Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer properties

► EF31 is a potent inhibitor of Iκβ kinase, NF-κB translocation, and NF-κB DNA-binding activity in RAW264.7 macrophages. ► EF31 blocks the expression of pro-inflammatory cytokine mRNA and protein. ► EF31 inhibits MAPK transcription factors. ► EF31 exhibits potent anti-cancer activity in various cancer cell lines.