کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5593710 | 1571145 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
paeoniflorinIRS-1STZSOCS2PI3KGSK-3βIL-1βJAK/STAT - JAK / STATAkt - آکتCognitive dysfunction - اختلال شناختیstreptozotocin - استرپتوزوتوسینDiabetic encephalopathy - انسفالوپاتی دیابتیinsulin receptor substrate-1 - انسولین گیرنده زیربخش 1Interleukin-1β - اینترلوکین-1βDiabetes - بیماری قندtumor necrosis factor-α - تومور نکروز عامل αDiabetes mellitus - دیابت قندیTNF-α - فاکتور نکروز توموری آلفاTau phosphorylation - فسفوریلاسیون تاوphosphoinositide 3-kinase - فسفینوزیتید 3-کینازprotein kinase B - پروتئین کیناز Bjanus kinase/signal transducer and activator of transcription - ژنوس کیناز / فرستنده سیگنال و فعال کننده رونویسیGlycogen synthase kinase-3β - گلیکوزین سنتاز کیناز 3β
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Paeoniflorin is a natural monoterpene glycoside in Paeonia lactiflora pall with various biological properties including promising anti-inflammatory activity. Current evidences support that inflammatory reaction, oxidative stress, as well as abnormal insulin signaling in the hippocampus are potential causes of tau hyperphosphorylation and finally induce cognitive dysfunction. The present study aims to explore the effects of paeoniflorin on the cognitive deficits and investigate the underlying mechanisms in diabetic rats induced by a high-sucrose, high-fat diet and low dose of streptozotocin (STZ). Paeoniflorin treatment effectively improved the performance of diabetic rats in the Morris water maze test via decreasing escape latency and increasing the spent time in the target quadrant. Immunohistochemistry staining also had shown that tau hyperphosphorylation in the hippocampus was prevented after paeoniflorin administration. This function was correlated with its abilities of reducing the brain inflammatory cytokines (IL-1β and TNF-α), decreasing suppressor of cytokine signaling 2 (SOCS2) expressions and promoting insulin receptor substrate-1 (IRS-1) activity. Additionally, we also found paeoniflorin administration significantly promoted the phosphorylation levels of protein kinase B (Akt) and glycogen synthase kinase-3β (GSK-3β). Together, these results showed that paeoniflorin had beneficial effects on relieving diabetes-associated cognitive deficits via regulating SOCS2/IRS-1 pathway and might provide a feasible method for the treatment of diabetes-associated cognitive dysfunction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 174, 15 May 2017, Pages 162-169
Journal: Physiology & Behavior - Volume 174, 15 May 2017, Pages 162-169
نویسندگان
Xiaoxu Sun, Shanshan Li, Lixing Xu, Hao Wang, Zhanqiang Ma, Qiang Fu, Rong Qu, Shiping Ma,