کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5553142 | 1557954 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anticancer activity of baicalein and luteolin studied in colorectal adenocarcinoma LoVo cells and in drug-resistant LoVo/Dx cells
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کلمات کلیدی
MDRSRBBcrpMDR1P-gpMRP1P-glycoprotein - P-گلیکوپروتئینRNA interference - RNA تداخل کنندهshort interfering RNA - RNA تداخل کوتاهRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهsiRNA - siRNAsulforhodamine B - سولفوردامین بMultidrug resistance - مقاومت چند داروییbreast cancer resistance protein - پروتئین مقاومت به سرطان سینهmultidrug resistance protein 1 - پروتئین مقاومتی چند دارویی 1
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Anticancer activity of baicalein and luteolin studied in colorectal adenocarcinoma LoVo cells and in drug-resistant LoVo/Dx cells Anticancer activity of baicalein and luteolin studied in colorectal adenocarcinoma LoVo cells and in drug-resistant LoVo/Dx cells](/preview/png/5553142.png)
چکیده انگلیسی
In these studies anticancer activity of natural occurring flavones, baicalein and luteolin was investigated in colon cancer cells LoVo and in their drug resistant subline LoVo/Dx. Inhibitory activity of these flavones on cells growth and their ability to induce apoptosis were observed. A less pronounced influence of studied flavones on proliferation and apoptosis of LoVo/Dx as compared with LoVo cells well correlated with significantly lower cytotoxicity of these compounds in drug-resistant cells. These effects may be related to overexpression of multidrug transporter P-glycoprotein in drug-resistant LoVo/Dx cells. Our studies indicated that baicalein could be a substrate of this drug transporter.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 88, April 2017, Pages 232-241
Journal: Biomedicine & Pharmacotherapy - Volume 88, April 2017, Pages 232-241
نویسندگان
Anna Palko-Labuz, Kamila Sroda-Pomianek, Anna Uryga, Edyta Kostrzewa-Suslow, Krystyna Michalak,