دانلود مقالات ISI درباره Pi3K + ترجمه فارسی

The Vascular Endothelial Growth Factor-A phosphorylates Murine Double Minute-2 on its Serine 166 via the Extracellular Signal-Regulated Kinase 1/2 and p90 Ribosomal S6 Kinase in primary human endothelial cells

Keywords: Angiogenesis; Endothelial cell; Skeletal muscle; ERK1/2; extracellular signal-regulated kinase 1/2; HIF-1α; hypoxia inducible factor-1α; HDMECs; human dermal microvascular endothelial cells; MAPK; mitogen activated protein kinases; Mdm2; murine double m

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Fluorescence bioimaging of intracellular signaling and its clinical application

Keywords: BAPTA-AM; acetoxymethyl ester of 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid; BiFC; bimolecular fluorescence complementation; CML; chronic myeloid leukemia; CFP; cyan-emitting mutant of green fluorescent protein; FRET; Förster resonance

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Distinctive and selective route of PI3K/PKCα-PKCδ/RhoA-Rac1 signaling in osteoclastic cell migration

Keywords: Osteoclastic cell migration; M-CSF; Osteopontin; PI3K; PKC; Small GTPase RhoA and Rac1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells

Keywords: Apo B; Sortilin; VLDL-B100; Liver; Neurotensin; Surface plasmon resonance; Apo B; apolipoprotein B; B100; apo B derived from unedited Apob mRNA; IDAD; insulin dependent apolipoprotein B degradation; McA; McArdle RH7777 cells; PI3K; Class Ia phosphatidyli

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

House dust mite extract induces growth factor expression in nasal mucosa by activating the PI3K/Akt/HIF-1α pathway

Keywords: Allergic rhinitis; Hypoxia-inducible factor 1; Growth factor; PI3K; Signaling pathway; Nasal mucosa;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathway

Keywords: Ischemia-reperfusion; H2S; HSP70; PI3K; Akt; Nrf2

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Phosphoinositide 3-kinase inhibitor LY294002 ameliorates the severity of myosin-induced myocarditis in mice

Keywords: PI3K; LY294002; Myosin-induced myocarditis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia-Reperfusion Injury in Diabetic Rats

Keywords: AAR; area at risk; antimiR; antimicroRNA; C; control; DR; diabetic rat; GLUT4; glucose transporter type 4; IGF-1R; insulinlike growth factor-1 receptor; InsR; insulin receptor; IS; infarct size; L; lentivirus vectors with let-7 antimiR; LY; LY294002; miRN

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Nutrient-dependent control of short neuropeptide F transcript levels via components of the insulin/IGF signaling pathway in the desert locust, Schistocerca gregaria

Keywords: sNPF; Feeding; FoxO; Growth factor; Insect; Insulin-related peptide; Insulin-like peptide; DILP; Drosophila insulin-like peptide; Drk; downstream of receptor kinase; EF1α; elongation factor 1 α; ERK; extracellular signal-regulated kinase; FoxO; Forkhead

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition

Keywords: Sphingosine-1-phosphate; Sphingosine-1-phosphate receptor 2; Endothelial cells; PI3K; Akt; Diabetes

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR

Keywords: AMPK; AMP-activated protein kinase; IGF; insulin-like growth factor; PI3K; phosphoinositide 3-kinase; RHEB; RAS homolog enriched in brain; TOR; target of rapamycin; TORC; TOR complex; TSC1/2; tuberous sclerosis 1 and 2; Invertebrate; TOR; Longevity; Rapam

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

AKT signaling in ERBB2-amplified breast cancer

Keywords: PI3K; mTOR; Trastuzumab; Targeted therapy; Drug resistance; AKT3

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of intracellular pathways through which TGF-β1 upregulates URG-4/URGCP gene expression in hepatoma cells

Keywords: URG-4/URGCP; TGF-β; Upregulation; MAPK/ERK; PI3K; Promoter

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Dixdc1 targets CyclinD1 and p21 via PI3K pathway activation to promote Schwann cell proliferation after sciatic nerve crush

Keywords: Dixdc1; Schwann cell; Cell proliferation; Cell cycle; PI3K; Sciatic nerve crush;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent

Keywords: MEK; PI3K; Combination; Isogenic; Biomarker;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma

Keywords: Q; quercetin; BL; Burkitt's lymphoma; BCR; B cell receptor; GC; Germinal Center; EBV; Epstein-Barr virus; PI3K; phosphatidylinositol-3-kinase; AKT; AKT or protein kinase B; mTOR; mammalian target of rapamycin; BEZ235; NVP-BEZ235; I-c-Myc; c-Myc inhibi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

3,3′-Diindolylmethane induces anti-human gastric cancer cells by the miR-30e-ATG5 modulating autophagy

Keywords: DIM; 3,3′-diindolylmethane; LC3; microtubule-associated protein light chain; ATG; autophagy-related gene; mRFP; monomeric red fluorescent protein; GFP; green fluorescent protein; siRNA; small interfering RNA; mRNA; messenger RNA; miRNA; microRNA; MREs;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Human herpesvirus 8-encoded chemokine vCCL2/vMIP-II is an agonist of the atypical chemokine receptor ACKR3/CXCR7

Keywords: ACKR; atypical chemokine receptor; CCKAR; cholecystokinin A receptor; CCL; chemokine (CC motif) ligand; CHO; Chinese hamster ovary; CXCL; chemokine (CXC motif) ligand; CX3CL; chemokine (CX3C motif) ligand; EBV; Epstein-Barr virus; ERK; extracellular rec

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways

Keywords: SG; Sophoraflavanone G; LPS; lipopolysaccharide; NO; nitric oxide; PGE2; prostaglandin E2; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; IL-1β; interleukin-1β; PI3K; phosphoinositi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Ghrelin ameliorates the human alveolar epithelial A549 cell apoptosis induced by lipopolysaccharide

Keywords: Apoptosis; ERK signaling; Ghrelin; LPS; PI3K/Akt signaling; PI3K; phosphoinositide 3-kinase; ERK; extracellular signal-regulated kinase; ARDS; acute respiratory distress syndrome; CCK-8; Cell Counting Kit-8; DAPI; 4,6-diamidino-2-phenylindole; FITC; fluor

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

IGFBP7 is involved in abalone metamorphosis

Keywords: BC; blank control; Dilp; Drosophila insulin-like peptide; dsRNA; double-stranded RNA; FSW; filtered seawater; GABA; γ-aminobutyric acid; GFP; green fluorescent protein; hpf; hours post-fertilization; IB; insulin-like growth factors binding; IIS; insulin/

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

A randomized phase II non-comparative study of PF-04691502 and gedatolisib (PF-05212384) in patients with recurrent endometrial cancer

Keywords: Endometrial cancer; Gedatolisib; mTOR; PI3K; Stathmin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibition of acquired-resistance hepatocellular carcinoma cell growth by combining sorafenib with phosphoinositide 3-kinase and rat sarcoma inhibitor

Keywords: Sorafenib; Hepatocellular carcinoma; Drug resistance; ERK; PI3K; MDR1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Effect of concurrent administration of nobiletin and β-lactoglobulin on the symptoms of Japanese cedar pollinosis models in mice

Keywords: β-LG; β-lactoglobulin; [Ca2+]i; intracellular Ca2+ concentration; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulphoxide; DNP; dinitrophenol; ELISA; enzyme-linked immunosorbent assay; FBS; foetal bovine serum; FcεRI; high-affinity immunogl

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Acetyl-l-carnitine restores synaptic transmission and enhances the inducibility of stable LTP after oxygen-glucose deprivation

Keywords: aCSF; artificial cerebrospinal fluid; Akt; protein kinase B; ALC; acetyl-l-carnitine; fEPSPs; field excitatory postsynaptic potentials; LTP; long-term potentiation; OGD; oxygen-glucose deprivation; PI3K; phosphoinositide 3-kinase; TBS; theta burst stimu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide

Keywords: Tec; lipopolysaccharide; mast cell; septic hypothermia; TNF-α; NF-κB; MAPKs; PI3K/Akt; ARE; Adenylate-uridylate-rich element; BMMC; Bone marrow-derived mast cell; CBMC; Cord blood-derived mast cell; MAL; MyD88-adaptor like protein; MAPK; Mitogen-act

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Randomized phase 1 study of the phosphatidylinositol 3-kinase δ inhibitor idelalisib in patients with allergic rhinitis

Keywords: Phosphatidylinositol 3-kinase; p110δ; grass pollen; allergen challenge chamber; Vienna Challenge Chamber; idelalisib; GS-1101; CCL17; CCL22; allergic rhinitis; TEAE; Treatment-emergent adverse event; TNNSS; Total nonnasal symptom score; TNSS; Total nasal

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells

Keywords: Cholesterol crystals; Inflammation; Syk; PI3K; S100 proteins; CHC; cholesterol crystals; Syk; spleen tyrosine kinase; PI3K; phosphoinositide-3 kinase; MMP; matrix metalloprotease; NLRP3; Nod-like receptor related protein 3; DAMPs; damage associated molecu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways

Keywords: FT; furotrilliumoside; LPS; lipopolysaccharide; NO; nitric oxide; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; IL-1β; interleukin-1β; PI3K; phosphoinositide-3-kinase; MARK; mitoge

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Rosmarinic acid stimulates liver regeneration through the mTOR pathway

Keywords: Liver regeneration; Rosmarinic acid; mTOR; Rosemary; Proliferation; Partial hepatectomy; RA; Rosmarinic acid; PH; Partial hepatectomy; PI3K; Phosphoinositide-3 kinase; mTOR; Mammalian target of rapamycin; S6K; S6 protein kinase 1; PCNA; Proliferating cell

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Phospholipids in Autophagosome Formation and Fusion

Keywords: ER; endoplasmic reticulum; PI; phosphatidylinositol; PI3K; PI 3-phosphate kinase; PI3P; PI 3-phosphate; PE; phosphatidylethanolamine; PS; phosphatidylserine; MTMR; myotubularin-related; PI4KIIα; PI 4-phosphate kinase type II α; TGN; trans-Golgi network;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

TLR signalling affects sperm mitochondrial function and motility via phosphatidylinositol 3-kinase and glycogen synthase kinase-3α

Keywords: TLR signalling; Sperm motility; Mitochondrial function; PI3K; GSK3α;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Desmethylanhydroicaritin isolated from Sophora flavescens, shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion

Keywords: MAPK; mitogen activated protein kinase; PI3K; phosphoinositide 3-kinase; MMP; matrix metalloproteinase; WST-1; 2-(4-iodophenyl)-3(40nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium; DAPI; 4,6-diamidino2-phenylindole dihydrochloride hydrate; PBS; phosphat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Recombinant Reg3α protein protects against experimental acute pancreatitis in mice

Keywords: Acute pancreatitis; Reg3α protein; l-arginine; Pancreatic acini; Necrosis; PMSF; phenylmethylsulfonyl fluoride; PBS; phosphate buffered saline; PVDF; polyvinylidene fluoride; TBST; tris-buffered saline and tween 20; MTT; (3-(4, 5-Dimethyl-2-thiazolyl)-2,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

R132H mutation in IDH1 gene reduces proliferation, cell survival and invasion of human glioma by downregulating Wnt/β-catenin signaling

Keywords: Mutant IDH1-R132H; β-Catenin; Glioma; Proliferation; Invasion; IDH1; isocitrate dehydrogenase 1; WHO; World Health Organization; EMT; epithelial-to-mesenchymal; DAB; diaminobenzidine; FBS; Fetal Bovine Serum; IDH1-wt; wild type IDH1; IDH1-mut; IDH1-R132H

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer

Keywords: Pancreatic cancer; T cells; Exhaustion; Immunotherapy; ACT; adoptive cell transfer; AP-1; activator protein-1; APC; antigen-presenting cells; CAR; chimeric antigen receptor; CTL; cytotoxic T cells; CTLA-4; cytotoxic T lymphocyte antigen 4; FDA; US Food an

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and anti-metastatic effects of pregn-17(20)-en-3-amine derivatives

Keywords: Pregn-17(20)-en-3-amine derivatives; Breast cancer; Anti-metastatic effect; PI3K; Akt; PKCζ; Integrin β1;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs

Keywords: Hepatitis C virus (HCV); HCV RNA translation modulation; PI3K; Akt isoforms; SREBPs; NS5A;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Sustained Akt Activity Is Required to Maintain Cell Viability in Seborrheic Keratosis, a Benign Epithelial Tumor

Keywords: PI3K; phosphatidylinositol 3-kinase; SCC; squamous cell carcinoma; SK; seborrheic keratosis;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

TLR2 controls random motility, while TLR7 regulates chemotaxis of microglial cells via distinct pathways

Keywords: Toll-like receptor; Migration; Chemotaxis; PI3K; Akt; Rac;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Hydrogen sulfide prevents Abeta-induced neuronal apoptosis by attenuating mitochondrial translocation of PTEN

Keywords: AD, Alzheimer’s disease; H(2)S, hydrogen sulfide; Aβ, Abeta; NaHS, sodium hydrosulfide; PTEN, phosphatase and tensin homologs deleted on chromosome 10hydrogen sulfide; apoptosis; PTEN; PI3K; Alzheimer’s disease

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents

Keywords: PI3K; Cancer; SBDD; Molecular planarity; Solubility; Pharmacokinetic profile

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis

Keywords: Arginase 1; Arg1; cyclooxygenase; COX; ALX/N-formyl peptide receptor 2; ALX/FPR2; hepatocytes; HPCs; interleukin 1; IL-1; ischemia/reperfusion; IR; Kupffer cell; KC; lipopolysaccharide; LPS; liposome clodronate; LC; lipoxins; Lxs; lipoxygenase; LOX; nucle

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Hypolipidaemic function of Hsian-tsao tea (Mesona procumbens Hemsl.): Working mechanisms and active components

Keywords: Mesona procumbens Hemsl; Hsian-tsao; hypolipidaemia; HepG2 cells; MAPK; AMPK; ACC; acetyl-CoA carboxylase; AD; an atherogenic diet without HT; ADH; an atherogenic diet with a high dose of HT; ADL; an atherogenic diet with a low dose of HT; AMPK; 5′ AMP-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Collagen XVII Shedding Suppresses Re-Epithelialization by Directing Keratinocyte Migration and Dampening mTOR Signaling

Keywords: ADAMs; a disintegrin and metalloproteinases; Akt; acutely transforming retrovirus AKT8 in rodent T-cell lymphoma; ECM; extracellular matrix; HD; hemidesmosome; mTOR; mechanistic target of rapamycin; PI3K; phosphoinositide 3-kinase;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose

Keywords: PKCβII; protein kinase C βII; ROS; reactive oxygen species; HUVECs; human umbilical vein endothelial cells; HAECs; human aortic endothelial cells; NF-κB; nuclear factor-κB; NO; nitric oxide; DMSO; dimethyl sulfoxide; ACh; acetylcholine; PE; phenylephr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes inflammatory responses in dendritic cells

Keywords: Syk; Toll-like receptor 4; Interferon-β; IL-10; PI3K; GSK3β;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

The G protein estrogen receptor (GPER) is regulated by endothelin-1 mediated signaling in cancer cells

Keywords: ET-1; endothelin-1; ETAR; endothelin receptor A; ETBR; endothelin receptor B; PI3K; phosphatidylinositol 3-kinase; ERK; extracellular signal-regulated kinase; CTGF; connective tissue growth factor; Egr-1; early related gene; HIF-1; hypoxia inducible facto

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells

Keywords: MCE; mitotic clonal expansion; C/EBP; CCAAT/enhancer-binding protein; PPARγ; peroxisome proliferator-activated receptor γ; IR; insulin receptor; PI3K; phosphoinositide 3-kinase; PKB; protein kinase B; Topo IIα and β; DNA Topoisomerase IIα and β; mTO

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement

Keywords: Cytokine; IL-6; Cancer stem cell; Chemoresistance and EMT; MAPK; mitogen-activated protein kinases; STAT3; signal transducer and activator of transcription 3; gp130; glycoprotein 130; C/EBP; CCAAT/enhancer-binding protein; JAK; Janus kinase; PI3K; phospho

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه