Antifilarial effects of polyphenol rich ethanolic extract from the leaves of Azadirachta indica through molecular and biochemical approaches describing reactive oxygen species (ROS) mediated apoptosis of Setaria cervi

- S. cervi is widely used as a model to screen antifilarials.
- Polyphenol rich EtOH extract of A. indica leaves were optimized by RSM.
- EEA was tested against mf and adults of S. cervi cultured in vitro.
- Morphological, molecular and biochemical alterations were examined.
- Apoptosis and ROS up regulation are the probable cause of effectiveness.