S6k1 is not required for Pten-deficient neuronal hypertrophy
Keywords: Pten; S6k1; PI3k; Hypertrophy; Neuron; mTor
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Roles and regulation of Wnt signaling and β-catenin in prostate cancer
Keywords: Wnt; β-catenin; Frizzled; Androgen receptor; Prostate cancer; E-cadherin; PI3K; Akt
Muscarinic acetylcholine receptors mediate oligodendrocyte progenitor survival through Src-like tyrosine kinases and PI3K/Akt pathways
Keywords: Oligodendrocytes; Muscarinic receptors; Myelin; Survival; PI3K; Akt; MAPK; SrcACh, acetylcholine; CCh, carbachol; mAChR, muscarinic acetylcholine receptors; bFGF, basic fibroblast growth factor; BSA, bovine serum albumin fraction V; CNS, central nervous s
Role of CDK5 in neuroprotection from serum deprivation by μ-opioid receptor agonist
Keywords: Cyclin-dependent kinase 5; p35; μ-Opioid agonist; Neuronal survival; Serum deprivation; Neuroprotection; p-STAT3; PI3K
ERK is an anti-inflammatory signal that suppresses expression of NF-κB-dependent inflammatory genes by inhibiting IKK activity in endothelial cells
Keywords: VEGF; vascular endothelial growth factor; HUVECs; human umbilical vein endothelial cells; bFGF; basic fibroblast growth factor; EGF; epidermal growth factor; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; KDR; Flk-1/kinase-insert domain contai
HSP70 Enhances Macrophage Phagocytosis by Interaction With Lipid Raft-Associated TLR-7 and Upregulating p38 MAPK and PI3K Pathways
Keywords: phagocytosis; macrophage activation; heat shock proteins; lipid raft; TLR7; p38 MAPk; PI3K
Galectin-8 binds specific β1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells
Keywords: Galectin-8; β1-integrins; T cell spreading; Lamellipodia; PI3K; ERK; Rac-1
Chronic Myeloid Leukemia: Diagnosis and Treatment
Keywords: ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AP; accelerated phase; ATP; adenosine triphosphate; BP; blast phase; CCGR; complete cytogenetic response; CHR; complete hematologic response; CML; chronic myeloid leukemia; CP; chronic phase;
Preconditioning Versus Postconditioning: Mechanisms and Therapeutic Potentials
Keywords: CABG; coronary artery bypass graft; eNOS; epithelial nitric oxide synthase; ERK; extracellular signal regulated kinases; KATP channel; adenosine triphosphate sensitive potassium channel; I/R; ischemia reperfusion injury; mPTP; mitochondrial permeability t
Inhibition of GSK3β by indirubins restores HIF-1α accumulation under prolonged periods of hypoxia/anoxia
Keywords: Hypoxia; PI3K; Akt; Indirubin; HIF-1α; Translation;
Failure to protect the myocardium against ischemia/reperfusion injury after chronic atorvastatin treatment is recaptured by acute atorvastatin treatment
Keywords: eNOS; endothelial nitric oxide synthase; I/R; ischemia/reperfusion; PI3K; phosphatidylinositol-3 kinase; PTEN; phosphatase and tensin homolog deleted on chromosome ten;
Up-regulation of PI3K/Akt signaling by 17β-estradiol through activation of estrogen receptor-α, but not estrogen receptor-β, and stimulates cell growth in breast cancer cells
Keywords: Estrogen receptor; PI3K; Phosphatidylinositol-3.4.5-trisphosphate; 17β-Estradiol;
Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway
Keywords: Fludarabine; MAPK; PI3K; JNK; Apoptosis; Leukemia;
Leucine suppresses myofibrillar proteolysis by down-regulating ubiquitin-proteasome pathway in chick skeletal muscles
Keywords: Leucine; Myofibrillar proteolysis; PI3K; PKC; Ubiquitin; Proteasome;
Leptin is an eosinophil survival factor
Keywords: Apoptosis; eosinophils; inflammation; leptin; signal transduction; ECP; Eosinophil cationic protein; GAPDH; Glyceraldehyde-3-phosphate dehydrogenase; MAPK; Mitogen-activated protein kinase; PI3K; Phosphatidylinositol-3-OH kinase; PS; Phosphatidylserine; S
Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts
Keywords: Cao2+; extracellular calcium; OSE; ovarian surface epithelial; GPCR; G-protein-coupled receptor; CaR; calcium-sensing receptor; IP3; inositol triphosphate; Cai2+; intracellular calcium; ERK; extracellular signal regulated cascade; MAP kinase; mitogen-acti
The Tyrosine Phosphatase, SHP-1, Is a Negative Regulator of Endothelial Superoxide Formation
Keywords: AS-ODN; antisense oligodesoxynucleotide; HUVEC; human umbilical vein endothelial cells; NAD(P)H; reduced nicotinamide adenine dinucleotide (phosphate); O2·â; superoxide radical; PI3K; phosphatidyl-inositol-3-kinase; PTP; protein tyrosine phosphatase; A
T cell-to-T cell clustering enhances NF-κB activity by a PI3K signal mediated by Cbl-b and Rho
Keywords: CD28; Clustering; Cell-cell adhesion; Cytoskeleton; TCR; RhoA; PI3K;
Balamuthia mandrillaris stimulates interleukin-6 release in primary human brain microvascular endothelial cells via a phosphatidylinositol 3-kinase-dependent pathway
Keywords: Balamuthia; Human brain microvascular endothelial cells; Blood-brain barrier; IL-6; PI3K;
Plasmin Induces Smooth Muscle Cell Proliferation1,2
Keywords: plasmin; proliferation; cell signaling; PI3K; akt; MAPK; smooth muscle cell;
Urokinase-Induced Smooth Muscle Cell Migration Requires PI3-K and Akt Activation1,2
Keywords: urokinase; ATF; migration; cell signaling; PI3K; akt; smooth muscle cell;
Truncated ALK derived from chromosomal translocation t(2;5)(p23;q35) binds to the SH3 domain of p85-PI3K
Keywords: PI3K; phosphatidyl inositol 3â²OH-kinase; SH2; SH3; src-homology 2; 3; S473; serine 473; TetR; bacterial tetracycline repressor-it contains a dimerization motive which has no mammalian homologue; T308; threonine 308; Y418; tyrosine 418; NPM/ALK; Intera
Activation of δ-, κ-, and μ-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells
Keywords: Akt; Cell survival; G protein-coupled receptor; Opioid; Tuberin; PI3K; Pertussis toxin; Neuronal survival; Phosphorylation; Growth factor;
Airway smooth muscle: A modulator of airway remodeling in asthma
Keywords: Asthma; signal transduction; smooth muscle; proliferation; synthetic function; ADAM; A disintegrinase and metalloproteinase; ASM; Airway smooth muscle; ECM; Extracellular matrix; ERK; Extracellular signal-regulated kinase; GPCR; G protein-coupled recept
Inhibition of phosphatidylinositol 3-kinase/Akt and histone deacetylase activity induces apoptosis in non-small cell lung cancer in vitro and in vivo
Keywords: GSKβ; phospho-ser/thr-Akt substrate; HDI; histone deacetylase inhibitor; LY; LY294002; NF-κB; nuclear factor-κB; NSCLC; non-small cell lung cancer; PI3K; phosphatidylinositol 3-kinase; RT-PCR; reverse transcriptase-polymerase chain reaction; TUNEL; t
Increased Vascular Endothelial Growth Factor Expression But Impaired Vascular Endothelial Growth Factor Receptor Signaling in the Myocardium of Type 2 Diabetic Patients With Chronic Coronary Heart Disease
Keywords: CHD; coronary heart disease; CVD; cardiovascular disease; EC; endothelial cell; eNOS; endothelial nitric oxide synthase; flt-1/VEGF-R1; fms-like tyrosine kinase 1/VEGF-receptor 1; flk-1/VEGF-R2; fetal liver kinase 1/VEGF-receptor 2; LV; left ventricle/ven
Modulation of Fgf8 activity during vertebrate brain development
Keywords: Development and regeneration; Pattern formation, compartments, and boundaries; Isthmic organizer; Mouse; Brain; MAPK phosphatase; ERK1/2; PI3K; Fgf8; Mkp3; Sprouty; Sef;
Serum withdrawal kills U937 cells by inducing a positive mutual interaction between reactive oxygen species and phosphoinositide 3-kinase
Keywords: ROS; reactive oxygen species; PI3K; phosphoinositide 3-kinase; LY; LY294002; SW; serum withdrawal; SAPK/JNK; stress-activated protein kinase/c-Jun N-terminal kinase; DPI; diphenyleneiodonium; PI3K-M; dominant-negative mutant of the p85 subunit of PI3K; DC
Epidermal growth factor enhances TNF-α-induced priming of human neutrophils
Keywords: EGF; epidermal growth factor; PMN; polymorphonuclear leukocytes; ROI; reactive oxygen intermediates; LTB4; leukotrien B4; MAPK; mitogen-activated protein kinase; PAF; platelet-activating factor; EGFR; EGF receptor; HB-EGF; heparin-binding epidermal growth
The link between PKCα regulation and cellular transformation
Keywords: ASO; Antisense oligonucleotides; B-CLL; B lymphocyte-chronic lymphocytic leukaemia; DAG; diacylglycerol; IP3; inositol-1,4,5-triphosphate; ERK-MAPK; extracellular-signal regulated kinase-mitogen activated protein kinase; PIP2; phosphatidylinositol-4,5-bis
Co-induction of cell death and survival pathways by phosphoinositide 3-kinase
Keywords: PI3K; phosphoinositide 3-kinase; SW; serum withdrawal; ROS; reactive oxygen species; SAPK/JNK; stress-activated protein kinase/c-Jun N-terminal kinase; IκB-M; dominant-negative mutant of IκB; PI3K-M; dominant-negative mutant of PI3K; Akt-M; dominant-neg
Cytokine mediated suppression of TF-1 apoptosis requires PI3K activation and inhibition of Bim expression
Keywords: Apoptosis; PI3K; Cytokine; Forkhead; Bcl-2;
Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes
Keywords: Chemokines; Migration; Lymphocytes; Lipid phosphatases; PI3K; SHIP; CXCR4;
Nuclear phospholipase C-β1b activation during G2/M and late G1 phase in nocodazole-synchronized HL-60 cells
Keywords: PLC; phospholipase C; PtdIns(4,5)P2; phosphatidylinositol 4,5-bisphosphate; DAG; diacylglycerol; Ins(1,4,5)P3; inositol(1,4,5)P3; PKC; protein kinase C; PI3K; phosphatidylinositol 3-kinase; MAPK; mitogen-activated protein kinase; MEK; MAP kinase kinase; P
The action of the mast cell product tryptase on cyclooxygenase-2 (COX2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2)
Keywords: Tryptase; Cyclooxygenase-2; MAP kinases; Transcription factors; cAMP; Ca2+; 15d-PGJ2; 15-deoxy-prostaglandin J2; AP-1; activator protein-1; BMK1/ERK5; big mitogen-activated kinase 1/extracellular signal-regulated kinase isoform 5; CO2; carbon dioxide; COX
Macrophage colony-stimulating factor receptor induces tyrosine phosphorylation of SKAP55R adaptor and its association with actin
Keywords: M-CSF; macrophage colony-stimulating factor; SFK; Src family kinases; PI3K; phosphatidyl inositol 3â² kinase; GFP; green fluorescent protein; SKAP55; Src kinase-associated phosphoprotein of 55 kDa; SKAP55R; SKAP55-related protein; SLAP130/Fyb; SLP-76-ass
ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages
Keywords: EN; ETV6-NTRK3; ETV6; ETS variant gene 6; NTRK3; neurotrophic tyrosine kinase, receptor, type 3; PTK; protein tyrosine kinase; ERK; extracellular signal-regulated kinase; IGFIR; insulin-like growth factor-I receptor; IRS-1; insulin receptor substrate-1;
Intracellular signal transduction pathways induced by leptin in C2C12 cells
Keywords: Leptin; C2C12 cells; Signal transduction; PI3K; phosphatidylinositol 3 kinase; Akt/PKB; protein kinase B; GSK3; glycogen synthase kinase 3; PKC-ζ; protein kinase C ζ; ERKs; extracellular signal-regulated kinases; P38 MAPK; p38 mitogen-activated protein
Optimal Classes of Chemotherapeutic Agents Sensitized by Specific Small-Molecule Inhibitors of Akt In Vitro and In Vivo
Keywords: Akt; inhibitors; chemosensitization; apoptosis; synergy; PI3K; phosphatidyl inositol 3' kinase; PTEN; phosphatase and tensin homolog deleted in chromosome 10; GSK3; glycogen synthase kinase 3;
MAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX
Keywords: CA IX; carbonic anhydrase protein; CA9; carbonic anhydrase gene; HIF; hypoxia inducible factor; PI3K; phosphatidylinositol-3-kinase; MAPK; mitogen-activated kinase; Carbonic anhydrase IX; Hypoxia; Cell density; MAPK pathway; Promoter activity; Transcripti
Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia
Keywords: Hypoxia resistance; Cancer; PI3K; mTOR; S6K; S6; ATP; Necrosis; Cell cycle;
TG1019/OXE, a Gαi/o-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis
Keywords: 5-Oxo-ETE; TG1019; OXE; Chemotaxis; PI3K; Phospholipase C; ERK; Calcium mobilization; U73122; LY294002; GPCR; Lipid mediator;
Targeted Inhibition of β-Adrenergic Receptor Kinase-1-Associated Phosphoinositide-3 Kinase Activity Preserves β-Adrenergic Receptor Signaling and Prolongs Survival in Heart Failure Induced by Calsequestrin Overexpression
Keywords: βAR; β-adrenergic receptor; βARK1; βAR kinase-1; cAMP; cyclic adenosine monophosphate; CSQ; calsequestrin; GSK; glycogen synthase kinase 3β; ISO; isoproterenol; MAPKs; mitogen-activated protein kinases; PKB; protein kinase B; PI3K; phosphoinositide-3
Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line
Keywords: cisplatin; cisdiamminedichloroplatinum; PI3K; phosphatidylinositol 3-kinase; PtdIns(3,4)P2; phosphatidylinositol-3,4-biphosphate; PtdIns(3,4,5)P3; phosphatidylinositol-3,4,5-triphosphate, siRNA, small interfering RNA; RT; reverse transcription; OVCAR-3 ce
Calcium-pH crosstalks in rat mast cells: modulation by transduction signals show non-essential role for calcium in alkaline-induced exocytosis
Keywords: PKC; protein kinase C; pHi; cytosolic pH; Gf; GF 109203X; OA; okadaic acid; CT; cholera toxin; PT; pertussis toxin; PI3K; phosphatitilinositol 3 kinase; Cytosolic pH; Cytosolic Ca2+; Mast cells; Transduction signal; Alkalinization;
Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress
Keywords: 2APB; 2-aminoethoxydiphenylborane; ATP; adenosine 5â²-triphosphate; FITC; fluorescein isothiocyanate; 5-HD; 5-hydroxydecanoic acid; IP3; inositol 1,4,5-trisphosphate; LDH; lactate dehydrogenase; PBS; phosphate buffered saline; PC; preconditioning; PI3K;
Inhibition of epidermal growth factor-induced cell transformation by tannins
Keywords: AP-1; activator protein 1; BME; basal medium Eagle; DMSO; dimethylsulfoxide; DTT; dithiothreitol; EBV-EA; Epsten-Barr virus early antigen; EGCG; (â)-epigallochatechin-3-gallate; EGF; epidermal growth factor; EGFR; EGF receptor; ERKs; extracellular-sig
Frutalin, a galactose-binding lectin, induces chemotaxis and rearrangement of actin cytoskeleton in human neutrophils: Involvement of tyrosine kinase and phosphoinositide 3-kinase
Keywords: Frutalin; Plant lectin; Galactose; Neutrophils; Chemotaxis; FAK; PI3K; Actin cytoskeleton; Oxidative burst; Signal transduction;
Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells
Keywords: Akt; protein kinase B; ERKs; extracellular signal-regulated kinases; ITCs; isothiocyanates; JNK; c-Jun N-terminal kinase; MAPKs; mitogen-activated protein kinases; MRP2; multidrug resistance-associated protein 2; NF-κB; nuclear factor-kappa B; NQO1; NADP
HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway: An unexpected effect on TRAIL-induced apoptosis
Keywords: TRAIL; Apoptosis; HER2/neu; Trastuzumab; PI3K; Breast cancerTNF, tumor necrosis factor; TRAIL, TNF-related apoptosis-inducing ligand; TRAIL-R, TRAIL-receptor; MAPK, mitogen-activated protein kinase; MEK, MAPK/ERK kinase; PI3K, phosphatidylinositol 3′ kina