Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil
Keywords: [11C]verapamil; [11C]D617; P-glycoprotein; PET; Pgp; Metabolite
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Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood-brain barrier: Protection by the antioxidant N-acetylcysteine
Keywords: Amyloid beta; Alzheimer's disease; Neuroinflammation; Oxidative stress; Lipopolysaccharide; LRP-1; Pgp; N-acetylcysteine;
Cardiovascular pharmacogenetics
Keywords: ABCB1; Human ABC transporter molecule; ACE; Angiotensin-converting enzyme; ADRB; Beta-adrenergic receptor gene; AF; Atrial fibrillation; ApoE; Apolipoprotein E; AR; Adrenergic receptor; CHD; Coronary heart disease; CYP; Cytochrome P450 enzyme; DCM; Dilate
Doing the methylene shuffle - Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine
Keywords: Mitotic kinesins; Eg5; Antimitotic agents; STLC; Molecular dynamics; KSP; cLogD7.4; calculated LogD7.4; cLogS; calculated Log S, where S is the solubility in mol/L; DMEM; Dulbecco's Modified Eagle Medium; Et2O; diethyl ether; EtOAc; ethyl acetate; GI50
Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy
Keywords: AED; antiepileptic drug; ANOVA; analysis of variance; BLA; basolateral nucleus of the amygdala; EEG; electroencephalogram; NeuN; neuronal nuclear antigen; PB; phenobarbital; SE; status epilepticus; SRS; spontaneous recurrent seizures; TLE; temporal lobe e
Innate immunity in cystic fibrosis lung disease
Keywords: Cystic fibrosis; Lung disease; Bacteria; Immunity; Innate immunity; Pattern recognition; Host defense; Chemokines; Toll-like receptors; Neutrophils; Macrophages; Phagocytosis; Migration; IL-17; PGP; Chemokines; Pseudomonas;
The transferrin receptor and the targeted delivery of therapeutic agents against cancer
Keywords: AD; adamantane; ADEPT; antibody-directed enzyme prodrug therapy; ADR; doxorubicin/adriamycin; Av; avidin; AVET; adenovirus-enhanced transferrinfection; ART; artemisinin; BAP; biotin-adaptor peptide; BBB; blood-brain barrier; BFU-E; blast forming unit-er
Strategies to lower the Pgp efflux liability in a series of potent indole azetidine MCHR1 antagonists
Keywords: MCH; Pgp; Indolyl azetidine; Dihydroindolyl azetidine; CNS penetration;
Basic aminopeptidase activity is an emerging biomarker in collagen-induced rheumatoid arthritis
Keywords: AACII; antibody anti-type II collagen; Ang; angiotensin; APB; basic aminopeptidase; BSA; bovine serum albumin; CII; type II collagen; CIA; collagen-induced arthritis; LDH; lactate dehydrogenase; LTA4; leukotriene-A4; LTA4H; leukotriene A4-hydrolase; MF; m
Evaluation of the P-glycoprotein- and breast cancer resistance protein-mediated brain penetration of 11C-labeled topotecan using small-animal positron emission tomography
Keywords: [11C]TPT; PET; Pgp; BCRP; Elacridar
Research ReportP-glycoprotein and breast cancer resistance protein expression and function at the blood-brain barrier and blood-cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats
Keywords: Pgp; Bcrp; Diabetes mellitus; Blood-brain barrier; Choroid plexus; ABC; ATP-binding cassette; aCSF; artificial cerebrospinal fluid; BBB; blood-brain barrier; BCEC; brain capillary endothelial cells; Bcrp; breast cancer resistance protein; BSA; bovine
Non-reducing trisaccharide fatty acid monoesters: Novel detergents in membrane biochemistry
Keywords: ABC; ATP-binding cassette; MDR; multidrug resistance; Pgp; P-glycoprotein; Ni-NTA; nickel nitriloacetic acid; HLB; hydrophilic-lipophilic balance; CMC; critical micelle concentration; DDM; β-dodecylmaltoside; OG; β-octylglucoside; SUL; sucrose monolau
Mitochondrial protein import machineries and lipids: A functional connection
Keywords: CDP-DAG; CDP-diacylglycerol; CL; cardiolipin; ER; endoplasmic reticulum; MDM; mitochondrial distribution and morphology; MIA; mitochondrial intermembrane space assembly; MLCL; monolysocardiolipin; Mmm1; maintenance of mitochondrial morphology; mtHsp70; mi
Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles
Keywords: Polymeric micelles; Cellular uptake; Multidrug resistance; Paclitaxel; Pgp
2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance
Keywords: Pgp; P-glycoprotein; MDR; multiple drug resistance; MRP; multidrug resistance protein; GTP; guanosine triphosphate; MCF-7; Michigan Cancer Foundation-7; NCI; National Cancer Institute; PCC; Pearson correlation coefficient; TLC; thin layer chromatography;
Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization
Keywords: ABI; 2-aryl-4-benzoyl-imidazoles; BCRP; breast cancer resistance protein; MDR; multidrug resistance; MRP; multidrug resistance-associated proteins; Pgp; P-glycoprotein; SAR; structure-activity relationships; SMART; 4-substituted methoxybenzoyl-aryl-thia
Phase I trials of amonafide as monotherapy and in combination with cytarabine in patients with poor-risk acute myeloid leukemia
Keywords: AML; Phase I; P-glycoprotein; Pgp; Multidrug resistance
The immediate large-scale dendritic plasticity of cortical pyramidal neurons subjected to acute epidural compression
Keywords: compression; microtubule; sensorimotor cortex; taxol; trauma; LY; Lucifer Yellow; MAP2; microtubule associated protein 2; PB; phosphate buffer; PBS; phosphate-buffered saline; PGP; protein gene product;
Lipid metabolism in Trypanosoma brucei
Keywords: ACS; fatty acyl-CoA synthetase; CoA; coenzyme A; CL; cardiolipin; DAG; diacylglycerol; ER; endoplasmic reticulum; EPC; ethanolamine phosphorylceramide; GPI; glycosylphosphatidylinositol; GPI-PLC; glycosylphosphatidylinositol phospholipase C; IPC; inositol
Methylcobalamin, but not methylprednisolone or pleiotrophin, accelerates the recovery of rat biceps after ulnar to musculocutaneous nerve transfer
Keywords: BPI; CMAP; methylcobalamin; methylprednisolone; pleiotrophin; CMAPs; compound muscle action potentials; EEN; end-to-end neurorrhaphy; Gap43; growth associated protein 43; MeB12; methylcobalamin; MEPs; motor end plates; MP; methylprednisolone; PGP; Protein
Evidence of Central and Peripheral Sensitization in a Rat Model of Narcotic Bowel-Like Syndrome
Keywords: Visceral Pain; Glia Cells; Morphine; CRD; colorectal distension; L6-S1; lumbar 6 to sacral 1; MRT; mean retention time; NBS; narcotic bowel syndrome; nor-BNI; nor-binaltorphimine; PGP; protein gene product; RMCP; rat mast cell protease;
Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen
Keywords: Neutrophil; Prolyl endopeptidase; PGP; Collagen; Inflammation
Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibility
Keywords: PZQ; praziquantel; Pgp; P-glycoprotein; ABC; ATP-binding-cassette; Schistosoma mansoni; P-glycoprotein; Multidrug resistance; Praziquantel; ABC transporter;
The cytoarchitecture and soma-dendritic arbors of the pyramidal neurons of aged rat sensorimotor cortex: An intracellular dye injection study
Keywords: cortex; dendrite; dendritic spine; plasticity; pyramidal; senile; DAB; 3-3â²-diaminobenzidine tetrahydrochloride; DAPI; 4â²,6-diamidino-2-phenyl-indole; LY; Lucifer Yellow; PB; phosphate buffer; PBS; phosphate-buffered saline; PGP; protein gene product;
Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain
Keywords: calcitonin-gene related peptide; immunohistochemistry; pain; sensory neuron; skin; transient receptor potential channels; CGRP; calcitonin gene-related peptide; CT; cycle threshold; F; female; HET; heterozygous; HO; homozygous; M; male; NF200; neurofilame
Caught in the Act: ATP hydrolysis of an ABC-multidrug transporter followed by real-time magic angle spinning NMR
Keywords: ABC; ATP binding cassette; NMR; nuclear magnetic resonance; ssNMR; solid state NMR; MAS; magic angle spinning; Pgp; P-glycoprotein; TMD; transmembrane domain; NBD; nucleotide binding domain; MD; membrane domain; DDM; n-dodecyl-β-d-maltoside; POPC; 1-palm
P-glycoprotein down-regulates expression of breast cancer resistance protein in a drug-free state
Keywords: MDR; multidrug resistance; Pgp; P-glycoprotein; MRP1; multidrug resistance-associated protein 1; BCRP; breast cancer resistance protein; ABC; ATP-binding cassette; JNK; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; DN-c-Jun; dominant
Restoration of Cough Reflex in Lung Transplant Recipients
Keywords: cough; denervation; innervation; lung transplantation; neurobiology; D5W; 5% dextrose water; EMG; electromyograph; NTR; neurotrophin; PGP; protein gene product; VR1; vanilloid receptor 1;
Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76
Keywords: RLIP76 (RalBP1); Ral-interacting protein; GSH; glutathione; GS-E; glutathione-electrophile conjugates; DNP-SG; dinitrophenyl S-glutathione; COL; colchicine; DOX; doxorubicin; 4HNE; 4-hydroxynonenal; IOVs; inside-out vesicles; LTC4; leukotriene C4; MEFs;
Synthesis of 2-aryl-4-(benzimidazol-2-yl)-1,2-dihydro[1,2,4]triazino-[4,5-a]benzimidazol-1-one derivatives with preferential cytotoxicity against carcinoma cell lines
Keywords: Condensed 1,2,4-triazine; Benzimidazole; Hydrazones; Topoisomerase; MRP-1; Pgp
Cells, mediators and Toll-like receptors in COPD
Keywords: COPD; Toll-like receptor; Corticosteroid; β2-adrenoceptor agonist; Chemokine; PGP
Capsaicin-induced neuronal death and proliferation of the primary sensory neurons located in the nodose ganglia of adult rats
Keywords: nodose ganglion; capsaicin; neurogenesis; neuronal death; rat; sensory neurons; BrdU; 5â²-bromo-2â²-deoxyuridine; cas-3; cleaved caspase 3; DAPI; 4â²,6-diamidino-2-phenylindole; -IR; -immunoreactivity; NfM; neurofilament-M; NG; nodose ganglion; PGP; pr
Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84)
Keywords: Intestine; T84; Pgp; MDR1; Induction
Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation
Keywords: cerebral microvessels; choroid plexus; luminal; abluminal; ABC transporter; Abc; ATP-binding cassette; BBB; blood-brain barrier; BMEC; brain microvessel endothelial cell; CSF; cerebrospinal fluid; CT; cycle threshold; DTT; dithiothreitol; EM; electron m
GIS-based greenery evaluation on campus master plan
Keywords: FASS; Faculty of Art & Social Science; GIS; Geographical Information System; IMRE; Institute of Materials Research and Engineering; I2R; Institute for Infocomm Research; KE7; King Edward VII; KRH; Kent Ridge Hall; LT; Lecture Theater; NUS; National Univer
Paclitaxel C-10 carbamates: Potential candidates for the treatment of neurodegenerative tauopathies
Keywords: Paclitaxel C-10 carbamates; Alzheimer’s disease; Neurodegenerative tauopathies; Microtubules stabilizing agent; Pgp
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP
Keywords: KSP inhibitors; Anti-mitotics; Multidrug-resistance; Pgp; hERG; Kinesins; Pyrazolobenzoxazines; [3+2] Cycloaddition; Quaternary center; Kinesin spindle protein; Cancer
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP
Keywords: KSP inhibitors; Antimitotics; Pgp; Kinesins; 1,4-Diaryl-4,5-dihydropyrazoles; Copper-mediated N-arylation; Kinesin spindle protein; Cancer
Knockdown of PgP resensitizes leukemic cells to proteasome inhibitors
Keywords: Cancer; Drug resistance; Proteasome inhibitors; Drug transporter; PgP; MDR-1;
Cholesterol: Coupling between membrane microenvironment and ABC transporter activity
Keywords: Lipid raft; ABC transporter; ABCB1; DRM; Pgp; Cholesterol; Membrane; Fluidity
Multidrug resistance protein 1 is not associated to detergent-resistant membranes
Keywords: ABC; ATP-binding cassette; AMP; adenosine monophosphate; ATP; adenosine triphosphate; CFTR; cystic fibrosis transmembrane conductance regulator; CRAC; cholesterol recognition/interaction amino acid consensus; DRM; detergent-resistant membrane; HEK; human
Overexpression, purification and characterization of a hexahistidine-tagged recombinant extended nucleotide-binding domain 1 (NBD1) of the Cryptosporidium parvum CpABC3 for rational drug design
Keywords: H6-NBD1; hexahistidine-tagged NBD1; HECAMEG; 6-0-[(N-heptylcarbamoyl)methyl]-α-d-glucopyranoside; IPTG; isopropyl-1-thio-β-d-galactopyranoside; Pgp; P-glycoprotein; NBD; nucleotide-binding domain; TMD; transmembrane domain; TNP-ATP; 2â²,3â²-O-(2,4,6-t
Evidence for changes in the transcription levels of two putative P-glycoprotein genes in sea lice (Lepeophtheirus salmonis) in response to emamectin benzoate exposure
Keywords: P-glycoprotein; Sea lice Lepeophtheirus salmonis; Quantitative RT-PCR; Emamectin benzoate; Up-regulation; ANOVA; analysis of variance; Ct; threshold cycle; DEPC; diethylpyrocarbonate; eEF1α; elongation factor 1; EMB; emamectin benzoate; EST; expressed se
Docetaxel-induced growth inhibition and apoptosis in androgen independent prostate cancer cells are enhanced by 1α,25-dihydroxyvitamin D3
Keywords: Prostate cancer; Docetaxel; 1α,25-Vitamin D3; Growth inhibition; Multidrug resistance proteins; 1,25-VD; 1α,25-dihydroxyvitamin D3; DX; Docetaxel; HRPC; hormone refractory prostate cancer; PSA; prostate specific antigen; PCa; prostate cancer; VDR; vitam
Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells
Keywords: PKC; Protein kinase C; TSA; Trichostatin A; TPA; 12-O-tetradecanoyl-13-phorbol acetate; Pgp; P-Glycoprotein; DNM; Daunomycin; VRP; Varapamil; iHDACs; Histone deacetylase inhibitors; MDR; Multidrug resistance; SAHA; Suberoylanilide hydroxamic acid; Protein
New insights into the regulation of cardiolipin biosynthesis in yeast: Implications for Barth syndrome
Keywords: CL; cardiolipin; CDP-DG; CDP-diacylglycerol; PGP; phosphatidylglycerolphosphate; PG; phosphatidylglycerol; PE; phosphatidylethanolamine; PC; phosphatidylcholine; PS; phosphatidylserine; PI; phosphatidylinositol; MLCL; monolyso-CL; VPA; valproate; AAC; ADP
Research ReportAn evaluation of distinct volumetric and functional MRI contributions toward understanding age and task performance: A study in the basal ganglia
Keywords: C; Caudate; PGp; Putamen/Globus Pallidus; PCTT; Percent Correct Target Trials; PCIT; Percent Correct Inhibition Trials; RTT; Response Time to Targets; BV; Brain Volume in the Anterior-Posterior Commissure Plane; Aging; fMRI; Imaging; Executive functioni
Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance
Keywords: CQ; chloroquine; MQ; mefloquine; AQ; amodiaquine; QN; quinine; QD; quinidine; CQR; chloroquine resistance (or resistant); PfCRT; Plasmodium falciparum chloroquine resistance transporter; MDR; multidrug resistance; QR; quinoline resistance; Pgp; P-glycopro
The Public-Key-Infrastructure of the Radiological Society of Germany
Keywords: Telemedicine; Teleradiology; German Signature Law; Internet; PGP