Asymmetric packaging of polymerases within vesicular stomatitis virus
Keywords: پلیمراز; VSV; RdRP; Polymerase; PALM; STORM; AFM; L protein; P protein; Viral replication;
مقالات ISI پلیمراز (ترجمه نشده)
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HCV versus HIV drug discovery: Déjà vu all over again?
Keywords: پلیمراز; HIV; HCV; Antivirals; Clinical development; Combination therapy; Single tablet regimen; Protease; Integrase; Polymerase; NS3; NS5A; Nucleoside; Non-nucleoside; NNI; CCR5;
Stopped-flow DNA polymerase assay by continuous monitoring of dNTP incorporation by fluorescence
Keywords: پلیمراز; Activity assay; Polymerase; Stopped-flow; Intercalating dye;
Polymerase complex with lysine at position 627 of the PB2 of influenza virus A/Hong Kong/483/97 (H5N1) efficiently transcribes and replicates virus genes in mouse cells
Keywords: پلیمراز; PB2; H5N1; Influenza A virus; Polymerase;
Discrimination against major groove adducts by Y-family polymerases of the DinB subfamily
Keywords: پلیمراز; pol; polymerase; E. coli; Escherichia coli; S. solfataricus; Sulfolobus solfataricus; fdA; N6-furfuryl-dA; ÉdA; 1,N6-ethenodeoxyadenosine; Human DNA polymerase kappa; Sulfolobus solfataricus Dpo4; Escherichia coli DinB; etheno-dA; Translesion synthesis;
RNA dependent RNA polymerase of HCV: A potential target for the development of antiviral drugs
Keywords: پلیمراز; Hepatitis C virus; Inhibitors; Polymerase; Replication; Genotypes;
Evaluation of 2′-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase
Keywords: پلیمراز; Hepatitis C; HCV; Nucleosides; NS5b; Polymerase; HCV NS5b polymerase
Identification of a T7 RNA polymerase variant that permits the enzymatic synthesis of fully 2′-O-methyl-modified RNA
Keywords: پلیمراز; RNA; Polymerase; Modified nucleotide; Aptamer
Community analysis of ammonia-oxidizing Betaproteobacteria at different seasons in microbial-earthworm ecofilters
Keywords: پلیمراز; CWs, constructed wetlands; MEE, microbial-earthworm ecofilter; VF, vermifiltration; OM, organic matter; S1, topsoil; S2, mid-level soil; S3, subsoil; SD, silver sand; DE, detritus; KNH3-NKNH3-N, NH3-N degradation rate constantAmmonia nitrogen; Polymerase
Nuclear import of the influenza A virus transcriptional machinery
Keywords: پلیمراز; NLS; nuclear localisation signal; NP; nucleoprotein; NPC; nuclear pore complex; PA; acidic polymerase subunit; PB1; basic polymerase subunit 1; PB2; basic polymerase subunit 2; Pol II; DNA-dependent RNA polymerase II; RanBP5; Ran binding protein 5; RNP; r
Mutations to A/Puerto Rico/8/34 PB1 gene improves seasonal reassortant influenza A virus growth kinetics
Keywords: پلیمراز; Influenza; Vaccine; Polymerase; Protein yield;
Complexity of RNA polymerase II elongation dynamics
Keywords: پلیمراز; Transcription; Elongation; Single-molecule; Splicing; Imaging; Polymerase
Redesigning the leaving group in nucleic acid polymerization
Keywords: پلیمراز; 3-phosphono-l-Ala; 3-phosphono-l-alanine; ALG; alternative leaving groups; ADP; adenosine diphosphate; AMP; adenosine monophosphate; ATP; adenosine triphosphate; CoASH; coenzyme A; dCMP; deoxycytidine monophosphate; dGMP; deoxyguanosine monophosphate; DNA
Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase
Keywords: پلیمراز; Influenza A Virus; Polymerase; Endonuclease;
Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies
Keywords: پلیمراز; Influenza virus; Polymerase; Monoclonal antibody; Protein interactions
Inhibitory effect of common microfluidic materials on PCR outcome
Keywords: پلیمراز; RBI, relative band intensity; SAVR, surface-area-to-volume ratio; WRBI, weighted RBIBovine serum albumin (BSA); Microfluidics; PCR (polymerase chain reaction); PCR compatibility; Polymerase; Surface passivation
Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase
Keywords: پلیمراز; HCV; NS5B; Co-crystal; Structure; Antiviral; Inhibitor; Polymerase
The Synthesis and evaluation of a novel class of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid Hepatitis C virus polymerase NS5B inhibitors
Keywords: پلیمراز; Hepatitis; Polymerase; NS5B; Inhibitors; Pyrazoles
Identification of influenza virus inhibitors which disrupt of viral polymerase protein–protein interactions
Keywords: پلیمراز; Influenza; Polymerase; Antiviral; ELISA
Nuclear localization of influenza B polymerase proteins and their binary complexes
Keywords: پلیمراز; Influenza B virus; Polymerase; Nuclear localization;
Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy
Keywords: پلیمراز; Cytomegalovirus; Resistance; Polymerase; Mutation; Phenotyping
7-Alkyl-N2-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity
Keywords: پلیمراز; Synthesis; Deazaguanines; Antibacterial; Polymerase; Gram+
Dual pro-drugs of 2′-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus
Keywords: پلیمراز; HCV; ProTide; Phosphoramidate; Nucleoside; Nucleotide; Polymerase; NS5B
Discovery of novel HCV polymerase inhibitors using pharmacophore-based virtual screening
Keywords: پلیمراز; HCV; NS5B; Polymerase; Virtual screening; Molecular docking; Pharmacophore
From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: Indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons
Keywords: پلیمراز; Hepatitis C virus; Antiviral; HCV; NS5B; Polymerase; Inhibitor; SAR
Bypass of N2-ethylguanine by human DNA polymerase κ
Keywords: پلیمراز; BSA; bovine serum albumin; DNA pol ι; DNA polymerase ι; N2-ethyl-Gua; N2-ethylguanine; pol; polymerase; Y-family DNA polymerase; Translesion synthesis; Alkylation DNA damage; Metal ion activation; Rapid kinetic analysis; DNA polymerase κ;
Kinetic mechanism of the ssDNA recognition by the polymerase X from African Swine Fever Virus. Dynamics and energetics of intermediate formations
Keywords: پلیمراز; ASFV; African Swine Fever Virus; DTT; dithiothreitol; ssDNA; single-stranded DNA; dsDNA; double-stranded DNA; εA; etheno-adenosine; CP; 7-Diethylamino-3-(4â²-maleimidylphenyl)-4-methylcoumarin; FRET; fluorescence resonance energy transfer; Polymerase; D
Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors
Keywords: پلیمراز; Hepatitis C; HCV; NS5B; Polymerase; Benzothiadiazine; Benzothiazine; Benzoisothiazole; Tetramic acid; Review;
Different Requirements for σ Region 4 in BvgA Activation of the Bordetella pertussis Promoters Pfim3 and PfhaB
Keywords: پلیمراز; BvgA; fim; sigma; polymerase; promoterCTD, C-terminal domain; RNAP, RNA polymerase; wt, wild type; PDB, Protein Data Bank; BG, Bordet–Gengou; MCS, multi-cloning site; EDTA, ethylenediaminetetraacetic acid; GTP, guanosine triphosphate; TBE, Tris/borate/EDT
Molecular Dynamics Simulations of Viral RNA Polymerases Link Conserved and Correlated Motions of Functional Elements to Fidelity
Keywords: پلیمراز; MD simulation; polymerase; poliovirus; conformational change; fidelityPV, poliovirus; CVB3, coxsackievirus B3; HRV16, human rhinovirus type 16; FMDV, foot-and-mouth disease virus; RdRp, RNA-dependent RNA polymerase; NTP, nucleoside triphosphate; MD, molec
Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus
Keywords: پلیمراز; HCV; ProTide; Phosphoramidate; Nucleoside; Nucleotide; Antiviral pro-drug; Polymerase; NS5B
Proximity between the cap and 5′ ε stem–loop structure is critical for the suppression of pgRNA translation by the hepatitis B viral polymerase
Keywords: پلیمراز; Hepatitis B virus; Polymerase; Translation; Encapsidation
Single-molecule analysis of the Escherichia coli replisome and use of clamps to bypass replication barriers
Keywords: پلیمراز; Single-molecule; Replisome; Replication barrier; Trombone model; Lagging strand; Polymerase; Helicase
Mechanism and evolution of DNA primases
Keywords: پلیمراز; Primase; Polymerase; NTP; dNTP; Mechanism; Inhibition; Counting; Fidelity; Misincorporation; Initiation
Research ArticleQuantitative assessment of the antiviral potencies of 21 shRNA vectors targeting conserved, including structured, hepatitis B virus sites
Keywords: پلیمراز; RNAi; RNA interference; siRNA; small interfering RNA; shRNA; small-hairpin RNA; RISC; RNA-induced silencing complex; HBV; hepatitis B virus; IFN; interferon; sgRNA; subgenomic RNA; HBeAg; hepatitis B virus e antigen; pgRNA; pregenomic RNA; PCR; polymerase
Hepatitis B Virology for Clinicians
Keywords: پلیمراز; Hepatitis B virus; Polymerase; Antiviral Therapy; cccDNA;
Single-molecule studies of DNA replisome function
Keywords: پلیمراز; DNA replication; Polymerase; Replisome; Single-molecule kinetics
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: Structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides
Keywords: پلیمراز; HCV; Polymerase; NS5B; Diels–Alder; DMPK
Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase
Keywords: پلیمراز; Hepatitis C virus; Polymerase; Pyrazolopyrimidin-ones; Anti-viral agents
A sensitive direct sequencing assay based on nested PCR for the detection of HBV polymerase and surface glycoprotein mutations
Keywords: پلیمراز; HBV; Mutations; Polymerase; Direct sequencing; Antiviral resistance; Nested PCR
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase
Keywords: پلیمراز; Hepatitis C virus; HCV; Polymerase; Benzodiazepine
Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors
Keywords: پلیمراز; HCV; NS5b; Polymerase; Inhibitor; Non-nucleoside; Replicon; 1,4-Benzothiazine; Computational; gamess; Conformation; Anion
3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase
Keywords: پلیمراز; HCV; NS5b; rdrp; Gamess; Polymerase; Hepatitis; Inhibitor; Non-nucleoside; Palm; Isoquinoline; 3-Hydroxyisoquinoline; Replicon; Dioxo-benzoisothiazole; Negishi; Suzuki; 2-Aminobenzenesulfonamide; N-tert-Butyl-2-chlorobenzene-sulfonamide; 3-Carbomethoxy-1,
Singly labeled smart probes for real-time monitoring of the kinetics of dNTP misincorporation and single nucleotide extension in DNA intra-molecular polymerization
Keywords: پلیمراز; Singly labeled smart probe; Polymerase; Klenow fragment; Misincorporation; Single nucleotide extension
Caractéristiques des souches virales responsables d’hépatites B chroniques en Algérie du Nord-Est
Keywords: پلیمراز; Virus de l’hépatite B; Génotype; Mutants précore; Polymérase; PhylogénieHepatitis B virus; Genotype; Precore mutants; Polymerase; Phylogeny
The Ebola virus ribonucleoprotein complex: A novel VP30–L interaction identified
Keywords: پلیمراز; Ebola virus; Polymerase; VP30; Protein–protein interaction; Ribonucleoprotein complex
δ-Di-carboxybutyl phosphoramidate of 2′-deoxycytidine-5′-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase
Keywords: پلیمراز; Polymerase; Modified nucleotide; Nucleotide analog; Phosphoramidate; HIV
New tools to study RNA interference to fish viruses: Fish cell lines permanently expressing siRNAs targeting the viral polymerase of viral hemorrhagic septicemia virus
Keywords: پلیمراز; siRNA; VHSV; Polymerase; Fish cell lines; EPC; Hairpin
Consensus nested PCR amplification and sequencing of diverse reptilian, avian, and mammalian orthoreoviruses
Keywords: پلیمراز; Reovirus; Orthoreovirus; Reptiles; Birds; Reptilian orthoreovirus; Nelson Bay virus; Consensus PCR; Polymerase
Self-guanylylation of birnavirus VP1 does not require an intact polymerase activity site
Keywords: پلیمراز; IBDV; Birnavirus; VP1; Protein priming; Polymerase; Guanylylation; RDRP