دانلود مقالات ISI درباره P-Gp + ترجمه فارسی

Determinants of Intestinal Availability for P-glycoprotein Substrate Drugs Estimated by Extensive Simulation With Mathematical Absorption Models

Keywords: drug-drug interaction; P-glycoprotein; physiologically based pharmacokinetic model; modeling and simulation; intestinal absorption; substrate drug; CLh; hepatic clearance; CLr; renal clearance; CYP3A; cytochrome P450 3A; DDI; drug-drug interaction; EQ

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2017 سفارش ترجمه

Halogenated naphthochalcones and structurally related naphthopyrazolines with antitumor activity

Keywords: ABC; adenosine triphosphate binding cassette; BCRP; breast cancer resistance protein; FTC; fumitremorgin C; MDR; multidrug resistance; P-gp; P-glycoptotein; SD; standard deviation; TdT; Terminal deoxyribonucleotide Transferase; Topo; topotecan; TUNEL; Ter

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Adenovirus vector infection of non-small-cell lung cancer cells is a trigger for multi-drug resistance mediated by P-glycoprotein

Keywords: P-glycoprotein; P-gp; Adenovirus; NSCLC; Multi-drug resistance; Doxorubicin;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

P-glycoprotein ATPase activity requires lipids to activate a switch at the first transmission interface

Keywords: P-glycoprotein; ABC protein; Disulfide cross-linking; Switch; Transmission interface; ATPase activity; ABC; ATP-binding cassette; P-gp; P-glycoprotein; NBD; nucleotide-binding domain; HEK; human embryonic kidney; TM; transmembrane; TMD; transmembrane doma

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

MiR-106a: Promising biomarker for cancer

Keywords: MiRNAs; micro RNAs; FASTK; Fas-activated serine/threonine kinase; MAPK; mitogen-activated protein kinase; NSCLC; non-small cell lung cancer; P-gp; P-glyco-protein; MDR; multidrug resistance; ABCA1; adenosine triphosphatase-binding cassette A1; TIMP2; tiss

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Optimization of amide-based EP3 receptor antagonists

Keywords: EP3 receptor; PGE2; GPCR; LipE; Metabolites; P-gp; Indazole;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Sinapine reverses multi-drug resistance in MCF-7/dox cancer cells by downregulating FGFR4/FRS2α-ERK1/2 pathway-mediated NF-κB activation

Keywords: Sinapine; Doxorubicin; MCF-7/dox; P-glycoprotein; NF-κB; FGFR4; FGFR; fibroblast growth factor receptor; FRS2α; FGFR substrate protein-2α; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Suitability of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine hair dyes

Keywords: AEP; 2-amino-5-ethylphenol; CEN; 2-chloro-6-ethylamino-4-nitrophenol; HAP; 4-hydroxypropylamino-3-nitrophenol; APB; HC Blue 16; HCR; HC Red no 13; HCY; HC Yellow no 13; HDAP; 1-hydroxyethyl-4,5-diamino pyrazole; ACP; 2-amino-6-chloro-4-nitrophenol; AHT; 4

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

18F-FCWAY, a serotonin 1A receptor radioligand, is a substrate for efflux transport at the human blood-brain barrier

Keywords: PET; Efflux transporter; P-gp; Blood brain barrier; 5-HT1A;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering

Keywords: Bioavailability; Caco2; P-gp; Efflux; Hydrogen bond acceptor;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

β-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function

Keywords: Multidrug resistant cancer; β-carotene; P-gp; Reversal effects; MDR; multidrug resistance; ABC; ATP-binding cassette; P-gp; P-glycoprotein; MRP1; multidrug resistance protein 1; BCRP; breast cancer resistance protein;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate

Keywords: Res; resveratrol; MTX; methotrexate; P-gp; P-glycoprotein; MRP2; multidrug resistance-associated protein 2; MDR1; multidrug resistance 1; OATs; organic anion transporters; DDIs; drug-drug interactions; Papp; apparent permeability coefficients; ER; Efflux

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

PXR variants: the impact on drug metabolism and therapeutic responses

Keywords: AF; activating function; BAMCA; bacterial artificial chromosome array-based methylated CpG island amplification; CYP; cytochrome P450; GST; glutathione S-transferase; MDR; multidrug resistance protein; NHR; nuclear hormone receptor; P-gp; P-glycoprotein

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Aromatic heterocyclic esters of podophyllotoxin exert anti-MDR activity in human leukemia K562/ADR cells via ROS/MAPK signaling pathways

Keywords: Podophyllotoxin; Anti-MDR activity; ROS/MAPK pathways; Cell cycle; Apoptosis; P-gp;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Polysorbate 20 increases oral absorption of digoxin in wild-type Sprague Dawley rats, but not in mdr1a(-/-) Sprague Dawley rats

Keywords: Digoxin; P-gp; Polysorbate; mdr1a(-/-) Sprague Dawley rats; MDCKII-MDR1 cells; Caco-2 cells

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Designing the angiogenic inhibitor for brain tumor via disruption of VEGF and IL17A expression

Keywords: Glioblastoma; Blood-brain-barrier; IL17A; VEGF; P-gp;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

PLGA-based nanoparticles: A new paradigm in biomedical applications

Keywords: Biodegradable; Poly(lactic-co-glycolic acid); Nanoparticles; Targeting; Sustained release; DCC; N,N-Dicyclohexylcarbodiimide; DDS; Drug delivery system; DNA; Deoxyribose nucleic acid; EDC; 1-ethyl-3-(3-dimethylaminopropyl carbodiimide); EGFR; Epidermal gr

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

Interactions of human P-glycoprotein transport substrates and inhibitors at the drug binding domain: Functional and molecular docking analyses

Keywords: CSA; cyclosporin A; DBD; drug-binding domain; DMD; defined molecular docking; EPI; epirubicin; LBE; lowest binding energy; MDA; molecular docking analysis; MDR; multidrug resistance; MFI; mean fluorescence intensity; P-gp; P-glycoprotein; R123; rhodamine

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

Effects of P-glycoprotein on the intestine and blood-brain barrier transport of YZG-331, a promising sedative-hypnotic compound

Keywords: YZG-331; Intestine; Brain; P-gp; ATPase;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2016 سفارش ترجمه

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

Keywords: Glioblastoma; Apoptosis resistance; Multidrug resistance; Translation inhibition; Lycorine; Haemanthamine; ATCC; American Type Culture Collection; DAPI; 4′,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; DMF; dimethylformamide; DMS

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2016 سفارش ترجمه

SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy

Keywords: ACUC; Animal Care and Use Committee; AGP; andrographolide; CDK; cyclin dependent kinase; DMSO; dimethyl sulfoxide; DOX; doxorubicin; ERK1/2; extracellular signal-regulated kinases 1/2; FBS; fetal bovine serum; HPLC; high performance liquid chromatography;

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2016 سفارش ترجمه

Phenyltetrazolyl-phenylamides: Substituent impact on modulation capability and selectivity toward the efflux protein ABCG2 and investigation of interaction with the transporter

Keywords: ABC-transporter; ABCG2; BCRP inhibitor; Synthesis; Structure-activity relationship; Enzyme kinetics; ABC; ATP-binding cassette; BCRP; breast cancer resistance protein (ABCG2); CsA; cyclosporine A; FTC; fumitremorgin C; Imax; maximal inhibition; i-Pr; isop

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2016 سفارش ترجمه

Ligand-based modeling of diverse aryalkylamines yields new potent P-glycoprotein inhibitors

Keywords: P-glycoprotein; Doxorubicin-resistant cells; Pharmacophore; QSAR; Virtual screening; GFA; genetic function algorithm; Hbic; hydrophobic; kNN; k nearest neighbor; MLR; multiple linear regression; P-gp; P-glycoprotein; NCI; National Cancer Institute; ROC; r

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2016 سفارش ترجمه

Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance

Keywords: ABCs; ATP-binding cassette superfamily; AUC; area under the curve; BBB; blood brain barrier; BCRP; breast cancer resistance protein; CMC; critical micellar concentration; CT; computed tomography; CUR; curcumin; DOX; doxorubicin; DSPE-PEG; 1,2-distearoyl-s

دانلود رایگان متن کامل مقاله ISI 73 صفحه سال انتشار : 2016 سفارش ترجمه

Polycations and their biomedical applications

Keywords: Ac-aCD; acetalated cyclodextrin; ASC; adipose-derived stromal cell; αSMA; α-smooth muscle actin; BMA; butyl methacylate; BMP; bone morphogenetic protein; BSA; bovine serum albumin; CDP; cyclodextrin-containing polymer; CPLA; cationic polylactide; cRGD;

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2016 سفارش ترجمه

Aristolochic acid I is a substrate of BCRP but not P-glycoprotein or MRP2

Keywords: AA; Aristolochic acid; AAI; Aristolochic acid I; AAN; Aristolochic acid nephropathy; BCRP; Breast cancer resistance protein; DMEM; Dulbecco's Modification of Eagle's Medium; FBS; Fetal bovine serum; HBSS; Hank's balanced salt solution; MRP2; Multidr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Pharmacokinetic synergy from the taxane extract of Taxus chinensis improves the bioavailability of paclitaxel

Keywords: Taxus chinensis var. mairei; Paclitaxel; Bioavailability; Pharmacokinetic synergy; Tissue distribution; Cytotoxicity; PTX; paclitaxel; P-gp; P-glycoprotein; CYP; cytochrome P450; MRP2; multidrug resistance protein 2; Cmax; peak plasma concentration; Tmax;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Reversal of P-glycoprotein-mediated multidrug resistance in MCF-7/Adr cancer cells by sesquiterpene coumarins

Keywords: Antiproliferation; Cancer; Multidrug resistance; P-gp; Sesquiterpene coumarins

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Multixenobiotic resistance efflux activity in Daphnia magna and Lumbriculus variegatus

Keywords: ABC protein; ATP-binding cassette transfer protein; Ca-AM; calcein-AM; MDR; multidrug resistance protein; MRP; multidrug resistance related protein; MXR; multixenobiotic resistance (protein); NBD; nucleotide binding domain; P-gp; permeability glycoprotein

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Research paperEffects of herbal drugs in Mahuang decoction and their main components on intestinal transport characteristics of Ephedra alkaloids evaluated by a Caco-2 cell monolayer model

Keywords: TCM; traditional Chinese medicine; MHP; multi-herb prescription; LEP; l-ephedrine; DPEP; d-pseudoephedrine; LMEP; l-methylephedrine; P-gp; P-glycoprotein; ER; efflux ratio; AP; apical; BL; basolateral; Papp; apparent permeability; PAB; permeability from A

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

High-performance thin-layer chromatography for the evaluation of voacamine intracellular concentration related to its cytotoxic effect

Keywords: VOA; voacamine; P-gp; P-glycoprotein; IMDM; Iscove's Modified Dulbecco's Medium; FBS; fetal bovine serum; Multidrug resistant tumor cells; Cytotoxicity; Voacamine; High-performance thin-layer chromatography; HPTLC-densitometry;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Cargoing P-gp inhibitors via nanoparticle sensitizes tumor cells against doxorubicin

Keywords: Cancer; P-gp; Multidrug resistance; Nanoparticle; Inhibitor

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Evaluation of dual P-gp-BCRP inhibitors as nanoparticle formulation

Keywords: Cancer; MDR; P-gp; BCRP; Nanoparticle

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of nifedipine in rats: Possible role of P-gp and CYP3A4 inhibition by HMG-CoA reductase inhibitors

Keywords: Nifedipine; HMG-CoA reductase inhibitors; Pharmacokinetics; P-gp; CYP3A4

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

P-glycoprotein inhibition by the agricultural pesticide propiconazole and its hydroxylated metabolites: Implications for pesticide-drug interactions

Keywords: ABC; ATP-binding cassette; ER; endoplasmic reticulum; U.S. FDA; U.S. Food and Drug Administration; NMQ; N-methyl quinidine; P-gp; P-glycoprotein; P-gp; MDR1; Conazoles; Propiconazole; Chemosensitization; ABC transporters;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo

Keywords: P-gp; P-glycoprotein; PCIS; Precision-Cut Intestinal Slices; R123; Rhodamine 123; DDI(s); drug-drug interaction(s); IC50; half maximal inhibitory concentration; ABC; ATP-binding cassette; CYP; cytochrome P450; CP100356; 4-(3,4-dihydro-6,7-dimethoxy-2(1H

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Medicarpin and millepurpan, two flavonoids isolated from Medicago sativa, induce apoptosis and overcome multidrug resistance in leukemia P388 cells

Keywords: Multidrug resistance; Apoptosis; Medicarpin; Millepurpan; Alfalfa; Flavonoids; DOX; doxorubicin; MED; medicarpin; MIL; millepurpan; P-gp; P-glycoprotein; VBL; vinblastine; VPL; verapamil.;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Revealing the fate of cell surface human P-glycoprotein (ABCB1): The lysosomal degradation pathway

Keywords: ABC; ATP-binding cassette; P-gp; P-glycoprotein; FITC; fluorescein isothiocianate; BafA1; bafilomycin A1; MG132; carbobenzoxy-l-leucyl-l-leucyl-l-leucinal; MG115; carbobenzoxy-l-leucyl-l-leucyl-l-norvalinal; PSI; proteasome inhibitor I; Rh123; rhodamine12

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia-Impact on enzyme activity and response to cytotoxics

Keywords: DMT; N-desmethyltamoxifen; AC; acid ceramidase; AML; acute myelogenous leukemia; SphK1; sphingosine kinase 1; S1-P; sphingosine 1-phosphate; GC; glucosylceramide; 4-HPR; fenretinide; GCS; glucosylceramide synthase; P-gp; P-glycoprotein; ATCC; American Typ

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Selective targeting of FAK–Pyk2 axis by alpha-naphthoflavone abrogates doxorubicin resistance in breast cancer cells

Keywords: α-Naphthoflavone; Doxorubicin; Chemotherapeutic resistance; Breast cancer; Focal adhesion kinaseANF, alpha-naphthoflavone; BCa, breast cancer; CI, combination index; Cy, cyanine; DMSO, dimethyl sulfoxide; Dox, doxorubicin; FAK, focal adhesion kinase; P-gp

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Hispidulin inhibits proliferation and enhances chemosensitivity of gallbladder cancer cells by targeting HIF-1α

Keywords: Gallbladder cancer; Hispidulin; HIF-1α; P-gp; Chemosensitivity;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Acute myeloid leukemia cells MOLM-13 and SKM-1 established for resistance by azacytidine are crossresistant to P-glycoprotein substrates

Keywords: AML; acute myeloid leukemia; AzaC; Azacytidine; CDNB; 1-chloro-2,4-dinitrobenzene; CisPt; cisplatin; Dox; doxorubicin; GST; glutathione S-transferase; MDR; multidrug resistance; MDS; myelodysplastic syndrome; MOLM-13; AML cell line derived from the periph

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Epothilone B induces human ovarian cancer OV-90 cell apoptosis via external pathway

Keywords: EpoB; Epothilone B; PTX; paclitaxel; PARP; poly(ADP-ribose) polymerase; P-gp; glycoprotein P; TRAIL; TNF-related apoptosis-inducing ligand; TUNEL; TdT-mediated dUTP Nick-End Labeling assay; Apoptosis; Epothilone B; Paclitaxel; PARP; TUNEL; TRAIL;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Memory recuperative potential of rifampicin in aluminum chloride-induced dementia: Role of pregnane X receptors

Keywords: Aβ; amyloid beta; AChE; acetylcholinesterase; AlCl3; aluminum chloride; BBB; blood-brain barrier; DMSO; dimethyl sulfoxide; ELT; escape latency time; GSH; glutathione; H&E; hematoxylin and eosin; MPO; myeloperoxidase; MWM; Morris water maze; P-gp; P-gl

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells

Keywords: Glioblastoma; MDR1; P-gp; Temozolomide; Chemoresistance;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2015 سفارش ترجمه

Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2)

Keywords: ABC; ATP-binding cassette; ALK; anaplastic lymphoma kinase; AUC; area under the plasma concentration-time curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; Cmax; maximum drug concentration in plasma; EML4; echinoderm microtubule-ass

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2015 سفارش ترجمه

Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells

Keywords: EGFR; Epidermal growth factor receptor; HER2; Human epidermal growth factor receptor 2; MES; 2-(N-morpholino)ethanesulfonic acid; PBS; Phosphate buffered saline; EDC; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; Sulfo-NHS; Sulfo-N-hydroxysuccinimide; NF

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2015 سفارش ترجمه

Current knowledge and pharmacological profile of berberine: An update

Keywords: 5-HT; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; AChE; acetylcholinesterase; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; BBB; blood brain barrier; BChE; butyrylcholinestesrase; CD; cluster of differentiation; Cdk; cyclin-dependent ki

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular mechanisms of rosmarinic acid from Salvia miltiorrhiza in acute lymphoblastic leukemia cells

Keywords: (ALL); acute lymphoblastic leukemia; MDR; multidrug resistance; ABC; ATP binding cassette; P-gp; P-glycoprotein; ROS; reactive oxygen species; H2DCF-DA; 2′,7′-dichlorofluorescin diacetate; DCF; 2′,7′-dichlorofluorescein; PARP; poly (ADP-ribose) po

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice

Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid-β precursor protein; BBB; blood-brain barrier; BCI; brain clearance index; CAA; cerebral amyloid angiopathy; DEA; diethylamine; EVOO; extra-virgin olive oil; FA; formic acid; IDE; insulin degradi

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2015 سفارش ترجمه