دانلود مقالات ISI درباره P-Gp + ترجمه فارسی

A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death

Keywords: Ardisiacrispin B; Cell cycle distribution; Cytotoxicity; Ferroptosis; Mitochondrial membrane potential; Saponin; ABC; ATP-binding cassette; BCRP; breast cancer resistance protein; DCF; dichlorofluoresceine; DMSO; dimethylsulfoxide; EGFR; epidermal growth

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Cigarette smoke condensate alters Saccharomyces cerevisiae efflux transporter mRNA and activity and increases caffeine toxicity

Keywords: ABC transporter; Pdr5; Snq2; Cigarette smoke; Caffeine; Saccharomyces cerevisiae; ABC; ATP-binding cassette; AαC; 2-amino-9H-pyrido[23-b]indole; 4- ABP; 4-aminobiphenyl; BaP; benzo(a)pyrene; BLAST; Basic local alignment search tool; BCRP; breast cancer r

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance: Focus on antiepileptic drugs

Keywords: Epilepsy; Dual flavonoid combinations; Flavonoids; In vitro studies; P-glycoprotein; Pharmacoresistance; AEDs; Antiepileptic drugs; CBZ; Carbamazepine; CBZ-E; Carbamazepine-10,11-epoxide; CNS; Central nervous system; DMSO; dimethyl sulfoxide; DMEM; Dulbec

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Novel cremochylomicrons for improved oral bioavailability of the antineoplastic phytomedicine berberine chloride: Optimization and pharmacokinetics

Keywords: BER; berberine chloride; CM; chylomicron; CrM; cremochylomicron; CHX; cycloheximide; P-gp; p-glycoprotein; PDI; polydispersity index; MRT; mean residence time; Berberine chloride (BER); Chylomicron (CM); Cremophor El; Lymphatic targeting; Cycloheximide (C

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells

Keywords: HCC; hepatocellular carcinoma; 5-FU; 5-fluorouracil; MEL; melittin; P-gp; P-glycoprotein; AMPs; antimicrobial peptides; LDH; lactate dehydrogenase; SEM; scanning electron microscope; BMSCs; bone mesenchymal stem cells; IGF-I; insulin­like growth factor I

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors

Keywords: Selective survivin inhibitors; Structure-activity relationships; Antiproliferative activities; P-glycoprotein overexpression; ABC; ATP-binding cassette; IAP; inhibitor of apoptosis proteins; P-gp; P-glycoprotein; RI; resistance index; SAR; structure-activ

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability

Keywords: ABC; ATP-binding cassette; ALK; anaplastic lymphoma kinase; ANOVA; analysis of variance; AUC; area under plasma concentration-time curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BTB; blood-testis barrier; Cbrain; brain concentrat

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Hexane fraction of adlay (Coix lachryma-jobi L.) testa ethanolic extract inhibits human uterine sarcoma cancer cells growth and chemosensitizes human uterine sarcoma cells to doxorubicin

Keywords: Adlay testa; Doxorubicin; MES-SA; MES-SA/Dx5; HUtSMCs; Multidrug resistance; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; AHE; the ethanoic extracts of adlay hull; ABE; the ethanoic extracts of adlay bran; ATE; the ethanoic extracts

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Concomitant Delivery of Paclitaxel and NuBCP-9 peptide for synergistic enhancement of cancer therapy

Keywords: Paclitaxel; nab-paclitaxel; polymeric nanoparticles; NuBCP-9; BCL-2; NP; nanoparticle; P-gp; Poly-glycoproteins; PTX; Paclitaxel; nab-paclitaxel; albumin based paclitaxel loaded nanoparticles; NuBCP-9; Nur77 derived BCL-2 converting 9 mer peptide; caspase

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Cytoprotection of lipoic acid against toxicity induced by saxitoxin in hippocampal cell line HT-22 through in silico modeling and in vitro assays

Keywords: ARE; antioxidant response element; BBB; blood brain barrier; CNS; central nervous system; dc-STX; dc-saxitoxin; DFT; density functional simulation; DHLA; dihidrolipoic acid; DMEM; Dulbenco's Modified Eagles Medium containing high glucose; DMSO; dimetils

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer's disease

Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; ApoE; apo-lipoprotein E; ABCA1; ATP-binding cassette transporter A1; BBB; blood-brain barrier; EVOO; extra-virgin olive oil; GFAP; glial fibrillary acidic protein; IL-1β; inter

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Optimization of maintenance therapy of Risperidone with CYP2D6 genetic polymorphisms through an extended translational framework-based prediction of target occupancies/clinical outcomes

Keywords: RO; receptor occupancy; EPS; extrapyramidal symptoms; PK; pharmacokinetic; PD; pharmacodynamic; EM; extensive metabolizer; IM; intermediate metabolizer; PM; poor metabolizer; PBPKPD; physiology-based pharmacokinetic and pharmacodynamic; P-gp; P-glycoprote

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

BCRP/ABCG2 and high-alert medications: Biochemical, pharmacokinetic, pharmacogenetic, and clinical implications

Keywords: ABC; ATP-binding cassette; AUC; area under the time-concentration curve; BCRP; breast cancer resistance protein; Cmax; maximum concentration; CYP; cytochrome P450; DOAC; direct oral anti-coagulant; GI; gastrointestinal; MRP1; multidrug resistance protei

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA)

Keywords: Antibiotic resistance; MRSA; VRSA; Multi-drug resistance; C. elegans; Caco-2; heterogeneous human epithelial colorectal adenocarcinoma cells; CFUs; colony forming units; HaCaT; human keratinocytes; Papp; apparent permeability; VISA; vancomycin-intermedia

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine

Keywords: Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site

Keywords: Tubulin inhibitor; Colchicine binding site; Combretastatin A-4; Pyrazole analogue; Anti-tumour; Co-crystal structure; ABC; ATP-binding cassette; P-gp; P-glycoprotein; MRP; multidrug resistant proteins; CA-4; combretastatin A-4; SARs; structure-activity re

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

Role of the efflux transporters BCRP and MRP1 in human placental bio-disposition of pravastatin

Keywords: ALP; alkaline phosphatase; AMP; adenosine monophosphate; ATP; adenosine triphosphate; BCRP; breast cancer resistance protein; ABCG2; ATP-binding cassette sub-family G member 2; DHA; dihydroalprenolol; IOVs; inside-out vesicles; MRPs; multidrug resistance-

دانلود رایگان متن کامل مقاله ISI 67 صفحه سال انتشار : 2018 سفارش ترجمه

Imaging techniques to study drug transporter function in vivo

Keywords: ABC; ATP-binding cassette; AD; Alzheimer's disease; ADME; absorption, distribution, metabolism and elimination; ATP; adenosine triphosphate; AUC; area under the curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BPND; non-displaceabl

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2018 سفارش ترجمه

Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption

Keywords: Biorelevant dissolution; Weak base; PBPK modeling; BCS class II; pH dependent solubility; ACAT; advanced compartmental absorption and transit model; ADAM; advanced dissolution, absorption and metabolism model; API; active pharmaceutical ingredient; ASD;

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2018 سفارش ترجمه

Clinical benefits and pharmacology of scutellarin: A comprehensive review

Keywords: Aβ; β-amyloid peptide; ACE; angiotensin-converting enzyme; AD; Alzheimer's disease; ADE; adverse drug effect; ADR; adverse drug reaction; AIF; apoptosis-inducing factor; Akt; protein kinase B or PKB; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activat

دانلود رایگان متن کامل مقاله ISI 116 صفحه سال انتشار : 2018 سفارش ترجمه

Attachment of a 'molecular spring' restores drug-stimulated ATPase activity to P-glycoprotein lacking both Q loop glutamines

Keywords: P-glycoprotein; ABC protein; Disulfide cross-linking; Molecular spring; Drug-stimulated ATPase activity; ABC; ATP-binding cassette; P-gp; P-glycoprotein; NBD; nucleotide-binding domain; HEK; human embryonic kidney; TM; transmembrane; TMD; transmembrane do

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Benzophenones and xanthone derivatives from Garcinia schomburgkiana-induced P-glycoprotein overexpression in human colorectal Caco-2 cells via oxidative stress-mediated mechanisms

Keywords: Guttiferone K; Oblongifolin C; Isojacaruebin; P-gp; Oxidative stress; MAPKs; AP-1; activator protein 1; DCFH-DA; 2′, 7′-dichlorofluorescin diacetate; GK; guttiferone K; ISO; isojacaruebin; MAPKs; mitogen-activated protein kinases; MDR; multidrug resis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewRole of Vitamin D in Amyloid clearance via LRP-1 upregulation in Alzheimer's disease: A potential therapeutic target?

Keywords: Aβ; Amyloid beta; AD; Alzheimer's disease; BBB; Blood-brain barrier; bEnd3; Brain Endothelial 3; 1,25-(OH)2D3; Calcitriol; CNS; Central nervous system; 25-(OH) D3; 25-hydroxyvitamin D3; LRP-1; Low density lipoprotein receptor related protein; P-gp; P-g

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

A short cross-linker activates human P-glycoprotein missing a catalytic carboxylate

Keywords: 1, 10-Phenanthroline (PubChemSID: 24278); Cyclosporine A (PubChemCID: 5284373); Verapamil hydrochloride (PubChemCID: 62969); Vinblastine (PubChemCID: 241903); n-dodecyl-β-D-maltoside (PubChemCID: 114880); ABC; ATP-binding cassette; P-gp; P-glycoprotein;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Exceptionally high UBE2C expression is a unique phenomenon in basal-like type breast cancer and is regulated by BRCA1

Keywords: UBE2C; ubiquitin-conjugating enzyme 2C; BBC; basal-like breast cancer; HR; hazard ratio; P-gp; P-glycoprotein; MRP1; multidrug resistance protein 1; BCRP; breast cancer resistance protein; SD; standard deviation; Breast cancer; UBE2C; BRCA1; Doxorubicin;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

NSCA-1-a novel N-substituted coumalamide derivative-increases Adriamycin sensitivity in HepG2/adriamycin cells through modulating Akt/GSK-3β signaling and p53-dependant apoptotic pathway

Keywords: HepG2/ADR; HepG2 cells with Adriamycin resistance; DOX; doxorubicin (also called Adriamycin); ADR; Adriamycin (also called Doxorubicin); NSCA-1; N-(3-((3 4-dimethoxybenzyl)oxy)phenyl)-2-oxo-2H-pyran-5-carboxamide; MDR; multidrug resistance; p-gp; P-glycop

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

The transepithelial transport mechanism of polybrominated diphenyl ethers in human intestine determined using a Caco-2 cell monolayer

Keywords: ABC transporters; ATP-binding cassette transporters; AP; apical; BCRP; breast cancer resistance protein; BL; basolateral; DMSO; dimethyl sulphoxide; EDTA; ethylenediamine tetraacetic acid; GC/MS; gas chromatography/mass spectrometry; MEM; minimum essentia

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Mdr1a plays a crucial role in regulating the analgesic effect and toxicity of aconitine by altering its pharmacokinetic characteristics

Keywords: AC; aconitine; AUC; area under concentration-time curve; cTnI; cardia troppnin I; CL; clearance; CK; creatine kinase; LD50; 5% half-lethal dose; LD50; half-lethal dose; NSE; neurone specific enolase; P-gp; P-glycoprotein; S100-β; neuron-enriched S100 bet

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

P-Glycoprotein in skin contributes to transdermal absorption of topical corticosteroids

Keywords: P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; SC; stratum corneum; ABC; ATP-binding cassette; MDR1; multidrug resistance 1; MDCK II; Madin-Darby canine kidney II; BL; basal; AP; apical; ER; efflux ratio; Papp; apparent permeability coeffic

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein

Keywords: Cucurbitacin E; CYP3A; P-glycoprotein; Hepatotoxicity; Drug-drug interactions; CuE; cucurbitacin E; P-gp; p-glycoprotein; Cmax; the maximum serum concentration; AUC; area under the concentration-time curve; CL; clearance; Vd; volume of distribution; t1/2;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception

Keywords: Pharmacokinetics; Inflammation; Nociception; Safety pharmacology; IS01957; Para-coumaric acid derivative; p-CA; Para coumaric acid; ADME; Absorption, distribution, metabolism and excretion; CH; Chlorpromazine hydrochloride; PS; Pentobarbital sodium; PBS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Anticancer activity of baicalein and luteolin studied in colorectal adenocarcinoma LoVo cells and in drug-resistant LoVo/Dx cells

Keywords: MDR; multidrug resistance; SRB; sulforhodamine B; siRNA; short interfering RNA; RNAi; RNA interference; Mdr1; multidrug resistance protein 1; P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; MRP1; multidrug resistance associated protein 1; β

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine

Keywords: ABC; ATP-binding cassette; AUC; area under the concentration-time curve; BBB; the blood-brain barrier; BPB; the blood-placental barrier; P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; ABCB1; the first member of subfamily B of the ABC transp

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Hypericum perforatum (St John's wort) beyond depression: A therapeutic perspective for pain conditions

Keywords: CREB; cyclic AMP response element binding protein; CYP; cytochrome P450; EMA; European Medicines Agency; HMPC; Herbal Medicinal Product Committee; iNOS; inducible nitric-oxide synthase; NO; nitric oxide; NF-kB; nuclear factor-kB; P-gp; P-glycoprotein; PKC

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and transport efficiency

Keywords: P-gp; P-glycoprotein; ABC; ATP-binding cassette; MDR; multidrug resistance; NBD; nucleotide-binding domain; TMD; transmembrane domain; IAAP; [125I]iodoarylazidoprazosin; TMRC; tetramethylrosamine chloride; DMEM; Dulbecco's modified Eagle's medium; FBS

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy

Keywords: MDR reversers; P-gp modulators; N-alkanol-N-cyclohexanol amine aryl esters; Chemosensitizers; Doxorubicin-resistant human erythroleukemia K562 cells (K562/DOX); Pirarubicin uptake; P-gp; P-glycoprotein; BCRP; Breast Cancer Resistance Protein; MRP1; Multi

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Intestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings

Keywords: drug interaction; inhibition; transporter; organic anion-transporting polypeptide transporters; intestinal absorption; polymorphism; AUC; area under the plasma concentration-time curve; DDIs; drug-drug interactions; EMA; European Medicines Agency; FDA

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

On the mechanism of substrate/non-substrate recognition by P-glycoprotein

Keywords: P-glycoprotein; P-gp; MDR1; ABCB1; Docking; Substrates;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment

Keywords: α-SMA; α-smooth muscle actin; AMPK; AMP-activated protein kinase; bHLH; basic Helix-Loop-Helix; DHA; docosahexaenoic acid (22:6n-3); Drp1; dynamin-related protein 1; ECM; extracellular matrix; EMT; epithelial-to-mesenchymal transition; EPA; eicosapentae

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Thiol-reactive drug substrates of human P-glycoprotein label the same sites to activate ATPase activity in membranes or dodecyl maltoside detergent micelles

Keywords: P-glycoprotein drug-binding sites; ABC protein; n-Dodecyl-β-D-maltoside detergent; Tariquidar; Thiol reactive verapamil and rhodamine; ABC; ATP-binding cassette; DM; n-dodecyl-β-D-maltoside; P-gp; P-glycoprotein; NBD; nucleotide-binding domain; HEK; hum

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Circadian Clock Is Involved in Regulation of Hepatobiliary Transport Mediated by Multidrug Resistance-Associated Protein 2

Keywords: ABC transporters; P-glycoprotein; multidrug resistance-associated proteins; pharmacokinetics; biliary excretion; ABC; ATP-binding cassette; Bcrp; breast cancer resistance protein; BMAL1; brain and muscle arnt-like protein-1; CLOCK; circadian locomotor out

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein

Keywords: Virtual screening; Docking; Tubulin; P-gp;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo

Keywords: 3OH-Qi; 3-hydroxy-quinidine; ADME-Tox; absorption, distribution, metabolism, excretion and toxicity; CP100356; N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine; CYP; cytochrome P450; DDI(s); drug

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug/multixenobiotic resistance (MDR/MXR) functional activity in the model teleost, Danio rerio (zebrafish)

Keywords: ABC; ATP-binding cassette; CYP; cytochrome P450; KTC; ketoconazole; MDR/MXR; multidrug/multixenobiotic resistance; P-gp; P-glycoprotein; PCN; pregnenolone 16α-carbonitrile; PXR; pregnane X-receptor; ARmax; maximum accumulation rate; Cmax; maximum concent

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban

Keywords: drug interactions; solute transporters; organic anion transporters (OAT); pharmacokinetics/pharmacodynamics; renal transport; BCRP; breast cancer resistance protein; CCK8; cholecystokinin-8; E217βG; estradiol 17β-D-glucuronide; E-sul; estrone 3-sulfate;

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2017 سفارش ترجمه

Structure−activity relationship study of novel 2-aminobenzofuran derivatives as P-glycoprotein inhibitors

Keywords: 2-Aminobenzofuran; Multidrug resistance; MDR; P-glycoprotein; P-gp; ABCB1; VVDIVTCFGFHMCM-UHFFFAOYSA-N; YISKRIBGSLFCKI-UHFFFAOYSA-N; JGWRKYGEHKPWNP-UHFFFAOYSA-N; XEHLQJGGWBPGQJ-UHFFFAOYSA-N; KXEXTQDMUJUNPJ-UHFFFAOYSA-N; LJOIMSPNCSVKOQ-UHFFFAOYSA-N; LRKBQV

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2017 سفارش ترجمه

Trimethyl chitosan based conjugates for oral and intravenous delivery of paclitaxel

Keywords: 2′SPTX; 2′-O-succinyl-paclitaxel; AUC; area under the concentrationtime curve; BSA; bovine serum albumin; CMC; critical micelle concentration; DMEM; Dulbecco's Modified Eagle Medium; DMSO; dimethyl sulfoxide; DSC; differential scanning calorimetry;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه

Coloaded Nanoparticles of Paclitaxel and Piperlongumine for Enhancing Synergistic Antitumor Activities and Reducing Toxicity

Keywords: paclitaxel; piperlongumine; nanoparticles; synergistic effect; 5-FU; 5-fluorouracil; C6; Coumarin-6; Cmax; maximum concentration; CD31; cluster of differentiation 31; CI; combination index; CLSM; confocal laser scanning microscopy; DL; drug loading; DMEM;

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2017 سفارش ترجمه

Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models

Keywords: cytochrome P450; drug interaction; hepatic clearance; mathematical model; organic anion-transporting polypeptide transporters; pharmacokinetics; AUC; area under the plasma concentration-time curve; CL; clearance; CLint,all; overall hepatic intrinsic cle

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites

Keywords: ABC transporters; transporters; skin; P-glycoprotein; tissue partition; ABCB1; ATP binding cassette subfamily B member 1; ABCG2; ATP binding cassette subfamily G member 2; BCRP; breast cancer resistance protein; CRC; colorectal cancer; CYP3A4; cytochrome

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه