Keywords: CoA; coenzyme A; TCA; tricarboxylic acid; [Ca2+]i; cytosolic free Ca2+; E-C; excitation-contraction; SR; sarcoplasmic reticulum; SERCA; SR Ca2+-ATPase; AMPK; adenosine monophosphate-activated protein kinase; MEF2; myocyte enhancer factor-2; PPAR; peroxiso
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Keywords: Ad; adenovirus; ADP; adenosine diphosphate; ATP; adenosine triphosphate; ATP-5β; ATP synthase 5β; BNP; brain natriuretic peptide; β-MHC; β-myosin heavy chain; CPT; carnitine palmitoyltransferase; Cyt b; cytochrome b; ERR; estrogen-related receptor; FA
Keywords: Coregulators; Metabolism; Skeletal muscle; PGC-1;
Keywords: DAG; diacylglycerol; dN/dS; rate of nonsynonymous-to-synonymous amino acid substitutions; EF-1α; elongation factor-1 alpha; G3P; glycerol 3-phosphate; GPAT; glycerol 3-phosphate acyltransferase; HKG; housekeeping gene; LPA; lysophosphatidic acid; LPAAT;
Keywords: ANOVA; analysis of variance; ATP; adenosine triphosphate; CK-MB; creatine kinase MB; Drp1; dynamin-related protein 1; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; LC3; microtubule associated protein 1A/1Â B light chain 3; Mfn1; 2 mitofusin 1 2; MOMP;
Keywords: UCP1; PPAR; PGC-1; RXR; Ambient temperature; Carps;
Keywords: ACS; acetyl CoA synthase; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; BDNF; brain derived neurotrophic factor; CPT1; carnitine palmitoyl transferase-1; CR; calorie restriction; CREB; cAMP responsive element binding; DG; dentate gyrus; DR;
Keywords: Melanoma; Mitochondria; Metabolism; PGC-1; MITF; Apoptosis;
Keywords: AICAR; 5â²aminoimidazole-4-carboxyamide-ribonucleoside; AD; Alzheimer's disease; ATF-2; activating transcription factor-2; AMPK; AMP-activated protein kinase; Bnip3; BCL2/adenovirus E1B 19Â kDa interacting protein 3; BnipL/Nix; BCL2/adenovirus E1B 19Â
Keywords: α1AT; α-1-antitrypsin; BM-MSCs; bone-marrow mesenchymal stem cells; COX1; subunit I of the cytochrome c oxidase; COX2; subunit II of the cytochrome c oxidase; COX4; subunit IV of the cytochrome c oxidase; DRP1; dynamin-related protein 1; ECAR; extracell
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Keywords: ER; endoplasmic reticulum; AMD; age-related macular degeneration; RPE; retinal pigment epithelium; PUFAs; polyunsaturated fatty acids; ROS; reactive oxygen species; NRF-2; nuclear factor-erythroid 2-related factor-2; ARE; antioxidant response element; Kea
Oxidative and energetic stresses mediate beta-cell dysfunction induced by PGC-1α
Keywords: Beta cell; Energetic stress; Insulin secretion; Oxidative stress; PGC-1;
Protective mechanisms involving enhanced mitochondrial functions and mitophagy against T-2 toxin-induced toxicities in GH3 cells
Keywords: ROS; Mitochondria; PGC-1; Antioxidant; Apoptosis; Mitophagy;
NF-κB-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis
Keywords: Viral myocarditis; Metabolic remodelling; Mitochondrial oxidative metabolism; Inflammation; NF-κB; PGC-1;
Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy
Keywords: 8-epi-PGF2α; 8-epi-prostaglandin F2α; 8-OH-dG; 8-hydroxy-2-deoxyguanosine; ACC; Acetyl-CoA carboxylase; AdipoR1 and AdipoR2; Adiponectin receptors 1 and 2; AMPK; AMP-dependent kinase; CKD; Chronic kidney disease; COL IV; Type IV collagen; eNOS; Endothel
Estrogen Signals Through Peroxisome Proliferator-Activated Receptorâγ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease
Keywords: NASH; PGC-1; ROS; PGC1B; ALT; alanine aminotransferase; ERA; estrogen receptor-α; 4-HNE; 4 hydroxynonenal; HFHF; high fat/high fructose; LH; liver hemizygous; LKO; liver-specific knockout; mRNA; messenger RNA; mtDNA; mitochondrial DNA; NAFLD; non-alcohol
Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis
Keywords: ACOX-1; acyl-coenzyme A oxidase 1; ALT; alanine aminotransferase; apoE; apolipoprotein E; Arg-1; arginase-1; ASTX; astaxanthin; Casp; caspase; CVD; cardiovascular disease; CPT-1α; carnitine palmitoyltransferase 1α; CD68; cluster of differentiation 68; C
Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents
Keywords: Estrogen-related receptor α; ERRα; Nuclear receptor; Anti-diabetic; Metabolic syndrome; Indazole; Thiazolidenedione; TZD; Insulin resistance; ERR; estrogen-related receptor; ER; estrogen receptor; ERE; estrogen response element; ERRE; estrogen-related r
Intercellular: local and systemic actions of skeletal muscle PGC-1s
Keywords: PGC-1; coactivators; skeletal muscle; metabolism; atrophy; hypertrophy
Gaining Insights into Diabetic Cardiomyopathy from Drosophila
Keywords: metabolism; obesity; cardiomyopathy; TOR; ATGL; PGC-1
Regulation of NAD biosynthetic enzymes modulates NAD-sensing processes to shape mammalian cell physiology under varying biological cues
Keywords: ADPR; ADP ribose; ARTs; ADP ribose transferases; ARTD1; poly-(ADP ribose) polymerase 1; NAADP; nicotinic acid adenine dinucleotide phosphate; CR; calorie restriction; PAR; poly-(ADP ribose); PGC-1; peroxisome proliferator-activated receptor-γ coactivator
PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids
Keywords: Beta cell; PGC-1; Insulin secretion; Lipid metabolism; Mitochondria; Lipolysis
The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo
Keywords: Inflammation; PGC-1; Skeletal muscle; Metabolism; Mitochondria; IL; interleukin; LPS; lipopolysaccharide; MCKα/β; muscle-specific PGC-1α/β transgenic mice; NFκB; nuclear factor κB; PGC-1; peroxisome proliferator-activated receptor γ coactivator 1;
Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression
Keywords: ACTB; Beta Cytoskeletal Actin; ALAS1; Delta-aminolevulinate synthase 1; ATP; Adenosine triphosphate; Ad; Adenoviral; B2M; β2m, Beta 2 microglobulin; BMI; Body mass index; COPD; Chronic obstructive pulmonary disease; CA; Constitutively active; COXIV; Cyto
ReviewThe many roles of PGC-1α in muscle - recent developments
Keywords: PPAR; peroxisomal proliferator activator receptor; PGC-1; PPARgamma-coactivator 1; CD36; Cluster of differentiation 36; CPT1; Carnitine palmitoyl transferase; NRF; Nuclear respiratory factor; ERR; Estrogen related receptor; MAPK; Microtubule associated pr
FABP3 and brown adipocyte-characteristic mitochondrial fatty acid oxidation enzymes are induced in beige cells in a different pathway from UCP1
Keywords: WAT; white adipose tissue; BAT; brown adipose tissue; UCP1; uncoupling protein 1; WA; white adipocyte; BA; brown adipocyte; FAO; fatty acid oxidation; FABP3; fatty acid binding protein3/heart-type fatty acid binding protein; Acyl-CoA; acyl-Coenzyme A; ACS
Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: A key to lean phenotype
Keywords: ACC; acetyl-CoA carboxylase; AMPK; AMP-activated protein kinase; aP2-Ucp1 mice; transgenic mice expressing UCP1 gene from the aP2 gene promoter; AA; arachidonic acid; ATM; adipose tissue macrophages; BAT; brown adipose tissue; BCAA; branched-chain amino a
PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner
Keywords: Hepatic; Metabolism; ChREBP; PGC-1
PGC-1β regulates mouse carnitine-acylcarnitine translocase through estrogen-related receptor α
Keywords: CACT; carnitine/acylcarnitine translocase; ERR; estrogen-related receptor; PGC-1; peroxisome proliferator-activated receptor gamma coactivator 1; PPAR; peroxisome proliferator-activated receptor; PPRE; peroxisome proliferator-activated receptor response e
The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging
Keywords: ALDH2; aldehyde dehydrogenase 2; AMPK; adenosine monophosphate kinase; CREB; cyclic AMP response element binding protein; GNAT; Gcn5-related N-acetyltransferase; HAT; histone acetyltransferase; HDAC; histone deacetylase; LCAD; long chain acetyl-CoA dehydr
Research ArticleLigand-dependent corepressor acts as a novel corepressor of thyroid hormone receptor and represses hepatic lipogenesis in mice
Keywords: LCOR; ligand-dependent corepressor; ob/ob; leptin-deficient; TR; thyroid hormone receptor; TH; thyroid hormone; SRC; steroid receptor coactivators; PGC-1; peroxisome proliferator-activated receptor gamma coactivator-1; NCOR; nuclear receptor corepressor;
Exercise induces mitochondrial biogenesis after brain ischemia in rats
Keywords: exercise; mitochondrial biogenesis; ischemic; neuroprotection; COXIV; C oxidase subunit IV; HSP60; heat shock protein-60; MCAO; middle cerebral artery occlusion; mtDNA; mitochondrial DNA; NRF-1; nuclear respiratory factor 1; PCR; polymerase chain reaction
A high-selenium diet induces insulin resistance in gestating rats and their offspring
Keywords: Akt2; serine/threonine protein kinase 2; BD; basal diet; FPG; fasting plasma glucose; FPI; fasting plasma insulin; FoxO1; forkhead box O1; Gapdh; glyceraldehyde-3-phosphate dehydrogenase; GDM; gestational diabetes mellitus; Gpx; glutathione peroxidase; HO
The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance
Keywords: PPAR; peroxisome proliferator-activated receptor; ERR; estrogen related receptor; PGC-1; PPAR gamma coactivator-1; FAO; fatty acid oxidation; FA; fatty acid; WT; wild-type; HF; high fat; NORC; Nutrition Oriented Research Center; WUSM; Washington Universit
Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction
Keywords: FFA; free fatty acid; PDX1; pancreatic and duodenal homeobox 1; GSIS; glucose-stimulated insulin secretion; JNK; Jun N-terminal kinase; SIRT1; sirtuin 1; PGC-1; peroxisome proliferator-activated receptor gamma coactivator 1; NeuroD; neurogenic differentia
Lipid metabolism in mammalian tissues and its control by retinoic acid
Keywords: ACC; acetyl-coA carboxylase; ACOX; acyl-CoA oxidase; AMPK; AMP-activated protein kinase; atRA; all-trans retinoic acid; BAT; brown adipose tissue; BCMO1; β,β-carotene monooxygenase 1; C/EBP; CCAAT-enhancer binding protein; CAC; carnitine/acylcarnitine c
PGC-1 family coactivators and cell fate: Roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling
Keywords: Mitochondrial biogenesis; Pgc-1; Retrograde signalling; Cancer; Apoptosis; Neurodegeneration; Cellular stress response;
The neurogenic basic helix-loop-helix transcription factor NeuroD6 enhances mitochondrial biogenesis and bioenergetics to confer tolerance of neuronal PC12-NeuroD6 cells to the mitochondrial stressor rotenone
Keywords: bHLH; basic helix-loop-helix; ETC; electron transfer chain; NADH; nicotinamide adenine dinucleotide ubiquinone oxidoreductase; OXPHOS; oxidative phosphorylation; PGC-1; peroxisome proliferator-activated receptor-γ coactivator 1; ROS; reactive oxygen spec
Thyroid hormone differentially modulates Warburg phenotype in breast cancer cells
Keywords: T3; triiodothyronine; T4; thyroxine; 2NBDG; 2-[N-(7-nitrobenz-2-oxa-1,3-diaxol-4-yl)amino]-2-deoxyglucose; DCFDA; 5-(and-6)-chloromethyl-2â²,7â²-dichlorodihydrofluorescein diacetate, acetyl ester; TMRM; tetramethyl rhodamine methyl ester; ROS; reactive
Impact of PGC-1α on the topology and rate of superoxide production by the mitochondrial electron transport chain
Keywords: Mitochondria; PGC-1; ROS; Respiration; Topology; Free radicals
G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart
Keywords: GIT1; PGC-1; Mitochondrial biogenesis; Heart failure; Hypertrophy
Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks
Keywords: Energy metabolism; Functional genomics; Nuclear receptors; PGC-1;
Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease
Keywords: Breast cancer; Chromatin immunoprecipitation; Energy metabolism; Mitochondrion; Nuclear receptor; PGC-1
Forebrain-specific constitutively active CaMKKα transgenic mice show deficits in hippocampus-dependent long-term memory
Keywords: ACSF; artificial cerebrospinal fluid; AMPK; 5Ⲡadenosine monophosphate-activated protein kinase; BDNF; brain-derived neurotrophic factor; CaM; Ca2+/calmodulin; CaMKI; CaM kinase I; CaMKIIα; Ca2+/calmodulin-dependent protein kinase IIα; CaMKIV; CaM kin
Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction
Keywords: DSS, dextran sodium sulfate; FoxO1a, forkhead box O1a; HNF-4α, hepatocyte nuclear factor-4α; HPRT1, hypoxanthine phosphoribosyltransferase 1; IBD, inflammatory bowel disease; IFN-γ, interferon-γ; IL-1β, interleukin-1β; NOS2, nitric oxide synthase 2; PGC-1
Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma
Keywords: Hepatitis C virus; NS5A; Lipid accumulation; PGC-1; PPARγ
A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARαâ/â mice possibly through PGC-1 mediated PPARδ coactivation
Keywords: ACO; fatty acyl-coenzyme A oxidase; ACS; acyl-coenzyme A synthetase; AF-2; activation function-2; LXXLL; leucine-rich amino acid domain; PGC-1; peroxisome proliferator-activated receptor γ coactivator-1; PPAR; peroxisome proliferator-activated receptor;
Hypoxia and the metabolic phenotype of prostate cancer cells
Keywords: ALDO; aldolase; CS; citrate synthase; COX; cytochrome c oxidase; DCA; dichloroacetate; G3PDH; glyceraldehyde-3-phosphate dehydrogenase; G6PDH; glucose-6-phosphate dehydrogenase; HK; hexokinase; HIF; hypoxia-inducible factor; LDH; lactate dehydrogenase; NR
Role of RIP140 in metabolic tissues: Connections to disease
Keywords: Nuclear receptor; Coregulator; RIP140; Metabolism; PGC-1
Mitochondrial function, content and ROS production in rat skeletal muscle: Effect of high-fat feeding
Keywords: Skeletal muscle; Mitochondria; PGC-1; ROS; High-fat diet; Lipid;