The cytoplasmic side of p53's oncosuppressive activities
Keywords: p53; Cytoplasm; Mitochondria; Apoptosis; Metabolism; Transcription-independent;
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All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis
Keywords: retina; visual cycle; all-trans-retinal; oxidative stress; DNA damage; p53; Bcl-2-associated Ã protein; apoptosis; ABCA4; ATP-binding cassette transporter; atRAL; all-trans-retinal; Bax; Bcl-2-associated Ã protein; Bim; Bcl-2-interacting mediator; B
Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides
Keywords: Apoptosis; Lung cancer; Telomere overhang; Senescence; p53; Angiogenesis
Protein Interaction Between p53 and Δ113p53 Is Required for the Anti-Apoptotic Function of Δ113p53
Keywords: p53; Δ113p53; Protein interaction; Apoptosis; Zebrafish
p53: The barrier to cancer stem cell formation
Keywords: Stem cells; p53; Loss of heterozygosity; Cancer stem cells; Tumorigenesis;
p53 mediated apoptosis by reduction sensitive shielding ternary complexes based on disulfide linked PEI ternary complexes
Keywords: Reduction-sensitive; Shielding; Intracellular; p53; Gene therapy; Cell apoptosis;
Cell cycle changes mediated by the p53/miR-34c axis are involved in the malignant transformation of human bronchial epithelial cells by benzo[a]pyrene
Keywords: Benzo[a]pyrene (BaP); p53; miR-34c; Malignant transformation; Cell cycle
Evidence that gastric pit dysplasia-like atypia is a neoplastic precursor lesion
Keywords: Chronic gastritis; Intestinal metaplasia; Ki-67; MUC; p53;
ATM-p53 pathway causes G2/M arrest, but represses apoptosis in pseudolaric acid B-treated HeLa cells
Keywords: Pseudolaric acid B; G2/M arrest; Apoptosis; ATM; p53;
Illuminating p53 function in cancer with genetically engineered mouse models
Keywords: p53; Tumor suppression; Mouse models;
Research PaperSwietenia macrophylla King induces mitochondrial-mediated apoptosis through p53 upregulation in HCT116 colorectal carcinoma cells
Keywords: Apoptosis; Bax/Bcl-2; Caspase; p53; ROS; Swietenia macrophylla;
Heme oxygenase-1 has antitumoral effects in colorectal cancer: Involvement of p53
Keywords: Heme oxygenase-1; Colorectal cancer; P53; Survival; Immunohistochemistry;
Mathematical modeling of p53 pulses in G2 phase with DNA damage
Keywords: Mathematical modeling; p53; DNA damage; G2 phase; Checkpoints; Dynamics
Post-transcriptional RNA regulons affecting cell cycle and proliferation
Keywords: RBP; RNA-binding protein; RNP; ribonucleoprotein; RNA regulons and PTROs; post-transcriptional rna operons and regulons; RRE; RNA recognition element; USER code; untranslated sequence element for regulation code; Posttranscriptional regulation; RNA-bindin
Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway
Keywords: DMAP1; ATM; p53; Neuroblastoma; MYCN
Reaction–diffusion systems for spatio-temporal intracellular protein networks: A beginner's guide with two examples
Keywords: Michaelis–Menten kinetics; Hill kinetics; Intracellular protein signalling; Spatial representation; Reaction–diffusion PDE models; Oscillations; p53; Leloup–Goldbeter FRQ model
Wild type p53 reactivation: From lab bench to clinic
Keywords: p53; Small molecule; Mdm2; MdmX; Apoptosis; ROS;
Tumor suppressor p53 and estrogen receptors in nuclear-mitochondrial communication
Keywords: estrogen receptor; p53; breast cancer; mitochondria; metabolism;
p53 and mitochondrial function in neurons
Keywords: p53; Mitochondria; Mitochondrial dynamics; Apoptosis; Mitophagy
Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis
Keywords: Lens; MDM2; MDMX; p53; Eyes; Lens dysmorphogenesis; Apoptosis; Cell proliferation; Lens development;
A comparative study of nucleostemin family members in zebrafish reveals specific roles in ribosome biogenesis
Keywords: Nucleostemin; Ribosome biogenesis; p53;
A flavonoid isolated from Streptomyces sp. (ERINLG-4) induces apoptosis in human lung cancer A549 cells through p53 and cytochrome c release caspase dependant pathway
Keywords: Streptomyces sp.; Caspases; Cytochrome c; p53; Molecular docking
Human papillomavirus types detected in skin warts and cancer differ in their transforming properties but commonly counteract UVB induced protective responses in human keratinocytes
Keywords: Skin cancer; Warts; Cutaneous HPV types; Beta HPVs; UVB; Skin; Apoptosis; p53; Bax; Bak;
Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations
Keywords: Phenethyl isothiocyanates; Oral squamous cell carcinoma; p53; Reactive oxygen species; Glutathione; DNA damage; Apoptosis; Free radicals
Nuclear NF-κB contributes to chlorpyrifos-induced apoptosis through p53 signaling in human neural precursor cells
Keywords: Chlorpyrifos; Human neural precursor cells; Reactive oxidative species; NF-κB; p53
15-Deoxy-Î12,14-prostaglandin J2 induces PPARγ- and p53-independent apoptosis in rabbit synovial cells
Keywords: 15d-PGJ2; PPARγ; Synovial; Apoptosis; p53; Caspase;
The role of ubiquitin modification in the regulation of p53
Keywords: p53; MDM2; MDMX;
IL-1Ra selectively protects intestinal crypt epithelial cells, but not tumor cells, from chemotoxicity via p53-mediated upregulation of p21WAF1 and p27KIP1
Keywords: IL-1Ra; Intestinal crypt epithelia; Chemotoxicity; p53; p21WAF1; p27KIP1
Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells
Keywords: Gingerol; Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL); Glioblastoma; Apoptosis; Reactive oxygen species (ROS); p53
Invadosomes in their natural habitat
Keywords: 2D; two-dimensional; 3D; three-dimensional; cAMP; 3, 5-cyclic adenosine monophosphate; Ab; antibody; AC; anchor cell; Arp2/3; complex containing actin regulators 2 and 3; BM; basement membrane; CAM; chicken chorioallantoic membrane; Cdc42; Cell division c
Mdm2 is required for maintenance of the nephrogenic niche
Keywords: Metanephric kidney; Nephron progenitor cells; Cap mesenchyme; Mdm2; p53;
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
Keywords: Ribosome biogenesis stress; p53; RPL5; RPL11; 5S rRNA; Ribosomopathies
p53 is involved in shrimp survival via its regulation roles on MnSOD and GPx in response to acute environmental stresses
Keywords: Acute environmental stresses; Cumulative mortalities; Enzymatic activities; Litopenaeus vannamei; p53; RNA interference (RNAi); Transcription expression; Tissue distribution;
p53 in neurodegenerative diseases and brain cancers
Keywords: p53; Signaling; Alzheimer's disease; Parkinson's disease; Cerebral cancers; Therapeutics
2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway
Keywords: Resin monomer; HEMA; Apoptosis; DNA damage; ATM; p53;
Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis
Keywords: Cancer; HDAC inhibitors; HDAC2; p53; RLIM; Sumoylation;
β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells
Keywords: βM; β-mangostin; MMP; mitochondrial membrane potential; NF-kB; nuclear factor-kappa B; TNF-α; tumour necrosis factor alpha; ROS; reactive oxygen species; DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; HCS; high content screening; PARP; poly ADP ribo
The p53 protein and its molecular network: Modelling a missing link between DNA damage and cell fate
Keywords: p53; DNA damage; ATM; Cell fate; Molecular mathematical model
The ING tumor suppressor genes: Status in human tumors
Keywords: ING1; ING4; Tumor suppressor gene; p53; MicroRNA;
Reactive oxygen species activate NFκB (p65) and p53 and induce apoptosis in RVFV infected liver cells
Keywords: Reactive oxygen species; p65; p53; Apoptosis; Liver cells; Rift Valley fever virus;
Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity
Keywords: p53; Ubiquitylation; Oligomerization; Transcription; Proteasome; OD; Oligomerization Domain; Bax; Bcl2-associated X protein; Bcl-XL; B-cell lymphoma-extralarge; PUMA; p5pregulated Modulator of Apoptosis; Noxa; Noxious stress induced protein; Bid; BH3 inte
JMJD2A attenuation affects cell cycle and tumourigenic inflammatory gene regulation in lipopolysaccharide stimulated neuroectodermal stem cells
Keywords: Inflammation; JMJD2A; Cell cycle; Neuroectodermal stem cell; p53
Antifilarial effects of polyphenol rich ethanolic extract from the leaves of Azadirachta indica through molecular and biochemical approaches describing reactive oxygen species (ROS) mediated apoptosis of Setaria cervi
Keywords: ANOVA; analysis of variance; Apaf; apoptotic protease activating factor; BCl-2; B-cell lymphoma 2; CED; cell-death abnormal; CM; culture media; CP; crude powder; DMSO; dimethyl sulfoxide; EEA; ethanolic extract of Azadirachta indica leaves; EGL; egg layin
ROS and RNS induced apoptosis through p53 and iNOS mediated pathway by a dibasic hydroxamic acid molecule in leukemia cells
Keywords: Apoptosis; HDAC3; iNOS; p53; Reactive nitrogen species; Reactive oxygen species
2-Phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53
Keywords: 2-Phenylethynesulfonamide (Pubmed CID 327653); l-Buthionine-sulfoximine (Pubmed CID 119565); N-acetyl cysteine (Pubmed CID 12035); Dithiothreitol (Pubmed CID 19001); Necrostatin-1 (Pubmed CID 282833); 3-Methyladenine (Pubmed CID 1673); Q-VD-OPh (Pubmed CI
Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D
Keywords: p53; Phosphorylation; Actinomycin D; Rapamycin; Survivin;
Mitochondrial matrix P53 sensitizes cells to oxidative stress
Keywords: Mitochondrial DNA; Oxidative stress; Oximetry; p53;
Vitamin D directly regulates Mdm2 gene expression in osteoblasts
Keywords: VDR; Mdm2; p53; Osteoblast differentiation; Gene regulation;
Aβ1-42 disrupts the expression and function of KLF2 in Alzheimer's disease mediated by p53
Keywords: Alzheimer's disease; Amyloid beta; Kruppel-like factor 2; p53;
A compound CP-31398 suppresses excitotoxicity-induced neurodegeneration
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; CP-31398; Nâ²-[2-[2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride; CNS; central nervous system; DAPI; 4â²,6â²-diamidino-2-phenylindole; DIV; days