دانلود مقالات ISI درباره Pi3K + ترجمه فارسی

Antibody-drug conjugates (ADCs): Potent biopharmaceuticals to target solid and hematological cancers- an overview

Keywords: Antibody-drug conjugates; Monoclonal antibodies; Anticancer; Drug resistance; Solid tumors; Hematological tumors; ADC; Antibody-Drug Conjugate; ALCL; Anaplastic Large Cell Lymphoma; ALL; Acute Lymphoblastic Leukemia; AML; Acute Myeloid Leukemia; BCMA; B C

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2018 سفارش ترجمه

ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK

Keywords: 2-NBDG; 2-(N-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]amino)-2-deoxyglucose; AICAR; 5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside; AMPK; AMP-activated protein kinase; AS160; Akt Substrate of 160 kDa; ATF4; Activating Transcription Factor 4; AUC; area un

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2018 سفارش ترجمه

The next generation of PI3K-Akt-mTOR pathway inhibitors in breast cancer cohorts

Keywords: Breast Cancer; PI3K/AKT/mTOR pathway; PI3K; AKT; mTOR; Clinical Trials;

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

The role of TAM family receptors and ligands in the nervous system: From development to pathobiology

Keywords: ACSF; artificial cerebral spinal fluid; APP; amyloid precursor protein; BBB; blood-brain-barrier; BCECs; brain capillary endothelial cells; C57Bl6/J; strain of mice for MOG-induce EAE and cuprizone studies; CNS; central nervous system; DKO; Gas6−/−Axl

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

Keywords: Akt; oncogene in the transforming retrovirus, AKT8; AP-1; activator protein 1; ARAF; v-raf murine sarcoma 3611 viral oncogene homologue; ASK1; apoptosis signal-regulating kinase 1; BCL2; B-cell lymphoma 2; BCL-XL; B-cell lymphoma extra large; BRAF; v-raf

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

Exploring the multifaceted roles of heat shock protein B8 (HSPB8) in diseases

Keywords: Aβ; amyloid β-peptide; ACD; α-crystallin domain; AD; Alzheimer disease; ALS; amyotrophic lateral sclerosis; AR; androgen receptor; BAG3; BCL2 associated athanogene 3; BMP; bone morphogenetic protein; CASA; chaperone-assisted selective autophagy; CHIP;

دانلود رایگان متن کامل مقاله ISI 71 صفحه سال انتشار : 2018 سفارش ترجمه

The genus Polygonatum: A review of ethnopharmacology, phytochemistry and pharmacology

Keywords: Aβ; Amyloid β-peptide; Ac; acetyl; AD; Alzheimer's disease; APP; Amyloid precursor protein; RAW264.7; Murine macrophage cells; Bel-7402; Human Hepatocellular Carcinoma cell line; BMSCs; Bone marrow stromal cells; ChAT; Choline acetyltransferase; DPPH;

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2018 سفارش ترجمه

Autophagy in ischemic stroke

Keywords: 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5′-triphosphate; BBB; blood-brain ba

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2018 سفارش ترجمه

Autophagy as a pharmacological target in hematopoiesis and hematological disorders

Keywords: 3-MA; 3-methyladenine; ALL; acute lymphoblastic leukemia; AMKL; acute megakaryoblastic leukemia; AML; acute myeloid leukemia; AMPK; 5′-adenosine monophosphate-activated protein kinase; APL; acute promyelocytic leukemia; Atg; autophagy-related proteins;

دانلود رایگان متن کامل مقاله ISI 80 صفحه سال انتشار : 2018 سفارش ترجمه

Impact of obesity and overweight on DNA stability: Few facts and many hypotheses

Keywords: AGEs; advanced glycation end products; AP-1; activating protein -1; APE1; apurinic/apyrimidinic endonuclease 1; BER; base excision repair; BMI; body mass index; CAF; cafeteria diet; CAT; Catalase; CBMN-Cyt; cytokinesis block micronucleus cytome assay; CEL

دانلود رایگان متن کامل مقاله ISI 89 صفحه سال انتشار : 2018 سفارش ترجمه

Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

Keywords: Nrf2; type 2 diabetes; natural products; hyperglycemia; cellular stress; insulin sensitivity; β-cell function; vascular complications; AGE; advanced glycation end products; AhR; arylhydrocarbon receptor; AMPK; AMP-activated kinase; ARE; antioxidant respo

دانلود رایگان متن کامل مقاله ISI 89 صفحه سال انتشار : 2018 سفارش ترجمه

Chronopathophysiological implications of orexin in sleep disturbances and lifestyle-related disorders

Keywords: Aβ; amyloid β; AI; androgeno-independent; BAT; brown adipose tissue; BNST; bed nucleus of the stria terminalis; CeA; central nucleus of amygdala; CSF; cerebrospinal fluid; DMNV; dorsal motor nucleus of the vagus; DORA; dual orexin receptor antagonist; D

دانلود رایگان متن کامل مقاله ISI 95 صفحه سال انتشار : 2018 سفارش ترجمه

Novel function of Porphyromonas gingivalis gingipains in the PI3K/Akt signaling pathway

Keywords: PI3K; phosphatidylinositol-3 kinase; GSK3; glycogen synthase kinase 3; mTOR; mammalian target of rapamycin; PDK1; 3-phosphoinositide-dependent protein kinase 1; LPS; lipopolysaccharide; Porphyromonas gingivalis; Virulence factors; Gingipains; PI3K/Akt sig

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibition of Rad51 sensitizes breast cancer cells with wild-type PTEN to olaparib

Keywords: PTEN; Phosphatase and tensin homologue; PARP; poly(ADP-ribose) polymerase; PI3K; PI3 kinase; RPA1; replication protein A1; DSB; double-strand breaks; HR; homologous recombination; SSB; single strand breaks; γH2AX; Phospho-histone H2AX; PMSF; phenylmethyl

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice

Keywords: EDL; Extensor digitorum longus; FL; Flavan 3-ol; GC; Gastrocnemius; MuRF1; Muscle ring finger-1; p70S6K; p70S6 kinase; PGC-1α; Proliferator-activated receptor gamma coactivator-1 alpha; PI3K; Phosphoinositide 3-kinase; SOL; Soleus; TA; Tibialis anterior;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Oncogenic mutations of PIK3CA and HRAS in carcinoma of cervix in South Indian women

Keywords: Oncogenic mutations; Cervical cancer; Peripheral blood; PCR-CTPP method; PIK3CA; Phosphatidylinositol-4,5-Bisphosphate; 3-Kinase Catalytic Subunit Alpha; HRAS; Harvey rat sarcoma viral oncogene homolog; EGF; Epidermal Growth Factor; PDGF; Platelet Derived

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma

Keywords: FGFR; Bladder cancer; PI3K; Synergy;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Matrine inhibits bladder cancer cell growth and invasion in vitro through PI3K/AKT signaling pathway: An experimental study

Keywords: Bladder cancer; Matrine; PI3K; AKT; Proliferation; Invasion;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibition of phosphatidylinositol-3-kinase by the furanosesquiterpenoid hibiscone C

Keywords: Hibiscone C; Wortmannin; PI3K; Furanosteroid; Furanosesquiterpenoid;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

The role of RAS mutations in MLL-rearranged leukaemia: A path to intervention?

Keywords: ALL; acute lymphoblastic leukaemia; iALL; infant ALL; MLL; myeloid/lymphoid leukaemia or mixed lineage leukaemia, also known as KMT2A; RAS; rat sarcoma; BCP-ALL; B-cell precursor ALL; EFS; event-free survival; OS; overall survival; WBC; white blood cell c

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

The Class I PI3K inhibitor S14161 induces autophagy in malignant blood cells by modulating the Beclin 1/Vps34 complex

Keywords: S14161; PI3K; Beclin 1; Vps34; Autophagy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Expression of ERK and Akt proteins in women with unexplained first-trimester recurrent miscarriage

Keywords: Recurrent miscarriage; Pregnancy loss; ERK protein; Akt protein; EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; MCL-1; myeloid leukemia cell-1; MMP; matrix metalloproteinase; PI3K; phospha

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor

Keywords: Cruciferous; Indole-3-carbinol; Anti-cancer; AHR; PI3K;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation

Keywords: Synthesis of O-substituted-2-morpholino-8-aryl-benzo-oxazin-4-one; DNA-PK; PI3K; PDE3A; Antiplatelet activity;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Phytol increases adipocyte number and glucose tolerance through activation of PI3K/Akt signaling pathway in mice fed high-fat and high-fructose diet

Keywords: Adipocyte number; Adipogenesis; Glucose tolerance; Phytol; PI3K/Akt; Mice; Akt; protein kinase B; aP2; adipocyte protein 2; AS160; Akt substrate of 160 kDa; AUC; area under the curve; C/EBPα; CCAAT-enhancer-binding proteins; FoxO1; Forkhead box protein

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Protein kinase C-eta regulates Mcl-1 level via ERK1

Keywords: DAG; diacylglycerol; ERK; extracellular signal-regulated kinase; GSK3; glycogen synthase kinase-3; MAPK; mitogen-activated protein kinase; Mcl-1; myeloid cell leukemia-1; Mule; Mcl-1 ubiquitin ligase; PI3K; phosphatidylinositol 3-kinase; PKC; protein kina

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

MEK and PI3K catalytic activity as predictor of the response to molecularly targeted agents in triple-negative breast cancer

Keywords: Catalytic activity; MEK; PI3K; Drug sensitivity; Triple-negative breast cancer; MAPK; mitogen-activated protein kinase; MEK; mitogen-activated protein kinase kinase; PI3K; phosphoinositide 3-kinase; TNBC; triple-negative breast cancer;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells

Keywords: LAPTM4B; lysosome-associated transmembrane protein 4β; EGFR; epidermal growth factor receptor; TAP; tandem affinity purification; TKI; tyrosine kinase inhibitor; HER; human epidermal growth factor receptor; BSA; bovine serum albumin; MCS; multiple clonin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Involvement of PI3K and PKA pathways in mouse tongue epithelial differentiation

Keywords: Epithelial differentiation; Tongue barrier formation; Keratinization; Multiple cell layer formation; PI3K; PKA;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Caractérisation de la machinerie de transport régulant la dégranulation mastocytaire

Keywords: Mastocyte; Récepteur IgE; Traffic vésiculaire; Moteur moléculaire; Granule de sécrétion; Kinésine-1; Rab27b; Slp3; PI3K; Mast cell; FcɛRI; Vesicle trafficking; Molecular motor; Secretory granule; Kinesin-1; Rab27b; Slp3; PI3K;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Nicotine suppresses the neurotoxicity by MPP+/MPTP through activating α7nAChR/PI3K/Trx-1 and suppressing ER stress

Keywords: PD; Parkinson's disease; MPP+1; methyl-4-phenylpyridinium ion; Trx-1; thioredoxin-1; ER; endoplasmic reticulum; GRP78/Bip; glucose-regulated protein 78; CHOP; C/EBP homologous protein; TH; tyrosine hydroxylase; PI3K; phosphatidylinositol 3-kinase; DA; d

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

miR-200c enhances sensitivity of drug-resistant non-small cell lung cancer to gefitinib by suppression of PI3K/Akt signaling pathway and inhibites cell migration via targeting ZEB1

Keywords: miR-200c; Drug-resistance; NSCLC; PI3K;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Too much of a good thing: How modulating LTB4 actions restore host defense in homeostasis or disease

Keywords: LT; leukotriene; PAMP; pathogen associated molecular patterns; PRR; pattern recognition receptor; AA; arachidonic acid; LO; lipoxygenase; cPLA2; cytosolic phospholipase A2; FLAP; 5-lipoxygenase-activating protein; cysLT; cysteinyl LT; BLT; B leukotriene r

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Oligomeric proanthocyanidin derived from grape seeds inhibited NF-κB signaling in activated HSC: Involvement of JNK/ERK MAPK and PI3K/Akt pathways

Keywords: Oligomeric proanthocyanidin; Hepatic stellate cell; MAPK; PI3K; Akt;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Ginsenoside Rg3 enhances the anti-proliferative activity of erlotinib in pancreatic cancer cell lines by downregulation of EGFR/PI3K/Akt signaling pathway

Keywords: Ginsenoside Rg3; Pancreatic cancer; Apoptosis; EGFR; PI3K;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination

Keywords: Insulin-like growth factor (IGF); Insulin receptor substrate (IRS)-2; Ubiquitin-specific protease 15 (USP15); Nedd4; Ubiquitination; IGF; insulin-like growth factor; IRS; insulin receptor substrate; PI3K; phosphatidylinositol 3-kinase; USP; ubiquitin-spec

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

The phosphatidyl inositol 3 kinase pathway does not suppress activation of the ARF and BIM genes by deregulated E2F1 activity

Keywords: E2F; RB; PI3K; Apoptosis; Gene regulation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Original ResearchClinical outcomes and prognostic factors of patients with advanced mesothelioma treated in a phase I clinical trials unit

Keywords: Mesothelioma; Phase 1; Drug development; PI3K; Targeted therapies;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Thyroid hormone induce a p53-dependent DNA damage through PI3K/Akt activation in sperm

Keywords: TH; thyroid hormone; PI3K; Phosphatidyl Inositol 3-kinase; MDM2; Murine Double Minute 2; TR; thyroxine receptor; TUNEL; terminal deoxynucleotidyl transferase dUTP nick-end labelling; MMP; mitochondrial membrane potential; Sperm motility; DNA damage; l-Thy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Simultaneous targeting PI3K and PERK pathways promotes cell death and improves the clinical prognosis in esophageal squamous carcinoma

Keywords: ESCC; PI3K; mTOR; PERK; LY294002; GSK2656157; Activating transcription factor 4; ATF4; Esophageal adenocarcinoma; EAC; Esophageal squamous cell carcinoma; ESCC; eukaryotic translation initiation factor 2-alpha; elF2α; phosphorylated elF2α; p-elF2α; Ove

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Schisandrin rescues depressive-like behaviors induced by chronic unpredictable mild stress via GDNF/ERK1/2/ROS and PI3K/AKT/NOX signaling pathways in mice

Keywords: CUMS; Chronic unpredictable mild stress; GDNF; Glial cell line-derived neurotrophic factor; TGF-β; Transforming growth factor-beta; ERK; Extracellular regulated protein kinases; PERK; Phosphorylase extracellular regulated protein kinases; NOX; NADPH oxid

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Taming Tricky DSBs: ATM on duty

Keywords: ATM; ataxia telangiectasia mutated; DSB; double strand breaks; DDR; DNA damage response; HR; homologous recombination; NHEJ; non-homologous end joining; PI3K; phosphoinositide 3-kinase; RNA pol II; RNA polymerase II; TAD; topologically associated domain;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

14-3-3γ regulates Copine1-mediated neuronal differentiation in HiB5 hippocampal progenitor cells

Keywords: CPNE1; Copine1; NF; neurofilament; PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase; AKT; Protein kinase B (PKB);; BiFC; bimolecular fluorescence complementation; VN/VC; N-terminal half/C-terminal half of Venus; IP; immunoprecipitation; MBP; myelin ba

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Targeting energy metabolism of cancer cells: Combined administration of NCL-240 and 2-DG

Keywords: ATP; adenosine triphosphate; HIF1-α; hypoxia inducible factor 1-α; GLUT; glucose transporter; DM-PIT-1; N-[(2-hydroxy-5-nitrophenyl)amino]carbonothioyl-3,5-dimethylbenzamide; PI3K; phosphoinositide 3-kinase; PIP3; phosphatidylinositol-3,4,5-triphosphate

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

MicroRNA-539 inhibits glioma cell proliferation and invasion by targeting DIXDC1

Keywords: miRNAs; microRNAs; DIX; disheveled axin; DIXDC1; disheveled-axin domain containing; UTR; untranslated region; FBS; fetal bovine serum; CCK-8; cell counting Kit-8; PI3K; phosphatidyl inositol 3-kinase; Wnt; wingless; DIXDC1; Glioma; MiR-539; Wnt;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

LncRNA MEG3 has anti-activity effects of cervical cancer

Keywords: lncRNA MEG3; Hela; PI3K; AKT; Bcl-2; Bax; P21; MMP-2; MMP-9;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

lncRNA LINC00152 knockdown had effects to suppress biological activity of lung cancer via EGFR/PI3K/AKT pathway

Keywords: lncRNA LINC00152; A549; H1299; EGFR; PI3K; AKT;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

RNA transcript expression of IGF-I/PI3K pathway components in regenerating skeletal muscle is sensitive to initial injury intensity

Keywords: Skeletal muscle; Regeneration; Insulin-like growth factor; PI3K; Akt; RNA;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Research PaperNeuron subset-specific Pten deletion induces abnormal skeletal activity in mice

Keywords: PI3K; mTOR; Osteoporosis; Fracture; BMD; Seizure, neurodevelopmental disorder; Epilepsy;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats

Keywords: Paeoniflorin; Diabetes; Cognitive dysfunction; SOCS2/IRS-1; Tau phosphorylation; Akt; protein kinase B; DE; diabetic encephalopathy; DM; diabetes mellitus; GSK-3β; glycogen synthase kinase-3β; IL-1β; interleukin-1β; IRS-1; insulin receptor substrate-1

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه