دانلود مقالات ISI درباره Pip3 + ترجمه فارسی

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

Keywords: PI3K pathway; Targeted therapy; Predictive biomarkers; 4EBP1; 4E-binding protein 1; AKT; protein kinase-B; AMPK; AMP-activated protein kinase; COSMIC; Catalogue of Somatic Mutations in Cancer; eIF4E; eukaryotic initiation factor 4E; ERK; extracellular-sig

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2014 سفارش ترجمه

Insulin-dependent apolipoprotein B degradation is mediated by autophagy and involves class I and class III phosphatidylinositide 3-kinases

Keywords: ERAD; endoplasmic reticulum-associated degradation; PI3K; phosphatidylinositide 3-kinase; PIP3; phosphatidylinositide (3,4,5) triphosphate; PI3P; phosphatidylinositide 3 monophosphate; PTEN; phosphatase and tensin homologue; PERPP; post-ER presecretory pr

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibitory effect of aqueous spinach extract on degranulation of RBL-2H3 cells

Keywords: BSA; bovine serum albumin; [Ca2+]i; intracellular Ca2+ concentration; DMEM; Dulbecco's Modified Eagle Medium; DNP; dinitrophenol; FBS; foetal bovine serum; FcεRI; high-affinity IgE receptor; HRP; horseradish peroxidase; HSA; human serum albumin; IgE; i

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway

Keywords: AKT; v-akt murine thymoma viral oncogene; CRC; colorectal cancer; FDR; false discovery rate; HECT; homologous to E6AP C terminus; KEGG; Kyoto Encyclopedia of Genes and Genomes; mut; mutated; NCBI; National Center for Biotechnology Information; PBS; phosph

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation

Keywords: Glycyrrhizic acid; 18β-Glycyrrhetinic acid; Glucocorticoid receptor; Phosphoinositide 3-kinase; Glucocorticoid resistance; 18βGA; 18β-glycyrrhetinic acid; Akt; protein kinase B; AP1; activator protein 1; COPD; chronic obstructive pulmonary disease; CRE

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway

Keywords: HLJDD; Huang-Lian-Jie-Du-Decotion; MCAO; middle cerebral artery occlusion; TTC; 2,3,5-triphenyltetrazolium chloride; HE; hematoxylin-eosin; NO; nitric oxide; MDA; malondialdehyde; GSH; glutathione; GSSG; glutathione disulfide; T-SOD; total superoxide di

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

B-lymphocyte lineage cells and the respiratory system

Keywords: B cells; plasma cells; plasmablasts; respiratory diseases; AID; Activation-induced cytidine deaminase; APRIL; A proliferation-inducing ligand; BAFF; B cell-activating factor of the TNF family; BAL; Bronchoalveolar lavage; BCMA; B-cell maturation antigen

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2013 سفارش ترجمه

β-Arrestin signal complex plays a critical role in adipose differentiation

Keywords: GHSR1a; growth hormone secretagogue receptor type 1a; PPARγ; peroxisome proliferator-activated receptor; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT/enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; PI3K; phosphatidy

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2013 سفارش ترجمه

Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases

Keywords: PI3Ks; phosphatidylinositol 3-kinases; PIP3; phosphatidylinositol 3,4,5-triphosphate; QPLD; Quantum-Polarized Ligand Docking; PI3K; Docking; Pharmacophore modeling; Apoptosis; LY294002; GSK2126458;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Increase in phosphorylation of PDK1 and cell survival after acute spinal cord injury

Keywords: PDK1; 3-Phosphoinositidedependent protein kinase-1; PKB; protein kinase B; PIP3; phosphoinositol 3,4,5-triphosphate; CNS; Central nervous system; SCI; Spinal cord injury; SDS; Sodium dodecyl sulfate; PAGE; Polyacrylamide gel electrophoresis; BSA; Bovine s

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Vav1 in differentiation of tumoral promyelocytes

Keywords: GEF; guanosine exchange factor; APL; acute promyelocytic leukemia; ATRA; All-trans retinoic acid; LIC; leukemia initiating cells; PMA; phorbol 12-myristate 13-acetate; PIP; phosphatidylinositol 4-phosphate; PIP2; phosphatidylinositol 4, 5-bisphosphate; PI

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Redox control of cytosolic Akt phosphorylation in PTEN null cells

Keywords: AMS; 4-acetamido-4-maleimidylstilbene-2, 2-disulfonic acid; DDC; diethyldithiocarbamate; DMSO; dimethyl sulfoxide; DPI; diphenyleneiodonium; MEFWT; wild-type mouse embryonic fibroblasts; MEFPTEN−/−; PTEN knockout mouse embryonic fibroblasts; O2•−;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Beyond 'furballs' and 'dumpling soups' - towards a molecular architecture of signaling complexes and networks

Keywords: Abl; Abelson tyrosine-protein kinase 1; ADAP1; arf-GAP with dual PH domain-containing protein 1; AFM; atomic force microscopy; cAMP; cyclic adenosine monophosphate; ApoER2; apolipoprotein E receptor 2; BCAR1; breast cancer anti-estrogen resistance 1; p130

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Modulation of FcεRI-dependent mast cell response by OX40L via Fyn, PI3K, and RhoA

Keywords: OX40L; Fyn; PI3K; mast cell; degranulation; anaphylaxis; BM; Bone marrow; Cbp; C-terminal Src kinase-binding protein; Csk; C-terminal Src kinase; DNP; Di-nitro-phenyl; MC; Mast cell; MTOC; Microtubule organizing center; NIH; National Institutes of Healt

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

3-Phosphoinositide-Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner

Keywords: PDK1; 3-phosphoinositide-dependent protein kinase 1; PI3K; phosphatidylinositol 3 kinase; PIP3; phosphatidylinositol 3,4,5 triphosphate; PH; pleckstrin homology; shRNA; short hairpin RNA;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function

Keywords: PI3Kδ; phosphoinositide 3-kinase delta; PIP3; phosphoinositide 3,4,5-triphosphates; SH2; Src homology-2; PH; pleckstrin homology; KD; kinase-dead; KO; knockout; BCR; B cell receptor; GPCR; G protein-coupled receptor; TCR; T cell receptor; FcεRI; high af

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Nonmuscle myosin IIA is required for lamellipodia formation through binding to WAVE2 and phosphatidylinositol 3,4,5-triphosphate

Keywords: Lamellipodia; Myosin IIA; PIP3; WAVE2; IGF-I

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Several agents and pathways regulate lipolysis in adipocytes

Keywords: Lipolysis; Adipose tissue; Intracellular signalling pathways; Hormone-sensitive lipase; Adipose triglyceride lipase; Antilipolysis; ACTH; adrenocorticotrophin hormone; AdPLA; adipose-specific phospholipase A2; Ang II; angiotensin II; ANP; atrial natriuret

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

A novel function for KIF13B in germ cell migration

Keywords: Xenopus; Primordial germ cells; KIF13B; PIP3;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

swap70 Promotes neural precursor cell cycle exit and oligodendrocyte formation

Keywords: CNS; central nervous system; OPCs; oligodendrocyte progenitor cells; GEF; guanine nucleotide exchange factor; PIP3; phosphatidylinositol-3,4,5-triphosphate; Neural precursor; Oligodendrocyte; Glia; Zebrafish; Neurogenesis;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer

Keywords: Colon Cancer; Neoplasm; Signal Transduction; Genetics; Tumor; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GPCR; G-protein-coupled receptor; IRS1; insulin receptor substrate 1; MEF; murine embryonic fibro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Animal models relevant to human prostate carcinogenesis underlining the critical implication of prostatic stem/progenitor cells

Keywords: ADT; androgen deprivation therapy; AI; androgen-independent; ALDH; aldehyde dehydrogenase; AR; androgen receptor; ARR2; two androgen-responsive regions; BM; bone marrow; CXCR4; CXC chemokine receptor 4; CK; cytokeratin; ECM; extracellular matrix; EGFR; ep

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Signal-transduction networks and the regulation of muscle protein degradation

Keywords: 15(S)-HETE; 15(S)-hydroxyeicosatetraenoic acid; ACh; acetylcholine; Akt; protein kinase B; CNTF; ciliary neurotrophic factor; EGF; epidermal growth factor; FGF; fibroblast growth factor; FOXO; forkhead transcription factor; Grb2; growth factor receptor bo

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Energy metabolism in adult neural stem cell fate

Keywords: ACC; adenylate cyclase complex; AICAR; aminoimidazole carboxamide ribonucleotide; AMPK; AMP-activated protein kinase; Aspm; abnormal spindle-like microcephaly-associated; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; bHLH;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2011 سفارش ترجمه

Addiction to protein kinase CK2: A common denominator of diverse cancer cells?

Keywords: ALCL; anaplastic large cell lymphoma; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; CML; chronic myeloid leukemia; MDR; multi-drug resistance; MM; multiple myeloma; NF-kB; nuclear factor-kB; PDK1; 3′-phosphoinositide-dependent kinase-1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

CaV2.1 channels are modulated by muscarinic M1 receptors through phosphoinositide hydrolysis in neostriatal neurons

Keywords: muscarinic receptors; Ca2+ channels; phosphatidylinositol (4,5) bisphosphate; phosphatidylinositol (3,4,5) trisphosphate; AHP; afterhyperpolarizing potential; ANOVA; one-way analysis of variance; DAG; diacilglicerol; DMSO; dimethylsulfoxide; ICa2+; Ca2+ c

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Predictive and Prognostic Biomarkers for Targeted Therapy in Metastatic Colorectal Cancer

Keywords: Bevacizumab; BRAF; EGFR; IGF-1R; NRAS; PIK3CA; PIP3; PTEN; KRAS; VEGF

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Directional control of WAVE2 membrane targeting by EB1 and phosphatidylinositol 3,4,5-triphosphate

Keywords: IGF-I; insulin-like growth factor I; siRNA; small interfering RNA; IGF-IR; IGF-I receptor; PI 3-kinase; phosphatidylinositol 3-kinase; PIP3; phosphatidylinositol 3,4,5-triphosphate; F-actin; actin filament; CLIP; cytoplasmic linker protein; CLAPS; CLIP-as

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Oscillatory control of insulin secretion

Keywords: Insulin secretion; Oscillations; Metabolism; Ca2+; cAMP; Phospholipase C; PIP2; PI3-kinase; PIP3

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2009 سفارش ترجمه

PKCepsilon mediates glucose-regulated insulin production in pancreatic beta-cells

Keywords: ER; endoplasmic reticulum; PKC; protein kinase C; RACK2; receptor for activated C kinase 2; COP1; coatomer protein 1; AUC; area under the curve; siRNA; small interfering RNA; DAG; diacylglycerol; PIP3; phosphatidylinositol 3,4,5-triphosphate; TGN; trans G

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

aPKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region

Keywords: aPKC; PtdIns(3,4,5)P3; PIP3; PtdIns(4,5)P2; PIP2; AktPH; PTEN; Membrane domain; Epithelial cell polarity; MDCK cells

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Three-dimensional microenvironments modulate fibroblast signaling responses

Keywords: ECM; extracellular matrix; FN; fibronectin; 3D; three-dimensional; 2D; two-dimensional; FAK; focal adhesion kinase; MAP kinase; mitogen-activated protein kinase; ERK1/2; extracellular signal-regulated kinase1/2; PI3K; phosphatidylinositol 3′-kinase; PIP3;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Protein kinase C-dependent antilipolysis by insulin in rat adipocytes

Keywords: β-AR; β-adrenergic receptor; α-AR; α-adrenergic receptor; PKA; protein kinase A; PKC; protein kinase C; PKB; protein kinase B; PDK; phosphoinositide-dependent protein kinase; PI3K; phosphatidylinositol 3-kinase; PIP3; phosphatidylinositol 3,4,5-tripho

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Tumour suppressors in liver carcinogenesis

Keywords: APC; adenomatous polyposis coli; HBx; Hepatitis B virus protein x; Hh; Hedgehog; HIT; histidine triad; mTOR; mammalian target of rapamycin; PI3K; phosphatidyl-inositide-3OH-kinase; PIP3; phosphatidyl-inositide-3, 4, 5-P3; S6K; S6 kinase;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Relationship between spleen tyrosine kinase and phosphatidylinositol 5′ phosphatase expression and secretion from human basophils in the general population

Keywords: Human; basophil; allergy; Fc receptors; ED50; Effective density for 50% of the maximal response; HRF; Histamine-releasing factor (p23); PI3; Phosphatidylinositol 3′; PIP3; Phosphatidylinositol 3,4,5 trisphosphate; SHIP; Phosphatidylinositol 5′ phospha

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Calmodulin potentiates Gβγ activation of phospholipase C-β3

Keywords: PLC; phosphatidylinositol phospholipid-specific phospholipase C; PE; phosphatidylethanolamine; PS; phosphatidylserine; PIP 16:0; synthetic phosphatidylinositol-4-phosphate with symmetric 16:0 saturated fatty acyl chains; PIP; phosphatidylinositol-4-phosph

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Biología molecular de los glioblastomas

Keywords: Glioblastoma; Biología molecular; ADN; ácido desoxiribonucleico; CDK4; quinasa 4 dependiente de ciclina; DMBT1; Deleted in Malignant Brain Tumors; EGF; factor del crecimiento epidérmico; EGFR; receptor del factor del crecimiento epidérmico; EGFR vIII;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons

Keywords: metalloendopeptidase; western blot analysis; cellular distribution; human brain; p42IP4; centaurin-α1; EDTA; ethylene diamine tetraacetate; GFAP; glial fibrillary acidic protein; HB-EGF; heparin-binding epidermal growth factor-like growth factor; HEK293;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury

Keywords: Bad phosphorylation; JNK; Akt; SP600125; bpV(pic); Cerebral ischemia; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; PI3K; phosphoinositide 3-kinase; ERK; Extracellular signal regulated kinase; PKA; protein kinase A; RTK; receptor t

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-κB activation in HL-60 cells

Keywords: PI 3-kinase; phosphoinositol 3-kinase; PIP3; phosphoinositol 3,4,5-trisphosphate; NF-κB; nuclear factor-kappaB; PTEN/MMAC; phosphatase and tensin homologue/mutated in multiple advanced cancers; PDTC; pyrrolidine dithiocarbamate; Dimethylsulfoxide; PTEN;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells

Keywords: P-Rex2b; GEF; Cell migration; Endothelial cell; HEK293T cell; Rac1; P-Rex2; PtdIns(3,4,5)P3-dependent Rac exchange factor 2; SRE.L; SRE-Luciferase reporter gene; S1P; spingosine-1 phosphate; GEF; guanine nucleotide exchange factor; PIP3; phosphatidylinosi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Dying a Thousand Deaths: Redundant Pathways From Different Organelles to Apoptosis and Necrosis

Keywords: Akt; proto-oncogene product of the viral oncogene v-akt; AIF; apoptosis inducing factor; Apaf-1; apoptotic protease activating factor-1; ATF6; activating transcription factor 6; Bad; heterodimeric partner for Bcl-xL and Bcl-2; Bak; Bcl2 homologous antagon

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Regulatory roles and molecular signaling of TNF family members in osteoclasts

Keywords: AP-1; activator protein-1; ASK1; apoptosis signal-regulated kinase-1; CARD; caspase recruiting domain; CFU-GM; colony forming unit-granulocyte/macrophage; CRD; cysteine-rich repeat; CTR; calcitonin receptor; DD; death domain; DED; death effector domain; E

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

Right time, right place: the organization of membrane proximal signaling

Keywords: AP-1; activator protein 1; Bam32; B-lymphocyte adaptor molecule of 32 kDa; BCR; B-cell receptor; Cbp; Csk binding protein; Csk; carboxyl-terminal Src kinase; DAG; diacylglycerol; DAPP1; dual adaptor for phosphotyrosine and 3-phosphoinositides; ERK; extra

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه

Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease

Keywords: Aβ; β-amyloid; AD; Alzheimer's disease; AIF; apoptosis-inducing factor; ALS; amyotrophic lateral sclerosis; Apaf-1; apoptotic protease-activating factor; APC; adenomatous polyposis coli; APP; amyloid precursor protein; BrdU; bromodeoxyuridine; CARD; cas

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2005 سفارش ترجمه