3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase

Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure–activity relationships are detailed, along with enzyme and cellular activity.

New isoquinoline-based non-nucleoside inhibitors (2, 3) of HCV NS5b RNA-dependent RNA-polymerase are described. Their syntheses and structure–activity relationships are detailed, along with enzyme and cellular activities.Figure optionsDownload as PowerPoint slide