کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5823950 | 1118376 | 2012 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Traditional West African pharmacopeia, plants and derived compounds for cancer therapy
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کلمات کلیدی
GSTcdc2Cdc25cP-gpHuman colorectal carcinomaPARPPKCJun N-terminal kinasesDMBA12-O-tetradecanoylphorbol-13-acetatePP2AGSHUDP-GTtPAEBV-EAJnkMDRNAD(P)H - NAD (P) HP-glycoprotein - P-گلیکوپروتئینp12 - P12Natural compounds - ترکیبات طبیعیAnticancer - ضد سرطانWest Africa - غرب آفریقاVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)phosphoinositol-3-kinase - فسفونیوزیتول 3-کینازMultidrug resistance - مقاومت چند داروییcyclin-dependent kinase inhibitor 1 - مهارکننده کیناز وابسته به سیکلین 1nicotinamide adenine dinucleotide phosphate-oxidase - نیکوتین آمید آدنین دیونوکلئوتید فسفات اکسیدازprotein phosphatase 2 - پروتئین فسفاتاز 2Protein kinase C - پروتئین کیناز سیp38 mitogen-activated protein kinases - پروتئین کیناز متیوژن فعال P38Traditional medicine - پزشکی سنتی یا طب سنتیPoly(ADP-ribose) polymerase - پلیمر (ADP-ribose) پلیمرازGlutathione - گلوتاتیونglutathione S transferase - گلوتاتیون S transferaseMedicinal plants - گیاهان دارویی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Traditional pharmacopeia is strongly involved in the continuous search for the well being of African populations. The World Health Organization (WHO) estimates that 80% of the population of developing countries relies on traditional medicine for their primary care needs. Medicinal plants are the major resource of this folk medicine where several species are used for the treatment of diseases with an inflammatory and/or infectious component as it is the case of old wounds, skin diseases and malfunctions affecting internal organs such as liver, lung, prostate and kidney. Many of these pathologies described by practitioners of traditional medicine have similarities with certain cancers, but the lack of training of many of these healers does not allow them to establish a link with cancer. However, ethnobotanical and ethnopharmacological surveys conducted by several researchers allowed to identify plants of interest for cancer treatment. Most scientific investigations on these plants demonstrated an anti-inflammatory or antioxidant effect, and sometimes, antiproliferative and cytotoxic activities against cancer cells were reported as well. The emergence of resistance to cancer chemotherapy has forced researchers to turn to natural products of plant and marine origin. In the West African sub-region, research on natural anti-cancer molecules is still in its infancy stage because of very limited financial resources and the scarcity of adequate technical facilities. However, several plants were investigated for their anticancer properties through north-south or south-south partnerships. In this review, we will review the role of West African traditional pharmacopeia in cancer treatment as well as medicinal plants with anti-cancer properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 84, Issue 10, 15 November 2012, Pages 1225-1240
Journal: Biochemical Pharmacology - Volume 84, Issue 10, 15 November 2012, Pages 1225-1240
نویسندگان
Wamtinga Richard Sawadogo, Marc Schumacher, Marie-Hélène Teiten, Mario Dicato, Marc Diederich,