Immune targeting of PD-1hi expressing cells during and after antiretroviral therapy in SIV-infected rhesus macaques
Keywords: PD-1; Treg; ART; Immunomodulation; Viremia;
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Recent advances in melanoma systemic therapy. BRAF inhibitors, CTLA4 antibodies and beyond
Keywords: Melanoma; Targeted therapy; Immunotherapy; Inhibitor; BRAF; NRAS; KIT; CTLA4; PD-1; PD-L1;
Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency
Keywords: Human; T cells; signal transducer and activator of transcription 3 deficiency; cell activation; naive B cells; Bcl6; B-cell lymphoma 6; CD40L; CD40 ligand; CD62L; L-selectin; CSR; Class-switch recombination; GC; Germinal center; ICOS; Inducible costimulat
Regulation of B7-H1 expression on peripheral monocytes and IFN-γ secretion in T lymphocytes by HBeAg
Keywords: Hepatitis B virus E antigen; B7-H1; PD-1; Toll-like receptors 2; Monocyte; Innate immunity; Regulate
Enhanced expression of LAG-3 on lymphocyte subpopulations from persistently lymphocytotic cattle infected with bovine leukemia virus
Keywords: LAG-3; MHC class II; PD-1; PD-L1; BLV; IFN-γ; IL-2
HCV-specific CD8+ cell detection at week 12 of chronic hepatitis C treatment with PEG-interferon-α2b/ribavirin correlates with infection resolution
Keywords: HCV-specific CTL response; Chronic hepatitis C; Sustained virologic response; Peg-interferon α2b; Ribavirin; PD-1; Treatment response predictive factor
Role of PD-L1/PD-1 in the immune response to respiratory viral infections
Keywords: PD-1; B7-H1; B7-DC; Viruses;
What are regulatory T cells (Treg) regulating in cancer and why?
Keywords: TGF-β; transforming growth factor beta; nTreg; natural regulatory T cells; iTreg; inducible regulatory T cells; PGE2; prostaglandin E2; COX2; cyclooxygenase 2; TIL; tumor infiltrating lymphocytes; CTL; cytotoxic T lymphocytes; NK cells; natural killer ce
The composition of the microenvironment in follicular lymphoma is associated with the stage of the disease
Keywords: Follicular lymphoma; PD-1; FoxP3; Microenvironment
Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers
Keywords: T cells; Silica; CTLA-4; PD-1; Polymorphisms; Autoimmunity
Research ArticleA predictive model of treatment outcome in patients with chronic HCV infection using IL28B and PD-1 genotyping
Keywords: HCV; hepatitis C virus; PD-1; Programmed Cell Death-1; Peg-IFN; pegylated interferon; KIR; killer immunoglobulin-like receptors; HLA; human leukocyte antigens; SVR; sustained virological responders; NR; non responders; CTL; cytolytic T lymphocytes; HC; he
The Role of Sipuleucel-T in Therapy for Castration-Resistant Prostate Cancer: A Critical Analysis of the Literature
Keywords: Immunotherapy; Prostate cancer; Sipuleucel-T; CTLA-4; PD-1; Prostvac VF Tricom; Ipilimumab
Influence of cytomegalovirus infection on immune cell phenotypes in patients with common variable immunodeficiency
Keywords: Human cytomegalovirus; common variable immunodeficiency; programmed death 1; late effector T cell; CD27; CD28; polyfunctional T cell; inflammatory disease; APC; Allophycocyanin; CMV; Cytomegalovirus; CVID; Common variable immunodeficiency; FITC; Fluoresce
Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy
Keywords: Respiratory allergies; sublingual immunotherapy; regulatory T cell; epigenetics; CTLA-4; Cytotoxic T-lymphocyte antigen 4; DM; Dust mite; Foxp3; Forkhead box protein 3; GITR; Glucocorticoid-induced TNF receptor; GPS; Grass pollen season; NDC; Nasal disk c
PD-L2 is expressed on activated human T cells and regulates their function
Keywords: PD-1; programmed death 1; PD-L; programmed death 1 ligand; APCs; antigen presenting cells; TcR; T cell receptor; mAb; monoclonal antibody; T cells; Cell activation; Costimulatory molecules; PD-L2;
Follicular programmed death 1–positive lymphocytes in the tumor microenvironment are an independent prognostic factor in follicular lymphoma
Keywords: PD-1; Follicular lymphoma; Prognostic factors
Impaired hepatitis B vaccine responses during chronic hepatitis C infection: Involvement of the PD-1 pathway in regulating CD4+ T cell responses
Keywords: HCV; hepatitis C virus; PD-1; programmed death-1; PDL-1; programmed death ligand-1; HIV; human immunodeficiency virus; PBMC; peripheral blood mononuclear cells; FACS; fluorescence-activated cell sorting; SD; standard deviation; STAT-1; signal transducer a
Characterization of CTLA-4, PD-1 and PDL-1 of swamp and riverine type water buffaloes
Keywords: CTLA-4; PD-1; PDL-1; Water buffalo
Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127− HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection
Keywords: HCV; Viral persistence; PD-1; CD127; PD-L1; z-VAD-fmk; Bim; Cytotoxic T lymphocytes; Chronic hepatitis; Apoptosis
Programmed death-1 is required for systemic self-tolerance in newly generated T cells during the establishment of immune homeostasis
Keywords: Autoimmunity; Tolerance; PD-1; Thymic selection; Co-inhibition;
Dysregulated Generation of Follicular Helper T Cells in the Spleen Triggers Fatal Autoimmune Hepatitis in Mice
Keywords: Autoimmune Liver Disease; Pathogenesis; Follicular Helper T Cells; AIH; autoimmune hepatitis; ANA; antinuclear antibody; APC; allo-phycocyanin; CXCR; CXC chemokine receptor; EAE; experimental autoimmune encephalomyelitis; GC; germinal center; ICOS; induci
Asthma translational medicine: Report card
Keywords: ACQ; asthma control questionnaire; AHR; airway hyper-responsiveness; AP-1; activator protein 1; APC; antigen-presenting cell; AQLQ; asthma quality-of-life questionnaire; BALF; bronchoalveolar lavage fluid; CTLA-4; cytotoxic T lymphocyte-associated antigen
PD-1, gender, and autoimmunity
Keywords: PD-1; Gender; Sex hormones; Autoimmunity; Systemic lupus erythematosus; Immune system
Reviews and feature articleTH2 heterogeneity: Does function follow form?
Keywords: TH2; heterogeneity; T cell; IL-5; differentiation; lineage; DC; Dendritic cell; ICCS; Intracellular cytokine staining; ICOS; Inducible costimulator; PD-1; Programmed death 1; TFH; Follicular helper; TSLP; Thymic stromal lymphopoietin;
Overexpression of programmed death-1 ligand-1 on NIT cells lead to negative regulation of allogeneic lymphocyte activation
Keywords: PD-L1; Alloimmune responses; Apoptosis; Cytokine; Negative regulation; NIT-1 cells; PD-1; Proliferation; Immune responses; Autoimmune diseases;
Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A
Keywords: T-lymphocytes; Demyelination; CMT; PD-1; RAG-1; Peripheral nerves; Macrophages; Schwann cells; Co-inhibitory molecule;
HCV Research 20 Years After Discovery: A Summary of the 16th International Symposium on Hepatitis C Virus and Related Viruses
Keywords: apo; apolipoprotein; CTLA-4; cytotoxic T-lymphocyte antigen 4; ER; endoplasmic reticulum; GADD45β; growth arrest and DNA damage-inducible 45β; GRE; GU-rich element; HVR1; hypervariable region 1; IFN; interferon; IL; interleukin; IRF; interferon-regulato
Receptors and ligands implicated in human T cell costimulatory processes
Keywords: ADA; adenosine deaminase; ALCAM; activated leukocyte cell adhesion molecule; BTLA; B- and T lymphocyte attenuator; BTNL2; butyrophilin-like 2; DAF; decay accelerating factor; DC-SIGN; dendritic cell-specific ICAM-3-grabbing nonintegrin; DR3; death recepto
IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo
Keywords: Ag; antigen; alumOVA; alum-precipitated ovalbumin; TFh cells; follicular helper CD4 T cells; LN; lymph node; OVA; ovalbumin; PD-1; programmed cell death gene-1; Th cells; Th cellsT helper cells; Aluminum adjuvant; CD4 T cells; CD8 T cells; Cytokines; Cyto
Programmed death 1 expression in variant immunoarchitectural patterns of nodular lymphocyte predominant Hodgkin lymphoma: comparison with CD57 and lymphomas in the differential diagnosis
Keywords: Nodular lymphocyte predominant Hodgkin lymphoma; PD-1; NAT-105; T-cell and histiocyte-rich B-cell lymphoma; Immunohistochemistry
Immunotherapy for Prostate Cancer: An Emerging Treatment Modality
Keywords: Prostate cancer; Vaccine; T cell; Lymphocyte; CTLA4; PD-1;
Immune responses to malignancies
Keywords: Cancer; immunity; tumor escape; immune suppression; effector T cells; Anx; Annexin V; APC; Antigen-presenting cell; APM; Antigen-processing machinery; β2 m; β2-microglobulin; CTL; Cytolytic T lymphocyte; DC; Dendritic cell; FasL; Fas ligand; FOXP3; Fork
Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B
Keywords: AA; amino acids; APC; allophycocyanin; CMV; cytomegalovirus; CTLA-4; cytotoxic T-lymphocyte-associated antigen-4; FITC; fluorescein isothiocyanate; FLU; influenza; IFN; interferon; IL; interleukin; LIL; liver infiltrating lymphocytes; PBMC; peripheral blo
Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4+ T lymphocytes via an interleukin-2-dependent mechanism
Keywords: T cell; Tolerance; Anergy; PD-1
Age-associated up-regulation of a negative co-stimulatory receptor PD-1 in mouse CD4+ T cells
Keywords: Co-stimulatory receptor; PD-1; T lymphocyte; Effector-memory T cell; Mouse; Aging
New insights into the immunopathogenesis of chronic hepatitis C
Keywords: Hepatitis C; Regulatory T cells; PD-1; Immunotherapy
Human iris pigment epithelial cells suppress T-cell activation via direct cell contact
Keywords: immune privilege; iris pigment epithelial cell; co-stimulatory molecule; PD-1; PD-L1; PD-L2
Differentiation-Induced Post-Transcriptional Control of B7-H1 in Human Trophoblast Cells
Keywords: Placenta; Trophoblast; Syncytiotrophoblast; Epidermal growth factor; Interferon-gamma; mTOR; Polysomal RNA; Phosphatidylinositol 3-kinase; B7-H1; PD-L1; PD-1
Increased programmed death-1+ tumor-infiltrating lymphocytes in classical Hodgkin lymphoma substantiate reduced overall survival
Keywords: Hodgkin lymphoma; PD-1; Prognosis; Receiver operating characteristics (ROC) curves; Tissue microarrays
The Accelerating Pace of HCV Research: A Summary of the 15th International Symposium on Hepatitis C Virus and Related Viruses
Keywords: CLDN1; claudin-1; HCVcc; cell culture-infectious virus; HCVpp; hepatitis C virus-pseudotyped viral particles; IFN; interferon; ISG; interferon-stimulated gene; OCLN; occludin; PD-1; programmed death-1; TLR; Toll-like receptor;
Programmed death-1 receptor negatively regulates LPS-mediated IL-12 production and differentiation of murine macrophage RAW264.7 cells
Keywords: PD-1; IL-12; SHP-2; JNK phosphorylation; Endocytic activity; Macrophages;
Prostate cancer lesions are surrounded by FOXP3+, PD-1+ and B7-H1+ lymphocyte clusters
Keywords: Tumour-infiltrating lymphocytes; FOXP3; Tregs; PD-1; B7-H1; Exhausted lymphocytes
Increased Programmed Death-1 Molecule Expression in Cytomegalovirus Disease and Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation
Keywords: Cytomegalovirus; PD-1; GVHD; Hematopoietic cell Transplant (HCT)
Maternal PD-1 regulates accumulation of fetal antigen-specific CD8+ T cells in pregnancy
Keywords: PD-1; PDCD1; B7-H1; T cells; Pregnancy; Maternal–fetal tolerance
Altered availability of PD-1/PD ligands is associated with the failure to control autoimmunity in NOD mice
Keywords: Costimulation; Diabetes; Autoimmunity; B7-H1; B7-DC; PD-1;
Effect of peptide pools on effector functions of antigen-specific CD8+ T cells
Keywords: CBA; cytokine bead array; CFSE; 5, 6-carboxyfluorescein diacetate succinimidyl ester; CMV; cytomegalo virus; EBV; Epstein-Barr virus; HCV; hepatitis C virus; HEV; hepatitis E virus; HDV; hepatitis D virus; HLA; human leukocyte antigen; ICS; intracellula
Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis
Keywords: ANCA; Vasculitis; CTLA-4; PD-1; SNP; Wegener's granulomatosis, Promoter polymorphism
Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia
Keywords: Non-Hodgkin lymphoma; PD-1; PD-L1, PD-L2; Immunohistochemistry; Chronic lymphocytic leukemia; Angioimmunoblastic T-cell lymphoma
Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment
Keywords: Hepatitis C virus; CD8+ T cells; CD4+ T cells; IFN α/ribavirin therapy; T cell failures; PD-1; PD-L1;
Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization
Keywords: CTLA; cytotoxic T-lymphocyte-associated antigen; EBV; Epstein-Barr virus; FACS; fluorescence-activated cell sorter; FITC; fluorescein isothiocyanate; Flu; influenza virus; HIV; human immunodeficiency virus; IFN; interferon; LIL; liver-infiltrating lym