دانلود مقالات ISI درباره Pi3K + ترجمه فارسی

Effects of bisphenol A on metabolism and evidences of a mode of action mediated through endocrine disruption

Keywords: Bisphenol A; BPA; Endocrine disruption; Obesity; Type 2 diabetes; Insulin; BAT; brown adipose tissue; BMI; body mass index; bw; body weight; DES; diethylstilbestrol; DM; Diabete mellitus; ED; endocrine disruptor; eGFR; estimated glomerular filtration; ERR

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Nesfatin-1 functions as a switch for phenotype transformation and proliferation of VSMCs in hypertensive vascular remodeling

Keywords: α-SMA; α-smooth muscle actin; BCA; Bicinchoninic acid; CCK-8; Cell counting kit-8; CDK2; cyclin dependent kinase 2; DAPI; 4′,6-diamidino-2-phenylindole; DBP; diastolic blood pressure; DMEM; Dulbecco's modified Eagle's medium; DHE; dhydroethidium; EdU;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Ecdysteroidogenesis and development in Heliothis virescens (Lepidoptera: Noctuidae): Focus on PTTH-stimulated pathways

Keywords: PG; prothoracic gland; BE; brain equivalent; PTTH; prothoracicotropic hormone; MAPK; mitogen-activated protein kinase; PI3K; phosphoinositide 3-kinase; Akt; protein kinase B; TOR; target of rapamycin; EIA; enzyme immunoassay; 4E-BP; translational represso

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

PI3K signaling pathways modulated white spot syndrome virus (WSSV) replication in Procambarus clarkii

Keywords: PI3K; WSSV replication; Apoptosis; Bax; Bax inhibitor-1; Lectin; Toll; Procambarus clarkii;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Muscle-protective effects of Schisandrae Fructus extracts in old mice after chronic forced exercise

Keywords: ANOVA; analysis of variance; A1R; adenosine A1 receptor; CAT; Catalase; DEXA; dual energy X-ray absorptiometry; DW; distilled water; GSH; Glutathione; HE; haematoxylin and eosin; HNE; hydroxynonenal; iNOS; inducible nitric oxide synthase; LDH; lactate deh

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation

Keywords: TSC; Tuberous Sclerosis Complex; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; LOH; loss of heterozygosity; iPSCs; induced pluripotent stem cells; NPCs; neural progenitor cells; PI3K; phosphoinositide 3-kinase; SENs; subependymal nodules; S

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

A partnership with the proteasome; the destructive nature of GSK3

Keywords: AMPK; AMP-activated protein kinase; ARE; antioxidant response element; β-TrCP; beta-transducin repeat containing protein; CKI; casein kinase-1; CHD; chromatin helicase DNA-binding factor; CRY; cryptochrome; EMT; epithelial-mesenchymal transition; FGD; fa

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Quercetin preserves redox status and stimulates mitochondrial function in metabolically-stressed HepG2 cells

Keywords: AmA; antimycin A; AMPK; adenosine monophosphate-activated protein kinase; CoQ; coenzyme Q10; DCF; 2′,7′-dichlorofluorescin; DCFH-DA; 2′,7′-dichlorofluorescin diacetate; ddPCR; droplet digital PCR; ETS; electron transfer system; FBS; fetal bovine s

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

ROS signalling in the biology of cancer

Keywords: AEJ; alternative end joining; ALL; acute lymphoblastic leukaemia; AML; acute myeloid leukaemia; Apaf-1; apoptotic protein activating factor 1; APL; acute promyelocytic leukaemia; ASK1; apoptosis signal regulating kinase 1; Bcr-Abl; breakpoint cluster-Abel

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

E3-ubiquitin ligase NEDD4 enhances bone formation by removing TGFβ1-induced pSMAD1 in immature osteoblast

Keywords: NEDD4; neural precursor cell-expressed, developmentally down-regulated protein 4; TGFβ1; transforming growth factor β1; BMP2; bone morphogenetic protein 2; PI3K; phosphatidylinositol-4,5-bisphosphate 3-kinase; AKT (PKB); protein kinase B; ERK; extracell

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

STX3 represses the stability of the tumor suppressor PTEN to activate the PI3K-Akt-mTOR signaling and promotes the growth of breast cancer cells

Keywords: STX3; Breast cancer; PTEN; PI3K; Akt; mTOR;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

Keywords: Autophagy; Combination therapy; Erlotinib; Vps34; High-content screening; AKT; Protein kinase B; ATG7; Autophagy-related protein 7; BafA1; Bafilomycin A1; Chk1; Checkpoint kinase 1; CQ; Chloroquine; FGFR; Fibroblast growth factor receptor; GFP; Green fluo

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Folic acid supplementation during pregnancy prevents cognitive impairments and BDNF imbalance in the hippocampus of the offspring after neonatal hypoxia-ischemia

Keywords: FA; folic acid; NTD; neural tube defects; WHO; World Health Organization; BDNF; brain-derived neurotrophic factor; HI; hypoxia-ischemia; PND; post-natal day; DAB; 3,3'-diaminobenzidine; PBS; phosphate-buffered saline; CA; Cornu Amonis; AOI; area of inte

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance

Keywords: ABCB1; ATP-binding cassette sub-family B member 1; AML; acute myeloid leukaemia; AMPK; adenosine monophosphate-activated protein kinase; ATM; Ataxia-telangiectasia mutated; AURKA; aurora kinase A; BER; base excision repair; Bim; B-cell lymphoma 2 interact

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma

Keywords: YKL-40; PTEN; PI3K; JAK2/STAT3; Transcriptomes;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Consider the context: Ras/ERK and PI3K/AKT/mTOR signaling outcomes are pituitary cell type-specific

Keywords: ERK; MAPK; PI3K; Pituitary; Lactotrope; Adenoma;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway

Keywords: Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Transcriptome analysis reveals novel insights into the response of low-dose benzo(a)pyrene exposure in male tilapia

Keywords: TGFi; TGF induced factor homeobox; TGF; transforming growth factor; IL1; interleukin 1; IL1i; IL1 inhibitors; IL1RL1; interleukin 1 receptor like 1; TNF; tumor necrosis factor; Nogo; reticulon 4 (RTN4/Nogo); NGF; nerve growth factor; STC; stanniocalcin 1;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Stimulation of the adenosine A3 receptor, not the A1 or A2 receptors, promote neurite outgrowth of retinal ganglion cells

Keywords: Adenosine receptors; Neuroregeneration; Glaucoma; Akt; 2-Cl-IB-MECA; IOP; intraocular pressure; RGC; retinal ganglion cell; NTG; normal tension glaucoma; AC; adenylyl cyclase; cAMP; cyclic adenosine monophosphate; PI3K; phosphoinositide 3-kinase; AdoR; ad

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Oxidative stress reduces trophoblast FOXO1 and integrin β3 expression that inhibits cell motility

Keywords: Bim; Bcl-2-like protein 11; ChIP; Chromatin immunoprecipitation; FasL; Fas ligand; FOXO; Forkhead box-containing O subfamily; FRE; FOXO1 response element; PI3K; phosphatidylinositol-3-kinase; PKB/AKT; PI3K-modulated protein kinase B; TRAIL; tumor necrosis

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Ca2+ signaling and Src-kinases-controlled cellular functions

Keywords: Ca2+ channels; Cell signaling; Phosphatases; Receptors; Src-family kinases; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxyli

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Thyroid hormones affect nitrergic innervation function in rat mesenteric artery: Role of the PI3K/AKT pathway

Keywords: Triiodothyronine; Rat mesenteric artery; Nitrergic innervation; Oxidative stress; PI3K/AKT pathway; DAF; diaminofluorescein; DEA NO; diethylamine NONOate; EFS; electric field stimulation; eNOS; endothelial nitric oxide synthase; iNOS; inducible nitric oxi

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2018 سفارش ترجمه

Astaxanthin: A mechanistic review on its biological activities and health benefits

Keywords: Astaxanthin (PubChem CID: 5368397); Beta-Carotene (PubChem CID: 5280489); Beta-Cryptoxanthin (PubChem CID: 5281235); Canthaxanthin (PubChem CID: 5281227); Lutein (PubChem CID: 5281243); Zeaxanthin (PubChem CID: 5280899); Alpha-Tocopherol (PubChem CID: 149

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Drosophila as a model for ageing

Keywords: 4EBP; translation initiation factor 4E binding protein; AMPK; AMP activated protein kinase; AOP; anterior open; ATF4; activating transcription factor 4; CHOP; C/EBP homologous protein; CR; calorie restriction; DR; dietary restriction; eIF; eukaryotic tran

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Emerging paradigms in the treatment of liver metastases in colorectal cancer

Keywords: CRC; colorectal cancer; mCRC; metastatic colorectal cancer; CLM; colorectal liver metastases; SR; surgical resection; PVE; portal vein embolism; RFA; radiofrequency ablation; APC; adenomatous polyposis coli; LOH; loss of heterozygosity; EGFR; epidermal gr

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Neuronal Growth Factor regulates Brain Specific Kinase 1 expression by inhibiting promoter methylation and promoting Sp1 recruitment

Keywords: NGF; DNA methylation; Brsk1; DNMT3B; MAPK; 5′Aza-dC; 5-aza-2′-deoxycytidine; AKT/PKB; Protein kinase B; BRSK 1/2; Brain-Specific Kinase 1/2; C-5; cytosine 5'; CNS; Central Nervous System; DNMT; DNA methyltransferase; EMSA; Electrophoretic Mobility S

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation

Keywords: ABL; Abelson murine leukemia viral oncogene homolog 1; ALIS; aggresome-like induced structure; ALL; acute lymphoblastic leukemia; BCR; breakpoint cluster region; CML; chronic myeloid leukemia; DCFH-DA; 2′, 7′-dichlorodihydrofluorescein diacetate; DCPI

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

Glucose dependent miR-451a expression contributes to parathyroid hormone mediated osteoblast differentiation

Keywords: Ovx; Ovariectomy; PTH; Parathyroid Hormone; miRNA; MicroRNA; μCT; Micro-computed tomography; BMD; Bone mineral density; BV/TV; Bone volume/Total volume; SMI; Structural model index; Tb.N; Trabecular number; Conn Dn; Connection density; Tb.Sp; trabecular

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Neuroprotective effect of zolpidem against glutamate-induced toxicity is mediated via the PI3K/Akt pathway and inhibited by PK11195

Keywords: ANC; adenine nucleotide carrier; H2O2; hydrogen peroxide; LDH; lactate dehydrogenase; mPTP; mitochondrial permeability transition pore; PI3K; phosphatidylinositol-3-kinase; PK11195; 1-(-2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

HDL-apoA-I induces the expression of angiopoietin like 4 (ANGPTL4) in endothelial cells via a PI3K/AKT/FOXO1 signaling pathway

Keywords: apoA-I; apolipoprotein A-I; ANGPTL4; angiopoietin like 4; CETP; cholesterol ester transfer protein; CHX; cycloheximide; CVD; cardiovascular disease; EBM; endothelial cell basal medium; eNOS; endothelial NO synthase; ERK; extracellular signal-regulated kin

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway

Keywords: HFD; high fat-diet; STZ; streptozotocin; IRS-1; insulin receptor substrate-1; PI3K; phosphatidylinositol 3-kinase; PEPCK; phosphoenolpyruvate carboxykinase; G6pase; glucose 6-phosphatase; FOXO1; forkhead box O1; GSK3β; glycogen synthase kinase-3β; GS; g

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity

Keywords: Vascular smooth muscle; Vasoproliferative disease; Vascular smooth muscle cell; Phenotype switching; Signalling pathways; AJ; adherens junction; ApoE; apolipoprotein E; BMP; bone morphogenetic protein; CAD; coronary artery diseases; CADASIL; cerebral auto

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux

Keywords: PI3K; AKT; mTOR; Inhibitors; Targeted therapy; Immunotherapy; Combination therapy; Tumor microenvironment; Immunotherapeutic resistance;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

EphBs and ephrin-Bs: Trans-synaptic organizers of synapse development and function

Keywords: βGal; β-Galactosidase; Aβ; amyloid-β; Abl; Abelson murine leukemia viral oncogene homolog; AD; Alzheimer's disease; AMPAR; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; APP; amyloid precursor protein; BLA; basolateral amygdala; CaMKI

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors

Keywords: ADCC; antibody dependent cell-mediated cytotoxic activity; ALL; acute lymphoid leukemia; AML; acute myeloid leukemia; CXCL; C-X-C motif chemokine ligand; ECM; extra-cellular matrix; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulat

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

STAT3: The art of multi-tasking of metabolic and immune functions in obesity

Keywords: Signal transducer and activator of transcription 3; Obesity; Metabolism; Lipid; Immune; AgRP; Agouti-related peptide; AMPK; AMP-activated protein kinase; AOX; acyl-CoA oxidase; ARC; arcuate nucleus; ATGL; adipose triglyceride lipase; BAT; brown adipose ti

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses

Keywords: AngII; Angiotensin II; AT1R; angiotensin type 1 receptor; βarr; β-Arrestin; DMR; dynamic mass redistribution; ERK; extracellular signal-regulated kinase; GPCR; G protein coupled receptor; PTX; pertussis toxin; PI3K; phosphoinoside 3-kinase; rVSMC; rat v

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

Sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β2-integrin-dependent function in human eosinophils

Keywords: Eosinophil; Siglec-8; β2-integrin; apoptosis; phosphoproteomics; reduced nicotinamide adenine dinucleotide phosphate oxidase (NADPH); p38; c-Jun N-terminal kinase (JNK); Akt; DAPI; 4′-6-Diamidino-2-pheynlindole dihydrochloride; DAVID; Database for Anno

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

Keywords: Epilepsy; Rapamycin; Everolimus; Pharmacokinetics; Tolerability; Levetiracetam; AKT; protein kinase B; ASD; anti-seizure drug; 4E-BP1; initiation factor 4E binding protein; HPβCD; hydroxypropyl-ß-cyclodextrin; MTD; maximal tolerated dose; MES-T; maximal

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation

Keywords: 3-MST; 3-mercaptopyruvate sulfurtransferase; 3B7NI; 3-bromo-7-nitroindazole; AOAA; aminooxyacetic acid; CBS; cystathionine-β-synthase; CO; carbon monoxide; CSE; cystathionine gamma lyase; eNOS; endothelial nitric oxide synthase; nNOS; neuronal nitric oxi

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2018 سفارش ترجمه

Atorvastatin impaired glucose metabolism in C2C12 cells partly via inhibiting cholesterol-dependent glucose transporter 4 translocation

Keywords: ABC; ATP-binding cassette; Akt; Protein kinase B; AUC; area under the concentrationtime curve; BW; body weight; CMC; carboxyl methyl cellulose; ERK; extracellular-regulated protein kinase; GCK; glucokinase; GLUT2; glucose transporter 2; GLUT4; glucose tra

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation

Keywords: BLI; bioluminescence imaging; BSA; bovine serum albumin; CTL; cytotoxic T lymphocytes; CRISPR/Cas; Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated nucleases; DEGs; differently expressed genes; DMEM; Dulbecco's modified Eagle's

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2018 سفارش ترجمه

Molecular mechanisms involved in epidermal growth factor receptor-mediated inhibition of dopamine D3 receptor signaling

Keywords: EGFR; epidermal growth factor receptor; D3R; dopamine D3 receptor; GFP; green fluorescent protein; Veh; vehicle; CRE-luci; cAMP response element-luciferase; GRK2; G protein-coupled receptor kinase 2; KD; knockdown; Forsk; forskolin; Co-IP; co-immunoprecip

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2018 سفارش ترجمه

Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes

Keywords: Cytomegalovirus; Monocytes; Small-molecule inhibitor; HCMV; human cytomegalovirus; h; hour; EGF; epidermal growth factor; EGFR; EGF receptor; αvβ3; alpha v beta 3 integrin; gB; glycoprotein B; gH; glycoprotein H; PI3K; phosphoinositide 3-kinase; PTEN; p

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2018 سفارش ترجمه

Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization

Keywords: 3-MA; 3-Methyl Adenine; Akt; Protein kinase B; AMP; Adenosine monophosphate; AMPK; AMP-activated protein kinase; Atg; Autophagy related genes; ATP; Adenosine triphosphate; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-associated X protein; BCL-2; B-

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2018 سفارش ترجمه

Cardiac repair by epicardial EMT: Current targets and a potential role for the primary cilium

Keywords: BBS8; Bardet-Biedl syndrome 8; bFGF; basic fibroblast growth factor; BMP; bone morphogenetic protein; BMSCs; bone marrow-derived hematopoietic stem cells; ECM; extracellular matrix; EGF; epidermal growth factor; EMT; epithelial-to-mesenchymal transition;

دانلود رایگان متن کامل مقاله ISI 58 صفحه سال انتشار : 2018 سفارش ترجمه

Dueling for dual inhibition: Means to enhance effectiveness of PI3K/Akt/mTOR inhibitors in AML

Keywords: AML; mTOR; PI3K; Akt; Resistance mechanisms; Dual inhibitors; Rapalogs;

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2018 سفارش ترجمه

Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells

Keywords: Siglec-8; endocytosis; eosinophil; mast cell; allergic diseases; chronic eosinophilic leukemia; systemic mastocytosis; immunotoxin; targeting; BIM; Bisindolylmaleimide I; DAPI; 4′-6-Diamidino-2-phenylindole; ITIM; Immunoreceptor tyrosine-based inhibitor

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2018 سفارش ترجمه

Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice

Keywords: Gene Regulation; Oncogene; Pancreas; Signal Transduction; ADM; acinar-to-ductal metaplasia; CCND1; cyclin D1; ChIP; chromatin immunoprecipitation; DMSO; dimethyl sulfoxide; IF; immunofluorescence; IHC; immunohistochemical; KLF; Krüppel-like factor; KRAS;

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2018 سفارش ترجمه

Antibody-drug conjugates (ADCs): Potent biopharmaceuticals to target solid and hematological cancers- an overview

Keywords: Antibody-drug conjugates; Monoclonal antibodies; Anticancer; Drug resistance; Solid tumors; Hematological tumors; ADC; Antibody-Drug Conjugate; ALCL; Anaplastic Large Cell Lymphoma; ALL; Acute Lymphoblastic Leukemia; AML; Acute Myeloid Leukemia; BCMA; B C

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2018 سفارش ترجمه