Molecular and cellular pharmacologyHyperglycemia induced down-regulation of renal P-glycoprotein expression
Keywords: P-glycoprotein; Diabetes; Kidney; Reactive oxygen species; PKC;
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Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
Keywords: AD; Alzheimer's disease; AKT; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor; aPKC; atypical protein kinase C; APP; amyloid-β precursor protein; ATG; AuTophaGy-related; BDNF; brain-derived neurotrophic factor; C/EBP; C
The membrane binding kinetics of full-length PKCα is determined by membrane lipid composition
Keywords: PKC; Protein kinase C; POPC; 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPS; 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine; PIP2; Phosphatidylinositol 4,5-bisphosphate; DOG; 1,2-Dioleoyl-sn-glycerol; IP3; Inositol 1,4,5-trisphosphate; PKCα; Rap
Emerging role of microglial kinin B1 receptor in diabetic pain neuropathy
Keywords: AGE; Advanced glycation end product; AMPA-R; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; ATP; Adenosine-5â²-triphosphate; B1R; Kinin B1 receptor; B2R; Kinin B2 receptor; BDNF; Brain derived neurotrophic factor; BK; Bradykinin; CCL2; C
Coordination of calcium signals by pituitary endocrine cells in situ
Keywords: ACTH; adrenocorticotrophic hormone; ATP; adenosine triphosphate; ATPase; ATP synthase; [Ca2+]i; intracellular calcium concentration; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; CICR; calcium-induced calcium release; DAG; di
Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy
Keywords: CIPN; cancer chemotherapy-induced peripheral neuropathy; CGRP; calcitonin gene related peptide; cGMP; cyclic guanosine monophosphate; CRPS-I; complex regional pain syndrome; Cyt C; cytochrome C; DRG; dorsal root ganglia; ERK; extracellular signal regulate
Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status
Keywords: AMPK; AMP-activated protein kinase; BH4; tetrahydrobiopterin; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; eNOS; endothelial nitric oxide synthase; FBS; fetal bovine serum; HA-tag; hemagglutinin tag; Hepes; 4-(2-hydroxyethyl)-1-pipe
Stimulation of Ca2Â +-sensing receptor inhibits the basolateral 50-pS K channels in the thick ascending limb of rat kidney
Keywords: External Ca2Â +; Inwardly-rectifying K channel; Phospholipase C; PKC;
Hierarchy between the transmembrane and cytoplasmic domains in the regulation of syndecan-4 functions
Keywords: ECM; extracellular matrix; FN; fibronectin; GAG; glycosaminoglycan; HSPG; heparan sulfate proteoglycan; PIP2; phosphatidylinositol 4,5-bisphosphate; PKC; protein kinase C; PMA; Phorbol 12-myristate 13-acetate; REF; rat embryo fibroblasts; Extracellular ma
Cardiovascular effects and molecular targets of resveratrol
Keywords: 4-HNE; 4-hydroxy-2-nonenal; ADMA; asymmetric dimethylarginine; AMPK; AMP-activated protein kinase; ApoE; apolipoprotein E; ARE; antioxidant response element; BH4; tetrahydrobiopterin; Cav-1; caveolin-1; COX-1; cyclooxygenase 1; CREB; cAMP response element
FMRFamide-related peptides: Anti-opiate transmitters acting in apoptosis
Keywords: ERK-1/2; extracellular signal-regulated protein kinase 1/2; Bcl-2; B-cell lymphoma 2; FADD; Fas-associated death domain; KOP; kappa (κ) opioid receptor; MEIS; homeobox protein Meis1; MOP; mu (μ) opioid receptor; Oct-1; octamer-binding protein 1; p38 MAP
Epac enhances excitation-transcription coupling in cardiac myocytes
Keywords: [Ca2Â +]; calcium concentration; [Ca2Â +]i; intracytoplasmic calcium concentration; [Ca2Â +]n; intranuclear calcium concentration; 2-APB; 2-aminoethoxydiphenyl borate; 8-pCPT; 8-(4-chlorophenylthio)-2-O-methyladenosine-3,5_-cyclic monophosphate; BP; band
Phospholipase A2 activating protein is required for 1α,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3
Keywords: PLAA; phospholipase A2 activating protein; Pdia3; protein-disulfide isomerase-associated 3; PKC; protein kinase C; PLA2; phospholipase A2; PGE2; prostaglandin E2; AA; arachidonic acid; PLC; phospholipase C; BS3; bis(sulfosuccinimidyl) substrate; 1α,25(OH
Prostaglandin F2α facilitates collagen synthesis in cardiac fibroblasts via an F-prostanoid receptor/protein kinase C/Rho kinase pathway independent of transforming growth factor β1
Keywords: PGF2α; Collagen; FP receptor; PKC; Rho kinase
Identification and functional characterization of zebrafish K2P10.1 (TREK2) two-pore-domain K+ channels
Keywords: AA; arachidonic acid; aa; amino acids; CDS; coding sequence; Erev; reversal potential; h; human; I; current; IKP; cardiac plateau current; ISH; in situ hybridization; K2P channel; two-pore-domain potassium channel; M1 and M2; first and second translation
Role of protein kinase C in phospholemman mediated regulation of α2β1 isozyme of Na+/K+-ATPase in caveolae of pulmonary artery smooth muscle cells
Keywords: PLM; Na+/K+-ATPase isozyme; Caveolae; PKC; PKA; DOPC; dioleoylphosphatidylcholine; DHPC; 1,2-diheptanoyl-sn-phosphatidylcholine;
Staurosporine-induced apoptosis presents with unexpected cholinergic effects in a differentiated neuroblastoma cell line
Keywords: AChE; acetylcholinesterase; AChE-T; tailed AChE; AChE-R; readthrough AChE; AMP-PNP; adenosine 5â²-(β,γ-imido)triphosphate; AV; Annexin V-FITC; ChAT; choline acetyltransferase; FBS; fetal bovine serum; HACU; high affinity choline uptake; HC-3; hemicholi
Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions
Keywords: NA; noradrenaline; AR; adrenergic receptor; PKC; protein kinase C; PI3K; phosphoinositide 3-kinase; S1P; sphingosine 1-phosphate; SPHK-1; sphingosine kinase-1; eGFP; enhanced green fluorescent protein; α1B-Adrenoceptor; α1B-Adrenergic receptor; Sphingos
Endocytosis and post-endocytic sorting of connexins
Keywords: CHO; Chinese hamster ovary; CIP75; connexin43-interacting protein of 75-kDa; CIP85; connexin43-interacting protein of 85-kDa; Dab2; disabled-2; EEA1; early endosomal autoantigen 1; EGF; epidermal growth factor; ENaC; amiloride-sensitive epithelial sodium
The role of amino acid transporters in GSH synthesis in the blood-brain barrier and central nervous system
Keywords: AA; amino acid; AARE; amino acids response elements; ApN; aminopeptidase N; ARE; antioxidant response element; BBB; blood-brain barrier; BEC; brain endothelial cell; CNS; central nervous system; CSF; cerebrospinal fluid; EC; endothelial cell; ERK; extra
Activation of Toll-like receptor 3 induces apoptosis of oral squamous carcinoma cells in vitro and in vivo
Keywords: TLR3; Toll-like receptor 3; dsRNA; double-stranded RNA; OSCC; oral squamous cell carcinoma; poly I:C; dsRNA-polyinosinic-polycytidilic acid; IFN-β; interferon-β; PRR; pattern recognition receptors; DCs; dendritic cells; siRNA; small interfering RNA; TUN
Notch signaling pathway regulates proliferation and differentiation of immortalized Müller cells under hypoxic conditions in vitro
Keywords: BrdU; 5-bromo-2â²-deoxyuridine; CRALBP; cellular retinaldehyde-binding protein; DAPI; 4â²,6-diamidino-2-phenylindole; DAPT; N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester; ERK; extracellular signal-regulated kinase; FGF2; fibrobl
Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells
Keywords: CTC; chelerythrine chloride; GPCR; G protein-coupled receptor; MCP-1; monocyte chemoattractant protein-1; pPaxillin; tyrosine 118 phosphorylated paxillin; PKC; protein kinase C; PMA; phorbol 12-myristate 13-acetate; RS; RS-102895; shRNA; short hairpin RNA
Diacylglycerol kinase ζ: At the crossroads of lipid signaling and protein complex organization
Keywords: APC; antigen-presenting cell; DAG; diacylglycerol; DGK; diacylglycerol kinase; GFP; green fluorescent protein; GPCR; G protein-coupled receptor; LTP; long-term potentiation; MARCKS; myristoylated alanine-rich C kinase substrate protein; PDZ-bm; PDZ bindin
Age-related cataracts: Homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection
Keywords: ARC; age-related cataract; ARE; antioxidant response element; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; Bip; ER-resident chaperone protein; CHOP; C/EBP homologous protein; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM
Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer properties
Keywords: A2780; human ovarian carcinoma cells; AP-1; activator protein 1; ATF-2; activating transcription factor-2; ANOVA; analysis of variance; CD; cluster of differentiation; DMSO; Dimethyl sulfoxide; DMEM; Dulbecco's modified Eagle's medium; EF24; 3,5-Bis(2-flu
Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves
Keywords: BCEC, bovine brain capillary endothelial cells; BK, bradykinin; Cx, connexin; CaMKII, Ca2+/calmodulin-dependent kinase II; DF, dextran fluorescein; ICW, intercellular Ca2+ wave; IP3, inositol-trisphosphate; LY, lucifer yellow; MLC, myosin light chain; PKC
Valproic acid induces the glutamate transporter excitatory amino acid transporter-3 in human oligodendroglioma cells
Keywords: DHK; dihydrokainate; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; DTT; 1,4-dithiothreitol; EAAC1; excitatory amino acid carrier 1; EBSS; Earle's balanced salt solution; EAAT1-2-3; excitatory amino acid transporter 1-2-3; FBS;
EGF-like peptide-enhanced cell movement in Dictyostelium is mediated by protein kinases and the activity of several cytoskeletal proteins
Keywords: EGF; epidermal growth factor; EGFL; EGF-like; EGFL1; 1st EGFL repeat of CyrA; EGFR; EGF receptor; EGFRL; EGFR-like protein; Ten14; 14th EGFL repeat of tenascin C; ECM; extracellular matrix; CaM; calmodulin; CaMBP; CaM binding protein; MHC; myosin II heavy
'PUFA-GPR40-CREB signaling' hypothesis for the adult primate neurogenesis
Keywords: AC; adenylyl cyclase; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ARA; arachidonic acid; BDNF; brain-derived neurotrophic factor; BrdU; bromodeoxyuridine; [Ca2+]i; intracellular Ca2+ concentration; CaMK; calmodulin-dependent kinase; cAMP;
17β-Estradiol stimulates the translocation of endogenous estrogen receptor α at the plasma membrane of normal anterior pituitary cells
Keywords: ER; estrogen receptor; PPT; 4,4â²,4â³-(4-propyl-[1H]-pyrazole-1,3,5-tryl) trisphenol, selective ERα agonist; ICI 182780; (7a,17b)-7-[9-[(4,4,5,5,5pentafluoropentyl) sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol; PKC; protein kinase C; Anterior pituit
Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners
Keywords: AMPK; AMP-activated protein kinase; ARF; ADP-ribosylation factor; CDK5; cyclin-dependent kinase 5; CEM; caveolin-enriched membrane; CRMP-2; collapsin response mediator protein-2; EGF; epidermal growth factor; EGFR; EGF receptor; GAP; GTPase-activating pro
IL1β-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells
Keywords: IL-1β; Interleukin 1-β; COX; Cyclooxygenase; PGE2; Prostaglandin E2; PKC; Protein kinase C; NS 398; N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide; STA; Staurosporine; BIM.; Bisindoylmalemide I; Colonic fibroblasts; Cyclooxygenase-2; Prostaglandi
The application of modular protein domains in proteomics
Keywords: pTyr; phosphotyrosine; PTM; post-translational modification; MS; mass spectrometry; PSSM; position specific scoring matrix; SH2; Src homology 2; SH3; Src homology 3; WW; tryptophan tryptophan; PDZ; post synaptic density protein 95-disks large protein 4-zo
Role of phospholipase Cε in physiological phosphoinositide signaling networks
Keywords: PLC; phosphoinositide-specific phospholipase C; PKC; protein kinase C; LPA; lysophosphatidic acid; S1P; sphingosine-1 phosphate; Epac; Exchange protein directly activated by cAMP; GPCR; G protein-coupled receptor; GEF; guanine nucleotide exchange factor;
Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
Keywords: AP-1; activator protein-1; ASC; apoptosis-associated speck-like protein containing a CARD domain; ASK; apoptosis signal-regulating kinase; ATM; Ataxia Telangiectasia Mutated; ATR; ATM and Rad 3-related; BRCA1; breast cancer 1; CARD; caspase activation and
Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38
Keywords: AKT/PKB; protein kinase B; AP-1; activator protein-1; ARE; antioxidant response element; CHX; cycloheximide; DAPI; 6-diamidino-2-phenylindole; DTT; dithiothreitol; ERK; extracellular regulated kinase; FBS; fetal bovine serum; GAPDH; glyceraldehyde-3-phosp
Melanocortin 5 receptor signaling and internalization: Role of MAPK/ERK pathway and β-arrestins 1/2
Keywords: CREB; cAMP-responsive element binding protein; ERK; extracellular-regulated protein kinase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GFP; green fluorescent protein; GPCR; G-protein coupled receptor; HRP; horseradish peroxidase; MC5R; melanocortin
Retinoid metabolism and its effects on the vasculature
Keywords: ADH; alcohol dehydrogenase; ADMA; asymmetric dimethylarginine; AP-1; activated protein-1; apo14; β-apo-14â²-carotenal; ARVM; adult rat ventricular myocytes; ATBC; Alpha-tocopherol Beta-carotene Cancer Prevention Study; atRA; all-trans retinoic acid; BCO
Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway
Keywords: EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; FGF; fibroblast growth factor; IGF; insulin-like growth factor; IGF-IR; type 1 IGF receptor; IR; insulin receptor; IRS; insulin receptor substrate; PI 3-kinase; phosphatidylinositol
Membrane-initiated actions of estradiol that regulate reproduction, energy balance and body temperature
Keywords: ERα; ERβ; GABAB receptor; Gαq-mER; GIRK channels; GnRH; μ-Opioid receptor; PKA; PKC; POMC
Zinc and the modulation of redox homeostasis
Keywords: Akt; protein kinase B; BDNF; brain-derived neurotrophic factor; ERK; extracellular signal-regulated kinases; GCL; glutamate-cysteine ligase; GSH; glutathione; GPCR; G-protein-coupled receptor; Keap1; Kelch-like ECH-associated protein; JNK; Jun N-termina
DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex
Keywords: [Na+]o; extracellular Na+ concentrations; ACSF; artificial cerebrospinal fluid; CHEL; chelerythrine; DAG; diacylglycerol; DOR; delta-opioid receptors; MOR; μ-opioid receptors; NTI; naltrindole; OGD; oxygen-glucose deprivation; PKC; protein kinase C; PKCÎ
Fighting fire with fire: Poisonous Chinese herbal medicine for cancer therapy
Keywords: APL; acute promyelocytic leukemia; CDKs; cyclin-dependent kinases; CHM; Chinese herbal medicine; DDS; drug delivery systems; FcÉRI; Fc epsilon receptor I; HUVEC; human umbilical vascular endothelial cells; MAPKs; mitogen-activated protein kinases; MMP-2/
Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists
Keywords: BSA; bovine serum albumin; C; carboxyl; Cx; connexin; Cx43; connexin43; DG; deoxyglucose; ET; endothelin; ERK; extracellular signal-regulated kinase; G; GTP-binding protein; GJ; gap junction; GJIC; gap junctional intercellular communication; GPCR; GTP-bin
The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner
Keywords: AC; adenylyl cyclase; Bmax; maximal binding capacity; BSA; bovine serum albumin; β2-AR; β2-adrenergic receptor; CA; [3H]-cAMP formed; CT; cytoplasmic tail; DA; dopamine; DMSO; dimethyl sulfoxide; EL3; third extracellular loop; EC50; effective concentrat
Apoptosis Resistance and PKC Signaling: Distinguishing Features of High and Low Metastatic Cells
Keywords: PKC; protein kinase C; SCVM; single-cell videomicroscopy; PuMA; pulmonary metastasis assay; TUNEL; terminal transferase dUTP nick end labeling;
Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
Keywords: 7-KC; 7-ketocholesterol; AAA; abdominal aortic aneurysm; AICAR; 5â²-aminoimidazole-4-carboxamide ribonucleoside; AMPK; adenosine monophosphate-activated protein kinase; AngII; angiotensin II; ApoE; apolipoprotein E; BH4; 5,6,7,8-tetrahydrobiopterin; CaMK
The C-terminus of human Cav2.3 voltage-gated calcium channel interacts with alternatively spliced calmodulin-2 expressed in two human cell lines
Keywords: Cav2.3; ion conducting α1 subunit of E-type voltage-gated Ca2 + channel; CDF; Ca2 + dependent facilitation; CDI; Ca2 + dependent inactivation; FLAG; a fusion tag consisting of eight amino acids (DYKDDDDK) including an enterokinase-cleavage site; HVA;
Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes
Keywords: Insulin secretion; Glycerolipid/fatty acid cycle; Glucolipotoxicity; Lipogenesis; Lipolysis; ABHD6; α/β-domain containing hydrolase-6; ADRP; adipocyte differentiation-related protein; AGPAT; 1-acyl-sn-glycerol-3-phosphate acyltransferase; AMPK; AMP acti