DDX3 regulates DNA damage-induced apoptosis and p53 stabilization
Keywords: DDX3; p53; Apoptosis; DNA damage; Camptothecin;
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A novel curcumin-based vaginal cream Vacurin selectively eliminates apposed human cervical cancer cells
Keywords: Curcumin; Cervical cancer; EGF receptor; p53; Rb; Human papillomavirus;
Arsenic trioxide (As2O3) induces apoptosis and necrosis mediated cell death through mitochondrial membrane potential damage and elevated production of reactive oxygen species in PLHC-1 fish cell line
Keywords: MTT; (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; IC50; inhibitory concentration; FACS; fluorescence-activated cell sorter; FITC/PI; fluorescein isothiocyanate propidium iodide; JC-1 dye; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethy
OncologyTwo α-dicarbonyls downregulate migration, invasion, and adhesion of liver cancer cells in a p53-dependent manner
Keywords: Adhesion; 3-Deoxyglucosone; Invasion; Methylglyoxal; Migration; p53;
Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway
Keywords: ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxy-amide-1-D-ribofuranoside; AMPK; AMP-activated protein kinase; PKC zeta; protein kinase C zeta; PLK-2; polo like kinase-2; AMPK; Breast tumor; Celastrol; p53; PKCzeta; PLK-2;
Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx
Keywords: PPM; protein phosphatase, magnesium-dependent; MKK4; mitogen-activated protein kinase kinase 4; MKK6; mitogen-activated protein kinase kinase 6; JNK; c-Jun amino-terminal kinase; Protein phosphatase 1; p53; Mdmx; Dephosphorylation; Stabilization;
The effect of vitamin C administration on monosodium glutamate induced liver injury. An experimental study
Keywords: Monosodium glutamate; Vitamin C; ki-67; p53; Histological; Histochemistry; Ultrastructure; Liver;
Thermal stress and cellular signaling processes in hemocytes of native (Mytilus californianus) and invasive (M. galloprovincialis) mussels: Cell cycle regulation and DNA repair
Keywords: Apurinic/apyrimidinic endonuclease (APE); Hemocytes; Mytilus californianus; M. galloprovincialis; p21; p53; Temperature stress;
miR-375 targets the p53 gene to regulate cellular response to ionizing radiation and etoposide in gastric cancer cells
Keywords: Gastric cancer; miR-375; P53; Ionizing radiation; Etoposide;
Effect of zinc oxide nanomaterials-induced oxidative stress on the p53 pathway
Keywords: Zinc oxide nanomaterials; Nanotoxicology; p53; Anti-oxidative defense; Reactive oxygen species;
Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts
Keywords: Cardiac fibrosis; S100A4; p53; Myofibroblast;
FAT10 protects cardiac myocytes against apoptosis
Keywords: NRCM; neonatal rat cardiac myocytes; H/R; hypoxia/reoxygenation; UPS; ubiquitin-proteasome system; MI; Myocardial infarction; LAD; left anterior descending artery; FITC; fluorescein isothiocyanate; Co-IP; co-immunoprecipitation; Lt-FAT10; lentivirus con
A review of the current understanding and clinical utility of miRNAs in esophageal cancer
Keywords: miRNA/miR; MicroRNA [ribonucleic acid]; EAC; Esophageal adenocarcinoma; BE; Barrett's esophagus; LGD; Low grade dysplasia; HGD; High grade dysplasia; ESCC; Esophageal squamous cell carcinoma; NE; Normal epithelium; qRT-PCR; Quantitative reverse transcript
PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53
Keywords: PRIMA-1; Autophagy; p53; LC3; Electron microscopy;
Synthesis, characterization, and anticancer activity of ruthenium(II)-β-carboline complex
Keywords: Ruthenium(II) complex; β-Carboline; Mitochondria; p53; Apoptosis; tpy; 2,2â²:6â²,2â³-terpyridine; Nh; Norharman; bpy; 2,2â²-bipyridine; phen; 1,10-phenanthroline; dpa; 2,2â²-dipyridylamine; dip; 4,7-dibenzyl-1,10-phenanthroline; PI; propidium iodide
Co-expression of antioxidant enzymes with expression of p53, DNA repair, and heat shock protein genes in the gamma ray-irradiated hermaphroditic fish Kryptolebias marmoratus larvae
Keywords: Gamma ray; Irradiation; DNA repair; P53; Heat shock protein; Kryptolebias marmoratus;
Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway
Keywords: Feline mammary carcinoma; Cancer stem cell; p53; Epithelial-mesenchymal transition;
The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury
Keywords: deacetylase; p21; p53;
Apoptosis and p53 are not involved in the anti-tumor efficacy of 125I-labeled monoclonal antibodies targeting the cell membrane
Keywords: Radioimmunotherapy; Auger electrons; p53; Apoptosis; 125I-mAbs;
PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage
Keywords: PHF20; Glioblastoma; PKB; p53; Protein phosphorylation;
The sulphydryl containing ACE inhibitor Zofenoprilat protects coronary endothelium from Doxorubicin-induced apoptosis
Keywords: Zofenoprilat; Doxorubicin; Coronary endothelium; Apoptosis; Hydrogen sulfide; P53; ERK1/2; Tumor; Cardiotoxicity;
Teroxirone inhibited growth of human non-small cell lung cancer cells by activating p53
Keywords: Teroxirone; Human non-small-cell-lung-cancer cells; Apoptosis; p53;
Biological clues to potent DNA-damaging activities in food and flavoring
Keywords: γ-H2AX; phosphorylated histone protein H2AX; 5-FU; fluorouracil; CHO; Chinese hamster ovary; CMV; cytomegalovirus; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; EGCG; epigallocatechin-3-gallate; FBS; fetal bovine serum; HEPES; 4
Sequence-specific and DNA structure-dependent interactions of Escherichia coli MutS and human p53 with DNA
Keywords: Biotin-streptavidin; Immobilized DNA substrates; MutS; p53; Protein-DNA binding; Unusual DNA structures;
Inhibition of UVB-induced skin phototoxicity by a grape seed extract as modulator of nitrosative stress, ERK/NF-kB signaling pathway and apoptosis, in SKH-1 mice
Keywords: AP-1; activator protein 1; Apaf; apoptotic protease activating factor-1; ABTS; 2â²-azino-bis(3-ethylbenzothiazoline-6-sulfonate; Bcl-2; B-cell lymphoma 2; Bax; Bcl-2-associated X protein; CPDs; cyclobutane pyrimidine dimers; DAB; diaminobenzidine tetrahy
Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus
Keywords: Iron oxide nanoparticles; Striatum; Hippocampus; Oxidative stress; Dopaminergic neuron; Neurotoxicity; JNK; p53;
Transcriptional cooperation between p53 and NF-κB p65 regulates microRNA-224 transcription in mouse ovarian granulosa cells
Keywords: miRNA; microRNA; GC; granulosa cell; E2; estradiol; TFs; transcriptional factors; NF-κB; nuclear factor-κB; GABRE; GABAA receptor ε subunit; nt; nucleotide; pri-miRNAs; primary microRNAs; RISC; RNA-induced silencing complex; SF-1; steroidogenic factor-
Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin
Keywords: DNA damage; Polyphenols; Micronucleus; p53; Quercetin; Curcumin; DNA repair;
MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes
Keywords: Lymhoproliferation; Theileria parva; MDM2; p53;
Streptococcus pneumoniae ClpP protease induces apoptosis via caspase-independent pathway in human neuroblastoma cells: Cytoplasmic relocalization of p53
Keywords: Streptococcus pneumoniae; ClpP; Caspase; AIF; p53;
Hip2 ubiquitin-conjugating enzyme overcomes radiation-induced G2/M arrest
Keywords: G2/M arrest; Hip2; p53; Radiation; Ubiquitination;
Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis
Keywords: Endothelial cells; p53; Xanthine dehydrogenase; Cigarette; Apoptosis; Free radicals;
The baculovirus sulfhydryl oxidase Ac92 (P33) interacts with the Spodoptera frugiperda P53 protein and oxidizes it in vitro
Keywords: Baculovirus; AcMPNV; Ac92; Sulfhydryl oxidase; p53;
Endogenous levels of Rad51 and Brca2 are required for homologous recombination and regulated by homeostatic re-balancing
Keywords: Rad51; Brca2; p53; Homeostatic control; Homologous recombination; siRNA knockdown;
Thioredoxin inhibits MPK38-induced ASK1, TGFâβ, and p53 function in a phosphorylation-dependent manner
Keywords: MPK38/MELK; Trx; ASK1; TGF-β; p53; Free radicals;
p53 Suppresses E2F1-dependent PLK1 expression upon DNA damage by forming p53-E2F1-DNA complex
Keywords: PLK1; p53; E2F1; Transcription regulation; DNA damage;
Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells
Keywords: Physalin A; A375-S2 cells; Apoptosis; Autophagy; p53; Noxa;
Cathepsin L silencing enhances arsenic trioxide mediated in vitro cytotoxicity and apoptosis in glioblastoma U87MG spheroids
Keywords: APL; acute promyelocytic leukaemia; As2O3; arsenic trioxide; CatL; Cathepsin L; Bax; BCL2-associated X protein; Bcl2; B-cell CLL/lymphoma2; ECM; extracellular matrix; GBM; glioblastoma multiforme; MTS; 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxypheny
Loss of p53 in stromal fibroblasts promotes epithelial cell invasion through redox-mediated ICAM1 signal
Keywords: Fibroblast; ICAM1; Invasion; Reactive nitrogen species; p53; Endothelial NO synthase; Free radicals;
Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish
Keywords: Cranial neural crest; Cardiac neural crest; eif3ba; nrp2b; p53; Zebrafish;
Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for treatment of human hepatocellular carcinoma
Keywords: Double-walled microspheres; PLGA; PLLA; Chitosan; p53; Doxorubicin;
Hsp90-targeted miRNA-liposomal formulation for systemic antitumor effect
Keywords: Hsp90; Glucocorticoid receptor; Liposome; Akt; p53; Cancer;
Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expression
Keywords: EGCG; NAG-1; p53; Head and neck cancer; Apoptosis; ATM;
Papillomavirus E6 oncoproteins
Keywords: Papillomavirus; Viral oncogenes; Transformation; Cervical cancer; Notch; Telomerase; P53; Ubiquitin;
Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2
Keywords: γGCS; gamma-glutamylcysteine synthetase; ARE; antioxidant responsive element; BAT; brown adipose tissue; CNC; Cap 'n' collar; COX; cytochrome c oxidase; CR; calorie restriction; CREB; cAMP response element-binding protein; ERRs; Estrogen-related rece
Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-κB/p53 signaling pathway
Keywords: 3-MA; 3-methyladenine; ANOVA; analysis of variance; BSA; bovine serum albumin; DMSO; dimethylsulfoxide; DRAM; damage-regulated autophagy modulator; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; H/I; hypoxia-ischemia; I/R; ischemia-reperfusion; PaCO
Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitors
Keywords: MDM2; p53; Dihydroimidazothiazole; Protein-protein interaction inhibitor;
Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53
Keywords: Pyrazoline; Anticancer; p53;
Regulation of the MIR155 host gene in physiological and pathological processes
Keywords: 3T3-L1; cell line derived from 3T3 cells; 3â²-UTR; 3â²-untranslated region; AICDA; activation-induced cytidine deaminase; AML; acute myeloid leukemia; Ang II; angiotensin II; AP-1; activator protein 1; AT1R; angiotensin II type 1 receptor; BACH1; basic
Helicobacter pylori infection and expressions of apoptosis-related proteins p53, ASPP2 and iASPP in gastric cancer and precancerous lesions
Keywords: Helicobacter pylori; Gastric carcinoma; P53; ASPP2; IASPPHelicobacter pylori; Carcinome gastrique; P53; ASPP2; PPEEE