کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10797842 | 1053228 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mitochondrial protein import machineries and lipids: A functional connection
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
MLCLTim22mtHsp70TIM23SAMPAMCDP-DAGPGPMIAToMMDMCDP-diacylglycerol - CDP-دی سیکللیسرولphosphatidic acid - اسید فسفاتیدیکtranslocase of outer membrane - انتقال غشای خارجیendoplasmic reticulum - شبکه آندوپلاسمی phosphatidylinositol - فسفاتیدیل اینوزیتولphosphatidylcholine - فسفاتیدیل کولینphosphatidylglycerol - فسفاتیدیل گلیسرولphosphatidylglycerol phosphate - فسفاتیدیل گلیسرول فسفاتphosphatidylethanolamine - فسفاتیدیلتانولامینPhosphatidylserine - فسفاتیدیلسرینsorting and assembly machinery - ماشین آلات مرتب سازی و مونتاژMonolysocardiolipin - مونولیسکوردیلوپینMitochondria - میتوکندریاProtein import - واردات پروتئینLipids - چربیهاCardiolipin - کاردیولیپین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Protein trafficking and translocation are essential processes in even the simplest living cells. The compartmentalisation within eukaryotic cells places a very high demand on the fidelity of protein trafficking and translocation, since a large percentage of the cell's protein complement is inserted into, or translocated across membranes. Indeed, most mitochondrial proteins are imported from the cytosol into the organelle and reach their final destination with the assistance of versatile translocation machineries. The first components involved in mitochondrial protein import were identified about 20Â years ago and over the last two decades many new factors and machineries have been brought to light. However, in spite of these discoveries we still have much to explore regarding the molecular mechanisms that distinguish the different mitochondrial import pathways. In particular, an open question that requires deeper exploration is the role of lipids and lipid modifying enzymes in this process. Mitochondrial biogenesis requires the coordinated synthesis and import of both proteins and phospholipids, however, these have typically been considered as distinct research fields. Recent findings have placed phospholipids at the forefront of research dealing with mitochondrial biogenesis, in particular their role in the regulation of mitochondrial transport machineries. This article is part of a Special Issue entitled Protein translocation across or insertion into membranes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1808, Issue 3, March 2011, Pages 1002-1011
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1808, Issue 3, March 2011, Pages 1002-1011
نویسندگان
Natalia Gebert, Michael T. Ryan, Nikolaus Pfanner, Nils Wiedemann, Diana Stojanovski,