Discovery of a new mexiletine-derived agonist of the hERG K+ channel
Keywords: پچ گیر; Ether-a-go-go Related Gene; hERG agonists; Patch clamp; Ion channels; Long term QT syndrome;
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A new interaction between proximal and distal C-terminus of Cav1.2 channels
Keywords: پچ گیر; Cav1.2; Cardiac myocytes; Calmodulin; Patch clamp; Pull-down assay;
Ion currents of cardiomyocytes in different regions of the Göttingen minipig heart
Keywords: پچ گیر; Cardiac electrophysiology; Delayed rectifier K+ channel; Göttingen minipig; Inward rectifier K+ channel; L-type Ca2Â + channel; Patch clamp; hERG; Ion channel; Heart;
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions
Keywords: پچ گیر; Episodic ataxia; Kv1.1 channel; Patch clamp; Genetics; Homology modeling;
CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2)
Keywords: پچ گیر; CORM-2 (PubChem CID: 10951331); CORM-3 (PubChem CID: 91826084); Potassium channel; K+ channel; Patch clamp; Carbon monoxide; Hemeoxygenase; Metal carbonyl;
Decreased calcium flux in Niemann-Pick type C1 patient-specific iPSC-derived neurons due to higher amount of calcium-impermeable AMPA receptors
Keywords: پچ گیر; NPC1; GluA2; AMPA; Calcium; Patch clamp; Fura2; iPSC derived neurons;
Enkephalin and neuropeptide-Y interaction in the intergeniculate leaflet network, a part of the mammalian biological clock
Keywords: پچ گیر; ACSF; artificial cerebro-spinal fluid; AP-5; 2-amino-5-phosphonopentanoic acid; Bic; bicuculline methiodide; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; EGTA; ethylene glycol tetraacetic acid; ENK; enkephalin; GABA; γ-aminobutyric acid; GGT; geniculo-gen
Hepatocellular differentiation status is characterized by distinct subnuclear localization and form of the chanzyme TRPM7
Keywords: پچ گیر; Nuclear envelope; Nucleus; Nucleolus; Hepatoma; Liver; α-Kinase; Patch clamp;
Single-molecule FRET studies of ion channels
Keywords: پچ گیر; Patch clamp; FRAP; Gramicidin; MscL; KirBac; NMDA;
Subtype-specific block of voltage-gated K+ channels by μ-conopeptides
Keywords: پچ گیر; Channel block; Pain; Patch clamp; Cone snails; Conotoxin; Neurotoxin; TTX; tetrodotoxin; KV channel; Voltage-gated K+ channel; NaV channel; Voltage-gated Na+ channel;
Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells
Keywords: پچ گیر; Neural induction; Neural progenitor cells; hiPSC; Electron microscopy; Patch clamp; 2D-3D neural induction; AD; Alzheimer's disease; AQP4; Aquaporin 4; ASD; Autism spectrum disorder; bFGF; Basic Fibroblast Growth Factor; CNS; Central Nervous System; D; Da
Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus
Keywords: پچ گیر; AHP; afterhyperpolarization; amp; amplitude; AP; action potential; 4-AP; 4-aminopyridine; BAC; bacterial artificial chromosome; Ccell; cell capacitance; CCHS; congenital central hypoventilation syndrome; DAB; 3,3â²-diaminobenzidine tetrahydrochloride; DA
Upregulation of basolateral small conductance potassium channels (KCNQ1/KCNE3) in ulcerative colitis
Keywords: پچ گیر; Human colonic crypts; Ulcerative colitis; KCNQ1/KCNE3 channels; Patch clamp;
Characterization of GABAA receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cells
Keywords: پچ گیر; CW-04-020; Diazepam; GABA; GABAA receptor; Human-induced pluripotent stem cell; HZ-166; iCell neuron; Ionflux; Patch clamp;
Two P2X1 receptor transcripts able to form functional channels are present in most human monocytes
Keywords: پچ گیر; Heterologous expression; P2X receptors; Blood cells; Patch clamp; P2X1del receptors;
Bio-hybrid interfaces to study neuromorphic functionalities: New multidisciplinary evidences of cell viability on poly(anyline) (PANI), a semiconductor polymer with memristive properties
Keywords: پچ گیر; Bio-hybrid neural interfaces; Polyaniline (PANI) films; Surface analysis; Cell viability; Immunofluorescence; Patch clamp;
pH-dependent inhibition of tetrodotoxin-resistant Na+ channels by diclofenac in rat nociceptive neurons
Keywords: پچ گیر; Acidosis; Inflammatory pain; NSAID; Patch clamp; Trigeminal ganglia; TTX-R Na+ channels;
The impact of the C-terminal domain on the gating properties of MscCG from Corynebacterium glutamicum
Keywords: پچ گیر; NCgl1221; Mechanosensitive channel; Glutamate efflux; Gating hysteresis; E. coli; Spheroplasts; Liposomes; Patch clamp;
Cd2+ sensitivity and permeability of a low voltage-activated Ca2+ channel with CatSper-like selectivity filter
Keywords: پچ گیر; Patch clamp; Heterologous expression; Fluorescence imaging; CatSper selectivity filter; T-type calcium channel
Mechanisms of acquired long QT syndrome in patients with propionic academia
Keywords: پچ گیر; Long QT syndrome; Repolarizing cardiac ion channels; Patch clamp; Arrhythmia; Propionic acidemia
Evaluation of nefazodone-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes
Keywords: پچ گیر; Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs); Cardiotoxicity; Nefazodone; Patch clamp; Action potentials; Ion channels
Research reportActivation of 5-hyrdoxytryptamine 7 receptors within the rat nucleus tractus solitarii modulates synaptic properties
Keywords: پچ گیر; Serotonin receptors; Autonomic nervous system; Patch clamp; EPSC; IPSC; Respiration;
Inhibition of calcium-permeable and calcium-impermeable AMPA receptors by perampanel in rat brain neurons
Keywords: پچ گیر; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CP-AMPARs; calcium-permeable AMPA receptors; CI-AMPARs; calcium-impermeable AMPA receptors; AMPA receptors; Anticonvulsants; Perampanel; Inhibition; Mechanisms; Patch clamp;
Comparison between mouse and sea urchin orthologs of voltage-gated proton channel suggests role of S3 segment in activation gating
Keywords: پچ گیر; HVCN1; hydrogen voltage-gated channel 1; Gating; Membrane protein; Proton transport; Sea urchin; Patch clamp; Hv1;
Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage
Keywords: پچ گیر; APP; β-amyloid precursor protein; bioFET; biologically coupled field effect transistor; CASP; caspase; CCD; charge-coupled device; CHX; cycloheximide; DMEM; Dulbecco's Modified Eagle's Medium; EEA1; early endosome antigen 1; EGFP; enhanced green fluoresc
Research articleContribution of persistent sodium currents to the excitability of tonic firing substantia gelatinosa neurons of the rat
Keywords: پچ گیر; INaP; persistent Na+ currents; INaT; transient Na+ currents; SEM; standard error of the mean; SG; substantia gelatinosa; Vc; trigeminal nucleus caudalis; INaP; Voltage-gated Na+ channels; Substantia gelatinosa; Trigeminal subnucleus caudalis; Patch clamp;
The effects of vasoactive peptide urocortin 2 on hemodynamics in spontaneous hypertensive rat and the role of L-type calcium channel and CRFR2
Keywords: پچ گیر; Urocortin; Spontaneously hypertension; L-type calcium channel; Corticotropin releasing factor; Patch clamp
Up-regulation of megakaryocytic Na+/Ca2+ exchange in klotho-deficient mice
Keywords: پچ گیر; Megakaryocytes; Platelets; Patch clamp; Cytosolic Ca2+;
A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity
Keywords: پچ گیر; Aβ, amyloid-β; BFCN, basal forebrain cholinergic neurons; α7-nAChRs, α7-containing nicotinic acetylcholine receptors; AD, Alzheimer disease; Patch clamp;
Neuropharmacology and analgesiaProton-induced currents in substantia gelatinosa neurons of the rat trigeminal subnucleus caudalis
Keywords: پچ گیر; ASICs; Substantia gelatinosa; Trigeminal subnucleus caudalis; Pain; Patch clamp;
Enhanced GABA action on the substantia gelatinosa neurons of the medullary dorsal horn in the offspring of streptozotocin-injected mice
Keywords: پچ گیر; Streptozotocin; Substantia gelatinosa neuron; Patch clamp; Diabetes mellitus; GABA
Multiple effects of anthracene-9-carboxylic acid on the TMEM16B/anoctamin2 calcium-activated chloride channel
Keywords: پچ گیر; Ca2Â +-activated Clâ channel; Patch clamp; ANO2; Blocker; A9M; A9C;
Inflammatory mediator-induced modulation of GABAA currents in human sensory neurons
Keywords: پچ گیر; CNS; central nervous system; DRG; dorsal root ganglion; GABA; γ-aminobuteric acid; GABAA receptor; A-type GABA receptor; PKA; protein kinase A; PKC; protein kinase C; THIP; agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol; TK; tyrosine kinase; dor
Enzymatic conversion of ATP to adenosine contributes to ATP-induced inhibition of glutamate release in rat medullary dorsal horn neurons
Keywords: پچ گیر; ATP; Presynaptic inhibition; Primary afferents; Medullary dorsal horn; Tissue nonspecific alkaline phosphatases; Patch clamp; αβ-me-ATP; αβ-methylene-ATP; APV; DL-2-amino-5-phosphonovaleric acid; ARL67156; 6-N,N-diethyl-β-γ-dibromomethylene-d-adenos
Genotype-dependent differences in age of manifestation and arrhythmia complications in short QT syndrome
Keywords: پچ گیر; Short QT syndrome; Mutation; Patch clamp; Meta-analysis; Computer simulation;
Research reportEnvironmental enrichment modulates intrinsic cellular excitability of hippocampal CA1 pyramidal cells in a housing duration and anatomical location-dependent manner
Keywords: پچ گیر; Learning and memory; Mouse; Action potential threshold; Input resistance; Patch clamp;
Orexins/hypocretins modulate the activity of NPY-positive and -negative neurons in the rat intergeniculate leaflet via OX1 and OX2 receptors
Keywords: پچ گیر; Bic; bicuculline methbromide; dLGN; dorsal part of lateral geniculate nucleus; DMSO; dimethyl sulfoxide; ENK; enkephalin; GHT; geniculo-hypothalamic tract; IGL; intergeniculate leaflet; Kyn; kynurenic acid sodium salt; mEPSC; miniature excitatory postsyna
Expression and functionality of transient receptor potential melastatin 4 (TRPM4)-like channels during development of the zebrafish
Keywords: پچ گیر; TRPM4; Zebrafish; Gene expression; Patch clamp; Embryonic development; Ca2+
Distinct electrophysiological and mechanical beating phenotypes of long QT syndrome type 1-specific cardiomyocytes carrying different mutations
Keywords: پچ گیر; Long QT syndrome; Induced pluripotent stem cell; Arrhythmia; Patch clamp; Calcium imaging; Digital image correlation
Inhibition of KCa3.1 by depolarisation and 2-aminoethoxydiphenyl borate (2-APB) during Ca2+ release activated Ca2+ (CRAC) entry in human erythroleukemia (HEL) cells: Implications for the interpretation of 2-APB inhibition of CRAC entry
Keywords: پچ گیر; 2-APB; Membrane potential; KCa3.1; HEL cells; CRAC channel; Patch clamp; Current clamp; Intracellular Ca2+
Open channel block of NMDA receptors by diphenhydramine
Keywords: پچ گیر; Diphenhydramine; NMDA receptor; Patch clamp; Sedation; Analgesia; Amnesia; LTP; Learning and memory;
Case studyA loss-of-function CACNA1A mutation causing benign paroxysmal torticollis of infancy
Keywords: پچ گیر; Benign paroxysmal torticollis of infancy; CACNA1A; P/Q channel; Patch clamp; Genetics;
Activation of galanin receptor 2 stimulates large conductance Ca2+-dependent K+ (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells
Keywords: پچ گیر; Endoplasmic reticulum; Neuropeptide; Patch clamp;
Research PaperSalvia miltiorrhiza (Danshen) inhibits L-type calcium current and attenuates calcium transient and contractility in rat ventricular myocytes
Keywords: پچ گیر; SM (PubChem CID: 105117); Verapamil hydrochloride (PubChem CID: 62969); SM; Patch clamp; L-type calcium current; Calcium transient; Myocyte contractility;
The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart
Keywords: پچ گیر; Calmodulin; Ca2+; Cav1.2; N-lobe; C-lobe; Patch clamp;
Impact of the whole-cell patch-clamp configuration on the pharmacological assessment of the hERG channel: Trazodone as a case example
Keywords: پچ گیر; hERG, human ether-a-go-go related gene; HEK-293, human embryonic kidney cells; IhERG, hERG K+ current; IKr, cardiac rapidly activating delayed rectifier K+ currenthERG channels; Methods; Patch clamp; HEK-293 cells; Trazodone; Whole-cell
Stimulation effect of wide type CFTR chloride channel by the naturally occurring flavonoid tangeretin
Keywords: پچ گیر; CFTR chloride channel; Tangeretin; Activator; Fluorescence quenching tests; Patch clamp; Short-circuit current
Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide
Keywords: پچ گیر; Domiphen bromide (PubChem CID: 10866); Didecyl dimethylammonium bromide (PubChem CID: 16957)Quaternary ammonium compounds; Patch clamp; HERG channel
Integrative understanding of hypoxic pulmonary vasoconstriction using in vitro models: from ventilated/perfused lung to single arterial myocyte
Keywords: پچ گیر; hypoxic pulmonary vasoconstriction; K+ channel; oxygen; patch clamp; pulmonary artery; smooth muscle
GATA-4 induces changes in electrophysiological properties of rat mesenchymal stem cells
Keywords: پچ گیر; CM; cardiomyocytes; MSC; mesenchymal stem cells; MSCNull; MSC transduced only with EGFP; MSCGATA-4; MSC transduced with GATA-4 and EGFP; IK1; inward rectifier K+ current; IKDR; delayed rectifier K+ current; Ito; transient outward K+ current; INa.TTX; TTX-