; ATP-binding cassette transporter; ADAR; adenosine deaminase acting on RNA; ADH; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; ALS; amyotrophic lateral sclerosis; AZIN1; antizyme inhibitor 1; AMPA; α-amino-3-hydroxy
Nitric oxide reverses drug resistance by inhibiting ATPase activity of p-glycoprotein in human multi-drug resistant cancer cells
Keywords: Nitric Oxide; Multi-drug resistance; P-gp protein; Adriamycin; Taxol; Free radical; P-gp; P-glycoprotein 170; MDR; multi-drug resistance; ADR; Adriamycin; TX; taxol; ËNO; nitric oxide; topo; topoisomerase; PPNO; propylamine nonoate; DETNO; diethylenetria
MicroRNA-132 and microRNA-212 mediate doxorubicin resistance by down-regulating the PTEN-AKT/NF-κB signaling pathway in breast cancer
Keywords: MDR; multi-drug resistance; qRT-PCR; quantitative real-time PCR; BCRP; breast cancer resistance protein; PTEN; phosphatase and tensin homolog deleted on chromosome ten; DMEM; Dulbecco's Modified Eagle medium; RPMI 1640; Roswell Park Memorial Institute m
Microdialysis combined with RRLC-MS/MS for the pharmacokinetics of two major alkaloids of Bi qi capsule and the potential roles of P-gp and BCRP on their penetration
Keywords: BQC; Bi qi capsule; BBB; blood-brain barrier; RRLC-MS/MS; rapid resolution liquid chromatography -tandem mass spectrometry; P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; CNS; central nervous system; CSF; cerebrospinal fluid; LLOQ; lower li
Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2
Keywords: ABC; ATP-binding cassette; AUC; area under the curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; GBM; glioblastoma; MGMT; O6-methylguanine-DNA methyltransferase; MRI; magnetic resonance imaging; P-gp; P-glycoprotein; WT; wild-type;
The combination of Puerariae Lobatae Radix and Chuanxiong Rhizoma enhanced the absorption and pharmacokinetics of puerarin by modulating the intestinal barrier and influenced gut microbiota
Keywords: Puerarin; Ligustrazine; Absorption; Pharmacokinetics; Intestinal barrier; Gut microbiota; Puerarin (PubChem CID: 5281807); Daidzein (PubChem CID: 5281708); Daidzin (PubChem CID: 107971); Ligustrazine (PubChem CID: 14296); PLR; Puerariae Lobatae Radix; CXR
Hypericin affects cancer side populations via competitive inhibition of BCRP
Keywords: ABC transporters; ATP-binding cassette transporters; ALDH; aldehyde dehydrogenase; BCRP; breast carcinoma resistance protein; CDH1; cadherin 1 gene encoding E-cadherin; CSLCs; cancer stem-like cells; DEAB; N,N-diethylaminobenzaldehyde; EDTA; ethylenediami
Mesoporous silica nanoparticles for drug and gene delivery
Keywords: AO; acridine orange; APTES; 3-aminopropyltriethoxysilane; APTMS; amino propyl trimethoxysilane; BCL-2; B-cell lymphoma-2; BCS; Biopharmaceutical Classification System; Bio-TEM; biological transmission electron microscopy; C dots; Cornell dots; CMC; critic
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents
Keywords: MDR reversers; P-gp modulators; Piperazine derivatives; Chemosensitizers; Doxorubicin-resistant human erythroleukemia K562â¯cells (K562/DOX); Pirarubicin uptake; P-gp; P-glycoprotein; MRP1; Multidrug Resistance associated Protein 1; BCRP; Breast Cancer R
Monoterpene indole alkaloid azine derivatives as MDR reversal agents
Keywords: ABC; ATP binding cassette; ABCB1; ATP binding cassette subfamily B member 1; ABCG2; ATP binding cassette subfamily G member 2; BCRP; breast cancer resistance protein; BHK-21; baby hamster kidney; CS; collateral sensitivity; FACS; fluorescence-activated ce
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR)
Keywords: P-gp; P-glycoprotein; SAR; Structure-activity relationships; DOX; Doxorubicin; EDCI; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimmide hydrochloride; HOBt; 1-Hydroxybenzotriazole hydrate; DMAP; 4-dimethylaminopyridine; P-gp modulators; MDR reversers; Heterod
Identification of small molecule activators for ErbB 4 receptor to enhance oligodendrocyte regeneration by in silico approach
Keywords: ADMET; adsorption distribution metabolism excretion toxicity; BBB; blood brain barrier; BS; bioavailability score; CNS; central nervous system; CT; C-terminal tail; ECD; extracellular domain; EGF; epidermal growth factor; ESOL; estimated solubility; EV; E
Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris
Keywords: Euphorbia lathyris; Euphorbia factor; Cytotoxicity; Collateral sensitivity; Multidrug resistance (MDR); EFL1-21; euphorbia factors L1-L21; MDR; multidrug resistance; P-gp; P-glycoprotein; ABC; ATP-binding cassette; SAR; structure activity relationship
Glutathione detonated and pH responsive nano-clusters of Au nanorods with a high dose of DOX for treatment of multidrug resistant cancer
Keywords: AuNR or DOX-AuNR-PCDA-PEG-Biotin; Au nanorods conjugated with doxorubicin and amphiphilic poly(curcumin-co-dithiodipropionic acid)-b-biotinylated poly(ethylene glycol); AuNR Cluster; the nano-cluster of Au nanorods conjugated with doxorubicin and amphiphi
MicroRNA-139-5p affects cisplatin sensitivity in human nasopharyngeal carcinoma cells by regulating the epithelial-to-mesenchymal transition
Keywords: Akt; protein kinase B; Bax; Bcl-2 associated X; Bcl-2; B-cell lymphoma 2; DAPI; 4â²,6-diamidino-2-phenylindole; DDP; cisplatin; EMT; epithelial-to-mesenchymal transition; FBS; fetal bovine serum; GAPDH; glyceraldeyde 3-phosphate dehydrogenase; HRP; horse