Blonanserin, a novel atypical antipsychotic agent not actively transported as substrate by P-glycoprotein

► Blonanserin is not a P-gp substrate in both in vitro and in vivo experiments. ► Brain distribution of blonanserin is unlikely to be affected by P-gp. ► For non P-gp substrate blonanserin, there is no need to worry about P-gp-mediated DDI.