کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10435859 911017 2016 73 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance
چکیده انگلیسی
Multidrug resistance in tumor involves multiple mechanisms, which mainly includes lowered extracellular pH, hypoxic region, and irregular vasculature in physiological level, and the alteration of apoptotic machineries, over-expression of efflux transporters, and enhanced repair mechanism of drug induced DNA damage in cellular level. With the increasing role of tumor microenvironment in multidrug resistance, cell proliferation and metastasis, this review will focus on the characteristics of tumor microenvironment and their targeting mechanisms with PEG-based amphiphilic nanoparticles to overcome chemoresistance.285
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 12, Issue 2, February 2016, Pages 269-286
نویسندگان
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