دانلود مقالات ISI درباره Pi3K + ترجمه فارسی

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Keywords:  + S; With serum;  − S; Without serum; CHX; Cycloheximide; DMEM; Dulbecco's modified Eagle's medium; ECL; Enhanced chemiluminescence; ETS; Externally transcribed spacer; Exp; Exponentially growing cells; FBS; Fetal bovine serum; h; Hour; LY; LY29400

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Imaging flow cytometry and GST pulldown assays provide new insights into channel catfish leukocyte immune-type receptor-mediated phagocytic pathways

Keywords: Phagocytosis; Immunoregulatory receptors; Intracellular signaling; Actin polymerization machinery; Imaging flow cytometry; Innate immunity; Channel catfish; Leukocyte immune-type receptors; IpLITR; channel catfish leukocyte immune-type receptor; CYT; cyto

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewCell Cycle Control by PTEN

Keywords: PTEN; phosphatase and tensin homolog; CIN; chromosome instability; CDK; cyclin-dependent Ser/Thr kinase; RB; retinoblastoma protein; SCF; Skp1/CUL1/F-box protein; APC/C; anaphase-promoting complex/cyclosome; CDH1; cdc20 homolog; PI3K; phosphoinositide 3-k

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance

Keywords: FDA; US Food and Drug Administration; EGFR; epidermal growth factor receptor; BTK; Bruton's tyrosine kinase; SPR; surface plasmon resonance; PI3K; phosphoinositide 3-kinase; SD; standard deviation; SE; standard error; PI3K; phosphoinositide 3-kinase; SPR;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Adenosine A2a receptor stimulation blocks development of nonalcoholic steatohepatitis in mice by multilevel inhibition of signals that cause immunolipotoxicity

Keywords: A2aR; adenosine A2a receptor; Th; T helper; NASH; nonalcoholic steatohepatitis; MCD; methionine-choline deficient; IL; interleukin; WT; wild type; NAFLD; nonalcoholic fatty liver disease; Treg; T regulatory; IFN; interferon; TNF; tumor necrosis factor; TG

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Novel anti-prostate cancer scaffold identified by the combination of in silico and cell-based assays targeting the PI3K-AKT-mTOR pathway

Keywords: AKT; protein kinase B; AR; androgen receptor; mTOR; mammalian target of rapamycin; PI3K; phosphatidylinositol-3-kinase; S6; ribosomal protein S6 kinase; SAR; structureactivity relationship; SBVS; structure-based virtual screening; In silico screening; Pro

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2

Keywords: Severe asthma; corticosteroids; airway hyperresponsiveness; miR-21; PI3 kinase; histone deacetylase 2; Chlamydia species; Haemophilus influenzae; influenza; respiratory syncytial virus; AAD; Allergic airway disease; AHR; Airway hyperresponsiveness; Ant-21

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)

Keywords: 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Distribution of BDNF and TrkB isoforms in growing antler tissues of red deer

Keywords: AACTB; actin-beta gene; B; bone; BDNF; brain-derived neurotrophic factor; BMPs; bone morphogenetic proteins; CA; non-mineralized cartilage; CP; chondroprogenitors; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; IGF-I; II insulin-lik

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study

Keywords: Activated phosphoinositide 3-kinase δ syndrome; p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency; phosphoinositide 3-kinase δ; PIK3CD gene; bronchiectasis; immunodeficiency; hematopoietic stem cell transplanta

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor

Keywords: aPKC; atypical protein kinase C; C2-ceramide; N-acetyl-D-sphingosine; CLP; contralateral paw; IgG; immunoglobin; NGF; nerve growth factor; nSMase; neutral sphingomyelinase; p75NTR; p75 neurotrophin receptor; PBS; phosphate buffered saline; PI3K; phosphati

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging

Keywords: 8-oxoG; 7,8-dihydro-8-oxoguanine; 8-oxodG; 7,8-dihydro-8-oxo-2′-deoxyguanosine; BER; base excision repair; DNA dsbs; double strand breaks; DNA ssbs; single strand breaks; GEF; guanine nucleotide exchange factor; GOrilla; Gene Ontology enrichment analysi

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474

Keywords: Phosphatidylinositol 3-kinase; PI3K; p110α; ZSTK474;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

S100A10 Regulates ULK1 Localization to ER-Mitochondria Contact Sites in IFN-γ-Triggered Autophagy

Keywords: ANXA2; annexin A2; ATG; autophagy-related; BECN1; Beclin 1; CANX; calnexin; CTSS; cathepsin S; ER; endoplasmic reticulum; HMGB1; high mobility group protein B1; HRP; horseradish peroxidase; MTOR; mechanistic target of rapamycin; PI3K; phosphatidylinositol

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Roles for RACK1 in cancer cell migration and invasion

Keywords: EMT; Epithelial to mesenchymal transition; FAK; Focal adhesion kinase; MMPs; Matrix metalloproteases; IGF-I; Insulin-like Growth Factor-1; IGF-IR; Insulin-like Growth Factor-1 Receptor; PP2A; Protein Phosphatase 2A; PI3K; Phosphoinositide 3-kinase; PI(3,4

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Sphingolipids and glycerophospholipids - The “ying and yang” of lipotoxicity in metabolic diseases

Keywords: AA; arachidonic acid; AKT; RAC-alpha serine/threonine-protein kinase; CCTα; choline-phosphate cytidylyltransferase A; CERK; Ceramide Kinase; C1P; ceramide-1-phosphate; CerS; ceramide synthase; CERT; ceramide transport protein; HDL; high-density lipoprote

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases

Keywords: ADP; adenosine 5′-diphosphate; AgRP; agouti-related peptide; AMPK; 5′-AMP-activated protein kinase; ApnA; diadenosine polyphosphate; ApoE; apolipoprotein E; AT1R; angiotensin II type 1 receptor; ATP; adenosine 5′-triphosphate; BN-PAGE; blue native-p

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Theaflavins from black tea affect growth, development, and motility in Dictyostelium discoideum

Keywords: Polyphenols; Theaflavins; Dictyostelium; Cell motility; Development; BTE; black tea extract; EGCG; epigallocatechin gallate; PI3K; phosphoinositide 3-kinase; PIP3; phosphatidylinositol (3,4,5)-trisphosphate; Theaflavin (PubChem CID: 114777); Theaflavin 3,

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways

Keywords: D-gal; D-galactose; H2S; Hydrogen Sulfide; ROS; Reactive Oxygen Species; CD; Common Deletion; GSH; Glutathione; SOD; Superoxide Dismutase; DMEM; Dulbecco's Modified Eagle Medium; PI3K; Phosphatidylinositol 3-kinase; CaMKKβ; Ca2+/calmodulin-dependent prot

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Role of PARL-PINK1-Parkin pathway in adipocyte differentiation

Keywords: Adipogenesis; Parkin; Peroxisome proliferator-activated receptor-γ (PPARγ); Presenilin associated rhomboid-like protein (PARL); PTEN-induced kinase 1 (PINK1); C/EBPα/β; CCAAT-enhancer-binding protein-α/− β; DRP1; dynamin-related protein-1; FABP4;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Coupling between the TRPC3 ion channel and the NCX1 transporter contributed to VEGF-induced ERK1/2 activation and angiogenesis in human primary endothelial cells

Keywords: BAPTA-AM; 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester); CRAC; Ca2 +-release activated Ca2 + channel; [Ca2 +]i; cytosolic Ca2 + concentration; DAG; diacylglycerol; EC; endothelial cell; eNOS; endothelial ni

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents

Keywords: MDR; BCR-ABL inhibitors; EGFR inhibitors; VEGFR inhibitors; Drug combinations; ABC; ATP binding cassette; ADME-tox; absorption, distribution, metabolism, excretion, toxicity; AKT; v-akt murine thymoma viral oncogene homolog; ALL; acute lymphoblastic leuke

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Management of Muscle-Invasive Urothelial Cancer and the Emerging Role of Immunotherapy in Advanced Urothelial Cancer

Keywords: AKT; AKT serine/threonine kinase 1; BCG; bacillus Calmette-Guérin; CTLA4; cytotoxic T-lymphocyte-associated protein 4; EGFR; epidermal growth factor receptor; FDA; Food and Drug Administration; FGFR; fibroblast growth factor receptor; GC; gemcitabine p

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

A dominant negative FGFR1 mutation identified in a Kallmann syndrome patient

Keywords: KS; Kallmann syndrome; IHH; isolated hypogonadotropic hypogonadism; FGFR1; fibroblast growth factor receptor 1; GnRH; gonadotropin-releasing hormone; PI3K; phosphiosidtide 3-linase; PLC; phospholipase C; PKC; protein kinase C; PCR; polymerase chain reacti

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

Keywords: Total Parenteral Nutrition; EGF; GLP-2; EGFR; PI3K; Mucosal Atrophy; bp; base pair; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GLP-2; glucagon-like peptide 2; GLP2R; glucagon-like peptide 2 receptor; GLP-2 (3-33); glucagon-like

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

Genome-wide DNA methylation variation in maternal and cord blood of gestational diabetes population

Keywords: GDM; gestational diabetes mellitus; DM; diabetes mellitus; BMI; body mass index; ADIPOQ; adiponectin gene; CpG; cytosine guanine dinucleotide; OGTT; oral glucose tolerance test; IADPSG; international association of diabetes and pregnancy study groups; IPA

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

S-nitrosylation of the IGF-1 receptor disrupts the cell proliferative action of IGF-1

Keywords: Insulin-like growth factor; Nitric oxide; S-Nitrosylation; Signal transduction; ERK; extracellular signal-regulated protein kinase; IGF-1; insulin-like growth factor-1; IGF-1R; insulin-like growth factor-1 receptor; IRS; insulin receptor substrate; MAPK;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Potential mechanisms of CD133 in cancer stem cells

Keywords: CD133; Cancer stem cells (CSCs); Autophagy; Lipid metabolism; Reactive oxygen species (ROS); PI3K; Src; EGFR;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design

Keywords: PIK3CA; PI3K; PIP2; PIP3; Fragment-based drug discovery;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis

Keywords: BH domain; BCL-2 homology domain; BIK; BCL-2 interacting killer; BOP protein; BH3-only protein; DARM1; Damage-mediated autophagy modulator; E1B; E1 beta subunit of branched-chain keto acid dehydrogenase; GFP; green fluorescent protein; GST; Glutathione-S-

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Functional integration of complex miRNA networks in central and peripheral lesion and axonal regeneration

Keywords: AAV(s); adeno-associated virus(es); ADAM; a disintegrin and metalloprotease; AGO(2); argonaut (2); AKT; protein kinase B; APC; adenomatous polyposis coli; ASO(s); antisense oligonucleotide(s); ATF3; activating transcription factor 3; BBB; blood brain barr

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway

Keywords: SETDB1; set domain, bifurcated 1; H3K9; histone H3 lysine 9; SSCs; spermatogonial stem cells; GDNF; glial cell line-derived neurotrophic factor; SFK; Src family kinase; PI3K; phosphatidylinositol 3-kinase; ESCs; embryo stem cells; DMEM/F12; Modified Eagle

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum

Keywords: aa; amino acid; ATF6; activating transcription factor 6; BIK; BCL2-interacting killer; BiP; binding immunoglobulin protein; CD86; cluster of differentiation 86; CHOP; CCAAT-enhancer-binding protein homologous protein; Derlin-1; degradation in ER protein 1

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Apolipoprotein A-IV exerts its anorectic action through a PI3K/Akt signaling pathway in the hypothalamus

Keywords: Apolipoprotein; PI3K/Akt signaling; Hypothalamus; Food intake; Obesity; ApoA-IV; apolipoprotein A-IV; PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase; Akt, also known PKB; protein kinase B; DMSO; dimethyl sulfoxide; PHF; pair-fed HF; aCSF; artificial

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Metabolic roles of poly(ADP-ribose) polymerases

Keywords: ABCA1; ATP-binding cassette sub-family A member 1; ACACA; acetyl-CoA carboxylase alpha; ACBD3; acyl-CoA binding domain containing 3; ACLY; ATP citrate lyase; ADP; adenosine diphosphate; ADPR; ADP-ribose; AFLD; alcoholic fatty liver disease; AIF; apoptosis

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Frequency and Prognostic Value of PTEN Loss in Patients with Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy

Keywords: kidney; ureter; carcinoma; neoplasm recurrence; local; PTEN phosphohydrolase; IHC; immunohistochemistry; LVI; lymphovascular invasion; mTOR; mammalian target of rapamycin; PI3K; phosphatidylinositol 3-kinase; PTEN; phosphatase and tensin homolog; RNU; rad

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis

Keywords: p38MAPK phosphorylation; ERK1/2 phosphorylation; Akt phosphorylation; Migration; Pyrazolylureas; Imidazopyrazole derivatives; HUVECs; Human umbilical vein endothelial cells; BMDCs; bone marrow-derived cells; bFGF; basic fibroblast growth factor; EMT; epit

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Fructose induced neurogenic hypertension mediated by overactivation of p38 MAPK to impair insulin signaling transduction caused central insulin resistance

Keywords: BP; blood pressure; CNS; central nervous system; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinases; HR; heart rate; IRS; insulin receptor substrate; MAPK; mitogen-activated protein kinase; MEK; MAP kinase-ERK kinase; NO;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

The alteration of autophagy and apoptosis in the hippocampus of rats with natural aging-dependent cognitive deficits

Keywords: MWM; Morris water maze; HE; Hematoxylin-eosin; Bax; Bcl-2 associated X Protein; Bcl-2; B-cell lymphoma-2; ULK-1; unc-51-like kinase 1; Beclin-1; B cell lymphoma/leukemia-2 binding protein 1; LC3; light chain 3; Akt; protein kinase B; PI3K; phosphatidylino

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Dihydromyricetin induces mitochondria-mediated apoptosis in HepG2 cells through down-regulation of the Akt/Bad pathway

Keywords: Dihydromyricetin; HepG2 cells; Hepatocellular carcinoma; Apoptosis; Akt/Bad signaling pathway; Mitochondrial apoptotic pathway; Annexin V-FITC; Annexin V-fluorescein isothiocyanate; DHM; dihydromyricetin; DMSO; dimethyl sulfoxide; GAPDH; glyceraldehyd

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors

Keywords: AhR; arylhydrocarbon receptor; AIP; AhR interacting protein; ARE; antioxidant response element; ARNT; AhR nuclear translocator; bHLH; basic helix-loop-helix (DNA binding and dimerisation domain); CAR; constitutive androstane receptor; CBP; CREB-binding pr

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Differences in Dural Penetration of Clival Chordomas Are Associated with Different Prognosis and Expression of Platelet-Derived Growth Factor Receptor-β

Keywords: Clival chordomas; Dura mater; Penetration; Platelet-derived growth factor receptor-β; Prognosis; mTOR; Mammalian target of rapamycin; NTR; Nontotal resection; OS; Overall survival; PDGFR-β; Platelet-derived growth factor receptor-β; PFS; Progression-fr

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

RhoA/ROCK pathway mediates leptin-induced uPA expression to promote cell invasion in ovarian cancer cells

Keywords: uPA; urokinase plasminogen activator; ObR; leptin receptor; OB-Rb; The long form of leptin receptor; RhoA; Ras homolog gene family, member A; ROCK; Rho-associated coiled-coil-forming protein kinase; siRNA; small interfering RNA; C3; C3 transferase; JAK; J

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice

Keywords: High glucose; Oxidative stress; Vitamin D; SIRT1/AMPK/IRS1/GLUT4; Glucose metabolism; 1,25(OH)2D3; 1,25-dihydroxyvitamin D3; AKT; serine/threonine protein kinase; AMPK; AMP activated protein kinase; GLUT1; glucose transporter 1; GLUT4; glucose transporter

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis

Keywords: YAP1; YES-Associated Protein; WWTR1; TAZ; AJ; adherens junction; AMOT; angiomotin; CC; cholangiocardinoma; HB; hepatoblastoma; HCC; hepatocellular carcinoma; HepSC; hepatic stellate cell; LATS; large tumor suppressor kinase; PI3K; phosphoinositide 3-kinas

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells

Keywords: AEBSF; 4-(2-aminoethyl)-benzolsulfonylfluorid; DMEM; Dulbecco's modified Eagle's medium; EGFR; epidermal growth factor receptor; Epo; erythropoietin; EpoR; erythropoietin receptor; Erk; extracellular signal regulated kinase; FCS; fetal calf serum; Gab1; G

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Anti-inflammatory effect of Cortex Eucommiae via modulation of the toll-like receptor 4 pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages

Keywords: CE; Cortex Eucommiae; LPS; lipopolysaccharide; HPLC; high-performance liquid chromatography; RT-PCR; reverse transcriptase-polymerase chain reaction; IC50; inhibitory concentration of 50%; TLR-4; toll-like receptor 4; Myd88; myeloid differentiation primar

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Intramuscular injection of exogenous leptin induces adiposity, glucose intolerance and fatty liver by repressing the JAK2-STAT3/PI3K pathway in a rat model

Keywords: Leptin; Obesity; Glucose intolerance; Fatty liver; JAK2-STAT3; PI3K;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Design and synthesis of novel 7-aminosubstituted pyrido[2,3-b]pyrazines exhibiting anti-breast cancer activity

Keywords: Breast cancer; Pyridopyrazine; In vivo activity; PI3K; Met translational medicine; Pharmacokinetic parameters;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Sphingosine kinase 1 (SK1) allosteric inhibitors that target the dimerization site

Keywords: SK; sphingosine kinase; S1P; sphingosine-1-phosphate; PKC-α; protein kinase C alpha; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinositol kinase; CKII; casein kinase II; EGFR; epidermal growth factor receptor; sphingosine kinase 1; alloster

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه