دانلود مقالات ISI درباره P-Gp + ترجمه فارسی

Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest

Keywords: MCF7/ADR, Adriamycin resistant human breast cancer cell line; MDR, multidrug resistance; Chk2, checkpoint kinase 2; NF-κB, nuclear factor-kappa B; PMSF, phenylmethylsulfonyl fluorideOroxylin A; MCF7/ADR; G2/M; P-gp; Chk2

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Twelve-Month Frequency of Drug-Metabolizing Enzyme and Transporter-Based Drug-Drug Interaction Potential in Patients Receiving Oral Enzyme-Targeted Kinase Inhibitor Antineoplastic Agents

Keywords: CYP; cytochrome; DDI; drug-drug interaction; FDA; Food and Drug Administration; HICL; Hierarchical Ingredient Code List; OAD; enzyme-targeted kinase inhibitor oral antineoplastic drug; p-gp; P-glycoprotein;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2

Keywords: Flavonoids; Benzoflavones; Breast cancer resistance protein (BCRP); P-gp; MRP1; Multidrug resistance (MDR)

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

The New Oral Anticoagulants in Clinical Practice

Keywords: AF; atrial fibrillation; AMPLIFY-EXT; Apixaban after the Initial Management of Pulmonary Embolism and Deep Vein Thrombosis with First-Line Therapy-Extended Treatment; aPTT; activated partial thromboplastin time; ARISTOTLE; Apixaban for Reduction in Stro

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

Intestinal drug transporters: An overview

Keywords: Intestinal drug transport; Transporter–enzyme interplay; P-gp; MRP; BCRP; PEPT; OCT; OCTN; OATP; MCT; BDDCS

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

Lipopolysaccharide-activated microglia lower P-glycoprotein function in brain microvascular endothelial cells

Keywords: BBB; blood-brain barrier; DPI; diphenyleneiodoniumchloride; LPS; lipopolysaccharide; NO; nitric oxide; P-gp; P-glycoprotein; RBEC; rat brain endothelial cell; ROS; reactive oxygen species; Blood-brain barrier; Microglia; P-glycoprotein; NADPH oxidase;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of Zuccagnia punctata extracts and their flavonoids on the function and expression of ABCB1/P-glycoprotein multidrug transporter

Keywords: CsA; cyclosporine A; DHC; 2′,4′-dihydroxychalcone; DHF; 3,7-dihydroxyflavone; DMSO; dimethylsulfoxide; HF; 7-hydroxyflavanone; HK-2; human proximal tubule cell line; P-gp; P-glycoprotein; R-123; Rhodamine-123; SQRT-PCR; Semiquantitative RT-PCR; VP; ve

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Determination of the enantioselectivity of six chiral aryloxy aminopropanol drugs transport across Caco-2 cell monolayers

Keywords: Chiral aryloxy aminopropanol drugs; Transport; Enantioselectivity; P-gp; Caco-2 cell

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

The absorption characterization effects and mechanism of Radix Angelicae dahuricae extracts on baicalin in Radix Scutellariae using in vivo and in vitro absorption models

Keywords: TCM; traditional Chinese medicine; Angelicae dahurica; Angelicae dahurica(Hoffm.)Benth.&Hook.f.ex Franch.&Sav.; Scutellaria; Scutellaria baicalensis Georgi.; Cou; coumarins; VO; volatile oil; P-gp; P-glycoprotein; SFE; supercritical fluid extraction; GC;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

The role of the intrinsic FAS pathway in Titanocene Y apoptosis: The mechanism of overcoming multiple drug resistance in malignant leukemia cells

Keywords: Multidrug resistance; Apoptosis; Titanocene; FADD; P-gp; ALL relapse;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Inductive modulation on P-glycoprotein and cytochrome 3A by resveratrol, a constituent of grapes

Keywords: CsA; cyclosporine; P-gp; P-glycoprotein; CYP3A4; cytochrome P450 3A4; RDS; resveratrol dietary supplement; HPLC; high-performance liquid chromatography; Cmax; the peak blood concentration; AUC0-t; the areas under the curves from time zero to last; MRT;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Salinomycin sensitizes antimitotic drugs-treated cancer cells by increasing apoptosis via the prevention of G2 arrest

Keywords: Sal; salinomycin; PAC; paclitaxcel; DOC; docetaxcel; VIN; vinblastine; COL; colchicine; DOX; doxorubicin; ETO; etoposide; SP; SP600125; P-gp; p-glycoprotein; DMSO; dimethylsulfoxide; FACS; fluorescence-activated cell sorting; FBS; fetal bovine serum; TCA;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Blonanserin, a novel atypical antipsychotic agent not actively transported as substrate by P-glycoprotein

Keywords: AUC0-6 h; Area under the plasma concentration time curve from 0 to 6 h; B/P; Brain/Plasma; BSA; Bovine serum albumin; Cmax; Maximum drug concentration; CNS; Central nervous system; DDI; Drug-drug interaction; EPS; Extrapyramidal symptoms; FBS; Fetal

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

Keywords: Metabolic stability; Human liver microsomes; Human hepatocytes; Intrinsic clearance; Hepatic transporters; Drug discovery; ADME; Absorption, distribution, metabolism, and excretion; AO; Aldehyde oxidase; BCRP; Breast cancer resistance protein; CYP; Cytoch

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Involvement of UDP-glucuronosyltranferases and sulfotransferases in the liver and intestinal first-pass metabolism of seven flavones in C57 mice and humans in vitro

Keywords: 3-HF; 3-hydroxyflavone; 4′-HF; 4′-hydroxyflavone; 5-HF; 5-hydroxyflavone; 7-HF; 7-hydroxyflavone; 3,5-diHF; 3,5-dihydroxyflavone; 3,7-diHF; 3,7-dihydroxyflavone; 3,4′-diHF; 3,4′-dihydroxyflavone; BCRP; breast cancer resistance protein; BSA; bovine

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

In vitro effect of quercetin on human gastric carcinoma: Targeting cancer cells death and MDR

Keywords: CAM; calcein AM assay; MDR; multi-drug resistance; NBDs; nucleotide binding domains; OD; optical density; P-gp; P-glycoprotein; P-line (P-cells); parental cells of human gastric carcinoma line EPG85-257P; RDB-line (RDB-cells); resistant cells of human gas

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance

Keywords: OSI-930; {N-(4-trifluoromethoxyphenyl)3-((quinolin-4-ylmethyl) amino) thiophene-2-carboxamide}; ABC; ATP binding cassette; ABCG2 (BCRP/MXR/ABCP); ABC subfamily G member 2; MDR; multidrug resistance; P-gp; P-glycoprotein; ABCCs (MRPs); ABC subfamily C memb

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells

Keywords: Quercetin; Methylated quercetin derivatives; Multidrug resistance (MDR); P-gp; BCRP; MRP1;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Role for Class I histone deacetylases in multidrug resistance

Keywords: Histone deacetylases; Multidrug resistance; P-gp; Sp1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Glycomic alterations are associated with multidrug resistance in human leukemia

Keywords: MDR; multidrug resistance; ADR; adriamycin; TM; tunicamycin; PBS; phosphate-buffered saline; PBST; PBS containing 0.1% Tween 20; TBS; tris buffered saline; FITC; fluorescein isothiocyanate; MALDI-TOF MS; matrix-assisted laser desorption/ionization time of

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

A brain-vectored angiopep-2 based polymeric micelles for the treatment of intracranial fungal infection

Keywords: Blood-brain barrier; Intracranial infection; Angiopep-2; Amphotericin B; Polymeric micelles; P-gp;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Traditional West African pharmacopeia, plants and derived compounds for cancer therapy

Keywords: CDC2; cell division control protein 2 homolog; CDC25C; M-phase inducer phosphatase 3; DMBA; dimethylbenzen(α)anthracene; DLD1; human colorectal carcinoma; EBV-EA; Epstein-Bar Virus Early Antigen in Raji cell line; GST; glutathione S transferase; GSH; glu

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Devil's Claw-A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens

Keywords: 5-LOX; 5-lipo-oxygenase; 6′-PCHG; 6′-O-p-coumaroylharpagide; 8-PCHG; 8-p-coumaroylharpagide; BCL; Bicuculline; COX-2; cyclooxygenase-2; CREB; cAMP response element-binding; CYP; cytochrome P450; DAD; diode array detection; DPPH; 2, 2-diphenyl-1-picryl

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2012 سفارش ترجمه

[11C]Sorafenib: Radiosynthesis and preliminary PET study of brain uptake in P-gp/Bcrp knockout mice

Keywords: [11C]sorafenib; PET; P-gp; Bcrp, [11C]phosgene

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells

Keywords: MDR1; multi-drug resistance gene 1 or ABCB1; P-gp; P-glycoprotein; ATP; adenosintriphosphate; ECAR; extracellular acidification rate; OCR; oxygen consumption rate; SEM; standard error of the mean; IDES; interdigitated electrode structure; ISFET; ion-sensi

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Arsenic trioxide reduces drug resistance to adriamycin in leukemic K562/A02 cells via multiple mechanisms

Keywords: Arsenic trioxide; K562/A02; GST-π; P-gp; MDR

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor

Keywords: Sf21; Spodoptera frugiperda 21; ABC; ATP binding cassette; P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; MRP1; multidrug resistance protein 1; NBD; nucleotide binding domain; TMD; transmembrane domain; LTC4; leukotriene C4; 8-N3ATP; 8-azid

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products

Keywords: AUC; area under the curve; CYP; cytochrome P450; MDR; multidrug resistance; P-gp; P-glycoprotein; P-glycoprotein; Oleocanthal; Cembratriene; γ-Tocotrienol; Asiatic acid; Intracellular accumulation;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin

Keywords: Moxifloxacin; Ciprofloxacin; Efflux; Mrp4; P-gp; Bcrp

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of simvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, after oral and intravenous administration in rats: possible role of P-glycoprotein and CYP3A4 inhibition by simvastatin

Keywords: diltiazem; desacetyldiltiazem; simvastatin; CYP3A; P-gp; pharmacokinetics; bioavailability; rats

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Are there new therapeutic options for treating lung cancer based on herbal medicines and their metabolites?

Keywords: Herbal medicine; Phytochemical; Lung cancer; Molecular targets; Apoptosis; Angiogenesis; BBSKE; 1,2-[bis (1,2-benzisoselenazolone-3 (2H)-ketone)] ethane; bFGF; basic fibroblast growth factor; CAM; complementary and alternative medicine; COX; cyclooxygenas

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Extraction of tacit knowledge from large ADME data sets via pairwise analysis

Keywords: Pairwise; ADME; Activity cliff; Switch; HLM; Permeability; MDCK; P-gp; MDR1; Lipophilicity; Log D; SAR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Oleanolic acid derivative methyl 3,11-dioxoolean-12-en-28-olate targets multidrug resistance related to ABCB1

Keywords: multidrug resistance; P-gp; oleanolic acid derivatives; acute lymphoblastic leukemia cells; chemotherapy

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2011 سفارش ترجمه

Interaction of angiotensin II type 1 receptor blockers with P-gp substrates in Caco-2 cells and hMDR1-expressing membranes

Keywords: Drug–drug interaction; P-gp; ARB; Intestine; IC50

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

(-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line

Keywords: Breast carcinoma; Tamoxifen; Green tea; MRP1; P-gp; BCRPEGCG, (-)-Epigallocatechin-3-gallate; MCF-7Tam, MCF-7 resistant to tamoxifen; MRP1, Multidrug Resistance Protein 1; P-gp, Glycoprotein P; BCRP, Breast Cancer Resistance Proteins; ERα, Estrogen Recept

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Synergistic influence of Abcb1 and Abcc2 on disposition and sterol lowering effects of ezetimibe in rats

Keywords: ezetimibe; disposition; ABCB1; ABCC2; MRP2; P-gp; transporter; PSC833;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Reciprocal competition between lipid nanocapsules and P-gp for paclitaxel transport across Caco-2 cells

Keywords: Nanoparticle; P-gp; Paclitaxel; Oral absorption; Drug resistance

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Enhanced bioaccumulation of dietary contaminants in catfish with exposure to the waterborne surfactant linear alkylbenzene sulfonate

Keywords: ABC transporters; ATP-binding cassette transporters; BaP; benzo(a)pyrene; BCRP; breast cancer resistance protein; DPH; 1,6-diphenyl - 1, 3, 5 - hexatriene; IVM; ivermectin; LAS; linear alkylbenzene sulfonate, C-12, sodium dodecylbenzene sulfonate; Meq

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

In vivo evaluation of [123I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine, an iodinated SPECT tracer for imaging the P-gp transporter

Keywords: P-gp; SPECT; Brain; [123I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Cyclooxygenase-2 inhibitors prevent trinitrobenzene sulfonic acid-induced P-glycoprotein up-regulation in vitro and in vivo

Keywords: P-gp; MDR1; COX-2-inhibitor; Caco-2; TNBS; Colitis

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Developmental expression of multidrug resistance phosphoglycoprotein (P-gp) in the mouse fetal brain and glucocorticoid regulation

Keywords: Fetal blood–brain barrier; Abcb1; P-gp; Multidrug resistance; [3H]digoxin; Dexamethasone; Neuroprotection

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays

Keywords: Macrolide; MDR1; P-gp; P-glycoprotein; ABCB1; Cellular accumulation; Rhodamine-123 efflux; ATPase activity; MES-SA/Dx5; ABC transporter; Azithromycin; Erythromycin; Clarithromycin; Roxithromycin; Telithromycin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Preservation of transendothelial glucose transporter 1 and P-glycoprotein transporters in a cortical slice culture model of the blood-brain barrier

Keywords: brain vasculature; endothelial cells; P-glycoprotein; glucose transporter 1; cortical organotypic slice cultures; mouse; ABC; ATP-binding cassette; BBB; blood-brain barrier; BS; blocking solution; COSCs; cortical organotypic slice cultures; DIV; day in

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders

Keywords: opioid; spinal cord; multiple sclerosis; astrocyte; allodynia; hyperalgesia; CCI; chronic constriction injury; CSF; cerebrospinal fluid; EAE; experimental autoimmune encephalomyelitis; GFAP; glial fibrillary acidic protein; GLT-1; glutamate transporter (E

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

The role of multixenobiotic transporters in predatory marine molluscs as counter-defense mechanisms against dietary allelochemicals

Keywords: ABC, ATP Binding Cassette; C-AM, Calcein-AM; MRP, Multidrug resistance-associated protein; P-gp, P-glycoproteinABC transporter; Allelochemical; Calcein-AM; Gorgonian; MK571; MRP; P-gp; Verapamil

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Emerging New Technologies in Pharamcogenomics: Rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1)

Keywords: ABCB1 (P-glycoprotein); ABC transporter; Single nucleotide polymorphisms (SNP); pharmacogenomics; QSAR analysis; personalized medicine; ABC; ATP-binding cassette; BBB; blood brain barrier; MD simulation; molecular dynamic simulation; MDR; multidrug resist

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Calcium Channel Blocker Verapamil Enhances Reticulum Stress and Death Induced by Proteasome Inhibition in Myeloma Cells

Keywords: ER; endoplasmic redculum; IKB; inhibitor of kappa B; MDR; multidrug resistance; NF-κB; nuclear factor kappa B; P-gp; p-glycoprotein; ROS; reactive oxygen species; UPR; unfolded protein response;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

In vivo evaluation of P-glycoprotein and breast cancer resistance protein modulation in the brain using [11C]gefitinib

Keywords: P-gp; BCRP; [11C]Gefitinib; GF120918; Cyclosporin A; Brain penetration

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Novel double coated nanocapsules for intestinal delivery and enhanced oral bioavailability of tacrolimus, a P-gp substrate drug

Keywords: Tacrolimus; Nanocapsules; P-gp; Oral absorption; Bioavailability

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp

Keywords: Astilbin; Taxifolin; P-gp; MRP2; Caco-2 cell; Absorption

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه