دانلود مقالات ISI درباره PD، بیماری پارکینسون + ترجمه فارسی

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

Keywords: PD، بیماری پارکینسون; ASK1, apoptosis signal-regulating kinase 1; Hsp, heat shock protein; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MPP+, 1-methyl-4-pyridinium; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson's disease; PGC-1α, pe

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Estradiol promotes proliferation of dopaminergic precursors resulting in a higher proportion of dopamine neurons derived from mouse embryonic stem cells

Keywords: PD، بیماری پارکینسون; DA, dopamine; E2, estradiol; ER, estrogen receptor; ESC, embryonic stem cells; FGF, Fibroblast growth factor; GAPDH, Glyceraldehyde phosphate dehydrogenase; PD, Parkinson's disease; SHH, Sonic hedgehog; TH, tyrosine hydroxylaseDopamine neurons; Embryonic

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Blockade of the translocation and activation of c-Jun N-terminal kinase 3 (JNK3) attenuates dopaminergic neuronal damage in mouse model of Parkinson's disease

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; DA, dopaminergic; SNc, substantia nigra pars compacta; NMDA, N-methyl-d-aspartate; DNQX, 6,7-dinitroquinoxaline-2,3(1H,4H)-dione; MAPK, mitogen-activated protein kinase; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; JNK, c-J

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Dopaminergic Modulation of Motor Maps in Rat Motor Cortex: An In Vivo Study

Keywords: PD، بیماری پارکینسون; dopamine; somatotopy; motor cortex; stimulation mapping; multielectrode arrayDA, dopamine; IPSC, inhibitory post-synaptic current; M1, primary motor cortex; NMDA, N-methyl-d-aspartate; PD, Parkinson's disease; PFC, prefrontal cortex; SCH 23390, R-(+),8-ch

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis

Keywords: PD، بیماری پارکینسون; UPLC/MS, ultra performance liquid chromatography/mass spectrometry; COMT, catechol-O-methyl transferase; PD, Parkinson's disease; PCA, principal component analysis; LTBS, liver toxicity biomarker study; TIC, total ion chromatogramsUPLC/MS; Metabonomics; T

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide

Keywords: PD، بیماری پارکینسون; LPS, lipopolysaccharide; CNS, central nerve system; E. coli, Escherichia coli; UTI, urinary tract infections; DA, dopamine; SN, substantia nigra; SNc, substantia nigra pars compacta; SNr, substantia nigra pars reticulate; PD, Parkinson's disease; 5-HT, se

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Reduced performance in balance, walking and turning tasks is associated with increased neck tone in Parkinson's disease

Keywords: PD، بیماری پارکینسون; ADL, activities of daily living; ANOVA, analysis of variance; BBS, Berg Balance Scale; PD, Parkinson's disease; PIGD, postural instability and gait difficulty, items 27–30 in UPDRS; TUG, Timed Up and Go test; UPDRS, Unified Parkinson's disease rating scal

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism

Keywords: PD، بیماری پارکینسون; AST, Astaxanthin; ROS, Reactive oxygen species; PD, Parkinson's disease; DHA-OOH, Docosahexaenoic acid hydroperoxide; 6-OHDA, 6-hydroxydopamine; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideAstaxanthin; Parkinson's disease; Neuronal ap

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models

Keywords: PD، بیماری پارکینسون; AAV, adeno-associated virus; AADC, aromatic l-amino acid decarboxylase; CT, X-ray computed tomography; FDOPA, 6-[18F]fluoro-l-dihydroxyphenylalanine; FMT, 6-[18F]fluoro-l-m-tyrosine; MR, magnetic resonance imaging; PD, Parkinson's disease; PET, Positron e

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Toxicokinetics and toxicodynamics of paraquat accumulation in mouse brain

Keywords: PD، بیماری پارکینسون; ANOVA, analysis of variance; BBB, blood brain barrier; FCtx, frontal cortex; PD, Parkinson's disease; PDP, Parkinson's disease phenotype; PQ, paraquat; ROS, reactive oxygen species; SN, substantia nigra; STR, striatum; TK, toxicokinetics; TD, toxicodynami

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

Keywords: PD، بیماری پارکینسون; SN, substantia nigra; PD, Parkinson's disease; MPP+, 1-methyl-4-phenylpyridinium; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; DMT1, divalent metal transporter 1; IRE, iron responsive element; TfR, transferrin receptor; UTR, untranslational region;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins

Keywords: PD، بیماری پارکینسون; DLST, dihydrolipoyl succinyl transferase; DLD, dihydrolipoamide dehydrogenase; OGDH, α-ketoglutarate dehydrogenase; KGDHC, α-ketoglutarate dehydrogenase complex; AD, Alzheimer's disease; HD, Huntington's disease; PD, Parkinson's disease; 8OH2dG, 8-hydroxy

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

E46K Parkinson’s-Linked Mutation Enhances C-Terminal-to-N-Terminal Contacts in α-Synuclein

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; αS, α-synuclein; PRE, paramagnetic relaxation enhancement; WT, wild type; RDC, residual dipolar coupling; HSQC, heteronuclear single quantum coherence; NIH, National Institutes of Healthsynuclein; Parkinson's; amyloid; protein agg

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Statins: Mechanisms of neuroprotection

Keywords: PD، بیماری پارکینسون; HMG-CoA, 3-hydroxy-3-methylglutaryl co-enzyme A; AD, Alzheimer's disease; PD, Parkinson's disease; MS, multiple sclerosis; CNS, central nervous system; BBB, blood–brain barrier; LDL, low-density lipoprotein; CSF, cerebrospinal fluid; FPP, farnesyl pyropho

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2009 سفارش ترجمه

Expression pattern of NuIP gene in adult mouse brain

Keywords: PD، بیماری پارکینسون; DA, dopamine; PD, Parkinson's disease; NuIP, Nurr1 interacting protein; VM, ventral mesencephalon; NRs, nuclear receptors; NLBD, Nurr1 ligand binding domain; RXRα, retinoid X receptor alphaNurr1; Protein interactor; G protein

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2009 سفارش ترجمه

CD 4+ T cells in the pathobiology of neurodegenerative disorders

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; AD, Alzheimer's disease; HAND, HIV-1 associated neurocognitive disorders; MP, mononuclear phagocytes; Treg, regulatory T cells; Teff, effector T cells; BBB, blood brain barrier.

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Structural Reorganization of α-Synuclein at Low pH Observed by NMR and REMD Simulations

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; NAC, non-amyloid β component; IDP, intrinsically disordered protein; R2CPMG, CPMG-type transverse relaxation; RDC, residual dipolar coupling; PRE, paramagnetic relaxation enhancement; MTSL, (1-oxy-2,2,5,5-tetra-methyl-3-pyrroline-

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Nanotechnological applications for the treatment of neurodegenerative disorders

Keywords: PD، بیماری پارکینسون; NDs, Neurodegenerative disorders; AD, Alzheimer's disease; PD, Parkinson's disease; BBB, Blood–brain barrier; CNS, Central nervous system; PBCA, Poly(butylcyanoacrylate); CQ, Clioquinol; ThT, Thioflavin-T; PEG, Polyethylene glycol; RES, Reticuloendothelia

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

At Low Concentrations, 3,4-Dihydroxyphenylacetic Acid (DOPAC) Binds Non-Covalently to α-Synuclein and Prevents Its Fibrillation

Keywords: PD، بیماری پارکینسون; DOPAC, 3,4-dihydroxyphenylacetic acid; α-Syn, α-synuclein; PD, Parkinson's disease; MS, mass spectrometry; ThT, thioflavin T; EM, electron microscopy; AFM, atomic force microscopy; SEC, size-exclusion chromatography; ESI, electrospray ionization; NBT, nit

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of α-Synuclein in a pH-Dependent Manner

Keywords: PD، بیماری پارکینسون; α-syn, α-synuclein; DA, dopamine; PD, Parkinson's disease; EM, electron microscopy; ThT, thioflavin T; DHI, 5,6-dihydroxylindole; FTIR, Fourier transform infrared spectroscopyα-synuclein; dopamine; Parkinson's disease; amyloid; oligomer

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2009 سفارش ترجمه

Secretion of DJ-1 into the serum of patients with Parkinson's disease

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; CNS, central nervous system; CFS, cerebrospinal fluid; 8-OHdG, 8-hydroxy-2-deoxyguanosine; 8-OHG, 8-hydroxyguanosineDJ-1; Parkinson's disease; Secretion; Biomarker

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Impact of Tyr to Ala mutations on α-synuclein fibrillation and structural properties

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; ThT, Thioflavin T; CD, circular dichroism; ATR, attenuated total reflectanceα-synuclein; Tyr's mutant; Fibrillation; Secondary structure; ThT fluorescence assay; Long-range intramolecular interaction

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Neuroprotective effects of rotigotine in the acute MPTP-lesioned mouse model of Parkinson's disease

Keywords: PD، بیماری پارکینسون; DA, dopamine; DAT, dopamine transporter; FJ, FluoroJade; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson's disease; SD, standard deviation; SN, substantia nigraRotigotine; Dopamine agonist; Continuous administration; Striatum; Substantia

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; CDKs, cyclin-dependent kinases; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MEF2, myocyte enhancer factor 2Parkinson's disease; cdk5; E2F-1; Cell cycle

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Emotion recognition impairment and apathy after subthalamic nucleus stimulation in Parkinson's disease have separate neural substrates

Keywords: PD، بیماری پارکینسون; DBS, deep brain stimulation; STN, subthalamic nucleus; PD, Parkinson's disease; UPDRS, unified Parkinson's Disease Rating Scale; H&Y, Hoehn and Yahr score; S&E, Schwab and England score; AES, Apathy Evaluation ScaleParkinson's disease; Deep brain stimulat

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Planning in Parkinson's disease: A matter of problem structure?

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; TOL, Tower of London; NART, National Adult Reading Test; MMSE, Mini Mental Status Exam; DRS-2, Dementia Rating Scale; BDI-II, Beck Depression Inventory-II; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders-IV; UPDRS, U

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid

Keywords: PD، بیماری پارکینسون; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; BSA, bovine serum albumin; CDK, cyclin-dependent kinase; CyD1, cyclin D1; CyE, cyclin E; HD, Huntington's disease; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson's disease; PV

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis

Keywords: PD، بیماری پارکینسون; DAPI, 4′,6-diamidino-2-phenylindole; DCF, 2′,7′-dichlorofluorescein; H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; H2O2, hydrogen peroxide; HO-1, heme oxygenase-1; MAP kinase, mitogen-activated protein kinase; PD, Parkinson's disease; PI3K, phospha

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Intracerebral VEGF injection highly upregulates AQP4 mRNA and protein in the perivascular space and glia limitans externa

Keywords: PD، بیماری پارکینسون; AQP4, aquaporin-4; BBB, blood–brain barrier; IR, immunoreactivity; PD, Parkinson's disease; SN, substantia nigra; VEGF, vascular endothelial growth factorBlood–brain barrier; FITC-albumin; Substantia nigra; Ventral mesencephalon

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Alteration in the differentiation-related molecular expression in the subventricular zone in a mouse model of Parkinson's disease

Keywords: PD، بیماری پارکینسون; GFAP, glial fibrillary acidic protein; Iba-1, ionized calcium-binding adapter molecule-1; KO, knockout; NSCs, neural stem cells; OB, olfactory bulb; PD, Parkinson's disease; PSA-NCAM, polysialylated neural cell adhesion molecule; SVZ, subventricular zoneP

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Neurotoxicity of MPTP to migrating neuroblasts: Studies in acute and subacute mouse models of Parkinson's disease

Keywords: PD، بیماری پارکینسون; Dcx, doublecortin; MAO-B, type B monoamine oxidase; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson's disease; RMS, rostral migratory stream; SN, substantia nigra; SVZ, subventricular zone; TH, tyrosine hydroxylase; TUNEL, terminal deoxy

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Oscillatory activity in the pedunculopontine area of patients with Parkinson's disease

Keywords: PD، بیماری پارکینسون; a.u., arbitrary units; DBS, deep brain stimulation; GPi, globus pallidus interna; LFP, local field potentials; MRI, magnetic resonance imaging; PD, Parkinson's disease; PPN, pedunculopontine nucleus; STN, subthalamic nucleus; UPDRS, unified Parkinson's di

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Functional effect of FGF2- and FGF8-expanded ventral mesencephalic precursor cells in a rat model of Parkinson's disease

Keywords: PD، بیماری پارکینسون; 6-OHDA, 6-hydroxydopamine; DA, Dopamine; DIV, Days in vitro; ED, Embryonic day; FGF, Fibroblast growth factor; HPLC, High performance liquid chromatography; -ir, Immunoreactive; NSCs, Neural stem cells; PD, Parkinson's disease; TH, Tyrosine hydroxylase; V

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

MsrA knockout mouse exhibits abnormal behavior and brain dopamine levels

Keywords: PD، بیماری پارکینسون; aCSF, artificial cerebrospinal fluid; AD, Alzheimer's disease; DA, dopamine; DAT, DA transporter; PD, Parkinson's disease; MetO, methionine sulfoxide; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Msr, methionine sulfoxide reductase; 6-OHDA, 6-hydro

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

The control of upright stance in young, elderly and persons with Parkinson's disease

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; COM, Centre of mass; COP, Centre of pressureParkinson's disease; Elderly; Postural control; Centre of pressure; Centre of mass

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Oxidative and nitrative protein modifications in Parkinson's disease

Keywords: PD، بیماری پارکینسون; α-syn, α-synuclein; PD, Parkinson's disease; SN, substantia nigra; PTM, posttranslational modification; GSH, glutathione (reduced); GSSG, glutathione (oxidized); MDA, malondialdehyde; HNE, 4-hydroxy-2-nonenal; 8OHG, 8-hydroxyguanosine; 3NT, 3-nitrotyrosin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

The firing activity of presumed cholinergic and non-cholinergic neurons of the pedunculopontine nucleus in 6-hydroxydopamine-lesioned rats: An in vivo electrophysiological study

Keywords: PD، بیماری پارکینسون; DRN, dorsal raphe nucleus; EP, entopeduncular nucleus; 6-OHDA, 6-hydroxydopamine; ISIH, interspike interval histogram; LDT, laterodorsal tegmental nucleus; PD, Parkinson's disease; PPN, pedunculopontine nucleus; SNc, substantia nigra pars compacta; SNr, s

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; MTT, MTT-tetrazole (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); ROS, oxygen free radicals; EM, electron microscopyParkinson disease; SH-SY5Y cells; Catuaba; Cytoprotective; Rotenone

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

The neuronal activity of thalamic parafascicular nucleus is conversely regulated by nigrostriatal pathway and pedunculopontine nucleus in the rat

Keywords: PD، بیماری پارکینسون; DA, dopamine; EP, entopeduncular nucleus; 6-OHDA, 6-hydroxydopamine; ISI, interspike interval; ISIH, interspike interval histogram; PD, Parkinson's disease; PF, thalamic parafascicular nucleus; PPN, pedunculopontine nucleus; SNc, substantia nigra pars com

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Crystal structure and molecular dynamics simulation of ubiquitin-like domain of murine parkin

Keywords: PD، بیماری پارکینسون; AR-JP, autosomal recessive juvenile Parkinsonism; esd, estimated standard deviation; DLM, dynamic light scattering; MD, molecular dynamics; PD, Parkinson's disease; rmsd, root-mean-square deviation; SAD, single-wavelength anomalous diffusion; Uld, ubiquit

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Developmental heptachlor exposure increases susceptibility of dopamine neurons to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)in a gender-specific manner

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; MPTP, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; DAT, dopamine transporter; VMAT2, vesicular monoamine transporter 2; TH, tyrosine hydroxylase; MPP+, N-methyl-4-phenyl pryidinium; DA, dopamine; 5-HT, serotonin; DOPAC, 3,4-dihyd

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Structural Characteristics of α-Synuclein Oligomers Stabilized by the Flavonoid Baicalein

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; AFM, atomic force microscopy; SEC, size exclusion chromatography; FTIR, Fourier transform infrared spectroscopy; SAXS, small-angle X-ray scattering; EM, electron microscopy; ATR, attenuated total reflectance; ThT, thioflavin T; PA

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway

Keywords: PD، بیماری پارکینسون; 6-OHDA, 6-hydroxydopamine; l-NOARG, NG-nitro-l-arginine; DA, dopaminergic; NOS, nitric oxide synthase; nNOS, neuronal nitric oxide synthase; TH, tyrosine-hydroxylase; PD, Parkinson's disease; TH+, tyrosine-hydroxylase positive; nNOS+, neuronal nitric oxid

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Sporadic midbrain dopamine neuron abnormalities in laboratory mice

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; PDP, Parkinson's disease phenotype; VM, ventral midbrain; STR, striatum; FCtx, frontal cortex; DA, dopamine; DAergic, dopaminergic; DOPAC, dihydroxyphenylacetic acid; HVA, homovanillic acid; SNpc, substantia nigra pars compacta; V

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures

Keywords: PD، بیماری پارکینسون; 6-OHDA, 6-hydroxydopamine; PD, Parkinson's disease; SN, substantia nigra; ROS, reactive oxygen species; CMC, carboxymethylcellulose; MFB, medial forebrain bundle; TH, tyrosine hydroxylase; DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, homovanillic acid; 5-H

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: Therapeutic implications for Parkinson's disease explained via in silico studies

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; SN, Substantia nigra; PN, Peroxynitrite; CI, Mitochondrial complex I; DTNB, 5,5-dithio-bis-2-nitrobenzoic acid; DTT, Dithiothreitol; 3-NT, 3-nitrotyrosine; ROS, Reactive oxygen species; RNS, Reactive nitrogen species; GSH, Glutath

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

α-Synuclein Selectively Binds to Anionic Phospholipids Embedded in Liquid-Disordered Domains

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; 18:0-SM, N-stearoyl-d-sphingomyelin; C6-NBD-PC, 1-palmitoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphocholine; GUV, giant unilamellar vesicle; PI(4,5)P2, phosphatidylinositol-4,5-bisphosphate; TMR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Characterization of Conformational and Dynamic Properties of Natively Unfolded Human and Mouse α-Synuclein Ensembles by NMR: Implication for Aggregation

Keywords: PD، بیماری پارکینسون; PD, Parkinson's disease; aS, α-synuclein; bS, β-synuclein; gS, γ-synuclein; NAC, non-Aβ amyloid component; SSP, secondary structure propensity; R1, longitudinal relaxation rate; R2, transverse relaxation rate; 1H-15N NOE, steady-state heteronuclear nuclea

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

An scFv Intrabody against the Nonamyloid Component of α-Synuclein Reduces Intracellular Aggregation and Toxicity

Keywords: PD، بیماری پارکینسون; syn, synuclein; NAC, nonamyloid component; scFv, single-chain variable fragment; PD, Parkinson's disease; htt, huntingtin; SAPE, streptavidin-R-phycoerythrin; CDR, complementarity-determining region; NLS, nuclear localization signal; DAPI, 4′,6-diamidino-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice

Keywords: PD، بیماری پارکینسون; DA, dopamine; H&E, hematoxylin and eosin; LB, Lewy body; PD, Parkinson's disease; SNc, substantia nigra pars compacta; Tg, transgenic; TH, tyrosine hydroxylase; VTA, ventral tegmental areaParkinson's disease; Animal model; α-Synuclein; Transgenic mouse; T

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه